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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of telomerase activity
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Accession:GO:0051972 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Telomerases catalyze extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence.
Synonyms:exact_synonym: telomerase regulator


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regulation of telomerase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase NOT|involved_in ISO (PMID:26586427) RGD PMID:26586427 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Hmbox1 homeobox containing 1 involved_in ISO (PMID:23685356) RGD PMID:23685356 NCBI chr15:48,194,709...48,326,310
Ensembl chr15:48,199,995...48,284,548
JBrowse link
G Nabp2 nucleic acid binding protein 2 NOT|involved_in ISO (PMID:25589350) RGD PMID:25589350 NCBI chr 7:2,820,006...2,825,627
Ensembl chr 7:2,820,007...2,825,608
JBrowse link
G Parp4 poly (ADP-ribose) polymerase family, member 4 involved_in ISO (PMID:15169895) RGD PMID:15169895 NCBI chr15:36,809,362...36,911,167 JBrowse link
negative regulation of telomerase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cers1 ceramide synthase 1 involved_in ISO (PMID:17548428) RGD PMID:17548428 NCBI chr16:20,845,580...20,860,789
Ensembl chr16:20,845,576...20,860,789
JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit NOT|involved_in ISO (PMID:18812185) RGD PMID:18812185 NCBI chr10:2,010,140...2,037,953
Ensembl chr10:2,010,648...2,037,891
JBrowse link
G Mcrs1 microspherule protein 1 involved_in ISO (PMID:15044100) RGD PMID:15044100 NCBI chr 7:140,910,420...140,919,234
Ensembl chr 7:140,910,423...140,919,234
JBrowse link
G Men1 menin 1 involved_in ISO (PMID:12837246) RGD PMID:12837246 NCBI chr 1:221,704,394...221,710,343
Ensembl chr 1:221,704,493...221,710,331
JBrowse link
G Pif1 PIF1 5'-to-3' DNA helicase involved_in ISO (PMID:16522649) RGD PMID:16522649 NCBI chr 8:71,124,477...71,133,460
Ensembl chr 8:71,125,414...71,132,629
JBrowse link
G Pinx1 PIN2/TERF1 interacting, telomerase inhibitor 1 involved_in ISO (PMID:11701125), (PMID:21119197) RGD PMID:11701125 PMID:21119197 NCBI chr15:47,211,682...47,270,343
Ensembl chr15:47,211,583...47,270,317
JBrowse link
G Pml PML nuclear body scaffold involved_in ISO (PMID:19567472) RGD PMID:19567472 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Pot1 protection of telomeres 1 involved_in IBA
ISO
PMID:21873635
(PMID:15632080)
RGD PMID:15632080, PMID:21873635 RGD:13792537 NCBI chr 4:51,888,632...51,946,764
Ensembl chr 4:51,888,634...51,946,715
JBrowse link
G Pot1b protection of telomeres 1B involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:7,845,697...7,902,270
Ensembl chr 9:7,845,845...7,891,514
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma IMP RGD PMID:16556873 RGD:1580657 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO (PMID:21531765) RGD PMID:21531765 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Ten1 TEN1 subunit of CST complex involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr10:105,073,077...105,095,094
Ensembl chr10:105,073,077...105,095,094
JBrowse link
G Terf1 telomeric repeat binding factor 1 involved_in ISO UniProtKB:O14746 (PMID:11971978) RGD PMID:11971978 NCBI chr 5:2,853,455...2,882,731
Ensembl chr 5:2,853,459...2,882,668
JBrowse link
G Tp53 tumor protein p53 involved_in ISO (PMID:10597287) RGD PMID:10597287 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
negative regulation of telomerase RNA reverse transcriptase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Parp3 poly (ADP-ribose) polymerase family, member 3 involved_in ISO (PMID:24528514) RGD PMID:24528514 NCBI chr 8:115,173,440...115,179,543
Ensembl chr 8:115,173,453...115,179,191
JBrowse link
positive regulation of telomerase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acd ACD, shelterin complex subunit and telomerase recruitment factor involved_in ISO
IBA
(PMID:17237768)
PMID:21873635
RGD PMID:17237768, PMID:21873635 RGD:13792537 NCBI chr19:37,665,289...37,668,043
Ensembl chr19:37,665,296...37,667,987
JBrowse link
G Aurkb aurora kinase B involved_in ISO (PMID:21531765) RGD PMID:21531765 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991
JBrowse link
G Cct2 chaperonin containing TCP1 subunit 2 involved_in ISO (PMID:25467444) RGD PMID:25467444 NCBI chr 7:60,106,532...60,122,779
Ensembl chr 7:60,109,974...60,122,805
JBrowse link
G Cct4 chaperonin containing TCP1 subunit 4 involved_in ISO (PMID:25467444) RGD PMID:25467444 NCBI chr14:107,767,392...107,780,270
Ensembl chr14:107,767,392...107,780,270
JBrowse link
G Ctnnb1 catenin beta 1 involved_in
acts_upstream_of
IEA
ISO
GO_REF:0000107
(MGI:5428344|PMID:22723415)
Ensembl
RGD
PMID:22723415 GO_REF:0000107 MGI:5428344 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Dkc1 dyskerin pseudouridine synthase 1 involved_in
acts_upstream_of_or_within
ISO (PMID:25467444)
MGI:3849598 (MGI:3047190|PMID:15240872)
RGD PMID:15240872 PMID:25467444 MGI:3047190 NCBI chr  X:155,844,914...155,862,363
Ensembl chr  X:155,844,857...155,862,475
JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist involved_in ISO (PMID:16545136) RGD PMID:16545136 NCBI chr 3:105,203,309...105,214,989
Ensembl chr 3:105,203,309...105,214,989
JBrowse link
G Grhl2 grainyhead-like transcription factor 2 involved_in ISO (PMID:19015635), (PMID:20938050) RGD PMID:19015635 PMID:20938050 NCBI chr 7:76,058,623...76,197,360
Ensembl chr 7:76,059,386...76,197,856
JBrowse link
G Hmbox1 homeobox containing 1 involved_in ISO (PMID:23685356) RGD PMID:23685356 NCBI chr15:48,194,709...48,326,310
Ensembl chr15:48,199,995...48,284,548
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 involved_in ISO (PMID:10197982) RGD PMID:10197982 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 involved_in ISO (PMID:10197982) RGD PMID:10197982 NCBI chr 9:17,817,791...17,823,163
Ensembl chr 9:17,817,721...17,823,243
JBrowse link
G Klf4 Kruppel like factor 4 involved_in ISO (PMID:20629177) RGD PMID:20629177 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 involved_in ISO
IEA
(PMID:21531765)
GO_REF:0000107
RGD
Ensembl
PMID:21531765 GO_REF:0000107 NCBI chr12:2,546,278...2,555,310
Ensembl chr12:2,548,218...2,555,164
JBrowse link
G Map3k4 mitogen activated protein kinase kinase kinase 4 involved_in ISO (PMID:21531765) RGD PMID:21531765 NCBI chr 1:48,625,714...48,711,642
Ensembl chr 1:48,625,743...48,711,642
JBrowse link
G Mapk1 mitogen activated protein kinase 1 involved_in ISO (PMID:21531765) RGD PMID:21531765 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk15 mitogen-activated protein kinase 15 involved_in ISO
IEA
(PMID:21531765)
GO_REF:0000107
RGD
Ensembl
PMID:21531765 GO_REF:0000107 NCBI chr 7:117,041,287...117,061,799
Ensembl chr 7:117,055,395...117,061,047
JBrowse link
G Mapk3 mitogen activated protein kinase 3 involved_in ISO (PMID:21531765) RGD PMID:21531765 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapkapk5 MAPK activated protein kinase 5 involved_in ISO (PMID:21531765) RGD PMID:21531765 NCBI chr12:40,510,378...40,529,332
Ensembl chr12:40,510,378...40,529,338
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor involved_in ISO (MGI:5810267|PMID:9637678) RGD PMID:9637678 MGI:5810267 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Naf1 nuclear assembly factor 1 ribonucleoprotein involved_in ISO
IEA
(PMID:27510903)
GO_REF:0000107
RGD
Ensembl
PMID:27510903 GO_REF:0000107 NCBI chr16:24,582,000...24,612,773
Ensembl chr16:24,578,678...24,612,732
JBrowse link
G Nek2 NIMA-related kinase 2 involved_in ISO (PMID:21531765) RGD PMID:21531765 NCBI chr13:110,511,546...110,524,750
Ensembl chr13:110,511,668...110,522,769
JBrowse link
G Nek7 NIMA-related kinase 7 involved_in IEA
ISO
GO_REF:0000107
(PMID:21531765)
Ensembl
RGD
PMID:21531765 GO_REF:0000107 NCBI chr13:55,485,759...55,617,534
Ensembl chr13:55,488,531...55,561,750
JBrowse link
G Nvl nuclear VCP-like involved_in ISO
IBA
(PMID:22226966)
PMID:21873635
RGD PMID:22226966, PMID:21873635 RGD:13792537 NCBI chr13:99,410,026...99,468,783
Ensembl chr13:99,410,026...99,468,778
JBrowse link
G Parm1 prostate androgen-regulated mucin-like protein 1 involved_in IMP
IBA
PMID:12772192
PMID:21873635
UniProt
GO_Central
PMID:12772192, PMID:21873635 RGD:8553456, RGD:13792537 NCBI chr14:17,972,914...18,076,870
Ensembl chr14:17,969,219...18,076,907
JBrowse link
G Parn poly(A)-specific ribonuclease involved_in ISO (PMID:26482878) RGD PMID:26482878 NCBI chr10:1,309,724...1,461,123
Ensembl chr10:1,308,414...1,461,269
JBrowse link
G Pkib cAMP-dependent protein kinase inhibitor beta involved_in ISO
IEA
(PMID:21531765)
GO_REF:0000107
RGD
Ensembl
PMID:21531765 GO_REF:0000107 NCBI chr20:40,616,868...40,712,598
Ensembl chr20:40,618,128...40,712,592
JBrowse link
G Pnkp polynucleotide kinase 3'-phosphatase involved_in ISO (PMID:21531765) RGD PMID:21531765 NCBI chr 1:100,853,475...100,859,202
Ensembl chr 1:100,853,902...100,859,084
JBrowse link
G Pot1 protection of telomeres 1 involved_in ISO (PMID:15181449), (PMID:16043710), (PMID:17237768) RGD PMID:15181449 PMID:16043710 PMID:17237768 NCBI chr 4:51,888,632...51,946,764
Ensembl chr 4:51,888,634...51,946,715
JBrowse link
G Prkcq protein kinase C, theta involved_in ISO
IEA
(PMID:21531765)
GO_REF:0000107
RGD
Ensembl
PMID:21531765 GO_REF:0000107 NCBI chr17:70,971,915...71,105,286
Ensembl chr17:70,971,915...71,105,286
JBrowse link
G Ptges3 prostaglandin E synthase 3 involved_in ISO (PMID:10197982), (PMID:19740745)
(MGI:5819359|PMID:10197982)
RGD PMID:10197982 PMID:19740745 MGI:5819359 NCBI chr 7:2,479,267...2,497,024
Ensembl chr 7:2,479,311...2,497,013
JBrowse link
G Tcp1 t-complex 1 involved_in ISO (PMID:25467444) RGD PMID:25467444 NCBI chr 1:48,025,664...48,033,343
Ensembl chr 1:48,025,663...48,033,396
JBrowse link
G Tnks tankyrase involved_in ISO (PMID:12782650) RGD PMID:12782650 NCBI chr16:60,925,093...61,067,192
Ensembl chr16:60,925,093...61,067,192
JBrowse link
G Wrap53 WD repeat containing, antisense to TP53 involved_in ISS
ISO
GO_REF:0000024
(MGI:6189679|PMID:29804836)
(PMID:19179534), (PMID:23685356), (PMID:25467444), (PMID:29804836)
UniProt
RGD
PMID:19179534 PMID:23685356 PMID:25467444 PMID:29804836 GO_REF:0000024 MGI:6189679 NCBI chr10:56,169,024...56,185,800
Ensembl chr10:56,169,025...56,185,857
JBrowse link
positive regulation of telomerase RNA reverse transcriptase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 involved_in IDA PMID:23184978 BHF-UCL PMID:23184978 RGD:11567256 NCBI chr 4:81,237,496...81,241,281
Ensembl chr 4:81,237,496...81,241,282
JBrowse link
G Hnrnpd heterogeneous nuclear ribonucleoprotein D involved_in ISO (MGI:5438900|PMID:22633954) RGD PMID:22633954 MGI:5438900 NCBI chr14:11,256,163...11,274,684
Ensembl chr14:11,256,268...11,274,578
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    biological regulation 13514
      regulation of molecular function 3070
        regulation of catalytic activity 2372
          regulation of transferase activity 901
            regulation of telomerase activity 52
              negative regulation of telomerase activity + 15
              positive regulation of telomerase activity 33
              regulation of telomerase RNA reverse transcriptase activity + 3
Path 2
Term Annotations click to browse term
  biological_process 19491
    metabolic process 11797
      cellular metabolic process 10755
        cellular aromatic compound metabolic process 5636
          nucleobase-containing compound metabolic process 5420
            nucleic acid metabolic process 4930
              DNA metabolic process 882
                regulation of DNA metabolic process 392
                  regulation of DNA biosynthetic process 125
                    regulation of telomerase activity 52
                      negative regulation of telomerase activity + 15
                      positive regulation of telomerase activity 33
                      regulation of telomerase RNA reverse transcriptase activity + 3
paths to the root