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ONTOLOGY REPORT - ANNOTATIONS

Term:relaxation of vascular associated smooth muscle
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Accession:GO:0060087 term browser browse the term
Definition:A negative regulation of smooth muscle contraction resulting in relaxation of vascular smooth muscle. The relaxation is mediated by a decrease in the phosphorylation state of myosin light chain. This can be achieved by removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases leading to a decrease myosin light chain kinase activity, and through calcium-independent pathways leading to a increase in myosin light chain phosphatase activity.
Synonyms:exact_synonym: relaxation of vascular smooth muscle;   vascular smooth muscle relaxation
 related_synonym: negative regulation of relaxation of vascular smooth muscle;   positive regulation of relaxation of vascular smooth muscle;   regulation of relaxation of vascular smooth muscle
 alt_id: GO:1905657;   GO:1905658;   GO:1905659


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relaxation of vascular associated smooth muscle term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2B adenosine A2b receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18340377) Ensembl
MGI		 PMID:18340377 GO_REF:0000107 NCBI chr17:15,850,362...15,975,746
Ensembl chr17:15,945,130...15,975,746 		JBrowse link
G GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16614755) Ensembl
MGI		 PMID:16614755 GO_REF:0000107 NCBI chr 4:155,666,848...155,737,059
Ensembl chr 4:155,666,726...155,737,059 		JBrowse link
G IRAG1 inositol 1,4,5-triphosphate receptor associated 1 acts_upstream_of_or_within ISO (PMID:15483626) MGI PMID:15483626 NCBI chr11:10,573,095...10,693,755
Ensembl chr11:10,573,091...10,693,988 		JBrowse link
G KCNMA1 potassium calcium-activated channel subfamily M alpha 1 involved_in
acts_upstream_of_or_within		 ISO (PMID:25139746)
(PMID:15867178)		 AgBase
MGI		 PMID:15867178 PMID:25139746 NCBI chr10:76,869,602...77,637,808
Ensembl chr10:76,869,601...77,638,369 		JBrowse link
G MIR153-1 microRNA 153-1 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 2:219,294,111...219,294,200
Ensembl chr 2:219,294,111...219,294,200 		JBrowse link
G MIR153-2 microRNA 153-2 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 7:157,574,336...157,574,422
Ensembl chr 7:157,574,336...157,574,422 		JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15483626) Ensembl
MGI		 PMID:15483626 GO_REF:0000107 NCBI chr10:50,990,888...52,298,350
Ensembl chr10:50,990,888...52,298,423 		JBrowse link
G RGS2 regulator of G protein signaling 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:192,809,039...192,812,275
Ensembl chr 1:192,809,039...192,812,275 		JBrowse link
G SOD1 superoxide dismutase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
ISS		 (PMID:12433839), (PMID:14679182) Ensembl
MGI
UniProt		 PMID:12433839 PMID:14679182 GO_REF:0000024 GO_REF:0000107 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G TRPC1 transient receptor potential cation channel subfamily C member 1 involved_in ISO (PMID:25139746) AgBase PMID:25139746 NCBI chr 3:142,724,034...142,807,888
Ensembl chr 3:142,724,034...142,807,888 		JBrowse link
G TRPV4 transient receptor potential cation channel subfamily V member 4 involved_in ISO (PMID:25139746) AgBase PMID:25139746 NCBI chr12:109,783,087...109,833,398
Ensembl chr12:109,783,087...109,833,406 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19669
    multicellular organismal process 8456
      negative regulation of multicellular organismal process 1488
        negative regulation of muscle contraction 38
          negative regulation of smooth muscle contraction 25
            relaxation of vascular associated smooth muscle 11
Path 2
Term Annotations click to browse term
  biological_process 19669
    biological regulation 13397
      regulation of biological process 13016
        regulation of multicellular organismal process 3587
          regulation of system process 737
            regulation of muscle system process 328
              regulation of muscle contraction 207
                negative regulation of muscle contraction 38
                  negative regulation of smooth muscle contraction 25
                    relaxation of vascular associated smooth muscle 11
paths to the root