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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of ryanodine-sensitive calcium-release channel activity
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Accession:GO:0060314 term browser browse the term
Definition:Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.


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regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASPH aspartate beta-hydroxylase TAS (PMID:22123818) BHF-UCL PMID:22123818 NCBI chr 8:61,500,556...61,714,609
Ensembl chr 8:61,500,556...61,714,640
JBrowse link
G CALM1 calmodulin 1 IDA (PMID:22067155) UniProtKB PMID:22067155 NCBI chr14:90,396,502...90,408,268
Ensembl chr14:90,396,502...90,408,268
JBrowse link
G CALM2 calmodulin 2 IDA (PMID:22067155) UniProtKB PMID:22067155 NCBI chr 2:47,160,082...47,176,936
Ensembl chr 2:47,160,083...47,176,921
JBrowse link
G CALM3 calmodulin 3 IDA (PMID:22067155) UniProtKB PMID:22067155 NCBI chr19:46,601,074...46,610,782
Ensembl chr19:46,601,074...46,610,782
JBrowse link
G CAMK2D calcium/calmodulin dependent protein kinase II delta TAS (PMID:12676813), (PMID:19482609) UniProtKB PMID:12676813, PMID:19482609 NCBI chr 4:113,451,032...113,762,177
Ensembl chr 4:113,451,032...113,761,927
JBrowse link
G DMD dystrophin IEA
ISS
(PMID:20080623) Ensembl
BHF-UCL
PMID:20080623 GO_REF:0000107 NCBI chr  X:31,119,219...33,339,460
Ensembl chr  X:31,097,677...33,339,441
JBrowse link
G FKBP1A FKBP prolyl isomerase 1A IDA
ISS
(PMID:7592869) BHF-UCL PMID:7592869 GO_REF:0000024 NCBI chr20:1,368,977...1,393,172
Ensembl chr20:1,368,978...1,393,172
JBrowse link
G FKBP1B FKBP prolyl isomerase 1B NOT IDA
IMP
(PMID:17921453)
(PMID:20431056)
(PMID:7592869)
BHF-UCL PMID:7592869, PMID:17921453, PMID:20431056 NCBI chr 2:24,033,205...24,067,743
Ensembl chr 2:24,049,701...24,063,681
JBrowse link
G HRC histidine rich calcium binding protein IGI (PMID:24125847) BHF-UCL PMID:24125847 NCBI chr19:49,151,198...49,155,464
Ensembl chr19:49,151,198...49,155,396
JBrowse link
G JPH1 junctophilin 1 TAS (PMID:19095005) BHF-UCL PMID:19095005 NCBI chr 8:74,234,700...74,321,540
Ensembl chr 8:74,234,700...74,321,540
JBrowse link
G JPH2 junctophilin 2 TAS (PMID:19095005) BHF-UCL PMID:19095005 NCBI chr20:44,106,590...44,187,946
Ensembl chr20:44,111,695...44,187,578
Ensembl chr20:44,111,695...44,187,578
JBrowse link
G JPH3 junctophilin 3 TAS (PMID:19095005) BHF-UCL PMID:19095005 NCBI chr16:87,601,835...87,698,156
Ensembl chr16:87,601,835...87,698,156
JBrowse link
G JPH4 junctophilin 4 TAS (PMID:19095005) BHF-UCL PMID:19095005 NCBI chr14:23,568,038...23,578,790
Ensembl chr14:23,568,035...23,578,790
JBrowse link
G JSRP1 junctional sarcoplasmic reticulum protein 1 ISO (MGI:MGI:3625379|PMID:16638807) MGI PMID:16638807 MGI:MGI:3625379 NCBI chr19:2,268,493...2,269,426
Ensembl chr19:2,252,252...2,269,759
JBrowse link
G JSRP1 junctional sarcoplasmic reticulum protein 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr19:2,252,252...2,260,813
Ensembl chr19:2,252,252...2,269,759
JBrowse link
G NOS1 nitric oxide synthase 1 TAS (PMID:21536106) BHF-UCL PMID:21536106 NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170
JBrowse link
G PDE4D phosphodiesterase 4D ISS (PMID:16213210) BHF-UCL PMID:16213210 NCBI chr 5:58,969,038...60,524,329
Ensembl chr 5:58,969,038...60,522,120
JBrowse link
G PLN phospholamban IEA Ensembl GO_REF:0000107 NCBI chr 6:118,548,296...118,561,716
Ensembl chr 6:118,548,296...118,561,716
JBrowse link
G PRKACA protein kinase cAMP-activated catalytic subunit alpha TAS (PMID:23507255) BHF-UCL PMID:23507255 NCBI chr19:14,091,688...14,117,762
Ensembl chr19:14,091,688...14,118,084
JBrowse link
G SELENON selenoprotein N IMP (PMID:18713863) UniProtKB PMID:18713863 NCBI chr 1:25,800,193...25,818,221
Ensembl chr 1:25,800,176...25,818,221
JBrowse link
negative regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALM1 calmodulin 1 IDA
ISS
(PMID:26164367) UniProtKB
BHF-UCL
PMID:26164367 GO_REF:0000024 NCBI chr14:90,396,502...90,408,268
Ensembl chr14:90,396,502...90,408,268
JBrowse link
G CALM2 calmodulin 2 IDA
ISS
(PMID:26164367) UniProtKB
BHF-UCL
PMID:26164367 GO_REF:0000024 NCBI chr 2:47,160,082...47,176,936
Ensembl chr 2:47,160,083...47,176,921
JBrowse link
G CALM3 calmodulin 3 IDA
ISS
(PMID:26164367) UniProtKB
BHF-UCL
PMID:26164367 GO_REF:0000024 NCBI chr19:46,601,074...46,610,782
Ensembl chr19:46,601,074...46,610,782
JBrowse link
G CASQ2 calsequestrin 2 IDA
ISS
(PMID:16601229) BHF-UCL PMID:16601229 GO_REF:0000024 NCBI chr 1:115,700,021...115,768,714
Ensembl chr 1:115,700,021...115,768,714
Ensembl chr 1:115,700,021...115,768,714
JBrowse link
G CLIC2 chloride intracellular channel 2 IEA
IDA
(PMID:15147738), (PMID:15916532) InterPro
BHF-UCL
PMID:15147738, PMID:15916532 GO_REF:0000002 NCBI chr  X:155,276,211...155,334,614
Ensembl chr  X:155,276,211...155,334,657
JBrowse link
G FKBP1A FKBP prolyl isomerase 1A NOT IDA (PMID:12443530) BHF-UCL PMID:12443530 NCBI chr20:1,368,977...1,393,172
Ensembl chr20:1,368,978...1,393,172
JBrowse link
G FKBP1B FKBP prolyl isomerase 1B IDA (PMID:12443530) BHF-UCL PMID:12443530 NCBI chr 2:24,033,205...24,067,743
Ensembl chr 2:24,049,701...24,063,681
JBrowse link
G GSTM2 glutathione S-transferase mu 2 IDA (PMID:17023043), (PMID:22406107) BHF-UCL PMID:17023043, PMID:22406107 NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551
JBrowse link
G GSTO1 glutathione S-transferase omega 1 IDA (PMID:11035031) BHF-UCL PMID:11035031 NCBI chr10:104,254,173...104,267,455
Ensembl chr10:104,235,356...104,267,459
JBrowse link
G PKD2 polycystin 2, transient receptor potential cation channel ISS BHF-UCL GO_REF:0000024 NCBI chr 4:88,007,635...88,077,779
Ensembl chr 4:88,007,635...88,077,777
JBrowse link
G SRI sorcin IDA (PMID:17699613) BHF-UCL PMID:17699613 NCBI chr 7:88,205,115...88,226,976
Ensembl chr 7:88,205,118...88,226,993
Ensembl chr 7:88,205,118...88,226,993
JBrowse link
G TRDN triadin TAS (PMID:17569730) BHF-UCL PMID:17569730 NCBI chr 6:123,216,339...123,636,950
Ensembl chr 6:123,216,339...123,637,093
JBrowse link
positive regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKAP6 A-kinase anchoring protein 6 ISS BHF-UCL GO_REF:0000024 NCBI chr14:32,203,610...32,837,684
Ensembl chr14:32,329,298...32,837,684
JBrowse link
G ASPH aspartate beta-hydroxylase TAS (PMID:15041652), (PMID:19567751) BHF-UCL PMID:15041652, PMID:19567751 NCBI chr 8:61,500,556...61,714,609
Ensembl chr 8:61,500,556...61,714,640
JBrowse link
G CALM1 calmodulin 1 IDA (PMID:20226167) BHF-UCL PMID:20226167 NCBI chr14:90,396,502...90,408,268
Ensembl chr14:90,396,502...90,408,268
JBrowse link
G CALM2 calmodulin 2 IDA (PMID:20226167) BHF-UCL PMID:20226167 NCBI chr 2:47,160,082...47,176,936
Ensembl chr 2:47,160,083...47,176,921
JBrowse link
G CALM3 calmodulin 3 IDA (PMID:20226167) BHF-UCL PMID:20226167 NCBI chr19:46,601,074...46,610,782
Ensembl chr19:46,601,074...46,610,782
JBrowse link
G GSTM2 glutathione S-transferase mu 2 IDA (PMID:17023043) BHF-UCL PMID:17023043 NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551
JBrowse link
G GSTO1 glutathione S-transferase omega 1 IDA (PMID:11035031) BHF-UCL PMID:11035031 NCBI chr10:104,254,173...104,267,455
Ensembl chr10:104,235,356...104,267,459
JBrowse link
G JPH2 junctophilin 2 IDA (PMID:20095964) UniProtKB PMID:20095964 NCBI chr20:44,106,590...44,187,946
Ensembl chr20:44,111,695...44,187,578
Ensembl chr20:44,111,695...44,187,578
JBrowse link
G TRDN triadin TAS
IBA
ISS
(PMID:19567751)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:19567751, PMID:21873635 GO_REF:0000024 NCBI chr 6:123,216,339...123,636,950
Ensembl chr 6:123,216,339...123,637,093
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18650
    biological regulation 13283
      regulation of biological quality 4617
        regulation of calcium ion transport into cytosol 127
          regulation of release of sequestered calcium ion into cytosol 96
            regulation of ryanodine-sensitive calcium-release channel activity 28
              negative regulation of ryanodine-sensitive calcium-release channel activity 12
              positive regulation of ryanodine-sensitive calcium-release channel activity 9
Path 2
Term Annotations click to browse term
  biological_process 18650
    biological regulation 13283
      regulation of biological quality 4617
        homeostatic process 2221
          chemical homeostasis 1388
            ion homeostasis 928
              cellular ion homeostasis 766
                cellular cation homeostasis 753
                  cellular metal ion homeostasis 670
                    cellular calcium ion homeostasis 528
                      regulation of cytosolic calcium ion concentration 415
                        positive regulation of cytosolic calcium ion concentration 372
                          calcium ion transport into cytosol 190
                            calcium ion transmembrane import into cytosol 165
                              release of sequestered calcium ion into cytosol 136
                                regulation of release of sequestered calcium ion into cytosol 96
                                  regulation of ryanodine-sensitive calcium-release channel activity 28
                                    negative regulation of ryanodine-sensitive calcium-release channel activity 12
                                    positive regulation of ryanodine-sensitive calcium-release channel activity 9
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.