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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of ryanodine-sensitive calcium-release channel activity
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Accession:GO:0060314 term browser browse the term
Definition:Any process that modulates the activity of a ryanodine-sensitive calcium-release channel. The ryanodine-sensitive calcium-release channel catalyzes the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts.


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regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALM1 calmodulin 1 ISO (PMID:22067155) UniProtKB
RGD
PMID:15628869, PMID:22067155 RGD:7241270 NCBI chr14:71,015,099...71,026,322
Ensembl chr19:52,121,687...52,131,135
JBrowse link
G CALM2 calmodulin 2 ISO (PMID:22067155) RGD
UniProtKB
PMID:15628869, PMID:22067155 RGD:7241270 NCBI chr2A:47,274,722...47,290,861 JBrowse link
G CALM3 calmodulin 3 ISO (PMID:22067155) RGD
UniProtKB
PMID:15628869, PMID:22067155 RGD:7241270 NCBI chr19:43,593,069...43,602,550
Ensembl chr19:52,121,687...52,131,135
JBrowse link
G DMD dystrophin ISO (MGI:MGI:4420848|PMID:20080623) BHF-UCL PMID:20080623 MGI:MGI:4420848 NCBI chr  X:23,728,650...26,338,849
Ensembl chr  X:31,282,415...33,492,733
JBrowse link
G FKBP1A FKBP prolyl isomerase 1A ISO (PMID:7592869)
(MGI:MGI:1195585|PMID:9461216)
BHF-UCL PMID:7592869, PMID:9461216 MGI:MGI:1195585 NCBI chr20:1,519,330...1,548,473 JBrowse link
G FKBP1B FKBP prolyl isomerase 1B NOT ISO (MGI:MGI:3621834|PMID:12837242)
(PMID:17921453)
(PMID:7592869)
(MGI:MGI:3836106|PMID:17921453)
(PMID:20431056)
BHF-UCL PMID:7592869, PMID:12837242, PMID:17921453, PMID:20431056 MGI:MGI:3621834, MGI:MGI:3836106 NCBI chr2A:24,047,287...24,065,765
Ensembl chr2A:24,145,893...24,159,082
JBrowse link
G HRC histidine rich calcium binding protein ISO (PMID:24125847) BHF-UCL PMID:24125847 NCBI chr19:46,162,231...46,166,606
Ensembl chr19:55,089,384...55,093,463
JBrowse link
G JPH3 junctophilin 3 ISO (MGI:MGI:3654871|PMID:16809425) UniProtKB PMID:16809425 MGI:MGI:3654871 NCBI chr16:68,276,459...68,379,909
Ensembl chr16:87,596,814...87,700,235
JBrowse link
G JSRP1 junctional sarcoplasmic reticulum protein 1 ISO (MGI:MGI:3625379|PMID:16638807) MGI PMID:16638807 MGI:MGI:3625379 NCBI chr19:1,263,581...1,279,318 JBrowse link
G PDE4D phosphodiesterase 4D ISO (MGI:MGI:3690823|PMID:16213210) BHF-UCL PMID:16213210 MGI:MGI:3690823 NCBI chr 5:53,510,287...55,039,181
Ensembl chr 5:55,749,214...56,670,111
JBrowse link
G PLN phospholamban ISO (MGI:MGI:1352171|PMID:10603936) MGI PMID:10603936 MGI:MGI:1352171 NCBI chr 6:116,357,335...116,370,382
Ensembl chr 6:120,509,510...120,509,668
JBrowse link
G SELENON selenoprotein N ISO (PMID:18713863) UniProtKB PMID:18713863 NCBI chr 1:25,058,907...25,076,817
Ensembl chr 1:26,127,125...26,141,745
JBrowse link
negative regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALM1 calmodulin 1 ISO (PMID:26164367) UniProtKB PMID:26164367 NCBI chr14:71,015,099...71,026,322
Ensembl chr19:52,121,687...52,131,135
JBrowse link
G CALM2 calmodulin 2 ISO (PMID:26164367) UniProtKB PMID:26164367 NCBI chr2A:47,274,722...47,290,861 JBrowse link
G CALM3 calmodulin 3 ISO (PMID:26164367) UniProtKB PMID:26164367 NCBI chr19:43,593,069...43,602,550
Ensembl chr19:52,121,687...52,131,135
JBrowse link
G CASQ2 calsequestrin 2 ISO (PMID:15041652)
PMID:17569730
(PMID:16601229)
BHF-UCL PMID:15041652, PMID:16601229, PMID:17569730 RGD:2314601 NCBI chr 1:86,795,392...86,864,196
Ensembl chr 1:121,844,097...121,913,311
JBrowse link
G CLIC2 chloride intracellular channel 2 ISO (PMID:15147738), (PMID:15916532) BHF-UCL PMID:15147738, PMID:15916532 NCBI chr  X:144,742,839...144,851,524
Ensembl chr  X:154,581,649...154,641,515
JBrowse link
G FKBP1A FKBP prolyl isomerase 1A NOT ISO (PMID:12443530) BHF-UCL PMID:12443530 NCBI chr20:1,519,330...1,548,473 JBrowse link
G FKBP1B FKBP prolyl isomerase 1B ISO (PMID:12443530) BHF-UCL PMID:12443530 NCBI chr2A:24,047,287...24,065,765
Ensembl chr2A:24,145,893...24,159,082
JBrowse link
G GSTM2 glutathione S-transferase mu 2 ISO (PMID:17023043), (PMID:22406107) BHF-UCL PMID:17023043, PMID:22406107 NCBI chr 1:112,043,201...112,050,810 JBrowse link
G GSTO1 glutathione S-transferase omega 1 ISO (PMID:11035031) BHF-UCL PMID:11035031 NCBI chr10:100,853,682...100,866,892
Ensembl chr10:104,313,024...104,325,733
JBrowse link
G PKD2 polycystin 2, transient receptor potential cation channel ISO (MGI:MGI:3708075|PMID:17404231) MGI PMID:17404231 MGI:MGI:3708075 NCBI chr 4:80,295,243...80,365,271
Ensembl chr 4:91,019,734...91,086,775
JBrowse link
G SRI sorcin ISO (PMID:17699613) BHF-UCL PMID:17699613 NCBI chr 7:80,199,719...80,214,733
Ensembl chr 7:93,850,496...93,864,029
JBrowse link
positive regulation of ryanodine-sensitive calcium-release channel activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKAP6 A-kinase anchoring protein 6 ISO PMID:12709444 BHF-UCL PMID:12709444 RGD:8554839 NCBI chr14:12,978,221...13,602,732
Ensembl chr14:31,395,026...31,792,166
JBrowse link
G CALM1 calmodulin 1 ISO (PMID:20226167) BHF-UCL PMID:20226167 NCBI chr14:71,015,099...71,026,322
Ensembl chr19:52,121,687...52,131,135
JBrowse link
G CALM2 calmodulin 2 ISO (PMID:20226167) BHF-UCL PMID:20226167 NCBI chr2A:47,274,722...47,290,861 JBrowse link
G CALM3 calmodulin 3 ISO (PMID:20226167) BHF-UCL PMID:20226167 NCBI chr19:43,593,069...43,602,550
Ensembl chr19:52,121,687...52,131,135
JBrowse link
G GSTM2 glutathione S-transferase mu 2 ISO (PMID:17023043) BHF-UCL PMID:17023043 NCBI chr 1:112,043,201...112,050,810 JBrowse link
G GSTO1 glutathione S-transferase omega 1 ISO (PMID:11035031) BHF-UCL PMID:11035031 NCBI chr10:100,853,682...100,866,892
Ensembl chr10:104,313,024...104,325,733
JBrowse link
G JPH2 junctophilin 2 ISO (PMID:20095964) UniProtKB PMID:20095964 NCBI chr20:40,439,975...40,517,438 JBrowse link
G TRDN triadin ISO (PMID:15041652), (PMID:15731460) BHF-UCL PMID:15041652, PMID:15731460 NCBI chr 6:121,010,234...121,424,644
Ensembl chr 6:125,134,433...125,546,537
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12529
    biological regulation 9138
      regulation of biological quality 3486
        regulation of calcium ion transport into cytosol 116
          regulation of release of sequestered calcium ion into cytosol 87
            regulation of ryanodine-sensitive calcium-release channel activity 21
              negative regulation of ryanodine-sensitive calcium-release channel activity 11
              positive regulation of ryanodine-sensitive calcium-release channel activity 8
Path 2
Term Annotations click to browse term
  biological_process 12529
    biological regulation 9138
      regulation of biological quality 3486
        homeostatic process 1790
          chemical homeostasis 1100
            ion homeostasis 719
              cellular ion homeostasis 572
                cellular cation homeostasis 560
                  cellular metal ion homeostasis 511
                    cellular calcium ion homeostasis 422
                      regulation of cytosolic calcium ion concentration 327
                        positive regulation of cytosolic calcium ion concentration 290
                          calcium ion transport into cytosol 165
                            calcium ion transmembrane import into cytosol 140
                              release of sequestered calcium ion into cytosol 116
                                regulation of release of sequestered calcium ion into cytosol 87
                                  regulation of ryanodine-sensitive calcium-release channel activity 21
                                    negative regulation of ryanodine-sensitive calcium-release channel activity 11
                                    positive regulation of ryanodine-sensitive calcium-release channel activity 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.