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ONTOLOGY REPORT - ANNOTATIONS

Term:cyclic purine nucleotide metabolic process
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Accession:GO:0052652 term browser browse the term
Definition:The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue and the base is a purine.
Synonyms:exact_synonym: cyclic purine nucleotide metabolism


show annotations for term's descendants           Sort by:
cyclic purine nucleotide metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ampd2 adenosine monophosphate deaminase 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:23911318)		 UniProt
RGD		 PMID:23911318 GO_REF:0000024 NCBI chr 2:195,707,609...195,720,454
Ensembl chr 2:195,707,610...195,720,271 		JBrowse link
cAMP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy1 adenylate cyclase 1 involved_in IDA
IBA		 PMID:21873635 RGD
GO_Central		 PMID:14985420 PMID:21873635 RGD:2312640, RGD:13792537 NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969 		JBrowse link
G Adcy10 adenylate cyclase 10 involved_in IDA
ISO
IMP		 (PMID:12609998), (PMID:15659711) RGD PMID:12609998 PMID:15659711 PMID:9874775 PMID:7225326 PMID:16627466 More... RGD:1299450, RGD:2313177, RGD:2313173, RGD:2313171 NCBI chr13:77,747,752...77,833,952
Ensembl chr13:77,768,468...77,833,951 		JBrowse link
G Adcy2 adenylate cyclase 2 involved_in IDA
IBA
IEA		 PMID:21873635
GO_REF:0000117
PMID:18164588
PMID:10427002		 UniProt
RGD		 PMID:11738086 PMID:21873635 PMID:18164588 PMID:10427002 PMID:12711600 GO_REF:0000117, RGD:2312641, RGD:13792537, RGD:8553431, RGD:10400857, RGD:2312674 NCBI chr 1:34,375,639...34,822,237
Ensembl chr 1:34,375,895...34,822,236 		JBrowse link
G Adcy3 adenylate cyclase 3 involved_in IDA
IEA
ISO
IBA		 GO_REF:0000117
(MGI:1889935|PMID:11055432)
PMID:24363043
PMID:21873635		 UniProt
RGD		 PMID:11055432 PMID:12711600 PMID:24363043 PMID:21873635 GO_REF:0000117 MGI:1889935, RGD:2312674, RGD:10400870, RGD:13792537 NCBI chr 6:27,100,089...27,203,686
Ensembl chr 6:27,124,828...27,203,686 		JBrowse link
G Adcy4 adenylate cyclase 4 involved_in IDA
IEA
IBA		 PMID:8900209
GO_REF:0000117
PMID:21873635		 UniProt
RGD		 PMID:11738086 PMID:12711600 PMID:8900209 PMID:21873635 GO_REF:0000117, RGD:2312641, RGD:2312674, RGD:8554340, RGD:13792537 NCBI chr15:29,266,280...29,282,153
Ensembl chr15:29,266,287...29,282,108 		JBrowse link
G Adcy5 adenylate cyclase 5 involved_in IDA
IBA
IEA
ISO		 PMID:21873635
GO_REF:0000117
(PMID:15385642), (PMID:24700542), (PMID:24740569)		 UniProt
RGD		 PMID:15385642 PMID:24700542 PMID:24740569 PMID:11738086 PMID:21873635 More... GO_REF:0000117, RGD:2312641, RGD:13792537, RGD:2315006, RGD:2312674 NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974 		JBrowse link
G Adcy6 adenylate cyclase 6 involved_in IDA
IMP
ISO
IEA
IBA		 (PMID:17916776), (PMID:18403039)
(MGI:4457984|PMID:20466003)
GO_REF:0000117
PMID:21873635		 RGD
UniProt		 PMID:17916776 PMID:18403039 PMID:20466003 PMID:15961389 PMID:11738086 More... GO_REF:0000117 MGI:4457984, RGD:1598749, RGD:2312641, RGD:2312654, RGD:2312678, RGD:2312674, RGD:2313211, RGD:2315006, RGD:13792537 NCBI chr 7:129,742,827...129,763,922
Ensembl chr 7:129,742,838...129,763,754 		JBrowse link
G Adcy7 adenylate cyclase 7 involved_in IDA
IBA
ISO		 PMID:21873635
(PMID:11113152), (PMID:17760784)		 RGD PMID:11113152 PMID:17760784 PMID:12711600 PMID:21873635 RGD:2312674, RGD:13792537 NCBI chr19:18,740,875...18,798,924
Ensembl chr19:18,740,875...18,776,311 		JBrowse link
G Adcy8 adenylate cyclase 8 involved_in IMP
IBA
IEA		 PMID:21873635
GO_REF:0000117		 UniProt
RGD		 PMID:16741924 PMID:19444869 PMID:19305019 PMID:21873635 GO_REF:0000117, RGD:2312769, RGD:2312785, RGD:7241269, RGD:13792537 NCBI chr 7:96,417,310...96,665,911
Ensembl chr 7:96,417,324...96,665,911 		JBrowse link
G Adcy9 adenylate cyclase 9 acts_upstream_of_or_within
involved_in		 IMP
ISO		 (MGI:76465|PMID:7575502), (MGI:80863|PMID:8662814)
(PMID:10987815), (PMID:9628827)		 RGD PMID:7575502 PMID:8662814 PMID:9628827 PMID:10987815 PMID:19444869 MGI:76465 MGI:80863, RGD:2312785 NCBI chr10:11,138,966...11,262,067
Ensembl chr10:11,139,446...11,262,066 		JBrowse link
cAMP catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde10a phosphodiesterase 10A involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563 		JBrowse link
G Pde4a phosphodiesterase 4A involved_in IEA
ISO
IDA		 GO_REF:0000041
(MGI:1927461|PMID:11267656)
PMID:21323643
(PMID:18095939)
(PMID:9677330)
(PMID:7888306)
(PMID:11306681)
PMID:8557632		 UniProt
RGD		 PMID:7888306 PMID:9677330 PMID:11267656 PMID:11306681 PMID:18095939 More... GO_REF:0000041 MGI:1927461, RGD:151356649, RGD:633604 NCBI chr 8:19,706,649...19,751,937
Ensembl chr 8:19,703,290...19,751,961 		JBrowse link
G Pde4b phosphodiesterase 4B involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 5:116,799,827...117,367,707
Ensembl chr 5:116,799,971...117,367,696 		JBrowse link
G Pde4c phosphodiesterase 4C involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr16:18,690,727...18,711,555
Ensembl chr16:18,691,700...18,710,640 		JBrowse link
G Pde4d phosphodiesterase 4D involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884 		JBrowse link
G Pde7a phosphodiesterase 7A involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 2:101,714,767...101,806,853
Ensembl chr 2:101,718,444...101,806,681 		JBrowse link
G Pde8a phosphodiesterase 8A involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:135,166,143...135,288,986
Ensembl chr 1:135,166,237...135,288,024 		JBrowse link
G Pde8b phosphodiesterase 8B involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 2:26,275,117...26,479,725
Ensembl chr 2:26,276,635...26,509,209 		JBrowse link
cAMP metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 acts_upstream_of_or_within ISO MGI:1856936 (MGI:76872|PMID:7595494) RGD PMID:7595494 MGI:76872 NCBI chr 3:36,906,771...37,169,191
Ensembl chr 3:36,910,427...37,168,944 		JBrowse link
G Epha2 Eph receptor A2 involved_in ISO (PMID:27385333) RGD PMID:27385333 NCBI chr 5:153,605,644...153,634,115
Ensembl chr 5:153,605,644...153,634,117 		JBrowse link
G Hrh3 histamine receptor H3 IDA RGD PMID:11130725 RGD:151708734 NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642 		JBrowse link
cGMP biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 involved_in
acts_upstream_of_or_within		 IEA
IBA
ISO		 GO_REF:0000107
PMID:21873635
MGI:3640802 (MGI:3640061|PMID:16614755)
(PMID:23505436)		 Ensembl
RGD		 PMID:16614755 PMID:23505436 PMID:21873635 GO_REF:0000107 MGI:3640061, RGD:13792537 NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671 		JBrowse link
G Gucy1a2 guanylate cyclase 1 soluble subunit alpha 2 involved_in IEA GO_REF:0000043
GO_REF:0000002		 UniProt
InterPro		 GO_REF:0000002 GO_REF:0000043 NCBI chr 8:500,212...900,201
Ensembl chr 8:500,212...889,203 		JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 involved_in ISO
IBA		 (PMID:23505436)
PMID:21873635		 RGD PMID:23505436 PMID:21873635 RGD:13792537 NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916 		JBrowse link
G Gucy1b2 guanylate cyclase 1 soluble subunit beta 2 involved_in IEA GO_REF:0000002
GO_REF:0000043		 InterPro
UniProt		 GO_REF:0000002 GO_REF:0000043 NCBI chr15:36,589,501...36,669,441
Ensembl chr15:36,598,883...36,669,441 		JBrowse link
G Gucy2c guanylate cyclase 2C involved_in IEA
IBA		 GO_REF:0000043
PMID:21873635		 UniProt PMID:21873635 GO_REF:0000043, RGD:13792537 NCBI chr 4:169,568,505...169,649,092
Ensembl chr 4:169,568,529...169,649,092 		JBrowse link
G Gucy2d guanylate cyclase 2D, retinal involved_in IEA
IBA
ISO		 GO_REF:0000107
PMID:21873635
(MGI:5049799|PMID:21598940)		 Ensembl
RGD		 PMID:21598940 PMID:21873635 GO_REF:0000107 MGI:5049799, RGD:13792537 NCBI chr10:53,954,918...53,975,576
Ensembl chr10:53,959,010...53,974,067 		JBrowse link
G Gucy2e guanylate cyclase 2E involved_in IDA
IBA
IEA		 PMID:11580282
PMID:21873635
GO_REF:0000043		 UniProt PMID:11580282 PMID:21873635 GO_REF:0000043, RGD:15023466, RGD:13792537 NCBI chr 1:152,739,775...152,774,474
Ensembl chr 1:152,739,775...152,774,473 		JBrowse link
G Gucy2f guanylate cyclase 2F involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:105,710,356...105,808,183
Ensembl chr  X:105,710,356...105,808,183 		JBrowse link
G Gucy2g guanylate cyclase 2G involved_in IEA
IBA		 GO_REF:0000043
PMID:21873635		 UniProt PMID:21873635 GO_REF:0000043, RGD:13792537 NCBI chr 1:254,237,778...254,280,277
Ensembl chr 1:254,239,174...254,280,277 		JBrowse link
G Nppa natriuretic peptide A acts_upstream_of
involved_in		 ISO
IEA
IBA
IMP		 (PMID:1672777)
GO_REF:0000107
PMID:21873635		 RGD
Ensembl		 PMID:1672777 PMID:21873635 PMID:10559136 GO_REF:0000107, RGD:13792537, RGD:619660 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Nppb natriuretic peptide B acts_upstream_of
involved_in		 ISO
IBA		 (PMID:1672777)
PMID:21873635		 RGD PMID:1672777 PMID:21873635 RGD:13792537 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Nppc natriuretic peptide C involved_in
acts_upstream_of		 IBA
ISO		 PMID:21873635
(MGI:2177134|PMID:11259675)
(PMID:1672777)		 RGD PMID:1672777 PMID:11259675 PMID:21873635 MGI:2177134, RGD:13792537 NCBI chr 9:87,320,051...87,324,251
Ensembl chr 9:87,320,051...87,324,251 		JBrowse link
G Npr1 natriuretic peptide receptor 1 involved_in ISO
IBA
IEA		 (PMID:1672777)
PMID:21873635
GO_REF:0000043		 RGD
UniProt		 PMID:1672777 PMID:21873635 GO_REF:0000043, RGD:13792537 NCBI chr 2:175,934,181...175,950,118
Ensembl chr 2:175,934,181...175,949,505 		JBrowse link
G Npr2 natriuretic peptide receptor 2 acts_upstream_of
involved_in		 ISO
IEA
IBA		 (PMID:1672777)
GO_REF:0000107
PMID:21873635
GO_REF:0000043		 RGD
Ensembl
UniProt		 PMID:1672777 PMID:21873635 GO_REF:0000043 GO_REF:0000107, RGD:13792537 NCBI chr 5:57,883,171...57,901,590
Ensembl chr 5:57,883,171...57,901,580 		JBrowse link
cGMP catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pde10a phosphodiesterase 10A involved_in IEA GO_REF:0000041 UniProt GO_REF:0000041 NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563 		JBrowse link
G Pde1a phosphodiesterase 1A IMP RGD PMID:16514069 RGD:2312521 NCBI chr 3:64,745,140...65,025,178
Ensembl chr 3:64,747,269...65,024,874 		JBrowse link
G Pde2a phosphodiesterase 2A involved_in ISO
IEA
IBA		 (PMID:19828435)
(MGI:4420377|PMID:19632989)
GO_REF:0000107
PMID:21873635		 RGD
Ensembl		 PMID:19632989 PMID:19828435 PMID:21873635 GO_REF:0000107 MGI:4420377, RGD:13792537 NCBI chr 1:155,823,590...155,915,434
Ensembl chr 1:155,813,180...155,915,434 		JBrowse link
G Pde5a phosphodiesterase 5A involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000041
GO_REF:0000107
(MGI:2450821|PMID:12554648)		 UniProt
Ensembl
RGD		 PMID:12554648 GO_REF:0000041 GO_REF:0000107 MGI:2450821 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701 		JBrowse link
G Pde9a phosphodiesterase 9A involved_in ISS
IEA
ISO
IBA		 GO_REF:0000024
GO_REF:0000041
(MGI:1266874|PMID:9624145), (MGI:5634842|PMID:25799991)
(PMID:25799991)
PMID:21873635		 UniProt
RGD		 PMID:9624145 PMID:25799991 PMID:21873635 GO_REF:0000024 GO_REF:0000041 MGI:1266874 MGI:5634842, RGD:13792537 NCBI chr20:9,469,809...9,562,949
Ensembl chr20:9,469,848...9,562,948 		JBrowse link
cGMP metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2b2 ATPase plasma membrane Ca2+ transporting 2 acts_upstream_of_or_within ISO MGI:1857092 (MGI:66348|PMID:7518067), (MGI:68066|PMID:3038581) RGD PMID:3038581 PMID:7518067 MGI:66348 MGI:68066 NCBI chr 4:146,896,332...147,140,665
Ensembl chr 4:146,896,332...147,140,665 		JBrowse link
G Npr2 natriuretic peptide receptor 2 involved_in ISO MGI:1856702 (MGI:3579766|PMID:15722353) RGD PMID:15722353 MGI:3579766 NCBI chr 5:57,883,171...57,901,590
Ensembl chr 5:57,883,171...57,901,580 		JBrowse link
G Pde5a phosphodiesterase 5A acts_upstream_of_or_within ISO (MGI:4361111|PMID:19474061), (MGI:4834094|PMID:20511540) RGD PMID:19474061 PMID:20511540 MGI:4361111 MGI:4834094 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701 		JBrowse link
G Pde9a phosphodiesterase 9A involved_in ISO
ISS		 (PMID:9624146)
GO_REF:0000024		 RGD
UniProt		 PMID:9624146 GO_REF:0000024 NCBI chr20:9,469,809...9,562,949
Ensembl chr20:9,469,848...9,562,948 		JBrowse link
G Rora RAR-related orphan receptor A acts_upstream_of_or_within ISO MGI:1857035 (MGI:66348|PMID:7518067) RGD PMID:7518067 MGI:66348 NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19818
    metabolic process 12096
      nitrogen compound metabolic process 8258
        cellular nitrogen compound metabolic process 4012
          purine-containing compound metabolic process 468
            purine nucleotide metabolic process 433
              cyclic purine nucleotide metabolic process 42
                3',5'-cyclic diguanylic acid metabolic process 0
                cAMP metabolic process + 21
                cGMP metabolic process + 21
Path 2
Term Annotations click to browse term
  biological_process 19818
    metabolic process 12096
      cellular metabolic process 7496
        cellular aromatic compound metabolic process 3078
          nucleobase-containing compound metabolic process 2826
            nucleobase-containing small molecule metabolic process 573
              nucleoside phosphate metabolic process 500
                nucleotide metabolic process 489
                  cyclic nucleotide metabolic process 43
                    cyclic purine nucleotide metabolic process 42
                      3',5'-cyclic diguanylic acid metabolic process 0
                      cAMP metabolic process + 21
                      cGMP metabolic process + 21
paths to the root