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ONTOLOGY REPORT - ANNOTATIONS

Term:synaptic transmission, GABAergic
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Accession:GO:0051932 term browser browse the term
Definition:The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
Synonyms:exact_synonym: synaptic transmission, GABA mediated;   synaptic transmission, gamma-aminobutyric acid mediated;   synaptic transmission, gamma-aminobutyric acid-ergic


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synaptic transmission, GABAergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH5A1 aldehyde dehydrogenase 5 family member A1 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr35:22,560,005...22,590,996
Ensembl chr35:22,560,008...22,587,875 		JBrowse link
G CACNA1A calcium voltage-gated channel subunit alpha1 A NOT|acts_upstream_of_or_within ISO (PMID:10322048) MGI PMID:10322048 NCBI chr20:48,747,087...49,036,627
Ensembl chr20:48,821,025...49,036,032 		JBrowse link
G CACNB4 calcium voltage-gated channel auxiliary subunit beta 4 NOT|acts_upstream_of_or_within ISO (PMID:10322048) MGI PMID:10322048 NCBI chr19:52,987,170...53,116,410
Ensembl chr19:52,993,618...53,116,140
Ensembl chr19:52,993,618...53,116,140 		JBrowse link
G CLCN3 chloride voltage-gated channel 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr25:20,528,708...20,616,687
Ensembl chr25:20,528,699...20,615,070 		JBrowse link
G CLSTN3 calsyntenin 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr27:37,879,047...37,913,317
Ensembl chr27:37,879,269...37,913,281 		JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit ISO RGD PMID:27690696 RGD:126781724 NCBI chr16:1,926,443...1,991,995
Ensembl chr16:1,925,956...1,991,838 		JBrowse link
G GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:49,006,981...49,065,205
Ensembl chr 4:49,009,495...49,062,581 		JBrowse link
G GABRA2 gamma-aminobutyric acid type A receptor subunit alpha2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr13:42,367,988...42,488,069
Ensembl chr13:42,368,949...42,488,075 		JBrowse link
G GABRA3 gamma-aminobutyric acid type A receptor subunit alpha3 involved_in IBA GO_Central GO_REF:0000033 NCBI chr  X:120,152,650...120,460,604
Ensembl chr  X:120,153,261...120,460,119 		JBrowse link
G GABRA4 gamma-aminobutyric acid type A receptor subunit alpha4 involved_in IBA GO_Central GO_REF:0000033 NCBI chr13:42,889,100...42,958,604
Ensembl chr13:42,897,655...42,959,206 		JBrowse link
G GABRA5 gamma-aminobutyric acid type A receptor subunit alpha5 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 3:33,663,414...33,746,120
Ensembl chr 3:33,664,169...33,744,328 		JBrowse link
G GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 involved_in ISO
IBA		 RGD
GO_Central		 PMID:16554486 GO_REF:0000033 RGD:1626493 NCBI chr 4:49,208,691...49,225,754
Ensembl chr 4:49,208,605...49,226,212 		JBrowse link
G GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 involved_in ISO PMID:12930820 BHF-UCL PMID:12930820 RGD:8554754 NCBI chr 4:49,342,527...49,579,697
Ensembl chr 4:49,342,508...49,578,092 		JBrowse link
G GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 involved_in ISO
IEA		 RGD
Ensembl		 PMID:12356876 GO_REF:0000107 RGD:727440 NCBI chr 3:33,878,948...34,101,987
Ensembl chr 3:33,878,904...34,097,764 		JBrowse link
G GABRE gamma-aminobutyric acid type A receptor subunit epsilon involved_in IBA GO_Central GO_REF:0000033 NCBI chr  X:119,913,867...119,937,867
Ensembl chr  X:119,913,867...119,937,909 		JBrowse link
G GABRG1 gamma-aminobutyric acid type A receptor subunit gamma1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr13:42,194,929...42,276,379
Ensembl chr13:42,200,202...42,276,711 		JBrowse link
G GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:48,794,770...48,901,859
Ensembl chr 4:48,796,852...48,901,548 		JBrowse link
G GABRG3 gamma-aminobutyric acid type A receptor subunit gamma3 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 3:32,956,061...33,641,971
Ensembl chr 3:32,964,122...33,642,686 		JBrowse link
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 acts_upstream_of ISO (PMID:17245443) MGI PMID:17245443 NCBI chr31:24,477,319...24,839,502
Ensembl chr31:24,478,696...24,839,434 		JBrowse link
G HAPLN4 hyaluronan and proteoglycan link protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:43,932,364...43,940,438
Ensembl chr20:43,933,769...43,938,262 		JBrowse link
G NLGN2 neuroligin 2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 5:32,338,602...32,351,546
Ensembl chr 5:32,340,335...32,352,412 		JBrowse link
G PRKCE protein kinase C epsilon acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr10:47,976,929...48,464,614
Ensembl chr10:47,976,768...48,535,296 		JBrowse link
G RAC1 Rac family small GTPase 1 acts_upstream_of_or_within ISO (PMID:23258346) MGI PMID:23258346 NCBI chr 6:11,726,259...11,758,532
Ensembl chr 6:11,655,494...11,757,216 		JBrowse link
G RAC3 Rac family small GTPase 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:293,260...295,990 JBrowse link
G SLITRK3 SLIT and NTRK like family member 3 acts_upstream_of_or_within ISO (PMID:29107521) MGI PMID:29107521 NCBI chr34:30,447,606...30,456,444
Ensembl chr34:30,447,659...30,450,598 		JBrowse link
G TPBG trophoblast glycoprotein acts_upstream_of_or_within ISO (PMID:27488640) MGI PMID:27488640 NCBI chr12:42,872,289...42,878,071
Ensembl chr12:42,871,239...42,875,151 		JBrowse link
G TPBG trophoblast glycoprotein acts_upstream_of_or_within IEA Ensembl GO_REF:0000107
G VPS54 VPS54 subunit of GARP complex involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:63,598,373...63,676,753
Ensembl chr10:63,599,229...63,676,747 		JBrowse link
gamma-aminobutyric acid secretion, neurotransmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BEST1 bestrophin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:54,468,844...54,483,565
Ensembl chr18:54,468,844...54,480,311 		JBrowse link
G NF1 neurofibromin 1 acts_upstream_of_or_within ISO (PMID:25242307) MGI PMID:25242307 NCBI chr 9:41,467,460...41,679,388
Ensembl chr 9:41,469,416...41,679,382 		JBrowse link
G PAK1 p21 (RAC1) activated kinase 1 acts_upstream_of_or_within ISO (PMID:25242307) MGI PMID:25242307 NCBI chr21:21,341,530...21,409,535
Ensembl chr21:21,265,484...21,408,416 		JBrowse link
negative regulation of synaptic transmission, GABAergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA1 adenosine A1 receptor NOT ISO in postnatal 30 day hippocampal CA1 neurons
in immature hippocampal CA1 neurons		 RGD PMID:12626609 RGD:1625273 NCBI chr 7:44,819...74,217
Ensembl chr 7:44,820...73,051 		JBrowse link
G BDNF brain derived neurotrophic factor acts_upstream_of_or_within ISO (PMID:16754670) MGI PMID:16754670 NCBI chr21:48,191,580...48,243,699
Ensembl chr21:48,192,670...48,204,480 		JBrowse link
G CNR2 cannabinoid receptor 2 ISO RGD PMID:19616018 RGD:2316192 NCBI chr 2:75,640,636...75,662,000
Ensembl chr 2:75,658,999...75,660,126 		JBrowse link
G CNTNAP2 contactin associated protein 2 involved_in ISO (PMID:28966979) MGI PMID:28966979 NCBI chr16:2,239,953...4,208,718
Ensembl chr16:2,243,918...4,208,416 		JBrowse link
G DRD4 dopamine receptor D4 ISO RGD PMID:12417643 RGD:401960856
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 ISO RGD PMID:12533604 RGD:1642497 NCBI chr31:24,477,319...24,839,502
Ensembl chr31:24,478,696...24,839,434 		JBrowse link
G HTR1B 5-hydroxytryptamine receptor 1B ISO RGD PMID:17229091 RGD:1626455 NCBI chr12:38,659,088...38,659,546 JBrowse link
G NPY5R neuropeptide Y receptor Y5 ISO RGD PMID:11796508 RGD:1625505 NCBI chr15:59,600,212...59,608,576
Ensembl chr15:59,606,902...59,608,273 		JBrowse link
G SLC6A1 solute carrier family 6 member 1 ISO RGD PMID:17317750 RGD:1643193 NCBI chr20:7,341,071...7,383,197
Ensembl chr20:7,341,072...7,383,287 		JBrowse link
G STXBP1 syntaxin binding protein 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:55,690,939...55,768,008
Ensembl chr 9:55,678,264...55,727,680 		JBrowse link
positive regulation of synaptic transmission, GABAergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2A adenosine A2a receptor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr26:28,141,076...28,150,600
Ensembl chr26:28,141,076...28,150,598 		JBrowse link
G ADRA1A adrenoceptor alpha 1A ISO RGD PMID:14532911 RGD:1625778 NCBI chr25:30,690,959...30,801,484
Ensembl chr25:30,693,571...30,801,486 		JBrowse link
G CA2 carbonic anhydrase 2 acts_upstream_of_or_within ISO (PMID:23881097) MGI PMID:23881097 NCBI chr29:31,959,225...31,975,309
Ensembl chr29:31,935,172...31,980,579 		JBrowse link
G CA7 carbonic anhydrase 7 acts_upstream_of_or_within ISO (PMID:23881097) MGI PMID:23881097 NCBI chr 5:82,446,239...82,455,445
Ensembl chr 5:82,446,246...82,455,590 		JBrowse link
G CCKBR cholecystokinin B receptor ISO RGD PMID:17904218 RGD:2311326 NCBI chr21:29,602,066...29,606,343
Ensembl chr21:29,604,150...29,605,725 		JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 ISO RGD PMID:17521572 RGD:2289989 NCBI chr37:19,029,647...20,134,576
Ensembl chr37:19,037,217...20,134,426 		JBrowse link
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 acts_upstream_of_or_within ISO (PMID:17245443) RGD
MGI		 PMID:12533604 PMID:17245443 RGD:1642497 NCBI chr31:24,477,319...24,839,502
Ensembl chr31:24,478,696...24,839,434 		JBrowse link
G HAP1 huntingtin associated protein 1 involved_in ISO PMID:20152113 UniProt PMID:20152113 RGD:10047142 NCBI chr 9:21,065,770...21,074,462
Ensembl chr 9:21,065,846...21,072,991 		JBrowse link
G KIF5B kinesin family member 5B involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:14,835,906...14,880,896
Ensembl chr 2:14,835,901...14,878,251 		JBrowse link
G NALCN sodium leak channel, non-selective involved_in IBA GO_Central GO_REF:0000033 NCBI chr22:50,821,983...51,142,000
Ensembl chr22:50,823,478...51,141,644 		JBrowse link
G NLGN1 neuroligin 1 involved_in ISO PMID:12930820 BHF-UCL PMID:12930820 RGD:8554754 NCBI chr34:37,397,772...38,203,634
Ensembl chr34:37,572,629...38,203,177 		JBrowse link
G NLGN2 neuroligin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:32,338,602...32,351,546
Ensembl chr 5:32,340,335...32,352,412 		JBrowse link
G NPS neuropeptide S involved_in
acts_upstream_of_or_within		 IBA
IEA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr28:36,488,430...36,492,524
Ensembl chr28:36,488,500...36,492,090 		JBrowse link
G OXTR oxytocin receptor ISO RGD PMID:11069593 RGD:2304220 NCBI chr20:9,358,797...9,382,308
Ensembl chr20:9,358,916...9,378,343 		JBrowse link
G PRKCE protein kinase C epsilon acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr10:47,976,929...48,464,614
Ensembl chr10:47,976,768...48,535,296 		JBrowse link
G TAC1 tachykinin precursor 1 ISO RGD PMID:19261870 RGD:2304250 NCBI chr14:22,631,106...22,640,283
Ensembl chr14:22,632,642...22,640,258 		JBrowse link
G TACR1 tachykinin receptor 1 ISO RGD PMID:19261870 RGD:2304250 NCBI chr17:48,038,010...48,178,971
Ensembl chr17:48,038,010...48,178,971 		JBrowse link
G ZDHHC12 zinc finger DHHC-type palmitoyltransferase 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:54,877,188...54,880,579
Ensembl chr 9:54,877,110...54,880,553 		JBrowse link
G ZDHHC3 zinc finger DHHC-type palmitoyltransferase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:43,379,669...43,433,101
Ensembl chr20:43,379,722...43,431,414 		JBrowse link
regulation of synaptic transmission, GABAergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAIAP3 BAI1 associated protein 3 involved_in ISO (PMID:23698091) UniProt PMID:23698091 NCBI chr 6:39,421,019...39,434,539
Ensembl chr 6:39,427,520...39,435,596 		JBrowse link
G CLN3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:18,252,543...18,266,033
Ensembl chr 6:18,254,139...18,266,033 		JBrowse link
G CNR1 cannabinoid receptor 1 ISO RGD PMID:19725112 RGD:2314643 NCBI chr12:47,537,240...47,560,723
Ensembl chr12:47,509,583...47,560,983 		JBrowse link
G CNTNAP4 contactin associated protein family member 4 involved_in ISO (PMID:24870235) UniProt PMID:24870235 NCBI chr 5:74,507,728...74,748,798
Ensembl chr 5:74,509,885...74,748,767 		JBrowse link
G DBI diazepam binding inhibitor, acyl-CoA binding protein acts_upstream_of_or_within ISO PMID:3456171 MGI PMID:3456171 RGD:8554715 NCBI chr19:30,640,429...30,645,704
Ensembl chr19:30,640,429...30,646,405 		JBrowse link
G DRD2 dopamine receptor D2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 5:19,732,842...19,795,241
Ensembl chr 5:19,732,836...19,795,241 		JBrowse link
G KCNK2 potassium two pore domain channel subfamily K member 2 involved_in ISO (PMID:22726831) UniProt PMID:22726831 NCBI chr 7:12,893,654...13,092,319
Ensembl chr 7:12,894,149...13,090,110 		JBrowse link
G KRAS KRAS proto-oncogene, GTPase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr27:22,261,753...22,296,704
Ensembl chr27:22,257,941...22,293,369 		JBrowse link
G NF1 neurofibromin 1 acts_upstream_of_or_within ISO (PMID:11793011) MGI PMID:11793011 NCBI chr 9:41,467,460...41,679,388
Ensembl chr 9:41,469,416...41,679,382 		JBrowse link
G NISCH nischarin ISO RGD PMID:16467528 RGD:1582692 NCBI chr20:37,278,660...37,312,549
Ensembl chr20:37,279,282...37,312,636 		JBrowse link
G NPAS4 neuronal PAS domain protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:50,905,614...50,912,119
Ensembl chr18:50,905,611...50,911,086 		JBrowse link
G PHF24 PHD finger protein 24 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr11:51,552,345...51,580,762
Ensembl chr11:51,569,770...51,577,059 		JBrowse link
G PLCL1 phospholipase C like 1 (inactive) involved_in
acts_upstream_of_or_within		 IBA
IEA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr37:7,235,403...7,575,429
Ensembl chr37:7,235,424...7,562,708 		JBrowse link
G PLCL2 phospholipase C like 2 involved_in
acts_upstream_of_or_within		 IEA
IBA		 InterPro
Ensembl
GO_Central		 GO_REF:0000002 GO_REF:0000033 GO_REF:0000107 NCBI chr23:25,814,392...25,999,666
Ensembl chr23:25,814,862...25,999,749 		JBrowse link
G PTEN phosphatase and tensin homolog acts_upstream_of_or_within ISO (PMID:24875179) MGI PMID:24875179 NCBI chr26:37,853,148...37,913,176
Ensembl chr26:37,835,661...37,913,176 		JBrowse link
G SLC38A1 solute carrier family 38 member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:8,110,327...8,179,394
Ensembl chr27:8,130,823...8,174,936 		JBrowse link
G USP46 ubiquitin specific peptidase 46 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:45,381,974...45,475,212
Ensembl chr13:45,384,641...45,439,096 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 22141
    cellular process 21672
      cell communication 6982
        cell-cell signaling 1470
          synaptic signaling 996
            trans-synaptic signaling 959
              anterograde trans-synaptic signaling 951
                chemical synaptic transmission 951
                  synaptic transmission, GABAergic 72
                    gamma-aminobutyric acid secretion, neurotransmission 3
                    negative regulation of synaptic transmission, GABAergic 10
                    positive regulation of synaptic transmission, GABAergic 19
                    regulation of synaptic transmission, GABAergic + 45
Path 2
Term Annotations click to browse term
  biological_process 22141
    biological regulation 12559
      regulation of biological process 12176
        signaling 6948
          cell-cell signaling 1470
            synaptic signaling 996
              trans-synaptic signaling 959
                anterograde trans-synaptic signaling 951
                  chemical synaptic transmission 951
                    synaptic transmission, GABAergic 72
                      gamma-aminobutyric acid secretion, neurotransmission 3
                      negative regulation of synaptic transmission, GABAergic 10
                      positive regulation of synaptic transmission, GABAergic 19
                      regulation of synaptic transmission, GABAergic + 45
paths to the root