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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of ryanodine-sensitive calcium-release channel activity
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Accession:GO:0060315 term browser browse the term
Definition:Any process that decreases the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.


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negative regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calm2 calmodulin 2 ISO (PMID:26164367) UniProtKB PMID:26164367 NCBI chrNW_004936508:5,207,909...5,223,780 JBrowse link
G Calm3 calmodulin 3 ISO (PMID:26164367) UniProtKB PMID:26164367 NCBI chrNW_004936664:471,446...480,858 JBrowse link
G Casq2 calsequestrin 2 ISO PMID:17569730
(PMID:16601229)
(PMID:15041652)
BHF-UCL PMID:15041652, PMID:16601229, PMID:17569730 RGD:2314601 NCBI chrNW_004936627:1,001,681...1,069,377 JBrowse link
G Clic2 chloride intracellular channel 2 ISO (PMID:15147738), (PMID:15916532) BHF-UCL PMID:15147738, PMID:15916532 NCBI chrNW_004936927:514,989...543,691 JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A NOT ISO (PMID:12443530) BHF-UCL PMID:12443530 NCBI chrNW_004936485:17,305,376...17,311,797 JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B ISO (PMID:12443530) BHF-UCL PMID:12443530 NCBI chrNW_004936493:7,916,002...7,922,747 JBrowse link
G Gsto1 glutathione S-transferase omega 1 ISO (PMID:11035031) BHF-UCL PMID:11035031 NCBI chrNW_004936600:1,932,152...1,943,342 JBrowse link
G LOC101967074 calmodulin ISO (PMID:26164367) UniProtKB PMID:26164367 NCBI chrNW_004936488:17,580,425...17,588,480 JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel ISO (MGI:MGI:3708075|PMID:17404231) MGI PMID:17404231 MGI:MGI:3708075 NCBI chrNW_004936905:76,781...128,995 JBrowse link
G Sri sorcin ISO (PMID:17699613) BHF-UCL PMID:17699613 NCBI chrNW_004936763:715,884...728,548 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12001
    cellular process 11174
      negative regulation of cellular process 4248
        negative regulation of calcium ion transport into cytosol 18
          negative regulation of release of sequestered calcium ion into cytosol 15
            negative regulation of ryanodine-sensitive calcium-release channel activity 10
Path 2
Term Annotations click to browse term
  biological_process 12001
    biological regulation 8793
      regulation of biological quality 3394
        homeostatic process 1727
          chemical homeostasis 1063
            ion homeostasis 692
              cellular ion homeostasis 548
                cellular cation homeostasis 536
                  cellular metal ion homeostasis 488
                    cellular calcium ion homeostasis 399
                      regulation of cytosolic calcium ion concentration 307
                        positive regulation of cytosolic calcium ion concentration 270
                          calcium ion transport into cytosol 156
                            calcium ion transmembrane import into cytosol 133
                              release of sequestered calcium ion into cytosol 108
                                regulation of release of sequestered calcium ion into cytosol 80
                                  negative regulation of release of sequestered calcium ion into cytosol 15
                                    negative regulation of ryanodine-sensitive calcium-release channel activity 10
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.