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ONTOLOGY REPORT - ANNOTATIONS

Term:synaptic transmission, GABAergic
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Accession:GO:0051932 term browser browse the term
Definition:The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
Synonyms:exact_synonym: synaptic transmission, GABA mediated;   synaptic transmission, gamma-aminobutyric acid mediated;   synaptic transmission, gamma-aminobutyric acid-ergic

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synaptic transmission, GABAergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH5A1 aldehyde dehydrogenase 5 family member A1 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr17:47,712,785...47,746,198
Ensembl chr17:47,709,888...47,745,830 		JBrowse link
G CACNA1A calcium voltage-gated channel subunit alpha1 A NOT|acts_upstream_of_or_within ISO (PMID:10322048) MGI PMID:10322048 NCBI chr 6:11,883,353...12,307,023 JBrowse link
G CACNB4 calcium voltage-gated channel auxiliary subunit beta 4 NOT|acts_upstream_of_or_within ISO (PMID:10322048) MGI PMID:10322048 NCBI chr10:37,240,749...37,518,174
Ensembl chr10:37,246,991...37,388,059 		JBrowse link
G CLCN3 chloride voltage-gated channel 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 7:115,826,756...115,926,842
Ensembl chr 7:115,826,778...115,928,609 		JBrowse link
G CLSTN3 calsyntenin 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr11:7,197,725...7,226,479
Ensembl chr11:7,197,539...7,226,651 		JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit ISO RGD PMID:27690696 RGD:126781724 NCBI chr21:117,380,518...117,515,224
Ensembl chr21:117,380,361...117,421,573 		JBrowse link
G GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:64,199,372...64,255,996
Ensembl chr23:64,200,752...64,255,996 		JBrowse link
G GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 ISO RGD PMID:16554486 RGD:1626493 NCBI chr23:64,020,770...64,038,419
Ensembl chr23:64,021,842...64,039,563 		JBrowse link
G GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 involved_in ISO PMID:12930820 BHF-UCL PMID:12930820 RGD:8554754 NCBI chr23:63,636,094...63,894,587
Ensembl chr23:63,637,109...63,893,370 		JBrowse link
G GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 involved_in ISO
IEA 		RGD
Ensembl		 PMID:12356876 GO_REF:0000107 RGD:727440 NCBI chr26:55,319,667...55,543,116
Ensembl chr26:55,471,907...55,538,855 		JBrowse link
G GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 involved_in ISO (PMID:14993607)
PMID:12930820 		UniProt
BHF-UCL		 PMID:12930820 PMID:14993607 RGD:8554754 NCBI chr23:64,422,519...64,512,124
Ensembl chr23:64,422,391...64,513,652 		JBrowse link
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 acts_upstream_of ISO (PMID:17245443) MGI PMID:17245443 NCBI chr 2:62,286,828...62,692,061 JBrowse link
G HAPLN4 hyaluronan and proteoglycan link protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:17,721,746...17,728,920
Ensembl chr 6:17,724,018...17,727,715 		JBrowse link
G NLGN2 neuroligin 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr16:6,781,510...6,796,304
Ensembl chr16:6,784,642...6,794,419 		JBrowse link
G PRKCE protein kinase C epsilon acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr14:61,022,903...61,570,390
Ensembl chr14:61,026,017...61,242,343 		JBrowse link
G RAC1 Rac family small GTPase 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr28:15,583,609...15,610,753
Ensembl chr28:15,583,516...15,610,328 		JBrowse link
G RAC3 Rac family small GTPase 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr16:73,919,086...73,921,647
Ensembl chr16:73,919,128...73,925,277 		JBrowse link
G SLITRK3 SLIT and NTRK like family member 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr15:24,361,523...24,374,865
Ensembl chr15:24,367,287...24,370,226 		JBrowse link
G TPBG trophoblast glycoprotein acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr13:7,047,658...7,051,390
Ensembl chr13:7,049,415...7,050,680 		JBrowse link
G VPS54 VPS54 subunit of GARP complex involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:43,000,960...43,127,129
Ensembl chr14:43,008,915...43,125,850 		JBrowse link
gamma-aminobutyric acid secretion, neurotransmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BEST1 bestrophin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:11,841,052...11,857,694
Ensembl chr 1:11,837,837...11,857,233 		JBrowse link
G NF1 neurofibromin 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr16:24,550,983...24,836,311
Ensembl chr16:24,550,977...24,836,307 		JBrowse link
G PAK1 p21 (RAC1) activated kinase 1 acts_upstream_of_or_within ISO (PMID:25242307) MGI PMID:25242307 NCBI chr 1:68,530,037...68,679,413
Ensembl chr 1:68,529,571...68,617,092 		JBrowse link
negative regulation of synaptic transmission, GABAergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA1 adenosine A1 receptor NOT ISO in immature hippocampal CA1 neurons
in postnatal 30 day hippocampal CA1 neurons 		RGD PMID:12626609 RGD:1625273 NCBI chr25:26,180,898...26,221,424
Ensembl chr25:26,182,446...26,220,776 		JBrowse link
G BDNF brain derived neurotrophic factor acts_upstream_of_or_within ISO (PMID:16754670) MGI PMID:16754670 NCBI chr 1:37,386,825...37,451,380
Ensembl chr 1:37,449,593...37,450,336 		JBrowse link
G CNR2 cannabinoid receptor 2 ISO RGD PMID:19616018 RGD:2316192 NCBI chr20:108,777,793...108,815,738
Ensembl chr20:108,813,579...108,814,661 		JBrowse link
G CNTNAP2 contactin associated protein 2 involved_in ISO (PMID:28966979) MGI PMID:28966979 NCBI chr21:114,741,918...116,988,691 JBrowse link
G DRD4 dopamine receptor D4 ISO RGD PMID:12417643 RGD:401960856 NCBI chr 1:454,018...459,582 JBrowse link
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 ISO RGD PMID:12533604 RGD:1642497 NCBI chr 2:62,286,828...62,692,061 JBrowse link
G HTR1B 5-hydroxytryptamine receptor 1B ISO RGD PMID:17229091 RGD:1626455 NCBI chr13:2,143,646...2,145,943
Ensembl chr13:2,144,313...2,145,485 		JBrowse link
G NPY5R neuropeptide Y receptor Y5 ISO RGD PMID:11796508 RGD:1625505 NCBI chr 7:109,790,907...109,801,929 JBrowse link
G SLC6A1 solute carrier family 6 member 1 ISO RGD PMID:17317750 RGD:1643193 NCBI chr22:47,033,436...47,076,785
Ensembl chr22:47,033,467...47,078,844 		JBrowse link
G STXBP1 syntaxin binding protein 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr12:10,440,061...10,519,798
Ensembl chr12:10,439,801...10,519,777 		JBrowse link
positive regulation of synaptic transmission, GABAergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2A adenosine A2a receptor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr19:7,691,678...7,706,781
Ensembl chr19:7,691,536...7,706,926 		JBrowse link
G ADRA1A adrenoceptor alpha 1A ISO RGD PMID:14532911 RGD:1625778 NCBI chr 8:24,884,187...24,985,824
Ensembl chr 8:24,885,741...24,983,125 		JBrowse link
G CA2 carbonic anhydrase 2 acts_upstream_of_or_within ISO (PMID:23881097) MGI PMID:23881097 NCBI chr 8:80,830,963...80,848,245
Ensembl chr 8:80,830,939...80,848,707 		JBrowse link
G CA7 carbonic anhydrase 7 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 5:52,541,008...52,551,307
Ensembl chr 5:52,541,527...52,551,389 		JBrowse link
G CCKBR cholecystokinin B receptor ISO RGD PMID:17904218 RGD:2311326 NCBI chr 1:58,555,463...58,569,949
Ensembl chr 1:58,555,321...58,568,031 		JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 ISO RGD PMID:17521572 RGD:2289989 NCBI chr10:97,099,090...98,281,697 JBrowse link
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 acts_upstream_of_or_within ISO (PMID:17245443) RGD
MGI		 PMID:12533604 PMID:17245443 RGD:1642497 NCBI chr 2:62,286,828...62,692,061 JBrowse link
G HAP1 huntingtin associated protein 1 involved_in ISO PMID:20152113 UniProt PMID:20152113 RGD:10047142 NCBI chr16:64,515,013...64,524,270 JBrowse link
G KIF5B kinesin family member 5B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:31,321,615...31,369,549
Ensembl chr 9:31,320,549...31,369,519 		JBrowse link
G NALCN sodium leak channel, non-selective involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 3:79,663,714...80,010,361
Ensembl chr 3:79,663,725...79,992,503 		JBrowse link
G NLGN1 neuroligin 1 involved_in ISO PMID:12930820 BHF-UCL PMID:12930820 RGD:8554754 NCBI chr15:15,129,976...16,017,107 JBrowse link
G NLGN2 neuroligin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:6,781,510...6,796,304
Ensembl chr16:6,784,642...6,794,419 		JBrowse link
G NPS neuropeptide S involved_in
acts_upstream_of_or_within 		IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr 9:120,168,749...120,176,288 JBrowse link
G OXTR oxytocin receptor ISO RGD PMID:11069593 RGD:2304220 NCBI chr22:44,746,108...44,764,501
Ensembl chr22:44,742,419...44,763,243 		JBrowse link
G PRKCE protein kinase C epsilon acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr14:61,022,903...61,570,390
Ensembl chr14:61,026,017...61,242,343 		JBrowse link
G TAC1 tachykinin precursor 1 ISO RGD PMID:19261870 RGD:2304250 NCBI chr21:51,339,085...51,347,561
Ensembl chr21:51,339,095...51,347,550 		JBrowse link
G TACR1 tachykinin receptor 1 ISO RGD PMID:19261870 RGD:2304250 NCBI chr14:32,080,319...32,236,556
Ensembl chr14:32,083,615...32,233,596 		JBrowse link
G ZDHHC12 zDHHC palmitoyltransferase 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:9,419,784...9,423,091
Ensembl chr12:9,419,852...9,422,774 		JBrowse link
G ZDHHC3 zDHHC palmitoyltransferase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:6,391,980...6,452,079
Ensembl chr22:6,403,431...6,452,037 		JBrowse link
regulation of synaptic transmission, GABAergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAIAP3 BAI1 associated protein 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:1,222,994...1,237,823
Ensembl chr 5:1,227,910...1,236,898 		JBrowse link
G CLN3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:26,320,132...26,343,009
Ensembl chr 5:26,320,061...26,337,402 		JBrowse link
G CNR1 cannabinoid receptor 1 ISO RGD PMID:19725112 RGD:2314643 NCBI chr13:12,626,259...12,653,253
Ensembl chr13:12,630,270...12,631,688 		JBrowse link
G CNTNAP4 contactin associated protein family member 4 involved_in ISO (PMID:24870235) UniProt PMID:24870235 NCBI chr 5:61,706,427...61,984,656
Ensembl chr 5:61,706,444...61,982,587 		JBrowse link
G DBI diazepam binding inhibitor, acyl-CoA binding protein acts_upstream_of_or_within ISO PMID:3456171 MGI PMID:3456171 RGD:8554715 NCBI chr10:10,956,529...10,962,135 JBrowse link
G DRD2 dopamine receptor D2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 1:104,774,632...104,843,417
Ensembl chr 1:104,774,180...104,842,736 		JBrowse link
G KCNK2 potassium two pore domain channel subfamily K member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:14,341,147...14,570,982
Ensembl chr25:14,340,123...14,487,420 		JBrowse link
G KRAS KRAS proto-oncogene, GTPase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr11:24,963,396...25,010,747
Ensembl chr11:24,973,619...25,005,191 		JBrowse link
G NF1 neurofibromin 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr16:24,550,983...24,836,311
Ensembl chr16:24,550,977...24,836,307 		JBrowse link
G NISCH nischarin ISO RGD PMID:16467528 RGD:1582692 NCBI chr22:13,821,026...13,860,430
Ensembl chr22:13,841,352...13,860,498 		JBrowse link
G NPAS4 neuronal PAS domain protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:7,856,222...7,874,812
Ensembl chr 1:7,856,939...7,862,052 		JBrowse link
G PHF24 PHD finger protein 24 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr12:45,635,910...45,661,692
Ensembl chr12:45,635,885...45,661,446 		JBrowse link
G PLCL1 phospholipase C like 1 (inactive) involved_in
acts_upstream_of_or_within 		IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr10:83,291,683...83,640,634
Ensembl chr10:83,574,894...83,642,768 		JBrowse link
G PLCL2 phospholipase C like 2 involved_in
acts_upstream_of_or_within 		IEA InterPro
Ensembl
TreeGrafter		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr15:61,745,338...61,940,176
Ensembl chr15:61,745,163...61,942,655 		JBrowse link
G PTEN phosphatase and tensin homolog acts_upstream_of_or_within ISO (PMID:24875179) MGI PMID:24875179 NCBI chr 9:81,308,058...81,412,386
Ensembl chr 9:81,309,099...81,409,146 		JBrowse link
G SLC38A1 solute carrier family 38 member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:42,415,986...42,502,794
Ensembl chr11:42,421,910...42,472,838 		JBrowse link
G USP46 ubiquitin specific peptidase 46 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:15,821,206...15,891,058
Ensembl chr 7:15,821,284...15,887,550 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19826
    cellular process 19340
      cell communication 6247
        cell-cell signaling 1375
          synaptic signaling 893
            trans-synaptic signaling 860
              anterograde trans-synaptic signaling 850
                chemical synaptic transmission 850
                  synaptic transmission, GABAergic 64
                    gamma-aminobutyric acid secretion, neurotransmission 3
                    negative regulation of synaptic transmission, GABAergic 10
                    positive regulation of synaptic transmission, GABAergic 19
                    regulation of synaptic transmission, GABAergic + 45
Path 2
Term Annotations click to browse term
  biological_process 19826
    biological regulation 12155
      regulation of biological process 11760
        signaling 6210
          cell-cell signaling 1375
            synaptic signaling 893
              trans-synaptic signaling 860
                anterograde trans-synaptic signaling 850
                  chemical synaptic transmission 850
                    synaptic transmission, GABAergic 64
                      gamma-aminobutyric acid secretion, neurotransmission 3
                      negative regulation of synaptic transmission, GABAergic 10
                      positive regulation of synaptic transmission, GABAergic 19
                      regulation of synaptic transmission, GABAergic + 45
paths to the root