Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of endopeptidase activity
go back to main search page
Accession:GO:0052548 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
Synonyms:related_synonym: protease regulator activity


show annotations for term's descendants           Sort by:
regulation of endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kng2 kininogen 2 IDA RGD PMID:3356189 RGD:1600550 NCBI chr11:77,913,876...77,936,247
Ensembl chr11:77,909,612...78,002,971 		JBrowse link
activation of cysteine-type endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pawr pro-apoptotic WT1 regulator IMP RGD PMID:10349840 RGD:9835366 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028 		JBrowse link
activation of cysteine-type endopeptidase activity involved in apoptotic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp4 caspase 4 TAS RGD PMID:11684090 RGD:632459 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Cck cholecystokinin IDA RGD PMID:11964411 RGD:625521 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084 		JBrowse link
G Tnfsf15 TNF superfamily member 15 IDA RGD PMID:11911831 RGD:634236 NCBI chr 5:77,134,885...77,156,171
Ensembl chr 5:77,139,878...77,156,228 		JBrowse link
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smad3 SMAD family member 3 IMP TGF-beta1-induced cleavage of BAD to its more active 15 kD form RGD PMID:11839804 RGD:2301029 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
negative regulation of cysteine-type endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Grk2 G protein-coupled receptor kinase 2 IMP RGD PMID:23690069 RGD:13792722 NCBI chr 1:201,580,823...201,601,580
Ensembl chr 1:201,581,480...201,601,582 		JBrowse link
G Htt huntingtin IMP RGD PMID:17124493 RGD:6902918 NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070 		JBrowse link
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor IDA RGD PMID:15211592 RGD:1625666 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386 		JBrowse link
G Akt2 AKT serine/threonine kinase 2 IMP caspase 3 RGD PMID:18348079 RGD:2313324 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817 		JBrowse link
G Arrb2 arrestin, beta 2 IMP RGD PMID:19171933 RGD:5510006 NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850 		JBrowse link
G Ep300 E1A binding protein p300 IMP cardiac myocytes RGD PMID:22562121 RGD:7327216 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Gpi glucose-6-phosphate isomerase IMP RGD PMID:12615053 RGD:1600634 NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086 		JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 IMP RGD PMID:15102845 RGD:1304324 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424 		JBrowse link
G Hnf1a HNF1 homeobox A IMP RGD PMID:21874357 RGD:150540304 NCBI chr12:41,638,536...41,672,806
Ensembl chr12:41,645,587...41,672,104 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B IDA reduced cleavage of Casp8 and Casp9 in brain following hypoxic/ischemic injury RGD PMID:16397188 RGD:1626654 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Il6 interleukin 6 IDA RGD PMID:19061939 RGD:2306937 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mdm2 MDM2 proto-oncogene IMP caspase-2, caspase-3 RGD PMID:19850968 RGD:2317361 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Por cytochrome p450 oxidoreductase IMP caspase-3 RGD PMID:19264869 RGD:2316785 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245 		JBrowse link
G Ptma prothymosin alpha IDA RGD PMID:12522243 RGD:734494 NCBI chr 9:87,176,251...87,180,333
Ensembl chr 9:87,176,230...87,180,333 		JBrowse link
negative regulation of endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin IDA RGD PMID:19240864 RGD:7411612 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Renbp renin binding protein IDA RGD PMID:11926999 RGD:727355 NCBI chr  X:151,661,463...151,670,538
Ensembl chr  X:151,661,458...151,670,516 		JBrowse link
G Serpine1 serpin family E member 1 IDA RGD PMID:10717410 RGD:8547889 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
negative regulation of serine-type endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Serpina1 serpin family A member 1 IDA RGD PMID:19240864 RGD:7411612 NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339 		JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 IDA RGD PMID:12771515 RGD:724699 NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642 		JBrowse link
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox12 arachidonate 12-lipoxygenase, 12S type IMP RGD PMID:15105833 RGD:2313858 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542 		JBrowse link
G Arrb1 arrestin, beta 1 IMP RGD PMID:19171933 RGD:5510006 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061 		JBrowse link
G Casp12 caspase 12 IMP RGD PMID:17083921 RGD:2311464 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Ccn2 cellular communication network factor 2 IMP caspase 3/7 RGD PMID:19625611 RGD:2314487 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Fas Fas cell surface death receptor IMP RGD PMID:15519734 RGD:8662904 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Hsf1 heat shock transcription factor 1 IMP RGD PMID:21192280 RGD:10403035 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 IMP RGD PMID:14522843 RGD:2304239 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha IMP RGD PMID:18322138 RGD:8693423 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862 		JBrowse link
G Pycard PYD and CARD domain containing IMP RGD PMID:19401709 RGD:5491174 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rhoa ras homolog family member A IMP RGD PMID:17425560 RGD:1642961 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Wdr35 WD repeat domain 35 IMP RGD PMID:20193664 RGD:11553917 NCBI chr 6:31,771,315...31,831,450
Ensembl chr 6:31,771,360...31,831,029 		JBrowse link
positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnf tumor necrosis factor IMP RGD PMID:12131680 RGD:14995454 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
positive regulation of endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akirin2 akirin 2 IMP MMP-9 RGD PMID:18460465 RGD:2306009 NCBI chr 5:49,108,231...49,122,566
Ensembl chr 5:49,108,220...49,122,568 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20413
    biological regulation 13755
      regulation of molecular function 323
        regulation of catalytic activity 195
          regulation of hydrolase activity 96
            regulation of peptidase activity 39
              regulation of endopeptidase activity 38
                negative regulation of endopeptidase activity + 19
                positive regulation of endopeptidase activity + 18
                regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process + 0
                regulation of cysteine-type endopeptidase activity + 31
                regulation of metalloendopeptidase activity + 0
                regulation of serine-type endopeptidase activity + 2
Path 2
Term Annotations click to browse term
  biological_process 20413
    metabolic process 11835
      organic substance metabolic process 11328
        macromolecule metabolic process 9578
          protein metabolic process 4746
            proteolysis 1615
              regulation of proteolysis 437
                regulation of peptidase activity 39
                  regulation of endopeptidase activity 38
                    negative regulation of endopeptidase activity + 19
                    positive regulation of endopeptidase activity + 18
                    regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process + 0
                    regulation of cysteine-type endopeptidase activity + 31
                    regulation of metalloendopeptidase activity + 0
                    regulation of serine-type endopeptidase activity + 2
paths to the root