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ONTOLOGY REPORT - ANNOTATIONS

Term:synaptic transmission, GABAergic
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Accession:GO:0051932 term browser browse the term
Definition:The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
Synonyms:exact_synonym: synaptic transmission, GABA mediated;   synaptic transmission, gamma-aminobutyric acid mediated;   synaptic transmission, gamma-aminobutyric acid-ergic

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synaptic transmission, GABAergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh5a1 aldehyde dehydrogenase 5 family member A1 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chrNW_004936671:843,577...865,798
Ensembl chrNW_004936671:843,577...865,881 		JBrowse link
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 NOT|acts_upstream_of_or_within ISO (PMID:10322048) MGI PMID:10322048 NCBI chrNW_004936469:25,494,820...25,745,783
Ensembl chrNW_004936469:25,494,883...25,740,223 		JBrowse link
G Clcn3 chloride voltage-gated channel 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936516:1,678,610...1,760,099
Ensembl chrNW_004936516:1,678,653...1,760,294 		JBrowse link
G Clstn3 calsyntenin 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936709:641,615...673,309
Ensembl chrNW_004936709:637,641...673,314 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit ISO RGD PMID:27690696 RGD:126781724 NCBI chrNW_004936527:5,024,077...5,069,152
Ensembl chrNW_004936527:5,024,068...5,063,939 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936515:1,806,721...1,859,227
Ensembl chrNW_004936515:1,805,239...1,859,600 		JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 ISO RGD PMID:16554486 RGD:1626493 NCBI chrNW_004936515:1,982,415...1,997,740
Ensembl chrNW_004936515:1,980,824...1,998,053 		JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta2 involved_in ISO PMID:12930820 BHF-UCL PMID:12930820 RGD:8554754 NCBI chrNW_004936515:2,127,107...2,359,697
Ensembl chrNW_004936515:2,127,693...2,355,090 		JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta3 involved_in ISO
IEA 		RGD
Ensembl		 PMID:12356876 GO_REF:0000107 RGD:727440 NCBI chrNW_004936471:39,791,633...40,193,049
Ensembl chrNW_004936471:39,791,613...40,187,923 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma2 involved_in ISO (PMID:14993607)
PMID:12930820 		UniProt
BHF-UCL		 PMID:12930820 PMID:14993607 RGD:8554754 NCBI chrNW_004936515:1,609,370...1,670,412
Ensembl chrNW_004936515:1,607,722...1,671,336 		JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 acts_upstream_of ISO (PMID:17245443) MGI PMID:17245443 NCBI chrNW_004936500:12,157,215...12,536,555
Ensembl chrNW_004936500:12,157,765...12,536,224 		JBrowse link
G Hapln4 hyaluronan and proteoglycan link protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936596:2,175,414...2,181,825
Ensembl chrNW_004936596:2,175,361...2,182,799 		JBrowse link
G LOC101960999 voltage-dependent P/Q-type calcium channel subunit alpha-1A NOT|acts_upstream_of_or_within ISO (PMID:10322048) MGI PMID:10322048 NCBI chrNW_004936659:2,201,606...2,269,625
Ensembl chrNW_004936659:2,192,610...2,392,638 		JBrowse link
G Nlgn2 neuroligin 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936595:692,340...704,650
Ensembl chrNW_004936595:692,334...704,602 		JBrowse link
G Prkce protein kinase C epsilon acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chrNW_004936508:6,018,374...6,495,216
Ensembl chrNW_004936508:6,017,551...6,494,427 		JBrowse link
G Rac1 Rac family small GTPase 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936750:107,689...122,679
Ensembl chrNW_004936750:107,689...122,676 		JBrowse link
G Rac3 Rac family small GTPase 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936594:5,527,788...5,530,694
Ensembl chrNW_004936594:5,528,908...5,531,420 		JBrowse link
G Slitrk3 SLIT and NTRK like family member 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936707:1,315,267...1,324,793
Ensembl chrNW_004936707:1,315,267...1,324,026 		JBrowse link
G Tpbg trophoblast glycoprotein acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936510:8,274,760...8,278,955
Ensembl chrNW_004936510:8,275,660...8,278,367 		JBrowse link
G Vps54 VPS54 subunit of GARP complex involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936491:8,835,397...8,922,403
Ensembl chrNW_004936491:8,833,285...8,922,711 		JBrowse link
gamma-aminobutyric acid secretion, neurotransmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Best1 bestrophin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936581:1,120,681...1,132,226
Ensembl chrNW_004936581:1,120,474...1,132,230 		JBrowse link
G Nf1 neurofibromin 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936538:3,394,623...3,596,025
Ensembl chrNW_004936538:3,398,222...3,595,261 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 acts_upstream_of_or_within ISO (PMID:25242307) MGI PMID:25242307 NCBI chrNW_004936498:6,001,126...6,135,663
Ensembl chrNW_004936498:6,001,014...6,086,614 		JBrowse link
negative regulation of synaptic transmission, GABAergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor NOT ISO in immature hippocampal CA1 neurons
in postnatal 30 day hippocampal CA1 neurons 		RGD PMID:12626609 RGD:1625273 NCBI chrNW_004936567:1,430,128...1,508,626
Ensembl chrNW_004936567:1,429,817...1,462,532 		JBrowse link
G Bdnf brain derived neurotrophic factor acts_upstream_of_or_within ISO (PMID:16754670) MGI PMID:16754670 NCBI chrNW_004936540:5,530,081...5,582,765
Ensembl chrNW_004936540:5,529,942...5,585,014 		JBrowse link
G Cnr2 cannabinoid receptor 2 ISO RGD PMID:19616018 RGD:2316192 NCBI chrNW_004936474:9,019,044...9,020,110
Ensembl chrNW_004936474:9,019,067...9,020,110 		JBrowse link
G Cntnap2 contactin associated protein 2 involved_in ISO (PMID:28966979) MGI PMID:28966979 NCBI chrNW_004936527:2,859,442...4,748,885
Ensembl chrNW_004936527:2,859,930...4,746,995 		JBrowse link
G Drd4 dopamine receptor D4 ISO RGD PMID:12417643 RGD:401960856 NCBI chrNW_004936888:468,334...471,254
Ensembl chrNW_004936888:468,403...471,205 		JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 ISO RGD PMID:12533604 RGD:1642497 NCBI chrNW_004936500:12,157,215...12,536,555
Ensembl chrNW_004936500:12,157,765...12,536,224 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B ISO RGD PMID:17229091 RGD:1626455 NCBI chrNW_004936890:154,252...157,044
Ensembl chrNW_004936890:155,233...156,408 		JBrowse link
G Npy5r neuropeptide Y receptor Y5 ISO RGD PMID:11796508 RGD:1625505 NCBI chrNW_004936555:2,248,699...2,252,637
Ensembl chrNW_004936555:2,248,699...2,252,637 		JBrowse link
G Slc6a1 solute carrier family 6 member 1 ISO RGD PMID:17317750 RGD:1643193 NCBI chrNW_004936602:2,359,151...2,397,346
Ensembl chrNW_004936602:2,357,607...2,379,061 		JBrowse link
G Stxbp1 syntaxin binding protein 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936487:15,300,758...15,367,475
Ensembl chrNW_004936487:15,300,952...15,365,713 		JBrowse link
positive regulation of synaptic transmission, GABAergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936619:597,970...618,564
Ensembl chrNW_004936619:608,441...616,779 		JBrowse link
G Adra1a adrenoceptor alpha 1A ISO RGD PMID:14532911 RGD:1625778 NCBI chrNW_004936757:149,366...237,710
Ensembl chrNW_004936757:150,496...237,710 		JBrowse link
G Ca2 carbonic anhydrase 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936544:362,591...379,151
Ensembl chrNW_004936544:362,591...380,223 		JBrowse link
G Ca7 carbonic anhydrase 7 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936475:17,112,004...17,120,105
Ensembl chrNW_004936475:17,112,004...17,120,105 		JBrowse link
G Cckbr cholecystokinin B receptor ISO RGD PMID:17904218 RGD:2311326 NCBI chrNW_004936842:329,551...341,491
Ensembl chrNW_004936842:329,376...341,808 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 ISO RGD PMID:17521572 RGD:2289989 NCBI chrNW_004936586:4,065,767...5,100,690
Ensembl chrNW_004936586:4,066,498...5,100,035 		JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 acts_upstream_of_or_within ISO (PMID:17245443) RGD
MGI		 PMID:12533604 PMID:17245443 RGD:1642497 NCBI chrNW_004936500:12,157,215...12,536,555
Ensembl chrNW_004936500:12,157,765...12,536,224 		JBrowse link
G Hap1 huntingtin associated protein 1 involved_in ISO PMID:20152113 UniProt PMID:20152113 RGD:10047142 NCBI chrNW_004936490:16,645,116...16,652,310
Ensembl chrNW_004936490:16,643,520...16,652,479 		JBrowse link
G Kif5b kinesin family member 5B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936574:780,074...823,858
Ensembl chrNW_004936574:779,777...823,970 		JBrowse link
G Nalcn sodium leak channel, non-selective involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936472:9,502,054...9,789,714
Ensembl chrNW_004936472:9,502,030...9,789,638 		JBrowse link
G Nlgn1 neuroligin 1 involved_in ISO PMID:12930820 BHF-UCL PMID:12930820 RGD:8554754 NCBI chrNW_004936703:951,935...1,415,991
Ensembl chrNW_004936703:758,647...1,414,185 		JBrowse link
G Nlgn2 neuroligin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936595:692,340...704,650
Ensembl chrNW_004936595:692,334...704,602 		JBrowse link
G Nps neuropeptide S involved_in
acts_upstream_of_or_within 		IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936486:15,172,068...15,175,568
Ensembl chrNW_004936486:15,172,256...15,175,339 		JBrowse link
G Oxtr oxytocin receptor ISO RGD PMID:11069593 RGD:2304220 NCBI chrNW_004936602:4,241,743...4,259,866
Ensembl chrNW_004936602:4,241,737...4,260,549 		JBrowse link
G Prkce protein kinase C epsilon acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936508:6,018,374...6,495,216
Ensembl chrNW_004936508:6,017,551...6,494,427 		JBrowse link
G Tac1 tachykinin precursor 1 ISO RGD PMID:19261870 RGD:2304250 NCBI chrNW_004936585:2,932,783...2,941,141
Ensembl chrNW_004936585:2,932,727...2,941,384 		JBrowse link
G Tacr1 tachykinin receptor 1 ISO RGD PMID:19261870 RGD:2304250 NCBI chrNW_004936556:1,266,621...1,421,271
Ensembl chrNW_004936556:1,266,613...1,421,275 		JBrowse link
G Zdhhc12 zDHHC palmitoyltransferase 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936487:16,201,288...16,203,818
Ensembl chrNW_004936487:16,199,742...16,203,858 		JBrowse link
G Zdhhc3 zDHHC palmitoyltransferase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936695:776,822...830,693
Ensembl chrNW_004936695:776,822...832,361 		JBrowse link
regulation of synaptic transmission, GABAergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Baiap3 BAI1 associated protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936694:2,542,521...2,556,540
Ensembl chrNW_004936694:2,543,195...2,556,540 		JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936501:11,955,334...11,967,338
Ensembl chrNW_004936501:11,955,184...11,967,436 		JBrowse link
G Cnr1 cannabinoid receptor 1 ISO RGD PMID:19725112 RGD:2314643 NCBI chrNW_004936510:3,779,930...3,806,615
Ensembl chrNW_004936510:3,781,210...3,802,693 		JBrowse link
G Cntnap4 contactin associated protein family member 4 involved_in ISO (PMID:24870235) UniProt PMID:24870235 NCBI chrNW_004936475:24,809,813...25,049,362
Ensembl chrNW_004936475:24,809,531...25,049,854 		JBrowse link
G Dbi diazepam binding inhibitor, acyl-CoA binding protein acts_upstream_of_or_within ISO PMID:3456171 MGI PMID:3456171 RGD:8554715 NCBI chrNW_004936469:50,981,198...50,986,224
Ensembl chrNW_004936469:50,980,595...50,986,506 		JBrowse link
G Drd2 dopamine receptor D2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936612:1,094,686...1,154,149
Ensembl chrNW_004936612:1,094,680...1,154,798 		JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936628:3,155,261...3,284,375
Ensembl chrNW_004936628:3,154,109...3,345,660 		JBrowse link
G Kras KRAS proto-oncogene, GTPase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936548:2,078,568...2,113,877
Ensembl chrNW_004936548:2,079,036...2,110,523 		JBrowse link
G Nf1 neurofibromin 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936538:3,394,623...3,596,025
Ensembl chrNW_004936538:3,398,222...3,595,261 		JBrowse link
G Nisch nischarin ISO RGD PMID:16467528 RGD:1582692 NCBI chrNW_004936473:3,295,515...3,331,324 JBrowse link
G Npas4 neuronal PAS domain protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936599:3,144,829...3,150,307
Ensembl chrNW_004936599:3,144,793...3,150,377 		JBrowse link
G Phf24 PHD finger protein 24 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chrNW_004936524:3,020,421...3,031,720
Ensembl chrNW_004936524:3,005,705...3,031,744 		JBrowse link
G Plcl1 phospholipase C like 1 (inactive) involved_in
acts_upstream_of_or_within 		IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936506:1,124,318...1,457,842
Ensembl chrNW_004936506:1,125,806...1,457,316 		JBrowse link
G Plcl2 phospholipase C like 2 acts_upstream_of_or_within
involved_in 		IEA Ensembl
TreeGrafter
InterPro		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936473:9,628,612...9,801,713
Ensembl chrNW_004936473:9,627,811...9,802,132 		JBrowse link
G Pten phosphatase and tensin homolog acts_upstream_of_or_within ISO (PMID:24875179) MGI PMID:24875179 NCBI chrNW_004936735:1,252,414...1,338,318
Ensembl chrNW_004936735:1,252,414...1,338,323 		JBrowse link
G Slc38a1 solute carrier family 38 member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936512:4,438,827...4,504,416
Ensembl chrNW_004936512:4,444,684...4,487,165 		JBrowse link
G Usp46 ubiquitin specific peptidase 46 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936482:15,539,123...15,603,733
Ensembl chrNW_004936482:15,538,504...15,603,693 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17413
    cellular process 17012
      cell communication 6280
        cell-cell signaling 1305
          synaptic signaling 853
            trans-synaptic signaling 818
              anterograde trans-synaptic signaling 810
                chemical synaptic transmission 810
                  synaptic transmission, GABAergic 64
                    gamma-aminobutyric acid secretion, neurotransmission 3
                    negative regulation of synaptic transmission, GABAergic 10
                    positive regulation of synaptic transmission, GABAergic 19
                    regulation of synaptic transmission, GABAergic + 45
Path 2
Term Annotations click to browse term
  biological_process 17413
    biological regulation 11396
      regulation of biological process 11032
        signaling 6245
          cell-cell signaling 1305
            synaptic signaling 853
              trans-synaptic signaling 818
                anterograde trans-synaptic signaling 810
                  chemical synaptic transmission 810
                    synaptic transmission, GABAergic 64
                      gamma-aminobutyric acid secretion, neurotransmission 3
                      negative regulation of synaptic transmission, GABAergic 10
                      positive regulation of synaptic transmission, GABAergic 19
                      regulation of synaptic transmission, GABAergic + 45
paths to the root