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ONTOLOGY REPORT - ANNOTATIONS


Term:cardiac epithelial to mesenchymal transition
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Accession:GO:0060317 term browser browse the term
Definition:A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.
Synonyms:exact_synonym: heart epithelial to mesenchymal transition



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cardiac epithelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam15 ADAM metallopeptidase domain 15 acts_upstream_of_or_within ISO (MGI:4458867|PMID:19156209) RGD PMID:19156209 MGI:4458867 NCBI chr 2:174,754,631...174,765,136
Ensembl chr 2:174,754,633...174,765,113
JBrowse link
G Bmp2 bone morphogenetic protein 2 involved_in ISO
IEA
(PMID:18184661)
GO_REF:0000107
RGD
Ensembl
PMID:18184661 GO_REF:0000107 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 involved_in ISO UniProtKB:Q9DBX7 (MGI:3783952|PMID:17303760) RGD PMID:17303760 MGI:3783952 NCBI chr 2:93,096,706...93,100,316
Ensembl chr 2:93,095,498...93,100,312
JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 involved_in ISO (MGI:3783952|PMID:17303760) RGD PMID:17303760 MGI:3783952 NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218
JBrowse link
G Heyl hes-related family bHLH transcription factor with YRPW motif-like involved_in ISO UniProtKB:Q9WV93 (MGI:3783952|PMID:17303760) RGD PMID:17303760 MGI:3783952 NCBI chr 5:135,508,160...135,525,152
Ensembl chr 5:135,508,160...135,525,152
JBrowse link
G Notch1 notch receptor 1 involved_in ISO (MGI:3783952|PMID:17303760) RGD PMID:17303760 MGI:3783952 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Olfm1 olfactomedin 1 involved_in ISS GO_REF:0000024 AgBase GO_REF:0000024 NCBI chr 3:11,520,522...11,558,240
Ensembl chr 3:11,520,729...11,558,239
JBrowse link
G Rtn4 reticulon 4 acts_upstream_of_or_within ISO (MGI:4458867|PMID:19156209) RGD PMID:19156209 MGI:4458867 NCBI chr14:103,450,074...103,497,687
Ensembl chr14:103,449,930...103,497,686
JBrowse link
G Tbx3 T-box transcription factor 3 involved_in ISO (PMID:22130515) RGD PMID:22130515 NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708
JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISS
ISO
GO_REF:0000024
(PMID:10092230)
AgBase
RGD
PMID:10092230 GO_REF:0000024 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 involved_in ISS GO_REF:0000024 AgBase GO_REF:0000024 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 involved_in ISO (PMID:18184661) RGD PMID:18184661 NCBI chr14:2,489,397...2,665,383
Ensembl chr14:2,489,397...2,663,341
JBrowse link
G Wnt16 Wnt family member 16 acts_upstream_of_or_within ISO (MGI:4458867|PMID:19156209) RGD PMID:19156209 MGI:4458867 NCBI chr 4:50,820,968...50,831,380
Ensembl chr 4:50,820,968...50,831,380
JBrowse link
G Wnt2 Wnt family member 2 acts_upstream_of_or_within ISO MGI:4361155 (MGI:4439199|PMID:20159597) RGD PMID:20159597 MGI:4439199 NCBI chr 4:46,328,408...46,374,673
Ensembl chr 4:46,333,998...46,374,402
JBrowse link
endocardial cushion to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvrl1 activin A receptor like type 1 NOT|involved_in ISO (MGI:2674189|PMID:12941632) RGD PMID:12941632 MGI:2674189 NCBI chr 7:132,239,200...132,256,592
Ensembl chr 7:132,239,729...132,256,591
JBrowse link
G Eng endoglin NOT|involved_in ISO (MGI:2674189|PMID:12941632) RGD PMID:12941632 MGI:2674189 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
JBrowse link
G Has2 hyaluronan synthase 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:1861536|PMID:10930438)
UniProt
RGD
PMID:10930438 GO_REF:0000024 MGI:1861536 NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933
JBrowse link
endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Efna1 ephrin A1 involved_in ISO (MGI:4847981|PMID:20960543) RGD PMID:20960543 MGI:4847981 NCBI chr 2:174,681,676...174,690,306
Ensembl chr 2:174,681,682...174,690,866
JBrowse link
G Erg ETS transcription factor ERG acts_upstream_of_or_within ISO MGI:5443838 (MGI:5442628|PMID:22932696) RGD PMID:22932696 MGI:5442628 NCBI chr11:34,678,614...34,900,951
Ensembl chr11:34,678,618...34,845,871
JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 acts_upstream_of_or_within ISO MGI:1341884 (MGI:3530185|PMID:15680351) RGD PMID:15680351 MGI:3530185 NCBI chr 2:93,096,706...93,100,316
Ensembl chr 2:93,095,498...93,100,312
JBrowse link
G Hey2 hes-related family bHLH transcription factor with YRPW motif 2 acts_upstream_of_or_within ISO MGI:1341800 (MGI:3530185|PMID:15680351) RGD PMID:15680351 MGI:3530185 NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218
JBrowse link
epithelial to mesenchymal transition involved in cardiac fibroblast development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir21 microRNA 21 involved_in ISO (PMID:23441172) RGD PMID:23441172 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348
JBrowse link
G Pdcd4 programmed cell death 4 involved_in IGI PMID:23441172 BHF-UCL PMID:23441172 RGD:10400865 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
JBrowse link
G Spry1 sprouty RTK signaling antagonist 1 involved_in IGI PMID:23441172 BHF-UCL PMID:23441172 RGD:10400865 NCBI chr 2:120,557,276...120,561,918
Ensembl chr 2:120,556,706...120,566,189
JBrowse link
epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp4 bone morphogenetic protein 4 NOT|involved_in ISO (MGI:3814273|PMID:18924235) RGD PMID:18924235 MGI:3814273 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Eng endoglin involved_in ISO (MGI:4368063|PMID:19703439) RGD PMID:19703439 MGI:4368063 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
JBrowse link
G Fgf8 fibroblast growth factor 8 involved_in
acts_upstream_of_or_within
ISO (MGI:4359139|PMID:19509466)
(MGI:5002778|PMID:21364285)
RGD PMID:19509466 PMID:21364285 MGI:4359139 MGI:5002778 NCBI chr 1:244,584,477...244,590,359
Ensembl chr 1:244,584,652...244,590,359
JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 acts_upstream_of_or_within ISO MGI:1860511 (MGI:3783952|PMID:17303760) RGD PMID:17303760 MGI:3783952 NCBI chr 2:93,096,706...93,100,316
Ensembl chr 2:93,095,498...93,100,312
JBrowse link
G Heyl hes-related family bHLH transcription factor with YRPW motif-like acts_upstream_of_or_within ISO MGI:1341800 (MGI:3783952|PMID:17303760) RGD PMID:17303760 MGI:3783952 NCBI chr 5:135,508,160...135,525,152
Ensembl chr 5:135,508,160...135,525,152
JBrowse link
G Msx1 msh homeobox 1 acts_upstream_of_or_within ISO MGI:97169 (MGI:3810851|PMID:18667074) RGD PMID:18667074 MGI:3810851 NCBI chr14:72,961,170...72,964,970
Ensembl chr14:72,961,148...72,964,966
JBrowse link
G Msx2 msh homeobox 2 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:97168 (MGI:3810851|PMID:18667074)
Ensembl
RGD
PMID:18667074 GO_REF:0000107 MGI:3810851 NCBI chr17:11,097,214...11,102,879
Ensembl chr17:11,097,103...11,102,879
JBrowse link
G Notch1 notch receptor 1 involved_in ISO (MGI:3027664|PMID:14701881) RGD PMID:14701881 MGI:3027664 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region involved_in ISO (MGI:3027664|PMID:14701881) RGD PMID:14701881 MGI:3027664 NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353
JBrowse link
G Smad4 SMAD family member 4 involved_in IEA
ISO
GO_REF:0000107
(MGI:4946551|PMID:21330551)
Ensembl
RGD
PMID:21330551 GO_REF:0000107 MGI:4946551 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
JBrowse link
G Snai1 snail family transcriptional repressor 1 involved_in ISO UniProtKB:Q3UZ96 (MGI:3808643|PMID:18663143) RGD PMID:18663143 MGI:3808643 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Snai2 snail family transcriptional repressor 2 acts_upstream_of_or_within ISO MGI:2447175 (MGI:3808643|PMID:18663143) RGD PMID:18663143 MGI:3808643 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Tmem100 transmembrane protein 100 acts_upstream_of_or_within ISO MGI:5432904 (MGI:5613881|PMID:25318679) RGD PMID:25318679 MGI:5613881 NCBI chr10:74,854,779...74,861,147
Ensembl chr10:74,854,468...74,862,941
JBrowse link
negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nog noggin involved_in IEA
ISO
GO_REF:0000107
(MGI:3783944|PMID:17218603)
Ensembl
RGD
PMID:17218603 GO_REF:0000107 MGI:3783944 NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339
JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISO (MGI:3830400|PMID:19161227) RGD PMID:19161227 MGI:3830400 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
positive regulation of cardiac epithelial to mesenchymal transition term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Emp2 epithelial membrane protein 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:6443292|PMID:30773261)
UniProt
RGD
PMID:30773261 GO_REF:0000024 MGI:6443292 NCBI chr10:5,360,073...5,394,734
Ensembl chr10:5,360,073...5,394,733
JBrowse link
G Jag1 jagged canonical Notch ligand 1 involved_in IGI PMID:20951801 BHF-UCL PMID:20951801 RGD:13601997 NCBI chr 3:124,406,794...124,442,220
Ensembl chr 3:124,406,794...124,442,209
JBrowse link
G Notch1 notch receptor 1 involved_in IGI PMID:20951801 BHF-UCL PMID:20951801 RGD:13601997 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISO (MGI:5300829|PMID:22186728) RGD PMID:22186728 MGI:5300829 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Twist1 twist family bHLH transcription factor 1 involved_in ISO (MGI:4838344|PMID:20804746) RGD PMID:20804746 MGI:4838344 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
JBrowse link
positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvr1 activin A receptor type 1 involved_in ISO (MGI:3610266|PMID:16140292) RGD PMID:16140292 MGI:3610266 NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241
JBrowse link
G Eng endoglin involved_in ISO (MGI:4368063|PMID:19703439) RGD PMID:19703439 MGI:4368063 NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
JBrowse link
G Tgfb2 transforming growth factor, beta 2 involved_in ISO (MGI:3830400|PMID:19161227) RGD PMID:19161227 MGI:3830400 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 involved_in ISO (MGI:3820811|PMID:18718461) RGD PMID:18718461 MGI:3820811 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 involved_in ISO (MGI:3801267|PMID:17050629) RGD PMID:17050629 MGI:3801267 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
regulation of epithelial to mesenchymal transition involved in endocardial cushion formation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tgfb1 transforming growth factor, beta 1 NOT|involved_in ISO (MGI:3830400|PMID:19161227) RGD PMID:19161227 MGI:3830400 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb3 transforming growth factor, beta 3 NOT|involved_in ISO (MGI:3830400|PMID:19161227) RGD PMID:19161227 MGI:3830400 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18737
    developmental process 6897
      anatomical structure morphogenesis 2987
        animal organ morphogenesis 1182
          heart morphogenesis 288
            cardiac epithelial to mesenchymal transition 39
              endocardial cushion to mesenchymal transition + 8
              epithelial to mesenchymal transition involved in cardiac fibroblast development 3
              epithelial to mesenchymal transition involved in coronary vasculature morphogenesis 0
              epithelial to mesenchymal transition involved in endocardial cushion formation + 20
              negative regulation of cardiac epithelial to mesenchymal transition + 2
              positive regulation of cardiac epithelial to mesenchymal transition + 9
              regulation of cardiac epithelial to mesenchymal transition + 12
Path 2
Term Annotations click to browse term
  biological_process 18737
    developmental process 6897
      anatomical structure development 6372
        multicellular organism development 5440
          system development 4941
            circulatory system development 1324
              heart development 716
                heart morphogenesis 288
                  cardiac epithelial to mesenchymal transition 39
                    endocardial cushion to mesenchymal transition + 8
                    epithelial to mesenchymal transition involved in cardiac fibroblast development 3
                    epithelial to mesenchymal transition involved in coronary vasculature morphogenesis 0
                    epithelial to mesenchymal transition involved in endocardial cushion formation + 20
                    negative regulation of cardiac epithelial to mesenchymal transition + 2
                    positive regulation of cardiac epithelial to mesenchymal transition + 9
                    regulation of cardiac epithelial to mesenchymal transition + 12
paths to the root