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ONTOLOGY REPORT - ANNOTATIONS


Term:hematopoietic stem cell differentiation
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Accession:GO:0060218 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
Synonyms:exact_synonym: haematopoietic stem cell differentiation;   haemopoietic stem cell differentiation;   hemopoietic stem cell differentiation


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hematopoietic stem cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in ISS
ISO
GO_REF:0000024
(MGI:5448499|PMID:22385964)
UniProt
RGD
PMID:22385964 GO_REF:0000024 MGI:5448499 NCBI chr 6:109,562,415...109,584,541
Ensembl chr 6:109,562,587...109,584,545
JBrowse link
G Cdk6 cyclin-dependent kinase 6 acts_upstream_of_or_within ISO MGI:3833563|MGI:5141514 (MGI:5140640|PMID:21508411) RGD PMID:21508411 MGI:5140640 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Chd2 chromodomain helicase DNA binding protein 2 acts_upstream_of_or_within ISO MGI:3800602 (MGI:3836861|PMID:19137022) RGD PMID:19137022 MGI:3836861 NCBI chr 1:134,757,934...134,873,053
Ensembl chr 1:134,757,934...134,871,167
JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit acts_upstream_of_or_within ISO MGI:2183947 (MGI:3715429|PMID:17554309) RGD PMID:17554309 MGI:3715429 NCBI chr 1:80,293,574...80,307,334
Ensembl chr 1:80,293,566...80,307,344
JBrowse link
G Ext1 exostosin glycosyltransferase 1 acts_upstream_of_or_within ISO (MGI:6406770|PMID:21148566) RGD PMID:21148566 MGI:6406770 NCBI chr 7:92,605,008...92,881,392
Ensembl chr 7:92,605,728...92,882,068
JBrowse link
G Hoxb4 homeo box B4 involved_in ISO (PMID:18932205) RGD PMID:18932205 NCBI chr10:84,167,331...84,169,913
Ensembl chr10:84,167,331...84,169,907
JBrowse link
G Lmbr1l limb development membrane protein 1-like involved_in ISO (MGI:6303730|PMID:31073040) RGD PMID:31073040 MGI:6303730 NCBI chr 7:140,585,512...140,600,797
Ensembl chr 7:140,585,832...140,600,818
JBrowse link
G Mir125b1 microRNA 125b-1 acts_upstream_of_or_within ISO (MGI:4822501|PMID:20660734) RGD PMID:20660734 MGI:4822501 NCBI chr 8:45,798,260...45,798,346
Ensembl chr 8:45,798,260...45,798,346
JBrowse link
G Mir125b2 microRNA 125b-2 acts_upstream_of_or_within ISO (MGI:4822501|PMID:20660734) RGD PMID:20660734 MGI:4822501 NCBI chr11:16,097,346...16,097,433 JBrowse link
G Mir126a microRNA 126a acts_upstream_of_or_within ISO (MGI:4822501|PMID:20660734) RGD PMID:20660734 MGI:4822501 NCBI chr 3:4,042,464...4,042,581
Ensembl chr 3:4,042,464...4,042,581
JBrowse link
G Mir130a microRNA 130a acts_upstream_of_or_within ISO (MGI:4822501|PMID:20660734) RGD PMID:20660734 MGI:4822501 NCBI chr 3:72,141,037...72,141,124
Ensembl chr 3:72,141,037...72,141,124
JBrowse link
G Mir155 microRNA 155 acts_upstream_of_or_within ISO (MGI:4822501|PMID:20660734) RGD PMID:20660734 MGI:4822501 NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667
JBrowse link
G Mir181c microRNA 181c acts_upstream_of_or_within ISO (MGI:4822501|PMID:20660734) RGD PMID:20660734 MGI:4822501 NCBI chr19:25,290,211...25,290,316
Ensembl chr19:25,290,211...25,290,316
JBrowse link
G Mir193b microRNA 193b acts_upstream_of_or_within ISO (MGI:4822501|PMID:20660734) RGD PMID:20660734 MGI:4822501 NCBI chr14:30,331,049...30,331,131
Ensembl chr14:30,331,049...30,331,131
JBrowse link
G Mir542 microRNA 542 acts_upstream_of_or_within ISO (MGI:4822501|PMID:20660734) RGD PMID:20660734 MGI:4822501 NCBI chr  X:158,152,146...158,152,224
Ensembl chr  X:158,152,146...158,152,224
JBrowse link
G Mir99a microRNA 99a acts_upstream_of_or_within ISO (MGI:4822501|PMID:20660734) RGD PMID:20660734 MGI:4822501 NCBI chr11:16,052,153...16,052,233
Ensembl chr11:16,052,153...16,052,233
JBrowse link
G Mllt3 MLLT3, super elongation complex subunit involved_in ISO (PMID:31776511) RGD PMID:31776511 NCBI chr 5:106,103,498...106,202,559
Ensembl chr 5:106,103,407...106,207,126
JBrowse link
G Sfrp1 secreted frizzled-related protein 1 involved_in ISO
IEA
(PMID:19778523)
GO_REF:0000107
RGD
Ensembl
PMID:19778523 GO_REF:0000107 NCBI chr16:73,372,007...73,410,777
Ensembl chr16:73,372,007...73,410,777
JBrowse link
G Sp7 Sp7 transcription factor involved_in ISO (PMID:18932205) RGD PMID:18932205 NCBI chr 7:143,957,316...143,967,488
Ensembl chr 7:143,958,858...143,967,484
JBrowse link
G Srf serum response factor acts_upstream_of_or_within ISO MGI:2176073|MGI:3046779 (MGI:4848276|PMID:20709909) RGD PMID:20709909 MGI:4848276 NCBI chr 9:16,737,637...16,747,226
Ensembl chr 9:16,737,642...16,747,225
JBrowse link
G Tal1 TAL bHLH transcription factor 1, erythroid differentiation factor acts_upstream_of_or_within ISO MGI:2176073|MGI:2450311|MGI:2450743|MGI:2661471 (MGI:3042823|PMID:14726374), (MGI:3580924|PMID:15677556) RGD PMID:14726374 PMID:15677556 MGI:3042823 MGI:3580924 NCBI chr 5:133,864,401...133,878,604
Ensembl chr 5:133,864,798...133,878,830
JBrowse link
G Terc telomerase RNA component acts_upstream_of_or_within ISO MGI:1857930 (MGI:3715429|PMID:17554309) RGD PMID:17554309 MGI:3715429 NCBI chr 2:116,432,723...116,433,110
Ensembl chr 2:116,432,691...116,433,110
JBrowse link
G Tp53 tumor protein p53 involved_in ISO (PMID:30146126) RGD PMID:30146126 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Ufl1 Ufm1-specific ligase 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:5818653|PMID:25952549)
UniProt
RGD
PMID:25952549 GO_REF:0000024 MGI:5818653 NCBI chr 5:39,616,479...39,650,894
Ensembl chr 5:39,615,956...39,650,895
JBrowse link
G Xrcc5 X-ray repair cross complementing 5 acts_upstream_of_or_within ISO MGI:2152542 (MGI:3715429|PMID:17554309) RGD PMID:17554309 MGI:3715429 NCBI chr 9:79,659,275...79,748,050
Ensembl chr 9:79,659,251...79,748,078
JBrowse link
negative regulation of hematopoietic stem cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hspa9 heat shock protein family A (Hsp70) member 9 involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:5784980|PMID:21123823)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:21123823 GO_REF:0000024 GO_REF:0000107 MGI:5784980 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
JBrowse link
G N4bp2l2 NEDD4 binding protein 2-like 2 involved_in ISO (PMID:19506020) RGD PMID:19506020 NCBI chr12:627,128...650,604
Ensembl chr12:628,488...650,376
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 involved_in ISO (MGI:5476857|PMID:23434824) RGD PMID:23434824 MGI:5476857 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Tcf15 transcription factor 15 involved_in IEA
ISO
GO_REF:0000107
(MGI:6479302|PMID:32669716)
Ensembl
RGD
PMID:32669716 GO_REF:0000107 MGI:6479302 NCBI chr 3:147,643,250...147,649,511
Ensembl chr 3:147,643,250...147,649,504
JBrowse link
positive regulation of hematopoietic stem cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Foxc1 forkhead box C1 involved_in ISO (MGI:5569870|PMID:24590069) RGD PMID:24590069 MGI:5569870 NCBI chr17:33,947,501...33,951,484
Ensembl chr17:33,947,506...33,951,484
JBrowse link
regulation of hematopoietic stem cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk6 cyclin-dependent kinase 6 acts_upstream_of_or_within ISO MGI:3053975 (MGI:5636128|PMID:25342715) RGD PMID:25342715 MGI:5636128 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:5487705|PMID:23403623)
UniProt
RGD
PMID:23403623 GO_REF:0000024 MGI:5487705 NCBI chr 6:1,428,845...1,466,193
Ensembl chr 6:1,428,834...1,466,201
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit involved_in ISO (MGI:6414739|PMID:32103174) RGD PMID:32103174 MGI:6414739 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link
G Pus7 pseudouridine synthase 7 involved_in ISO (PMID:29628141) RGD PMID:29628141 NCBI chr 4:7,889,727...7,931,357
Ensembl chr 4:7,889,869...7,930,706
JBrowse link
G Setd1a SET domain containing 1A, histone lysine methyltransferase involved_in ISO (PMID:27141965) RGD PMID:27141965 NCBI chr 1:199,222,584...199,247,993
Ensembl chr 1:199,225,100...199,247,988
JBrowse link
G Ythdf2 YTH N(6)-methyladenosine RNA binding protein 2 involved_in ISO (MGI:6316688|PMID:30065315), (MGI:6317061|PMID:30150673) RGD PMID:30065315 PMID:30150673 MGI:6316688 MGI:6317061 NCBI chr 5:150,364,490...150,390,173
Ensembl chr 5:150,365,101...150,390,099
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19599
    cellular process 18451
      cellular developmental process 4460
        cell differentiation 4364
          hematopoietic progenitor cell differentiation 162
            hematopoietic stem cell differentiation 35
              negative regulation of hematopoietic stem cell differentiation 4
              positive regulation of hematopoietic stem cell differentiation 1
              regulation of hematopoietic stem cell differentiation + 11
Path 2
Term Annotations click to browse term
  biological_process 19599
    developmental process 6753
      anatomical structure development 6178
        multicellular organism development 5617
          system development 5288
            animal organ development 4053
              hematopoietic or lymphoid organ development 1026
                hemopoiesis 974
                  hematopoietic progenitor cell differentiation 162
                    hematopoietic stem cell differentiation 35
                      negative regulation of hematopoietic stem cell differentiation 4
                      positive regulation of hematopoietic stem cell differentiation 1
                      regulation of hematopoietic stem cell differentiation + 11
paths to the root