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ONTOLOGY REPORT - ANNOTATIONS

Term:synaptic transmission, GABAergic
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Accession:GO:0051932 term browser browse the term
Definition:The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
Synonyms:exact_synonym: synaptic transmission, GABA mediated;   synaptic transmission, gamma-aminobutyric acid mediated;   synaptic transmission, gamma-aminobutyric acid-ergic


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synaptic transmission, GABAergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH5A1 aldehyde dehydrogenase 5 family member A1 acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr 6:24,332,093...24,370,764
Ensembl chr 6:24,665,026...24,705,151 		JBrowse link
G CACNA1A calcium voltage-gated channel subunit alpha1 A NOT|acts_upstream_of_or_within ISO (PMID:10322048) MGI PMID:10322048 NCBI chr19:12,769,586...13,189,022
Ensembl chr19:13,507,102...13,804,729 		JBrowse link
G CACNB4 calcium voltage-gated channel auxiliary subunit beta 4 NOT|acts_upstream_of_or_within ISO (PMID:10322048) MGI PMID:10322048 NCBI chr2B:39,137,777...39,399,007
Ensembl chr2B:156,379,469...156,639,328 		JBrowse link
G CLCN3 chloride voltage-gated channel 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 4:161,838,061...161,943,072
Ensembl chr 4:173,925,474...174,011,681 		JBrowse link
G CLSTN3 calsyntenin 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr12:7,260,361...7,288,903
Ensembl chr12:7,175,951...7,204,526 		JBrowse link
G EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit ISO RGD PMID:27690696 RGD:126781724 NCBI chr 7:140,536,962...140,613,104
Ensembl chr 7:153,017,590...153,059,726 		JBrowse link
G GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:157,234,725...157,287,475
Ensembl chr 5:163,928,392...163,981,117 		JBrowse link
G GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 ISO RGD PMID:16554486 RGD:1626493 NCBI chr 5:157,072,915...157,089,994
Ensembl chr 5:163,767,304...163,784,331 		JBrowse link
G GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 involved_in ISO PMID:12930820 BHF-UCL PMID:12930820 RGD:8554754 NCBI chr 5:156,678,750...156,937,614
Ensembl chr 5:163,374,346...163,632,301 		JBrowse link
G GABRB3 gamma-aminobutyric acid type A receptor subunit beta3 involved_in ISO
IEA 		RGD
Ensembl		 PMID:12356876 GO_REF:0000107 RGD:727440 NCBI chr15:3,129,481...3,357,495
Ensembl chr15:23,981,359...24,058,357 		JBrowse link
G GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 involved_in ISO PMID:12930820
(PMID:14993607) 		BHF-UCL
UniProt		 PMID:12930820 PMID:14993607 RGD:8554754 NCBI chr 5:157,436,113...157,529,586
Ensembl chr 5:164,068,122...164,222,179 		JBrowse link
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 acts_upstream_of ISO (PMID:17245443) MGI PMID:17245443 NCBI chr21:15,976,931...16,357,578
Ensembl chr21:29,364,269...29,743,379 		JBrowse link
G HAPLN4 hyaluronan and proteoglycan link protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:18,694,303...18,701,553
Ensembl chr19:19,699,817...19,703,735 		JBrowse link
G NLGN2 neuroligin 2 acts_upstream_of_or_within ISO (PMID:29107521) MGI PMID:29107521 NCBI chr17:7,438,853...7,454,014 JBrowse link
G PRKCE protein kinase C epsilon acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr2A:45,757,629...46,294,064
Ensembl chr2A:46,688,436...47,220,313 		JBrowse link
G RAC1 Rac family small GTPase 1 acts_upstream_of_or_within ISO (PMID:23258346) MGI PMID:23258346 NCBI chr 7:7,039,379...7,068,866 JBrowse link
G RAC3 Rac family small GTPase 3 acts_upstream_of_or_within ISO (PMID:23258346) MGI PMID:23258346 NCBI chr17:76,436,264...76,439,492
Ensembl chr17:82,133,217...82,143,623 		JBrowse link
G SLITRK3 SLIT and NTRK like family member 3 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 3:162,207,530...162,223,830
Ensembl chr 3:170,265,342...170,268,275 		JBrowse link
G TPBG trophoblast glycoprotein acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 6:80,265,172...80,273,022
Ensembl chr 6:83,530,571...83,531,915 		JBrowse link
G VPS54 VPS54 subunit of GARP complex involved_in IEA Ensembl GO_REF:0000107 NCBI chr2A:63,959,930...64,087,102
Ensembl chr2A:65,086,374...65,176,634 		JBrowse link
gamma-aminobutyric acid secretion, neurotransmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BEST1 bestrophin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:57,314,430...57,329,450
Ensembl chr11:60,672,835...60,687,417 		JBrowse link
G NF1 neurofibromin 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr17:25,425,081...25,703,689
Ensembl chr17:26,160,855...26,439,295 		JBrowse link
G PAK1 p21 (RAC1) activated kinase 1 acts_upstream_of_or_within ISO (PMID:25242307) MGI PMID:25242307 NCBI chr11:72,372,577...72,524,817
Ensembl chr11:76,015,998...76,104,197 		JBrowse link
negative regulation of synaptic transmission, GABAergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA1 adenosine A1 receptor NOT ISO in immature hippocampal CA1 neurons
in postnatal 30 day hippocampal CA1 neurons 		RGD PMID:12626609 RGD:1625273 NCBI chr 1:178,728,751...178,769,066
Ensembl chr 1:183,023,466...183,063,760 		JBrowse link
G BDNF brain derived neurotrophic factor acts_upstream_of_or_within ISO (PMID:16754670) MGI PMID:16754670 NCBI chr11:27,618,322...27,687,661
Ensembl chr11:27,520,312...27,589,239 		JBrowse link
G CNR2 cannabinoid receptor 2 ISO RGD PMID:19616018 RGD:2316192 NCBI chr 1:23,066,153...23,108,065
Ensembl chr 1:24,050,008...24,051,090 		JBrowse link
G CNTNAP2 contactin associated protein 2 involved_in ISO (PMID:28966979) MGI PMID:28966979 NCBI chr 7:137,858,607...140,150,820
Ensembl chr 7:150,345,240...152,626,818 		JBrowse link
G DRD4 dopamine receptor D4 ISO RGD PMID:12417643 RGD:401960856 NCBI chr11:640,401...646,775 JBrowse link
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 ISO RGD PMID:12533604 RGD:1642497 NCBI chr21:15,976,931...16,357,578
Ensembl chr21:29,364,269...29,743,379 		JBrowse link
G HTR1B 5-hydroxytryptamine receptor 1B ISO RGD PMID:17229091 RGD:1626455 NCBI chr 6:75,309,078...75,313,747
Ensembl chr 6:78,596,408...78,597,580 		JBrowse link
G NPY5R neuropeptide Y receptor Y5 ISO RGD PMID:11796508 RGD:1625505 NCBI chr 4:155,603,739...155,612,302 JBrowse link
G SLC6A1 solute carrier family 6 member 1 ISO RGD PMID:17317750 RGD:1643193 NCBI chr 3:10,930,455...10,976,968
Ensembl chr 3:11,296,023...11,323,624 		JBrowse link
G STXBP1 syntaxin binding protein 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 9:98,731,527...98,811,608
Ensembl chr 9:127,434,080...127,486,152 		JBrowse link
positive regulation of synaptic transmission, GABAergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2A adenosine A2a receptor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr22:5,233,876...5,248,622
Ensembl chr22:22,104,253...22,114,189 		JBrowse link
G ADRA1A adrenoceptor alpha 1A ISO RGD PMID:14532911 RGD:1625778 NCBI chr 8:25,947,996...26,138,022
Ensembl chr 8:22,853,677...23,044,388 		JBrowse link
G CA2 carbonic anhydrase 2 acts_upstream_of_or_within ISO (PMID:23881097) MGI PMID:23881097 NCBI chr 8:81,991,037...82,009,010
Ensembl chr 8:83,597,440...83,632,580 		JBrowse link
G CA7 carbonic anhydrase 7 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr16:47,161,021...47,170,800
Ensembl chr16:66,262,362...66,271,665 		JBrowse link
G CCKBR cholecystokinin B receptor ISO RGD PMID:17904218 RGD:2311326 NCBI chr11:6,393,435...6,405,821
Ensembl chr11:6,075,816...6,088,145 		JBrowse link
G ERBB4 erb-b2 receptor tyrosine kinase 4 ISO RGD PMID:17521572 RGD:2289989 NCBI chr2B:98,625,630...99,795,371
Ensembl chr2B:217,069,644...218,272,006 		JBrowse link
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 acts_upstream_of_or_within ISO (PMID:17245443) RGD
MGI		 PMID:12533604 PMID:17245443 RGD:1642497 NCBI chr21:15,976,931...16,357,578
Ensembl chr21:29,364,269...29,743,379 		JBrowse link
G HAP1 huntingtin associated protein 1 involved_in ISO PMID:20152113 UniProt PMID:20152113 RGD:10047142 NCBI chr17:15,578,658...15,596,313
Ensembl chr17:15,797,949...15,810,299 		JBrowse link
G KIF5B kinesin family member 5B involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:32,138,964...32,186,448
Ensembl chr10:32,731,150...32,778,242 		JBrowse link
G NALCN sodium leak channel, non-selective involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr13:82,215,094...82,573,501
Ensembl chr13:101,354,054...101,693,223 		JBrowse link
G NLGN1 neuroligin 1 involved_in ISO PMID:12930820 BHF-UCL PMID:12930820 RGD:8554754 NCBI chr 3:170,416,885...171,333,094
Ensembl chr 3:178,810,253...179,503,756 		JBrowse link
G NLGN2 neuroligin 2 involved_in ISO (PMID:15620359) BHF-UCL PMID:15620359 NCBI chr17:7,438,853...7,454,014 JBrowse link
G NPS neuropeptide S involved_in
acts_upstream_of_or_within 		IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr10:124,135,616...124,139,845
Ensembl chr10:128,384,897...128,388,217 		JBrowse link
G OXTR oxytocin receptor ISO RGD PMID:11069593 RGD:2304220 NCBI chr 3:8,701,344...8,721,706 JBrowse link
G PRKCE protein kinase C epsilon acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr2A:45,757,629...46,294,064
Ensembl chr2A:46,688,436...47,220,313 		JBrowse link
G TAC1 tachykinin precursor 1 ISO RGD PMID:19261870 RGD:2304250 NCBI chr 7:89,675,834...89,684,391
Ensembl chr 7:103,257,501...103,266,389 		JBrowse link
G TACR1 tachykinin receptor 1 ISO RGD PMID:19261870 RGD:2304250 NCBI chr2A:75,111,339...75,267,320
Ensembl chr2A:76,614,478...76,771,018 		JBrowse link
G ZDHHC12 zDHHC palmitoyltransferase 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:99,844,535...99,847,806
Ensembl chr 9:128,510,739...128,514,004 		JBrowse link
G ZDHHC3 zDHHC palmitoyltransferase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:44,816,359...44,877,318
Ensembl chr 3:45,880,773...45,931,695 		JBrowse link
regulation of synaptic transmission, GABAergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAIAP3 BAI1 associated protein 3 involved_in IEA Ensembl GO_REF:0000107 Ensembl chr16:1,390,160...1,403,978 JBrowse link
G CNR1 cannabinoid receptor 1 ISO RGD PMID:19725112 RGD:2314643 NCBI chr 6:86,017,141...86,044,889 JBrowse link
G CNTNAP4 contactin associated protein family member 4 involved_in ISO (PMID:24870235) UniProt PMID:24870235 NCBI chr16:56,512,541...57,138,499
Ensembl chr16:76,199,706...76,484,466 		JBrowse link
G DBI diazepam binding inhibitor, acyl-CoA binding protein acts_upstream_of_or_within ISO PMID:3456171 MGI PMID:3456171 RGD:8554715 NCBI chr2B:6,309,048...6,314,660
Ensembl chr2B:119,887,728...119,892,986 		JBrowse link
G DRD2 dopamine receptor D2 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr11:108,289,838...108,357,174
Ensembl chr11:112,132,703...112,198,935 		JBrowse link
G KCNK2 potassium two pore domain channel subfamily K member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:190,576,180...190,807,367
Ensembl chr 1:195,430,994...195,662,840 		JBrowse link
G KRAS KRAS proto-oncogene, GTPase acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr12:61,062,689...61,108,524
Ensembl chr12:63,679,293...63,724,335 		JBrowse link
G LOC117978823 battenin involved_in ISO (PMID:29135436) UniProt PMID:29135436
G NF1 neurofibromin 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr17:25,425,081...25,703,689
Ensembl chr17:26,160,855...26,439,295 		JBrowse link
G NISCH nischarin ISO RGD PMID:16467528 RGD:1582692 NCBI chr 3:52,397,576...52,435,127
Ensembl chr 3:53,626,317...53,662,567 		JBrowse link
G NPAS4 neuronal PAS domain protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:61,778,329...61,784,010
Ensembl chr11:65,103,097...65,108,825 		JBrowse link
G PHF24 PHD finger protein 24 acts_upstream_of_or_within ISO (PMID:25242222) MGI PMID:25242222 NCBI chr 9:34,735,800...34,829,555
Ensembl chr 9:35,611,517...35,635,964 		JBrowse link
G PLCL1 phospholipase C like 1 (inactive) involved_in
acts_upstream_of_or_within 		IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr2B:85,054,907...85,397,171
Ensembl chr2B:202,947,927...203,286,649 		JBrowse link
G PLCL2 phospholipase C like 2 involved_in
acts_upstream_of_or_within 		IEA InterPro
Ensembl
TreeGrafter		 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:16,736,430...17,015,531
Ensembl chr 3:17,154,500...17,351,287 		JBrowse link
G PTEN phosphatase and tensin homolog acts_upstream_of_or_within ISO (PMID:24875179) MGI PMID:24875179 NCBI chr10:84,587,841...84,689,043
Ensembl chr10:88,093,539...88,194,605 		JBrowse link
G SLC38A1 solute carrier family 38 member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:42,464,360...42,550,324
Ensembl chr12:43,362,597...43,413,616 		JBrowse link
G USP46 ubiquitin specific peptidase 46 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:71,305,286...71,373,257
Ensembl chr 4:77,861,053...77,920,759 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19315
    cellular process 18867
      cell communication 6066
        cell-cell signaling 1341
          synaptic signaling 869
            trans-synaptic signaling 833
              anterograde trans-synaptic signaling 825
                chemical synaptic transmission 825
                  synaptic transmission, GABAergic 64
                    gamma-aminobutyric acid secretion, neurotransmission 3
                    negative regulation of synaptic transmission, GABAergic 10
                    positive regulation of synaptic transmission, GABAergic 19
                    regulation of synaptic transmission, GABAergic + 45
Path 2
Term Annotations click to browse term
  biological_process 19315
    biological regulation 11855
      regulation of biological process 11474
        signaling 6031
          cell-cell signaling 1341
            synaptic signaling 869
              trans-synaptic signaling 833
                anterograde trans-synaptic signaling 825
                  chemical synaptic transmission 825
                    synaptic transmission, GABAergic 64
                      gamma-aminobutyric acid secretion, neurotransmission 3
                      negative regulation of synaptic transmission, GABAergic 10
                      positive regulation of synaptic transmission, GABAergic 19
                      regulation of synaptic transmission, GABAergic + 45
paths to the root