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ONTOLOGY REPORT - ANNOTATIONS

Term:synaptic transmission, GABAergic
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Accession:GO:0051932 term browser browse the term
Definition:The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
Synonyms:exact_synonym: synaptic transmission, GABA mediated;   synaptic transmission, gamma-aminobutyric acid mediated;   synaptic transmission, gamma-aminobutyric acid-ergic

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synaptic transmission, GABAergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh5a1 aldehyde dehydrogenase 5 family member A1 acts_upstream_of ISO (PMID:11544478), (PMID:15262267) MGI PMID:11544478 PMID:15262267 NCBI chrNW_004955483:2,467,425...2,494,416
Ensembl chrNW_004955483:2,467,425...2,494,416 		JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A NOT|acts_upstream_of_or_within ISO (PMID:10322048) MGI PMID:10322048 NCBI chrNW_004955415:32,182,536...32,457,511
Ensembl chrNW_004955415:32,183,442...32,400,595 		JBrowse link
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 NOT|acts_upstream_of_or_within ISO (PMID:10322048) MGI PMID:10322048 NCBI chrNW_004955440:17,364,996...17,497,446
Ensembl chrNW_004955440:17,371,321...17,497,616 		JBrowse link
G Clcn3 chloride voltage-gated channel 3 acts_upstream_of_or_within ISO (PMID:21378974) MGI PMID:21378974 NCBI chrNW_004955403:36,625,871...36,710,201
Ensembl chrNW_004955403:36,625,770...36,710,201 		JBrowse link
G Clstn3 calsyntenin 3 acts_upstream_of_or_within ISO (PMID:24094106) MGI PMID:24094106 NCBI chrNW_004955413:4,690,637...4,719,929
Ensembl chrNW_004955413:4,690,637...4,719,929 		JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit ISO RGD PMID:27690696 RGD:126781724 NCBI chrNW_004955491:4,215,353...4,292,229
Ensembl chrNW_004955491:4,215,298...4,292,235 		JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha1 involved_in ISO PMID:12930820
(PMID:23909897) 		BHF-UCL
UniProt		 PMID:12930820 PMID:23909897 RGD:8554754 NCBI chrNW_004955408:15,608,984...15,662,309
Ensembl chrNW_004955408:15,608,984...15,662,597 		JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 ISO RGD PMID:16554486 RGD:1626493 NCBI chrNW_004955408:15,464,426...15,479,653
Ensembl chrNW_004955408:15,464,368...15,480,330 		JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta2 involved_in ISO PMID:12930820 BHF-UCL PMID:12930820 RGD:8554754 NCBI chrNW_004955408:15,126,235...15,363,169
Ensembl chrNW_004955408:15,131,909...15,363,169 		JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta3 involved_in ISO (PMID:14993607) RGD
UniProt		 PMID:12356876 PMID:14993607 RGD:727440 NCBI chrNW_004955533:2,879,437...2,938,952
Ensembl chrNW_004955533:2,573,599...2,938,952 		JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma2 involved_in ISO PMID:12930820
(PMID:14993607) 		BHF-UCL
UniProt		 PMID:12930820 PMID:14993607 RGD:8554754 NCBI chrNW_004955408:15,766,161...15,857,121
Ensembl chrNW_004955408:15,765,984...15,857,244 		JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 acts_upstream_of ISO (PMID:17245443) MGI PMID:17245443 NCBI chrNW_004955407:28,899,643...29,308,936
Ensembl chrNW_004955407:28,899,899...29,308,470 		JBrowse link
G Hapln4 hyaluronan and proteoglycan link protein 4 involved_in ISO (PMID:30125937) UniProt PMID:30125937 NCBI chrNW_004955524:2,594,097...2,598,855
Ensembl chrNW_004955524:2,595,426...2,598,861 		JBrowse link
G Nlgn2 neuroligin 2 acts_upstream_of_or_within ISO (PMID:29107521) MGI PMID:29107521 NCBI chrNW_004955467:9,504,974...9,520,059
Ensembl chrNW_004955467:9,504,974...9,520,059 		JBrowse link
G Prkce protein kinase C epsilon acts_upstream_of ISO (PMID:17875639) MGI PMID:17875639 NCBI chrNW_004955441:12,642,703...13,142,396
Ensembl chrNW_004955441:12,642,697...13,139,372 		JBrowse link
G Rac1 Rac family small GTPase 1 acts_upstream_of_or_within ISO (PMID:23258346) MGI PMID:23258346 NCBI chrNW_004955460:13,270,159...13,295,562
Ensembl chrNW_004955460:13,270,159...13,311,351 		JBrowse link
G Rac3 Rac family small GTPase 3 acts_upstream_of_or_within ISO (PMID:23258346) MGI PMID:23258346 NCBI chrNW_004955506:1,139,098...1,142,443
Ensembl chrNW_004955506:1,137,204...1,141,336 		JBrowse link
G Slitrk3 SLIT and NTRK like family member 3 acts_upstream_of_or_within ISO (PMID:29107521) MGI PMID:29107521 NCBI chrNW_004955448:14,846,976...14,852,612
Ensembl chrNW_004955448:14,846,976...14,852,612 		JBrowse link
G Tpbg trophoblast glycoprotein acts_upstream_of_or_within ISO (PMID:27488640) MGI PMID:27488640 NCBI chrNW_004955411:10,203,144...10,206,711 JBrowse link
G Vps54 VPS54 subunit of GARP complex involved_in ISO (PMID:20643756) MGI PMID:20643756 NCBI chrNW_004955424:20,329,009...20,443,652
Ensembl chrNW_004955424:20,327,754...20,445,980 		JBrowse link
gamma-aminobutyric acid secretion, neurotransmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Best1 bestrophin 1 involved_in ISO (PMID:20929730) UniProt PMID:20929730 NCBI chrNW_004955511:5,773,025...5,783,800
Ensembl chrNW_004955511:5,773,670...5,780,540 		JBrowse link
G Nf1 neurofibromin 1 acts_upstream_of_or_within ISO (PMID:25242307) MGI PMID:25242307 NCBI chrNW_004955481:6,145,855...6,404,179
Ensembl chrNW_004955481:6,145,855...6,404,179 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 acts_upstream_of_or_within ISO (PMID:25242307) MGI PMID:25242307 NCBI chrNW_004955414:14,365,325...14,447,470
Ensembl chrNW_004955414:14,365,157...14,450,611 		JBrowse link
negative regulation of synaptic transmission, GABAergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor NOT ISO in immature hippocampal CA1 neurons
in postnatal 30 day hippocampal CA1 neurons 		RGD PMID:12626609 RGD:1625273 NCBI chrNW_004955406:39,148,811...39,183,577
Ensembl chrNW_004955406:39,149,689...39,187,688 		JBrowse link
G Bdnf brain derived neurotrophic factor acts_upstream_of_or_within ISO (PMID:16754670) MGI PMID:16754670 NCBI chrNW_004955476:6,773,244...6,822,201
Ensembl chrNW_004955476:6,772,088...6,822,588 		JBrowse link
G Cnr2 cannabinoid receptor 2 ISO RGD PMID:19616018 RGD:2316192 NCBI chrNW_004955452:3,763,742...3,795,069
Ensembl chrNW_004955452:3,763,742...3,795,069 		JBrowse link
G Cntnap2 contactin associated protein 2 involved_in ISO (PMID:28966979) MGI PMID:28966979 NCBI chrNW_004955491:1,983,002...3,982,510
Ensembl chrNW_004955491:1,984,050...3,981,830 		JBrowse link
G Drd4 dopamine receptor D4 ISO RGD PMID:12417643 RGD:401960856 NCBI chrNW_004955476:11,424,347...11,426,962
Ensembl chrNW_004955476:11,424,411...11,426,960 		JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 ISO RGD PMID:12533604 RGD:1642497 NCBI chrNW_004955407:28,899,643...29,308,936
Ensembl chrNW_004955407:28,899,899...29,308,470 		JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B ISO RGD PMID:17229091 RGD:1626455 NCBI chrNW_004955502:5,640,919...5,646,899
Ensembl chrNW_004955502:5,645,644...5,646,816 		JBrowse link
G Npy5r neuropeptide Y receptor Y5 ISO RGD PMID:11796508 RGD:1625505 NCBI chrNW_004955403:41,667,632...41,675,619
Ensembl chrNW_004955403:41,667,632...41,675,619 		JBrowse link
G Slc6a1 solute carrier family 6 member 1 ISO RGD PMID:17317750 RGD:1643193 NCBI chrNW_004955429:13,930,899...13,946,010
Ensembl chrNW_004955429:13,930,905...13,947,389 		JBrowse link
G Stxbp1 syntaxin binding protein 1 acts_upstream_of_or_within ISO (PMID:17167098) MGI PMID:17167098 NCBI chrNW_004955419:963,829...1,000,759
Ensembl chrNW_004955419:963,829...1,000,759 		JBrowse link
positive regulation of synaptic transmission, GABAergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor acts_upstream_of_or_within ISO (PMID:10934242) MGI PMID:10934242 NCBI chrNW_004955455:7,886,720...7,906,214
Ensembl chrNW_004955455:7,895,974...7,906,505 		JBrowse link
G Adra1a adrenoceptor alpha 1A ISO RGD PMID:14532911 RGD:1625778 NCBI chrNW_004955403:49,394,173...49,485,881
Ensembl chrNW_004955403:49,399,127...49,485,934 		JBrowse link
G Ca2 carbonic anhydrase 2 acts_upstream_of_or_within ISO (PMID:23881097) MGI PMID:23881097 NCBI chrNW_004955417:3,388,110...3,402,798
Ensembl chrNW_004955417:3,386,087...3,402,363 		JBrowse link
G Ca7 carbonic anhydrase 7 acts_upstream_of_or_within ISO (PMID:23881097) MGI PMID:23881097 NCBI chrNW_004955433:23,365,832...23,374,517
Ensembl chrNW_004955433:23,365,718...23,374,548 		JBrowse link
G Cckbr cholecystokinin B receptor ISO RGD PMID:17904218 RGD:2311326 NCBI chrNW_004955414:22,001,351...22,011,275
Ensembl chrNW_004955414:22,000,436...22,011,433 		JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 ISO RGD PMID:17521572 RGD:2289989 NCBI chrNW_004955457:3,177,905...4,236,152
Ensembl chrNW_004955457:3,177,991...4,228,558 		JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 acts_upstream_of_or_within ISO (PMID:17245443) RGD
MGI		 PMID:12533604 PMID:17245443 RGD:1642497 NCBI chrNW_004955407:28,899,643...29,308,936
Ensembl chrNW_004955407:28,899,899...29,308,470 		JBrowse link
G Kif5b kinesin family member 5B involved_in ISO (PMID:20152113) UniProt PMID:20152113 NCBI chrNW_004955429:23,632,246...23,678,797
Ensembl chrNW_004955429:23,631,282...23,678,562 		JBrowse link
G Nlgn1 neuroligin 1 involved_in ISO PMID:12930820 BHF-UCL PMID:12930820 RGD:8554754 NCBI chrNW_004955420:3,360,745...4,171,587
Ensembl chrNW_004955420:3,549,021...4,167,493 		JBrowse link
G Nlgn2 neuroligin 2 involved_in ISO (PMID:15620359) BHF-UCL PMID:15620359 NCBI chrNW_004955467:9,504,974...9,520,059
Ensembl chrNW_004955467:9,504,974...9,520,059 		JBrowse link
G Oxtr oxytocin receptor ISO RGD PMID:11069593 RGD:2304220 NCBI chrNW_004955561:340,387...354,499
Ensembl chrNW_004955561:337,902...354,336 		JBrowse link
G Prkce protein kinase C epsilon acts_upstream_of_or_within ISO (PMID:17875639) MGI PMID:17875639 NCBI chrNW_004955441:12,642,703...13,142,396
Ensembl chrNW_004955441:12,642,697...13,139,372 		JBrowse link
G Tac1 tachykinin precursor 1 ISO RGD PMID:19261870 RGD:2304250 NCBI chrNW_004955432:13,991,647...13,999,665
Ensembl chrNW_004955432:13,991,414...13,999,728 		JBrowse link
G Tacr1 tachykinin receptor 1 ISO RGD PMID:19261870 RGD:2304250 NCBI chrNW_004955424:10,614,340...10,761,872
Ensembl chrNW_004955424:10,614,340...10,761,872 		JBrowse link
G Zdhhc12 zDHHC palmitoyltransferase 12 involved_in ISO (PMID:25025157) UniProt PMID:25025157 NCBI chrNW_004955570:1,131,234...1,133,909
Ensembl chrNW_004955570:1,131,234...1,133,909 		JBrowse link
G Zdhhc3 zDHHC palmitoyltransferase 3 involved_in ISO (PMID:17151279) UniProt PMID:17151279 NCBI chrNW_004955420:26,698,168...26,736,364
Ensembl chrNW_004955420:26,698,168...26,733,953 		JBrowse link
regulation of synaptic transmission, GABAergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Baiap3 BAI1 associated protein 3 involved_in ISO (PMID:23698091) UniProt PMID:23698091 NCBI chrNW_004955442:15,884,034...15,897,894
Ensembl chrNW_004955442:15,884,034...15,898,396 		JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in ISO (PMID:29135436) UniProt PMID:29135436 NCBI chrNW_004955493:6,696,520...6,707,849
Ensembl chrNW_004955493:6,696,241...6,707,849 		JBrowse link
G Cnr1 cannabinoid receptor 1 ISO RGD PMID:19725112 RGD:2314643 NCBI chrNW_004955411:15,052,151...15,077,320
Ensembl chrNW_004955411:15,052,163...15,077,320 		JBrowse link
G Cntnap4 contactin associated protein family member 4 involved_in ISO (PMID:24870235) UniProt PMID:24870235 NCBI chrNW_004955484:258,232...521,133
Ensembl chrNW_004955484:256,328...521,073 		JBrowse link
G Dbi diazepam binding inhibitor, acyl-CoA binding protein acts_upstream_of_or_within ISO PMID:3456171 MGI PMID:3456171 RGD:8554715 NCBI chrNW_004955459:10,342,528...10,347,700
Ensembl chrNW_004955459:10,342,251...10,347,733 		JBrowse link
G Drd2 dopamine receptor D2 acts_upstream_of_or_within ISO (PMID:10934242)
(PMID:15080900) 		MGI PMID:10934242 PMID:15080900 NCBI chrNW_004955412:15,054,255...15,114,558
Ensembl chrNW_004955412:15,054,038...15,114,573 		JBrowse link
G Kcnk2 potassium two pore domain channel subfamily K member 2 involved_in ISO (PMID:22726831) UniProt PMID:22726831 NCBI chrNW_004955406:2,793,493...2,975,322
Ensembl chrNW_004955406:2,791,803...2,975,322 		JBrowse link
G Kras KRAS proto-oncogene, GTPase acts_upstream_of_or_within ISO (PMID:11793011) MGI PMID:11793011 NCBI chrNW_004955413:20,298,852...20,328,756
Ensembl chrNW_004955413:20,298,824...20,328,758 		JBrowse link
G Nf1 neurofibromin 1 acts_upstream_of_or_within ISO (PMID:11793011) MGI PMID:11793011 NCBI chrNW_004955481:6,145,855...6,404,179
Ensembl chrNW_004955481:6,145,855...6,404,179 		JBrowse link
G Nisch nischarin ISO RGD PMID:16467528 RGD:1582692 NCBI chrNW_004955430:2,443,029...2,488,267
Ensembl chrNW_004955430:2,443,029...2,491,123 		JBrowse link
G Npas4 neuronal PAS domain protein 4 involved_in ISO (PMID:18815592) UniProt PMID:18815592 NCBI chrNW_004955422:18,907,328...18,913,088
Ensembl chrNW_004955422:18,907,322...18,913,428 		JBrowse link
G Phf24 PHD finger protein 24 acts_upstream_of_or_within ISO (PMID:25242222) MGI PMID:25242222 NCBI chrNW_004955472:1,186,021...1,204,018
Ensembl chrNW_004955472:1,185,110...1,204,040 		JBrowse link
G Plcl1 phospholipase C like 1 (inactive) acts_upstream_of_or_within ISO (PMID:16754670)
(PMID:15464766) 		MGI PMID:15464766 PMID:16754670 NCBI chrNW_004955403:2,643,092...2,904,651
Ensembl chrNW_004955403:2,641,360...2,693,352 		JBrowse link
G Plcl2 phospholipase C like 2 acts_upstream_of_or_within ISO (PMID:16754670) MGI PMID:16754670 NCBI chrNW_004955430:9,157,074...9,347,366
Ensembl chrNW_004955430:9,157,074...9,348,563 		JBrowse link
G Pten phosphatase and tensin homolog acts_upstream_of_or_within ISO (PMID:24875179) MGI PMID:24875179 NCBI chrNW_004955425:5,007,811...5,091,829
Ensembl chrNW_004955425:5,014,147...5,091,829 		JBrowse link
G Slc38a1 solute carrier family 38 member 1 involved_in ISO (PMID:31050701) UniProt PMID:31050701 NCBI chrNW_004955500:5,393,211...5,468,827
Ensembl chrNW_004955500:5,398,358...5,462,042 		JBrowse link
G Usp46 ubiquitin specific peptidase 46 involved_in ISO (PMID:19465912) UniProt PMID:19465912 NCBI chrNW_004955447:17,915,451...17,975,149
Ensembl chrNW_004955447:17,900,611...17,971,601 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12628
    cellular process 12059
      cell communication 4610
        cell-cell signaling 1215
          synaptic signaling 780
            trans-synaptic signaling 754
              anterograde trans-synaptic signaling 747
                chemical synaptic transmission 747
                  synaptic transmission, GABAergic 61
                    gamma-aminobutyric acid secretion, neurotransmission 3
                    negative regulation of synaptic transmission, GABAergic 10
                    positive regulation of synaptic transmission, GABAergic 16
                    regulation of synaptic transmission, GABAergic + 42
Path 2
Term Annotations click to browse term
  biological_process 12628
    biological regulation 9097
      regulation of biological process 8796
        signaling 4579
          cell-cell signaling 1215
            synaptic signaling 780
              trans-synaptic signaling 754
                anterograde trans-synaptic signaling 747
                  chemical synaptic transmission 747
                    synaptic transmission, GABAergic 61
                      gamma-aminobutyric acid secretion, neurotransmission 3
                      negative regulation of synaptic transmission, GABAergic 10
                      positive regulation of synaptic transmission, GABAergic 16
                      regulation of synaptic transmission, GABAergic + 42
paths to the root