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ONTOLOGY REPORT - ANNOTATIONS


Term:synaptic transmission, GABAergic
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Accession:GO:0051932 term browser browse the term
Definition:The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
Synonyms:exact_synonym: synaptic transmission, GABA mediated;   synaptic transmission, gamma-aminobutyric acid mediated;   synaptic transmission, gamma-aminobutyric acid-ergic


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synaptic transmission, GABAergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit JBrowse link 8 84,338,631 84,640,251 RGD:2290270
G Cacnb4 calcium channel, voltage-dependent, beta 4 subunit JBrowse link 2 52,428,320 52,676,609 RGD:2290270
G Clcn3 chloride channel, voltage-sensitive 3 JBrowse link 8 60,910,389 60,983,317 RGD:2290270
G Clstn3 calsyntenin 3 JBrowse link 6 124,430,756 124,464,784 RGD:2290270
G Dnm1 dynamin 1 JBrowse link 2 32,308,471 32,353,349 RGD:2290270
G Gabra1 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1 JBrowse link 11 42,130,939 42,183,066 RGD:2290270
G Gabra2 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 2 JBrowse link 5 70,958,392 71,095,849 RGD:2290270
G Gabra3 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 3 JBrowse link X 72,432,676 72,656,919 RGD:2290270
G Gabra4 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4 JBrowse link 5 71,569,734 71,658,308 RGD:2290270
G Gabra5 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5 JBrowse link 7 57,407,669 57,591,016 RGD:2290270
G Gabra6 gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6 JBrowse link 11 42,306,437 42,321,072 RGD:2290270
G Gabrb2 gamma-aminobutyric acid (GABA) A receptor, subunit beta 2 JBrowse link 11 42,419,515 42,632,591 RGD:2290270
G Gabrb3 gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 JBrowse link 7 57,590,518 57,828,802 RGD:2290270
G Gabre gamma-aminobutyric acid (GABA) A receptor, subunit epsilon JBrowse link X 72,256,926 72,274,828 RGD:2290270
G Gabrg1 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 1 JBrowse link 5 70,751,047 70,842,617 RGD:2290270
G Gabrg2 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 JBrowse link 11 41,910,190 42,000,857 RGD:2290270
G Gabrg3 gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3 JBrowse link 7 56,716,463 57,387,215 RGD:2290270
G Rac1 Rac family small GTPase 1 JBrowse link 5 143,505,481 143,528,031 RGD:2290270
G Rac3 Rac family small GTPase 3 JBrowse link 11 120,721,468 120,723,969 RGD:2290270
gamma-aminobutyric acid secretion, neurotransmission term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nf1 neurofibromin 1 JBrowse link 11 79,339,590 79,581,609 RGD:2290270
G Pak1 p21 (RAC1) activated kinase 1 JBrowse link 7 97,788,541 97,912,381 RGD:2290270
negative regulation of synaptic transmission, GABAergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adora1 adenosine A1 receptor JBrowse link 1 134,199,215 134,235,457 RGD:2290270
G Bdnf brain derived neurotrophic factor JBrowse link 2 109,674,700 109,727,043 RGD:2290270
G Cnr2 cannabinoid receptor 2 (macrophage) JBrowse link 4 135,895,189 135,920,219 RGD:2290270
G Grik1 glutamate receptor, ionotropic, kainate 1 JBrowse link 16 87,895,897 88,290,863 RGD:2290270
G Htr1b 5-hydroxytryptamine (serotonin) receptor 1B JBrowse link 9 81,628,291 81,633,832 RGD:2290270
G Npy5r neuropeptide Y receptor Y5 JBrowse link 8 66,679,965 66,688,094 RGD:2290270
G Slc6a1 solute carrier family 6 (neurotransmitter transporter, GABA), member 1 JBrowse link 6 114,282,635 114,317,525 RGD:2290270
G Stxbp1 syntaxin binding protein 1 JBrowse link 2 32,787,607 32,847,237 RGD:2290270
positive regulation of synaptic transmission, GABAergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adora2a adenosine A2a receptor JBrowse link 10 75,316,877 75,334,792 RGD:2290270
G Adra1a adrenergic receptor, alpha 1a JBrowse link 14 66,635,251 66,771,240 RGD:2290270
G Car2 carbonic anhydrase 2 JBrowse link 3 14,886,269 14,900,770 RGD:2290270
G Car7 carbonic anhydrase 7 JBrowse link 8 104,534,694 104,550,347 RGD:2290270
G Cckbr cholecystokinin B receptor JBrowse link 7 105,425,676 105,436,339 RGD:2290270
G Erbb4 erb-b2 receptor tyrosine kinase 4 JBrowse link 1 68,031,884 69,108,576 RGD:2290270
G Grik1 glutamate receptor, ionotropic, kainate 1 JBrowse link 16 87,895,897 88,290,863 RGD:2290270
G Hap1 huntingtin-associated protein 1 JBrowse link 11 100,347,327 100,356,982 RGD:2290270
G Kif5b kinesin family member 5B JBrowse link 18 6,201,005 6,241,524 RGD:2290270
G Nlgn1 neuroligin 1 JBrowse link 3 25,421,808 26,332,866 RGD:2290270
G Nlgn2 neuroligin 2 JBrowse link 11 69,823,123 69,837,784 RGD:2290270
G Nps neuropeptide S JBrowse link 7 135,268,619 135,272,942 RGD:2290270
G Oxtr oxytocin receptor JBrowse link 6 112,473,683 112,491,035 RGD:2290270
G Prkce protein kinase C, epsilon JBrowse link 17 86,167,785 86,657,919 RGD:2290270
G Tac1 tachykinin 1 JBrowse link 6 7,555,061 7,562,978 RGD:2290270
G Tacr1 tachykinin receptor 1 JBrowse link 6 82,402,003 82,560,104 RGD:2290270
regulation of synaptic transmission, GABAergic term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Baiap3 BAI1-associated protein 3 JBrowse link 17 25,242,659 25,256,364 RGD:2290270
G Cnr1 cannabinoid receptor 1 (brain) JBrowse link 4 33,923,171 33,948,831 RGD:2290270
G Cntnap4 contactin associated protein-like 4 JBrowse link 8 112,569,798 112,882,707 RGD:2290270
G Dbi diazepam binding inhibitor JBrowse link 1 120,113,280 120,121,096 RGD:2290270
G Drd2 dopamine receptor D2 JBrowse link 9 49,340,360 49,408,177 RGD:2290270
G Kras Kirsten rat sarcoma viral oncogene homolog JBrowse link 6 145,216,699 145,250,420 RGD:2290270
G Nf1 neurofibromin 1 JBrowse link 11 79,339,590 79,581,609 RGD:2290270
G Npas4 neuronal PAS domain protein 4 JBrowse link 19 4,984,353 5,003,439 RGD:2290270
G Phf24 PHD finger protein 24 JBrowse link 4 42,872,618 42,944,752 RGD:2290270
G Plcl1 phospholipase C-like 1 JBrowse link 1 55,405,946 55,754,285 RGD:2290270
G Plcl2 phospholipase C-like 2 JBrowse link 17 50,508,865 50,688,494 RGD:2290270
G Pten phosphatase and tensin homolog JBrowse link 19 32,757,577 32,826,160 RGD:2290270
G Usp46 ubiquitin specific peptidase 46 JBrowse link 5 73,998,726 74,068,411 RGD:2290270

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23109
    signaling 6649
      cell-cell signaling 1645
        synaptic signaling 899
          trans-synaptic signaling 874
            anterograde trans-synaptic signaling 865
              chemical synaptic transmission 865
                synaptic transmission, GABAergic 56
                  gamma-aminobutyric acid secretion, neurotransmission 2
                  negative regulation of synaptic transmission, GABAergic 8
                  positive regulation of synaptic transmission, GABAergic 16
                  regulation of synaptic transmission, GABAergic + 36
Path 2
Term Annotations click to browse term
  biological_process 23109
    cellular process 15852
      cell communication 6716
        cell-cell signaling 1645
          synaptic signaling 899
            trans-synaptic signaling 874
              anterograde trans-synaptic signaling 865
                chemical synaptic transmission 865
                  synaptic transmission, GABAergic 56
                    gamma-aminobutyric acid secretion, neurotransmission 2
                    negative regulation of synaptic transmission, GABAergic 8
                    positive regulation of synaptic transmission, GABAergic 16
                    regulation of synaptic transmission, GABAergic + 36
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.