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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of ryanodine-sensitive calcium-release channel activity
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Accession:GO:0060314 term browser browse the term
Definition:Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.


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regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calm2 calmodulin 2 ISO (PMID:22067155) UniProtKB
RGD
PMID:15628869, PMID:22067155 RGD:7241270 NCBI chrNW_004936508:5,207,909...5,223,780 JBrowse link
G Calm3 calmodulin 3 ISO (PMID:22067155) UniProtKB
RGD
PMID:15628869, PMID:22067155 RGD:7241270 NCBI chrNW_004936664:471,446...480,858 JBrowse link
G Dmd dystrophin ISO (MGI:MGI:4420848|PMID:20080623) BHF-UCL PMID:20080623 MGI:MGI:4420848 NCBI chrNW_004936553:7,157,526...7,943,703 JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A ISO (PMID:7592869)
(MGI:MGI:1195585|PMID:9461216)
BHF-UCL PMID:7592869, PMID:9461216 MGI:MGI:1195585 NCBI chrNW_004936485:17,305,376...17,311,797 JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B NOT ISO (MGI:MGI:3836106|PMID:17921453)
(PMID:7592869)
(MGI:MGI:3621834|PMID:12837242)
(PMID:20431056)
(PMID:17921453)
BHF-UCL PMID:7592869, PMID:12837242, PMID:17921453, PMID:20431056 MGI:MGI:3621834, MGI:MGI:3836106 NCBI chrNW_004936493:7,916,002...7,922,747 JBrowse link
G Hrc histidine rich calcium binding protein ISO (PMID:24125847) BHF-UCL PMID:24125847 NCBI chrNW_004936664:3,088,072...3,092,034 JBrowse link
G Jph3 junctophilin 3 ISO (MGI:MGI:3654871|PMID:16809425) UniProtKB PMID:16809425 MGI:MGI:3654871 NCBI chrNW_004936641:1,619,640...1,668,480 JBrowse link
G Jsrp1 junctional sarcoplasmic reticulum protein 1 ISO (MGI:MGI:3625379|PMID:16638807) MGI PMID:16638807 MGI:MGI:3625379 NCBI chrNW_004936588:1,345,880...1,349,583 JBrowse link
G LOC101967074 calmodulin ISO (PMID:22067155) UniProtKB
RGD
PMID:15628869, PMID:22067155 RGD:7241270 NCBI chrNW_004936488:17,580,425...17,588,480 JBrowse link
G Pde4d phosphodiesterase 4D ISO (MGI:MGI:3690823|PMID:16213210) BHF-UCL PMID:16213210 MGI:MGI:3690823 NCBI chrNW_004936480:8,123,437...9,235,586 JBrowse link
G Pln phospholamban ISO (MGI:MGI:1352171|PMID:10603936) MGI PMID:10603936 MGI:MGI:1352171 NCBI chrNW_004936658:1,443,626...1,453,770 JBrowse link
G Selenon selenoprotein N ISO (PMID:18713863) UniProtKB PMID:18713863 NCBI chrNW_004936474:10,381,646...10,396,638 JBrowse link
negative regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calm2 calmodulin 2 ISO (PMID:26164367) UniProtKB PMID:26164367 NCBI chrNW_004936508:5,207,909...5,223,780 JBrowse link
G Calm3 calmodulin 3 ISO (PMID:26164367) UniProtKB PMID:26164367 NCBI chrNW_004936664:471,446...480,858 JBrowse link
G Casq2 calsequestrin 2 ISO PMID:17569730
(PMID:16601229)
(PMID:15041652)
BHF-UCL PMID:15041652, PMID:16601229, PMID:17569730 RGD:2314601 NCBI chrNW_004936627:1,001,681...1,069,377 JBrowse link
G Clic2 chloride intracellular channel 2 ISO (PMID:15147738), (PMID:15916532) BHF-UCL PMID:15147738, PMID:15916532 NCBI chrNW_004936927:514,989...543,691 JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A NOT ISO (PMID:12443530) BHF-UCL PMID:12443530 NCBI chrNW_004936485:17,305,376...17,311,797 JBrowse link
G Fkbp1b FKBP prolyl isomerase 1B ISO (PMID:12443530) BHF-UCL PMID:12443530 NCBI chrNW_004936493:7,916,002...7,922,747 JBrowse link
G Gsto1 glutathione S-transferase omega 1 ISO (PMID:11035031) BHF-UCL PMID:11035031 NCBI chrNW_004936600:1,932,152...1,943,342 JBrowse link
G LOC101967074 calmodulin ISO (PMID:26164367) UniProtKB PMID:26164367 NCBI chrNW_004936488:17,580,425...17,588,480 JBrowse link
G Pkd2 polycystin 2, transient receptor potential cation channel ISO (MGI:MGI:3708075|PMID:17404231) MGI PMID:17404231 MGI:MGI:3708075 NCBI chrNW_004936905:76,781...128,995 JBrowse link
G Sri sorcin ISO (PMID:17699613) BHF-UCL PMID:17699613 NCBI chrNW_004936763:715,884...728,548 JBrowse link
positive regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap6 A-kinase anchoring protein 6 ISO PMID:12709444 BHF-UCL PMID:12709444 RGD:8554839 NCBI chrNW_004936494:6,744,923...7,228,670 JBrowse link
G Calm2 calmodulin 2 ISO (PMID:20226167) BHF-UCL PMID:20226167 NCBI chrNW_004936508:5,207,909...5,223,780 JBrowse link
G Calm3 calmodulin 3 ISO (PMID:20226167) BHF-UCL PMID:20226167 NCBI chrNW_004936664:471,446...480,858 JBrowse link
G Gsto1 glutathione S-transferase omega 1 ISO (PMID:11035031) BHF-UCL PMID:11035031 NCBI chrNW_004936600:1,932,152...1,943,342 JBrowse link
G LOC101967074 calmodulin ISO (PMID:20226167) BHF-UCL PMID:20226167 NCBI chrNW_004936488:17,580,425...17,588,480 JBrowse link
G Trdn triadin ISO (PMID:15041652), (PMID:15731460) BHF-UCL PMID:15041652, PMID:15731460 NCBI chrNW_004936802:389,653...637,372 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11968
    biological regulation 8764
      regulation of biological quality 3376
        regulation of calcium ion transport into cytosol 107
          regulation of release of sequestered calcium ion into cytosol 80
            regulation of ryanodine-sensitive calcium-release channel activity 19
              negative regulation of ryanodine-sensitive calcium-release channel activity 10
              positive regulation of ryanodine-sensitive calcium-release channel activity 6
Path 2
Term Annotations click to browse term
  biological_process 11968
    biological regulation 8764
      regulation of biological quality 3376
        homeostatic process 1723
          chemical homeostasis 1058
            ion homeostasis 688
              cellular ion homeostasis 545
                cellular cation homeostasis 533
                  cellular metal ion homeostasis 485
                    cellular calcium ion homeostasis 398
                      regulation of cytosolic calcium ion concentration 306
                        positive regulation of cytosolic calcium ion concentration 270
                          calcium ion transport into cytosol 156
                            calcium ion transmembrane import into cytosol 133
                              release of sequestered calcium ion into cytosol 108
                                regulation of release of sequestered calcium ion into cytosol 80
                                  regulation of ryanodine-sensitive calcium-release channel activity 19
                                    negative regulation of ryanodine-sensitive calcium-release channel activity 10
                                    positive regulation of ryanodine-sensitive calcium-release channel activity 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.