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ONTOLOGY REPORT - ANNOTATIONS

Term:cardiac epithelial to mesenchymal transition
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Accession:GO:0060317 term browser browse the term
Definition:A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
Synonyms:exact_synonym: heart epithelial to mesenchymal transition


show annotations for term's descendants           Sort by:
cardiac epithelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam15 ADAM metallopeptidase domain 15 acts_upstream_of_or_within ISO
IEA		 (PMID:19156209)
GO_REF:0000107		 RGD
Ensembl		 PMID:19156209 GO_REF:0000107 NCBI chr 2:177,052,363...177,062,879
Ensembl chr 2:174,754,633...174,765,113 		JBrowse link
G Bmp2 bone morphogenetic protein 2 involved_in ISO
IEA		 (PMID:18184661)
GO_REF:0000107		 RGD
Ensembl		 PMID:18184661 GO_REF:0000107 NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 involved_in ISO UniProtKB:Q9DBX7 (PMID:17303760) RGD PMID:17303760 NCBI chr 2:95,003,935...95,006,457
Ensembl chr 2:93,095,498...93,100,312 		JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 involved_in ISO
IEA		 (PMID:17303760)
GO_REF:0000107		 RGD
Ensembl		 PMID:17303760 GO_REF:0000107 NCBI chr 1:28,641,100...28,651,187
Ensembl chr 1:26,822,131...26,832,218 		JBrowse link
G Heyl hes-related family bHLH transcription factor with YRPW motif-like involved_in ISO
IEA		 UniProtKB:Q9WV93 (PMID:17303760)
GO_REF:0000107		 RGD
Ensembl		 PMID:17303760 GO_REF:0000107 NCBI chr 5:140,793,271...140,810,262
Ensembl chr 5:135,508,160...135,525,152 		JBrowse link
G Notch1 notch receptor 1 involved_in ISO
IEA		 (PMID:17303760)
GO_REF:0000107		 RGD
Ensembl		 PMID:17303760 GO_REF:0000107 NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Olfm1 olfactomedin 1 involved_in ISS GO_REF:0000024 AgBase GO_REF:0000024 NCBI chr 3:31,918,512...31,956,261
Ensembl chr 3:11,520,729...11,558,239 		JBrowse link
G Rtn4 reticulon 4 acts_upstream_of_or_within ISO
IEA		 (PMID:19156209)
GO_REF:0000107		 RGD
Ensembl		 PMID:19156209 GO_REF:0000107 NCBI chr14:107,651,001...107,698,610
Ensembl chr14:103,449,930...103,497,686 		JBrowse link
G Tbx3 T-box transcription factor 3 involved_in ISO
IEA		 (PMID:22130515)
GO_REF:0000107		 RGD
Ensembl		 PMID:22130515 GO_REF:0000107 NCBI chr12:42,540,378...42,555,490
Ensembl chr12:36,881,445...36,893,708 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:10092230)		 UniProt
Ensembl
RGD		 PMID:10092230 GO_REF:0000024 GO_REF:0000107 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 involved_in ISS GO_REF:0000024 AgBase GO_REF:0000024 NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 involved_in ISO
IEA		 (PMID:18184661)
GO_REF:0000107		 RGD
Ensembl		 PMID:18184661 GO_REF:0000107 NCBI chr14:2,634,294...2,810,269
Ensembl chr14:2,489,397...2,663,341 		JBrowse link
G Wnt16 Wnt family member 16 acts_upstream_of_or_within ISO
IEA		 (PMID:19156209)
GO_REF:0000107		 RGD
Ensembl		 PMID:19156209 GO_REF:0000107 NCBI chr 4:51,786,728...51,797,137
Ensembl chr 4:50,820,968...50,831,380 		JBrowse link
G Wnt2 Wnt family member 2 acts_upstream_of_or_within ISO MGI:4361155 (PMID:20159597) RGD PMID:20159597 NCBI chr 4:47,294,300...47,340,284
Ensembl chr 4:46,333,998...46,374,402 		JBrowse link
endocardial cushion to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvrl1 activin A receptor like type 1 NOT|involved_in ISO (PMID:12941632) RGD PMID:12941632 NCBI chr 7:134,117,917...134,135,306
Ensembl chr 7:132,239,729...132,256,591 		JBrowse link
G Eng endoglin NOT|involved_in ISO (PMID:12941632) RGD PMID:12941632 NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:15,934,518...15,973,230 		JBrowse link
G Has2 hyaluronan synthase 2 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:10930438)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:10930438 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:90,002,929...90,028,933
Ensembl chr 7:88,113,326...88,128,933 		JBrowse link
endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Efna1 ephrin A1 involved_in ISO (PMID:20960543) RGD PMID:20960543 NCBI chr 2:176,979,434...176,988,675
Ensembl chr 2:174,681,682...174,690,866 		JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 acts_upstream_of_or_within ISO MGI:1341884 (PMID:15680351) RGD PMID:15680351 NCBI chr 2:95,003,935...95,006,457
Ensembl chr 2:93,095,498...93,100,312 		JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 acts_upstream_of_or_within ISO
IEA		 MGI:1341800 (PMID:15680351)
GO_REF:0000107		 RGD
Ensembl		 PMID:15680351 GO_REF:0000107 NCBI chr 1:28,641,100...28,651,187
Ensembl chr 1:26,822,131...26,832,218 		JBrowse link
epithelial to mesenchymal transition involved in cardiac fibroblast development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir21 microRNA 21 involved_in ISO (PMID:23441172) RGD PMID:23441172 NCBI chr10:71,902,600...71,902,691
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Pdcd4 programmed cell death 4 involved_in IGI PMID:23441172 BHF-UCL PMID:23441172 RGD:10400865 NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:252,921,392...252,944,275 		JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 involved_in IGI PMID:23441172 BHF-UCL PMID:23441172 RGD:10400865 NCBI chr 2:122,484,995...122,490,008
Ensembl chr 2:120,556,706...120,566,189 		JBrowse link
epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 NOT|involved_in ISO (PMID:18924235) RGD PMID:18924235 NCBI chr15:22,098,191...22,113,145
Ensembl chr15:19,618,542...19,623,306 		JBrowse link
G Eng endoglin involved_in ISO (PMID:19703439) RGD PMID:19703439 NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:15,934,518...15,973,230 		JBrowse link
G Fgf8 fibroblast growth factor 8 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:21364285)
GO_REF:0000107
(PMID:19509466)		 RGD
Ensembl		 PMID:19509466 PMID:21364285 GO_REF:0000107 NCBI chr 1:254,533,504...254,539,605
Ensembl chr 1:244,584,652...244,590,359 		JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 acts_upstream_of_or_within ISO MGI:1860511 (PMID:17303760) RGD PMID:17303760 NCBI chr 2:95,003,935...95,006,457
Ensembl chr 2:93,095,498...93,100,312 		JBrowse link
G Heyl hes-related family bHLH transcription factor with YRPW motif-like acts_upstream_of_or_within ISO
IEA		 MGI:1341800 (PMID:17303760)
GO_REF:0000107		 RGD
Ensembl		 PMID:17303760 GO_REF:0000107 NCBI chr 5:140,793,271...140,810,262
Ensembl chr 5:135,508,160...135,525,152 		JBrowse link
G Msx1 msh homeobox 1 acts_upstream_of_or_within ISO MGI:97169 (PMID:18667074) RGD PMID:18667074 NCBI chr14:77,185,802...77,189,735
Ensembl chr14:72,961,148...72,964,966 		JBrowse link
G Msx2 msh homeobox 2 acts_upstream_of_or_within ISO
IEA		 MGI:97168 (PMID:18667074)
GO_REF:0000107		 RGD
Ensembl		 PMID:18667074 GO_REF:0000107 NCBI chr17:11,102,284...11,107,949
Ensembl chr17:11,097,103...11,102,879 		JBrowse link
G Notch1 notch receptor 1 involved_in ISO
IEA		 (PMID:14701881)
GO_REF:0000107		 RGD
Ensembl		 PMID:14701881 GO_REF:0000107 NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region involved_in ISO (PMID:14701881) RGD PMID:14701881 NCBI chr14:61,551,366...61,736,220
Ensembl chr14:57,338,507...57,523,353 		JBrowse link
G Smad4 SMAD family member 4 involved_in IEA
ISO		 GO_REF:0000107
(PMID:21330551)		 Ensembl
RGD		 PMID:21330551 GO_REF:0000107 NCBI chr18:69,518,988...69,549,684
Ensembl chr18:67,243,742...67,274,438 		JBrowse link
G Snai1 snail family transcriptional repressor 1 involved_in ISO
IEA		 UniProtKB:Q3UZ96 (PMID:18663143)
GO_REF:0000107		 RGD
Ensembl		 PMID:18663143 GO_REF:0000107 NCBI chr 3:176,667,476...176,671,965
Ensembl chr 3:156,248,485...156,252,969 		JBrowse link
G Snai2 snail family transcriptional repressor 2 acts_upstream_of_or_within
involved_in		 ISO MGI:2447175 (PMID:18663143) RGD PMID:18663143 NCBI chr11:99,686,934...99,690,349
Ensembl chr11:86,181,909...86,186,200 		JBrowse link
G Tmem100 transmembrane protein 100 acts_upstream_of_or_within ISO
IEA		 MGI:5432904 (PMID:25318679)
GO_REF:0000107		 RGD
Ensembl		 PMID:25318679 GO_REF:0000107 NCBI chr10:75,351,891...75,357,748
Ensembl chr10:74,854,468...74,862,941 		JBrowse link
negative regulation of cardiac epithelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir19a microRNA 19a acts_upstream_of ISO (PMID:27098600) RGD PMID:27098600 NCBI chr15:98,588,131...98,588,212
Ensembl chr15:92,180,912...92,180,993 		JBrowse link
G Mir19b1 microRNA 19b-1 acts_upstream_of ISO (PMID:27098600) RGD PMID:27098600 NCBI chr15:98,588,433...98,588,519
Ensembl chr15:92,181,214...92,181,300 		JBrowse link
G Mir19b2 microRNA 19b-2 acts_upstream_of ISO (PMID:27098600) RGD PMID:27098600 NCBI chr  X:137,343,058...137,343,153
Ensembl chr  X:132,422,072...132,422,167 		JBrowse link
G Nog noggin involved_in IEA
ISO		 GO_REF:0000107
(PMID:17218603)		 Ensembl
RGD		 PMID:17218603 GO_REF:0000107 NCBI chr10:74,625,874...74,627,501
Ensembl chr10:74,128,712...74,130,339 		JBrowse link
negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfb2 transforming growth factor, beta 2 involved_in ISO
IEA		 (PMID:19161227)
GO_REF:0000107		 RGD
Ensembl		 PMID:19161227 GO_REF:0000107 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
positive regulation of cardiac epithelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 involved_in ISO
IEA		 (PMID:16140292)
GO_REF:0000107		 RGD
Ensembl		 PMID:16140292 GO_REF:0000107 NCBI chr 3:63,387,378...63,506,980
Ensembl chr 3:42,978,561...43,098,241 		JBrowse link
G Emp2 epithelial membrane protein 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:30773261)		 UniProt
RGD		 PMID:30773261 GO_REF:0000024 NCBI chr10:5,866,869...5,901,533
Ensembl chr10:5,360,073...5,394,733 		JBrowse link
G Jag1 jagged canonical Notch ligand 1 involved_in IGI PMID:20951801 BHF-UCL PMID:20951801 RGD:13601997 NCBI chr 3:144,859,453...144,894,883
Ensembl chr 3:124,406,794...124,442,209 		JBrowse link
G Notch1 notch receptor 1 involved_in IGI PMID:20951801 BHF-UCL PMID:20951801 RGD:13601997 NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISO
IEA		 (PMID:22186728)
GO_REF:0000107		 RGD
Ensembl		 PMID:22186728 GO_REF:0000107 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Twist1 twist family bHLH transcription factor 1 involved_in ISO (PMID:20804746) RGD PMID:20804746 NCBI chr 6:56,402,309...56,404,303
Ensembl chr 6:50,674,678...50,677,653 		JBrowse link
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eng endoglin involved_in ISO (PMID:19703439) RGD PMID:19703439 NCBI chr 3:36,332,190...36,370,324
Ensembl chr 3:15,934,518...15,973,230 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISO
IEA		 (PMID:19161227)
GO_REF:0000107		 RGD
Ensembl		 PMID:19161227 GO_REF:0000107 NCBI chr13:100,691,540...100,793,227
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 involved_in IEA
ISO		 GO_REF:0000107
(PMID:18718461)		 Ensembl
RGD		 PMID:18718461 GO_REF:0000107 NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 involved_in ISO
IEA		 (PMID:17050629)
GO_REF:0000107		 RGD
Ensembl		 PMID:17050629 GO_REF:0000107 NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:115,794,537...115,883,228 		JBrowse link
regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfb1 transforming growth factor, beta 1 NOT|involved_in ISO (PMID:19161227) RGD PMID:19161227 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfb3 transforming growth factor, beta 3 NOT|involved_in ISO (PMID:19161227) RGD PMID:19161227 NCBI chr 6:111,435,170...111,457,646
Ensembl chr 6:105,704,236...105,726,564 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20558
    developmental process 7149
      anatomical structure morphogenesis 3017
        animal organ morphogenesis 1174
          heart morphogenesis 299
            cardiac epithelial to mesenchymal transition 41
              endocardial cushion to mesenchymal transition + 7
              epithelial to mesenchymal transition involved in cardiac fibroblast development 3
              epithelial to mesenchymal transition involved in coronary vasculature morphogenesis 0
              epithelial to mesenchymal transition involved in endocardial cushion formation + 18
              negative regulation of cardiac epithelial to mesenchymal transition + 5
              positive regulation of cardiac epithelial to mesenchymal transition + 9
              regulation of cardiac epithelial to mesenchymal transition + 15
Path 2
Term Annotations click to browse term
  biological_process 20558
    developmental process 7149
      anatomical structure development 6646
        multicellular organism development 5353
          system development 4635
            circulatory system development 1387
              heart development 750
                heart morphogenesis 299
                  cardiac epithelial to mesenchymal transition 41
                    endocardial cushion to mesenchymal transition + 7
                    epithelial to mesenchymal transition involved in cardiac fibroblast development 3
                    epithelial to mesenchymal transition involved in coronary vasculature morphogenesis 0
                    epithelial to mesenchymal transition involved in endocardial cushion formation + 18
                    negative regulation of cardiac epithelial to mesenchymal transition + 5
                    positive regulation of cardiac epithelial to mesenchymal transition + 9
                    regulation of cardiac epithelial to mesenchymal transition + 15
paths to the root