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ONTOLOGY REPORT - ANNOTATIONS


Term:negative regulation of telomerase activity
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Accession:GO:0051974 term browser browse the term
Definition:Any process that stops or reduces the activity of the enzyme telomerase, which catalyzes of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
Synonyms:exact_synonym: down regulation of telomerase activity;   downregulation of telomerase activity
 narrow_synonym: inhibition of telomerase activity
 related_synonym: telomerase inhibitor


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negative regulation of telomerase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cers1 ceramide synthase 1 ISO (PMID:17548428) RGD PMID:17548428 NCBI chr16:20,845,580...20,860,789
Ensembl chr16:20,845,576...20,860,789
JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit NOT ISO (PMID:18812185) RGD PMID:18812185 NCBI chr10:2,010,140...2,037,953
Ensembl chr10:2,010,648...2,037,891
JBrowse link
G Mcrs1 microspherule protein 1 ISO (PMID:15044100) RGD PMID:15044100 NCBI chr 7:140,910,420...140,919,234
Ensembl chr 7:140,910,423...140,919,234
JBrowse link
G Men1 menin 1 ISO (PMID:12837246) RGD PMID:12837246 NCBI chr 1:221,704,394...221,710,343
Ensembl chr 1:221,704,493...221,710,331
JBrowse link
G Pif1 PIF1 5'-to-3' DNA helicase ISO (PMID:16522649) RGD PMID:16522649 NCBI chr 8:71,124,477...71,133,460
Ensembl chr 8:71,125,414...71,132,629
JBrowse link
G Pinx1 PIN2/TERF1 interacting, telomerase inhibitor 1 ISO (PMID:11701125), (PMID:21119197) RGD PMID:11701125, PMID:21119197 NCBI chr15:47,211,682...47,270,343
Ensembl chr15:47,211,583...47,270,317
JBrowse link
G Pml PML nuclear body scaffold ISO (PMID:19567472) RGD PMID:19567472 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Pot1 protection of telomeres 1 ISO
IBA
(PMID:15632080)
PMID:21873635
RGD PMID:15632080, PMID:21873635 RGD:13792537 NCBI chr 4:51,888,632...51,946,764
Ensembl chr 4:51,888,634...51,946,715
JBrowse link
G Pot1b protection of telomeres 1B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:7,845,697...7,902,270
Ensembl chr 9:7,845,845...7,891,514
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma IMP RGD PMID:16556873 RGD:1580657 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase ISO (PMID:21531765) RGD PMID:21531765 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Ten1 TEN1 subunit of CST complex IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr10:105,073,077...105,095,094
Ensembl chr10:105,073,077...105,095,094
JBrowse link
G Terf1 telomeric repeat binding factor 1 ISO UniProtKB:O14746 (PMID:11971978) RGD PMID:11971978 NCBI chr 5:2,853,455...2,882,731
Ensembl chr 5:2,853,459...2,882,668
JBrowse link
G Tp53 tumor protein p53 ISO (PMID:10597287) RGD PMID:10597287 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
negative regulation of telomerase RNA reverse transcriptase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Parp3 poly (ADP-ribose) polymerase family, member 3 ISO (PMID:24528514) RGD PMID:24528514 NCBI chr 8:115,173,440...115,179,543
Ensembl chr 8:115,173,453...115,179,191
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    biological regulation 13769
      regulation of molecular function 3074
        regulation of catalytic activity 2350
          negative regulation of catalytic activity 854
            negative regulation of transferase activity 291
              negative regulation of telomerase activity 15
                negative regulation of telomerase RNA reverse transcriptase activity 1
Path 2
Term Annotations click to browse term
  biological_process 20020
    metabolic process 12263
      cellular metabolic process 11073
        cellular aromatic compound metabolic process 5700
          nucleobase-containing compound metabolic process 5488
            nucleic acid metabolic process 4984
              DNA metabolic process 923
                regulation of DNA metabolic process 395
                  regulation of DNA biosynthetic process 125
                    regulation of telomerase activity 52
                      negative regulation of telomerase activity 15
                        negative regulation of telomerase RNA reverse transcriptase activity 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.