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ONTOLOGY REPORT - ANNOTATIONS

Term:long-term synaptic depression
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Accession:GO:0060292 term browser browse the term
Definition:A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse.
Synonyms:broad_synonym: long term depression
 related_synonym: LTD


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long-term synaptic depression term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABHD6 abhydrolase domain containing 6, acylglycerol lipase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20657592) Ensembl
MGI		 PMID:20657592 GO_REF:0000107 NCBI chr20:32,301,120...32,331,030
Ensembl chr20:32,302,104...32,330,998 		JBrowse link
G ADORA1 adenosine A1 receptor involved_in
acts_upstream_of		 IEA
ISO		 (PMID:24259587) Ensembl
MGI		 PMID:24259587 GO_REF:0000107 NCBI chr 7:44,819...74,217
Ensembl chr 7:44,820...73,051 		JBrowse link
G ARF1 ADP ribosylation factor 1 involved_in ISO PMID:23889934 UniProt PMID:23889934 RGD:8553918 NCBI chr14:835,476...836,424
Ensembl chr14:835,476...836,424 		JBrowse link
G CD38 CD38 molecule ISO RGD PMID:10097163 RGD:2307271 NCBI chr 3:64,529,129...64,577,755
Ensembl chr 3:64,529,721...64,578,099 		JBrowse link
G DRD1 dopamine receptor D1 acts_upstream_of_or_within ISO (PMID:14981263) MGI PMID:14981263 NCBI chr 4:37,550,454...37,554,641
Ensembl chr 4:37,549,708...37,553,287 		JBrowse link
G DRD5 dopamine receptor D5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:13679419) Ensembl
MGI		 PMID:13679419 GO_REF:0000107 NCBI chr 3:69,621,187...69,623,522
Ensembl chr 3:69,621,734...69,623,893 		JBrowse link
G GRIA1 glutamate ionotropic receptor AMPA type subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24259587) Ensembl
MGI		 PMID:24259587 GO_REF:0000107 NCBI chr 4:55,801,269...56,103,383
Ensembl chr 4:55,803,296...56,103,669 		JBrowse link
G GRID2IP Grid2 interacting protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18509461) Ensembl
MGI		 PMID:18509461 GO_REF:0000107 NCBI chr 6:11,834,841...11,860,326
Ensembl chr 6:11,835,961...11,870,109 		JBrowse link
G GRM2 glutamate metabotropic receptor 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:8662555) Ensembl
MGI		 PMID:8662555 GO_REF:0000107 NCBI chr20:37,915,178...37,926,276
Ensembl chr20:37,915,665...37,924,296 		JBrowse link
G MGLL monoglyceride lipase acts_upstream_of_or_within ISO (PMID:20657592) MGI PMID:20657592 NCBI chr20:1,765,650...1,880,710
Ensembl chr20:1,766,216...1,943,588 		JBrowse link
G PICK1 protein interacting with PRKCA 1 involved_in ISO PMID:21252856 UniProt PMID:21252856 RGD:8554238 NCBI chr10:26,595,301...26,614,170
Ensembl chr10:26,595,768...26,613,756 		JBrowse link
G PLK2 polo like kinase 2 involved_in ISO PMID:21382555 UniProt PMID:21382555 RGD:7241548 NCBI chr 2:45,359,865...45,365,496
Ensembl chr 2:45,360,374...45,367,441 		JBrowse link
G PRRT1 proline rich transmembrane protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:1,545,384...1,549,015
Ensembl chr12:1,542,789...1,548,964 		JBrowse link
G PTEN phosphatase and tensin homolog ISO NMDA receptor-dependent RGD PMID:20628354 RGD:4144068 NCBI chr26:37,853,148...37,913,176
Ensembl chr26:37,835,661...37,913,176 		JBrowse link
G PTK2B protein tyrosine kinase 2 beta ISO RGD PMID:20826662 RGD:10041066 NCBI chr25:30,137,546...30,264,221
Ensembl chr25:30,138,209...30,264,133 		JBrowse link
G SHANK2 SH3 and multiple ankyrin repeat domains 2 involved_in ISO (MGI:5432970|PMID:22699620) BHF-UCL PMID:22699620 MGI:5432970 NCBI chr18:47,477,625...47,915,557
Ensembl chr18:47,635,788...47,912,117 		JBrowse link
G SHANK3 SH3 and multiple ankyrin repeat domains 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:16,621,445...16,665,366 JBrowse link
G SLC24A2 solute carrier family 24 member 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16407245) Ensembl
MGI		 PMID:16407245 GO_REF:0000107 NCBI chr11:39,273,285...39,521,223
Ensembl chr11:39,278,370...39,519,222 		JBrowse link
G SORCS2 sortilin related VPS10 domain containing receptor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:59,319,707...59,679,071
Ensembl chr 3:59,255,848...59,679,049 		JBrowse link
G SRF serum response factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16600861) Ensembl
MGI		 PMID:16600861 GO_REF:0000107 NCBI chr12:11,664,441...11,673,846
Ensembl chr12:11,664,527...11,671,533 		JBrowse link
G STXBP1 syntaxin binding protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17110441) Ensembl
MGI		 PMID:17110441 GO_REF:0000107 NCBI chr 9:55,690,939...55,768,008
Ensembl chr 9:55,678,264...55,727,680 		JBrowse link
negative regulation of long-term synaptic depression term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA1 adenosine A1 receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24259587) Ensembl
MGI		 PMID:24259587 GO_REF:0000107 NCBI chr 7:44,819...74,217
Ensembl chr 7:44,820...73,051 		JBrowse link
G AGER advanced glycosylation end-product specific receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:1,574,251...1,577,410
Ensembl chr12:1,574,251...1,577,129 		JBrowse link
G FMR1 Fragile X messenger ribonucleoprotein 1 involved_in ISO (MGI:2136541|PMID:11438589) UniProt PMID:11438589 MGI:2136541 NCBI chr  X:116,249,079...116,287,008
Ensembl chr  X:116,249,142...116,321,439 		JBrowse link
positive regulation of long-term synaptic depression term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCY8 adenylate cyclase 8 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:27,723,530...27,937,821
Ensembl chr13:27,723,530...27,937,734 		JBrowse link
G CBLN1 cerebellin 1 precursor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:65,974,989...65,978,464
Ensembl chr 2:65,974,981...65,977,179 		JBrowse link
G FMR1 Fragile X messenger ribonucleoprotein 1 ISO RGD PMID:28894415 RGD:38501107 NCBI chr  X:116,249,079...116,287,008
Ensembl chr  X:116,249,142...116,321,439 		JBrowse link
G GRID2 glutamate ionotropic receptor delta type subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr32:15,322,256...16,787,966
Ensembl chr32:15,322,738...16,753,656 		JBrowse link
G IQSEC2 IQ motif and Sec7 domain ArfGEF 2 ISO RGD PMID:27009485 RGD:11049506 NCBI chr  X:44,861,813...44,915,011
Ensembl chr  X:44,872,888...44,913,704 		JBrowse link
G KCNB1 potassium voltage-gated channel subfamily B member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:36,016,800...36,118,873
Ensembl chr24:36,025,472...36,117,934 		JBrowse link
G LOC611446 leukocyte immunoglobulin-like receptor subfamily A member 6 involved_in ISO (MGI:5511064|PMID:24052308) ARUK-UCL PMID:24052308 MGI:5511064 NCBI chr 1:102,955,916...102,978,669 JBrowse link
G MAPT microtubule associated protein tau ISO RGD PMID:24298146 RGD:10412705 NCBI chr 9:9,572,174...9,674,082
Ensembl chr 9:9,570,557...9,674,349 		JBrowse link
G PPP1R9A protein phosphatase 1 regulatory subunit 9A ISO RGD PMID:16899074 RGD:10002752 NCBI chr14:20,251,791...20,563,315
Ensembl chr14:20,251,738...20,557,208 		JBrowse link
G STAU2 staufen double-stranded RNA binding protein 2 ISO RGD PMID:21508097 RGD:10043164 NCBI chr29:21,995,229...22,292,107
Ensembl chr29:21,996,108...22,283,355 		JBrowse link
regulation of long-term synaptic depression term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARC activity regulated cytoskeleton associated protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:36,743,027...36,744,266 JBrowse link
G BCL2L1 BCL2 like 1 involved_in ISO PMID:23792689 CAFA PMID:23792689 RGD:12793033 NCBI chr24:21,145,214...21,209,425
Ensembl chr24:21,145,215...21,196,355 		JBrowse link
G DGKI diacylglycerol kinase iota involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21119615) Ensembl
MGI		 PMID:21119615 GO_REF:0000107 NCBI chr16:10,975,394...11,250,430
Ensembl chr16:10,682,935...11,248,029 		JBrowse link
G GNAL G protein subunit alpha L ISO RGD PMID:31678405 RGD:150429833 NCBI chr 7:77,378,134...77,521,215
Ensembl chr 7:77,413,986...77,521,042 		JBrowse link
G PENK proenkephalin involved_in ISO (MGI:7260092|PMID:35201898) UniProt PMID:35201898 MGI:7260092 NCBI chr29:7,757,543...7,763,137
Ensembl chr29:7,757,857...7,762,398 		JBrowse link
G SHANK3 SH3 and multiple ankyrin repeat domains 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:16,621,445...16,665,366 JBrowse link
G SORCS3 sortilin related VPS10 domain containing receptor 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:24069373) Ensembl
MGI		 PMID:24069373 GO_REF:0000107 NCBI chr28:16,909,908...17,491,097
Ensembl chr28:16,909,856...17,489,418 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17917
    negative regulation of biological process 5778
      negative regulation of signaling 1606
        negative regulation of synaptic transmission 73
          long-term synaptic depression 38
            negative regulation of long-term synaptic depression 3
            positive regulation of long-term synaptic depression 10
            regulation of long-term synaptic depression + 19
Path 2
Term Annotations click to browse term
  biological_process 17917
    biological regulation 12438
      regulation of biological process 12078
        signaling 6873
          cell-cell signaling 1461
            synaptic signaling 985
              trans-synaptic signaling 951
                anterograde trans-synaptic signaling 942
                  chemical synaptic transmission 942
                    modulation of chemical synaptic transmission 725
                      negative regulation of synaptic transmission 73
                        long-term synaptic depression 38
                          negative regulation of long-term synaptic depression 3
                          positive regulation of long-term synaptic depression 10
                          regulation of long-term synaptic depression + 19
paths to the root