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ONTOLOGY REPORT - ANNOTATIONS


Term:long-term synaptic depression
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Accession:GO:0060292 term browser browse the term
Definition:A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse.
Synonyms:broad_synonym: long term depression
 related_synonym: LTD


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long-term synaptic depression term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd6 abhydrolase domain containing 6, acylglycerol lipase ISO (MGI:MGI:4829719|PMID:20657592) RGD PMID:20657592 MGI:MGI:4829719 NCBI chr15:18,647,903...18,695,133
Ensembl chr15:18,647,844...18,695,133
JBrowse link
G Arf1 ADP-ribosylation factor 1 IDA PMID:23889934 UniProt PMID:23889934 RGD:8553918 NCBI chr10:45,562,700...45,579,214
Ensembl chr10:45,563,547...45,579,029
JBrowse link
G Cd38 CD38 molecule IMP RGD PMID:10097163 RGD:2307271 NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672
JBrowse link
G Drd1 dopamine receptor D1 ISO
IEA
MGI:MGI:1857158 (MGI:MGI:3036431|PMID:14981263)
GO_REF:0000107
RGD
Ensembl
PMID:14981263 GO_REF:0000107, MGI:MGI:3036431 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd5 dopamine receptor D5 ISO
IEA
(MGI:MGI:3586401|PMID:13679419)
GO_REF:0000107
RGD
Ensembl
PMID:13679419 GO_REF:0000107, MGI:MGI:3586401 NCBI chr14:77,220,579...77,222,006
Ensembl chr14:77,220,579...77,222,006
JBrowse link
G Gria1 glutamate ionotropic receptor AMPA type subunit 1 ISO
IEA
MGI:MGI:99401 (MGI:MGI:5529732|PMID:24259587)
GO_REF:0000107
RGD
Ensembl
PMID:24259587 GO_REF:0000107, MGI:MGI:5529732 NCBI chr10:42,441,723...42,760,200
Ensembl chr10:42,614,713...42,760,200
JBrowse link
G Grid2ip Grid2 interacting protein ISO MGI:MGI:3796575 (MGI:MGI:3796257|PMID:18509461) RGD PMID:18509461 MGI:MGI:3796257 NCBI chr12:13,221,334...13,257,365
Ensembl chr12:13,221,513...13,251,112
JBrowse link
G Mgll monoglyceride lipase ISO (MGI:MGI:4829719|PMID:20657592) RGD PMID:20657592 MGI:MGI:4829719 NCBI chr 4:120,671,436...120,773,458
Ensembl chr 4:120,671,489...120,771,088
JBrowse link
G Pick1 protein interacting with PRKCA 1 IDA PMID:21252856 UniProt PMID:21252856 RGD:8554238 NCBI chr 7:120,465,472...120,484,824
Ensembl chr 7:120,465,130...120,484,840
JBrowse link
G Plk2 polo-like kinase 2 IDA PMID:21382555 UniProt PMID:21382555 RGD:7241548 NCBI chr 2:41,911,143...41,916,901
Ensembl chr 2:41,911,131...41,916,901
JBrowse link
G Pten phosphatase and tensin homolog IMP NMDA receptor-dependent RGD PMID:20628354 RGD:4144068 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptk2b protein tyrosine kinase 2 beta IMP RGD PMID:20826662 RGD:10041066 NCBI chr15:42,827,306...42,947,796
Ensembl chr15:42,827,310...42,947,656
JBrowse link
G Shank2 SH3 and multiple ankyrin repeat domains 2 ISO
ISS
(MGI:MGI:5432970|PMID:22699620)
GO_REF:0000024
RGD
BHF-UCL
PMID:22699620 GO_REF:0000024, MGI:MGI:5432970 NCBI chr 1:217,149,156...217,593,950
Ensembl chr 1:217,151,166...217,592,763
JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 ISO
IEA
(MGI:MGI:5320264|PMID:21795692)
GO_REF:0000107
RGD
Ensembl
PMID:21795692 GO_REF:0000107, MGI:MGI:5320264 NCBI chr 7:130,474,278...130,534,679
Ensembl chr 7:130,474,279...130,534,679
JBrowse link
G Slc24a1 solute carrier family 24 member 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:70,409,683...70,438,352
Ensembl chr 8:70,408,528...70,436,028
JBrowse link
G Slc24a2 solute carrier family 24 member 2 ISO
IBA
MGI:MGI:3663782 (MGI:MGI:3640012|PMID:16407245)
PMID:21873635
RGD PMID:16407245, PMID:21873635 MGI:MGI:3640012, RGD:13792537 NCBI chr 5:105,336,287...105,579,959
Ensembl chr 5:105,336,262...105,582,375
JBrowse link
G Sorcs2 sortilin-related VPS10 domain containing receptor 2 ISO (MGI:MGI:6305031|PMID:27457814) RGD PMID:27457814 MGI:MGI:6305031 NCBI chr14:79,538,911...79,912,333
Ensembl chr14:79,538,911...79,912,333
JBrowse link
G Srf serum response factor ISO MGI:MGI:2385465|MGI:MGI:2678305 (MGI:MGI:3652465|PMID:16600861) RGD PMID:16600861 MGI:MGI:3652465 NCBI chr 9:16,737,637...16,747,226
Ensembl chr 9:16,737,642...16,747,225
JBrowse link
G Stxbp1 syntaxin binding protein 1 ISO MGI:MGI:2183278 (MGI:MGI:3695670|PMID:17110441) RGD PMID:17110441 MGI:MGI:3695670 NCBI chr 3:11,823,779...11,885,479
Ensembl chr 3:11,823,785...11,885,417
JBrowse link
negative regulation of long-term synaptic depression term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor ISO MGI:MGI:95808 (MGI:MGI:5529732|PMID:24259587) RGD PMID:24259587 MGI:MGI:5529732 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Ager advanced glycosylation end product-specific receptor IEA
ISO
GO_REF:0000107
ComplexPortal:CPX-1134 (PMID:20739563)
Ensembl
RGD
PMID:20739563 GO_REF:0000107 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Fmr1 FMRP translational regulator 1 ISO
ISS
(MGI:MGI:2136541|PMID:11438589)
GO_REF:0000024
RGD
UniProt
PMID:11438589 GO_REF:0000024, MGI:MGI:2136541 NCBI chr  X:154,684,924...154,722,369
Ensembl chr  X:154,684,935...154,722,314
JBrowse link
positive regulation of long-term synaptic depression term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy8 adenylate cyclase 8 ISS
ISO
IEA
GO_REF:0000024
(MGI:MGI:1860567|PMID:10864938)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:10864938 GO_REF:0000024, GO_REF:0000107, MGI:MGI:1860567 NCBI chr 7:105,353,883...105,593,372
Ensembl chr 7:105,353,913...105,592,804
JBrowse link
G Cbln1 cerebellin 1 precursor ISO (PMID:27418511) RGD PMID:27418511 NCBI chr19:20,607,507...20,611,316
Ensembl chr19:20,607,507...20,611,316
JBrowse link
G Fmr1 FMRP translational regulator 1 IMP RGD PMID:28894415 RGD:38501107 NCBI chr  X:154,684,924...154,722,369
Ensembl chr  X:154,684,935...154,722,314
JBrowse link
G Grid2 glutamate ionotropic receptor delta type subunit 2 IEA
ISO
GO_REF:0000107
(PMID:27418511)
Ensembl
RGD
PMID:27418511 GO_REF:0000107 NCBI chr 4:94,068,112...95,476,864
Ensembl chr 4:94,696,965...95,442,778
JBrowse link
G Iqsec2 IQ motif and Sec7 domain ArfGEF 2 IMP RGD PMID:27009485 RGD:11049506 NCBI chr  X:22,212,137...22,293,810
Ensembl chr  X:22,212,132...22,294,402
JBrowse link
G Kcnb1 potassium voltage-gated channel subfamily B member 1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(MGI:MGI:5634878|PMID:24494598)
Ensembl
UniProt
RGD
PMID:24494598 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5634878 NCBI chr 3:163,850,785...163,935,610
Ensembl chr 3:163,850,785...163,935,617
JBrowse link
G Mapt microtubule-associated protein tau IMP RGD PMID:24298146 RGD:10412705 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Pirb paired Ig-like receptor B ISO UniProtKB:P05067|UniProtKB:P49768 (MGI:MGI:5511064|PMID:24052308) RGD PMID:24052308 MGI:MGI:5511064 NCBI chr 1:64,074,097...64,081,568
Ensembl chr 1:64,074,231...64,081,438
JBrowse link
G Ppp1r9a protein phosphatase 1, regulatory subunit 9A IMP RGD PMID:16899074 RGD:10002752 NCBI chr 4:29,976,485...30,247,371
Ensembl chr 4:29,978,739...30,241,911
JBrowse link
G Stau2 staufen double-stranded RNA binding protein 2 IMP RGD PMID:21508097 RGD:10043164 NCBI chr 5:2,257,910...2,497,429 JBrowse link
regulation of long-term synaptic depression term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arc activity-regulated cytoskeleton-associated protein ISS
ISO
GO_REF:0000024
(MGI:MGI:6148485|PMID:29264923)
UniProt
RGD
PMID:29264923 GO_REF:0000024, MGI:MGI:6148485 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541
JBrowse link
G Bcl2l1 Bcl2-like 1 IMP PMID:23792689 CAFA PMID:23792689 RGD:12793033 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Dgki diacylglycerol kinase, iota ISO MGI:MGI:3584141 (MGI:MGI:4936793|PMID:21119615) RGD PMID:21119615 MGI:MGI:4936793 NCBI chr 4:64,365,115...64,831,473
Ensembl chr 4:64,374,342...64,831,473
JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 ISO
IEA
ISS
(MGI:MGI:5320264|PMID:21795692)
GO_REF:0000107
RGD
Ensembl
PMID:21795692, PMID:21795692 GO_REF:0000107, MGI:MGI:5320264, RGD:7349315 NCBI chr 7:130,474,278...130,534,679
Ensembl chr 7:130,474,279...130,534,679
JBrowse link
G Sorcs3 sortilin-related VPS10 domain containing receptor 3 ISO MGI:MGI:5562419 (MGI:MGI:5559089|PMID:24069373) RGD PMID:24069373 MGI:MGI:5559089 NCBI chr 1:267,986,305...268,620,331
Ensembl chr 1:268,189,277...268,620,331
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    biological regulation 13773
      regulation of biological quality 4280
        regulation of synaptic plasticity 342
          long-term synaptic depression 35
            negative regulation of long-term synaptic depression 3
            positive regulation of long-term synaptic depression 10
            regulation of long-term synaptic depression + 17
Path 2
Term Annotations click to browse term
  biological_process 20027
    cellular process 18798
      cell communication 7664
        cell-cell signaling 1738
          synaptic signaling 917
            trans-synaptic signaling 889
              anterograde trans-synaptic signaling 880
                chemical synaptic transmission 880
                  modulation of chemical synaptic transmission 656
                    regulation of synaptic plasticity 342
                      long-term synaptic depression 35
                        negative regulation of long-term synaptic depression 3
                        positive regulation of long-term synaptic depression 10
                        regulation of long-term synaptic depression + 17
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.