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ONTOLOGY REPORT - ANNOTATIONS


Term:synaptic transmission, GABAergic
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Accession:GO:0051932 term browser browse the term
Definition:The vesicular release of gamma-aminobutyric acid (GABA). from a presynapse, across a chemical synapse, the subsequent activation of GABA receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
Synonyms:exact_synonym: synaptic transmission, GABA mediated;   synaptic transmission, gamma-aminobutyric acid mediated;   synaptic transmission, gamma-aminobutyric acid-ergic


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synaptic transmission, GABAergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1a calcium voltage-gated channel subunit alpha1 A NOT|acts_upstream_of_or_within ISO MGI:1856209 (MGI:1340444|PMID:10322048) RGD PMID:10322048 MGI:1340444 NCBI chr19:25,453,236...25,749,550
Ensembl chr19:25,526,751...25,749,550
JBrowse link
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 NOT|acts_upstream_of_or_within ISO MGI:1856936 (MGI:1340444|PMID:10322048) RGD PMID:10322048 MGI:1340444 NCBI chr 3:37,950,846...38,211,478
Ensembl chr 3:37,955,069...38,090,526
JBrowse link
G Clcn3 chloride voltage-gated channel 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2447864 (MGI:5006894|PMID:21378974)
Ensembl
RGD
PMID:21378974 GO_REF:0000107 MGI:5006894 NCBI chr16:32,448,821...32,520,649
Ensembl chr16:32,449,116...32,519,148
JBrowse link
G Clstn3 calsyntenin 3 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:5521290 (MGI:5516394|PMID:24094106)
Ensembl
RGD
PMID:24094106 GO_REF:0000107 MGI:5516394 NCBI chr 4:157,044,736...157,078,013
Ensembl chr 4:157,043,925...157,078,130
JBrowse link
G Dnm1 dynamin 1 acts_upstream_of_or_within ISO MGI:3033341 (MGI:4821669|PMID:20700442) RGD PMID:20700442 MGI:4821669 NCBI chr 3:11,338,081...11,382,043
Ensembl chr 3:11,338,083...11,382,043
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit IMP RGD PMID:27690696 RGD:126781724 NCBI chr 4:77,284,404...77,347,011
Ensembl chr 4:77,284,404...77,347,011
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 involved_in IBA
IDA
PMID:21873635
PMID:12930820
GO_Central
BHF-UCL
PMID:21873635, PMID:12930820 RGD:13792537, RGD:8554754 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302
JBrowse link
G Gabra3 gamma-aminobutyric acid type A receptor subunit alpha 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:152,414,332...152,642,607
Ensembl chr  X:152,414,615...152,642,531
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:39,154,072...39,230,994
Ensembl chr14:39,154,529...39,231,695
JBrowse link
G Gabra5 gamma-aminobutyric acid type A receptor subunit alpha 5 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:112,833,941...112,947,482
Ensembl chr 1:112,833,944...112,947,451
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 involved_in IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:16554486, PMID:21873635 RGD:1626493, RGD:13792537 NCBI chr10:27,847,447...27,862,896
Ensembl chr10:27,847,439...27,862,868
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 involved_in IDA PMID:12930820 BHF-UCL PMID:12930820 RGD:8554754 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 IDA RGD PMID:12356876 RGD:727440 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gabre gamma-aminobutyric acid type A receptor subunit epsilon involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:152,220,180...152,237,347
Ensembl chr  X:152,218,707...152,237,361
JBrowse link
G Gabrg1 gamma-aminobutyric acid type A receptor subunit gamma 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:39,964,502...40,051,306
Ensembl chr14:39,964,588...40,049,354
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 involved_in IBA
IDA
PMID:21873635
PMID:12930820
GO_Central
BHF-UCL
PMID:21873635, PMID:12930820 RGD:13792537, RGD:8554754 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gabrg3 gamma-aminobutyric acid type A receptor subunit gamma 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:112,158,525...112,812,267
Ensembl chr 1:112,158,519...112,811,936
JBrowse link
G Grm1 glutamate metabotropic receptor 1 involved_in TAS PMID:11530226 UniProt PMID:11530226 RGD:8553469 NCBI chr 1:4,753,141...5,165,859
Ensembl chr 1:4,753,144...5,165,859
JBrowse link
G Grm4 glutamate metabotropic receptor 4 involved_in TAS PMID:11906782 UniProt PMID:11906782 RGD:8554275 NCBI chr20:6,745,682...6,791,521
Ensembl chr20:6,745,682...6,791,519
JBrowse link
G Rac1 Rac family small GTPase 1 acts_upstream_of_or_within ISO MGI:2180784 (MGI:5569596|PMID:23258346) RGD PMID:23258346 MGI:5569596 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rac3 Rac family small GTPase 3 acts_upstream_of_or_within ISO MGI:97845 (MGI:5569596|PMID:23258346) RGD PMID:23258346 MGI:5569596 NCBI chr10:109,903,920...109,906,596
Ensembl chr10:109,904,259...109,906,232
JBrowse link
G Tpbg trophoblast glycoprotein acts_upstream_of_or_within ISO MGI:4459319 (MGI:5790502|PMID:27488640) RGD PMID:27488640 MGI:5790502 NCBI chr 8:93,491,761...93,495,132
Ensembl chr 8:93,491,761...93,495,130
JBrowse link
gamma-aminobutyric acid secretion, neurotransmission term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nf1 neurofibromin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1339975 (MGI:5620820|PMID:25242307)
Ensembl
RGD
PMID:25242307 GO_REF:0000107 MGI:5620820 NCBI chr10:66,732,460...66,928,706
Ensembl chr10:66,690,133...66,928,903
JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 acts_upstream_of_or_within ISO MGI:97306 (MGI:5620820|PMID:25242307) RGD PMID:25242307 MGI:5620820 NCBI chr 1:162,768,156...162,883,356
Ensembl chr 1:162,768,156...162,883,355
JBrowse link
negative regulation of synaptic transmission, GABAergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora1 adenosine A1 receptor NOT IMP
IDA
in immature hippocampal CA1 neurons
in postnatal 30 day hippocampal CA1 neurons
RGD PMID:12626609, PMID:12626609 RGD:1625273, RGD:1625273 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Bdnf brain-derived neurotrophic factor acts_upstream_of_or_within ISO (MGI:3694324|PMID:16754670) RGD PMID:16754670 MGI:3694324 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Cnr2 cannabinoid receptor 2 IMP RGD PMID:19616018 RGD:2316192 NCBI chr 5:154,242,010...154,268,126
Ensembl chr 5:154,260,062...154,268,126
JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 IDA RGD PMID:12533604 RGD:1642497 NCBI chr11:27,811,954...28,213,940
Ensembl chr11:27,811,957...27,971,359
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B IMP RGD PMID:17229091 RGD:1626455 NCBI chr 8:89,113,984...89,130,830
Ensembl chr 8:89,129,453...89,130,991
JBrowse link
G Npy5r neuropeptide Y receptor Y5 IMP RGD PMID:11796508 RGD:1625505 NCBI chr16:24,796,685...24,805,730
Ensembl chr16:24,797,124...24,805,079
JBrowse link
G Slc6a1 solute carrier family 6 member 1 IMP RGD PMID:17317750 RGD:1643193 NCBI chr 4:146,258,842...146,292,176
Ensembl chr 4:146,276,862...146,292,213
JBrowse link
G Stxbp1 syntaxin binding protein 1 acts_upstream_of_or_within ISO (MGI:3691953|PMID:17167098) RGD PMID:17167098 MGI:3691953 NCBI chr 3:11,823,779...11,885,479
Ensembl chr 3:11,823,785...11,885,417
JBrowse link
positive regulation of synaptic transmission, GABAergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor acts_upstream_of_or_within ISO MGI:94924 (MGI:3655944|PMID:10934242) RGD PMID:10934242 MGI:3655944 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Adra1a adrenoceptor alpha 1A IDA RGD PMID:14532911 RGD:1625778 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Car2 carbonic anhydrase 2 acts_upstream_of_or_within ISO MGI:103100 (MGI:5506965|PMID:23881097) RGD PMID:23881097 MGI:5506965 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Car7 carbonic anhydrase 7 acts_upstream_of_or_within ISO MGI:88269 (MGI:5506965|PMID:23881097) RGD PMID:23881097 MGI:5506965 NCBI chr19:636,545...645,935
Ensembl chr19:636,545...645,937
JBrowse link
G Cckbr cholecystokinin B receptor IMP RGD PMID:17904218 RGD:2311326 NCBI chr 1:170,262,218...170,272,298
Ensembl chr 1:170,262,156...170,272,298
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 IMP RGD PMID:17521572 RGD:2289989 NCBI chr 9:75,021,790...76,178,936
Ensembl chr 9:75,021,790...75,528,644
JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 acts_upstream_of_or_within IDA
ISO
MGI:2176347 (MGI:3769099|PMID:17245443) RGD PMID:17245443, PMID:12533604 MGI:3769099, RGD:1642497 NCBI chr11:27,811,954...28,213,940
Ensembl chr11:27,811,957...27,971,359
JBrowse link
G Hap1 huntingtin-associated protein 1 involved_in IMP
IDA
PMID:20152113 UniProt PMID:20152113, PMID:20152113 RGD:10047142, RGD:10047142 NCBI chr10:88,257,975...88,266,210
Ensembl chr10:88,257,976...88,266,210
JBrowse link
G Kif5b kinesin family member 5B involved_in ISO (MGI:5582163|PMID:20152113) RGD PMID:20152113 MGI:5582163 NCBI chr17:54,181,416...54,219,048
Ensembl chr17:54,181,419...54,212,096
JBrowse link
G Nlgn1 neuroligin 1 involved_in IDA PMID:12930820 BHF-UCL PMID:12930820 RGD:8554754 NCBI chr 2:111,057,291...111,973,681
Ensembl chr 2:111,057,291...111,793,326
JBrowse link
G Nlgn2 neuroligin 2 involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:5284797|PMID:15620359)
GO_REF:0000107
BHF-UCL
RGD
Ensembl
PMID:15620359 GO_REF:0000024 GO_REF:0000107 MGI:5284797 NCBI chr10:56,431,586...56,444,847
Ensembl chr10:56,431,573...56,444,847
JBrowse link
G Nps neuropeptide S involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:4950795|PMID:21437203)
RGD PMID:21437203, PMID:21873635 MGI:4950795, RGD:13792537 NCBI chr 1:207,508,414...207,512,195
Ensembl chr 1:207,508,414...207,512,195
JBrowse link
G Oxtr oxytocin receptor IMP RGD PMID:11069593 RGD:2304220 NCBI chr 4:144,399,326...144,417,598
Ensembl chr 4:144,403,358...144,416,116
JBrowse link
G Prkce protein kinase C, epsilon acts_upstream_of_or_within ISO MGI:2152043 (MGI:3762436|PMID:17875639) RGD PMID:17875639 MGI:3762436 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
JBrowse link
G Tac1 tachykinin, precursor 1 IDA RGD PMID:19261870 RGD:2304250 NCBI chr 4:33,638,853...33,646,819
Ensembl chr 4:33,638,709...33,646,819
JBrowse link
G Tacr1 tachykinin receptor 1 IMP RGD PMID:19261870 RGD:2304250 NCBI chr 4:113,247,236...113,416,139
Ensembl chr 4:113,247,795...113,414,504
JBrowse link
G Zdhhc12 zinc finger DHHC-type palmitoyltransferase 12 involved_in ISS
ISO
GO_REF:0000024
(MGI:5586946|PMID:25025157)
UniProt
RGD
PMID:25025157 GO_REF:0000024 MGI:5586946 NCBI chr 3:8,656,397...8,659,102
Ensembl chr 3:8,656,412...8,659,102
JBrowse link
G Zdhhc3 zinc finger DHHC-type palmitoyltransferase 3 involved_in ISO (MGI:6393119|PMID:17151279) RGD PMID:17151279 MGI:6393119 NCBI chr 8:132,156,216...132,204,484
Ensembl chr 8:132,160,172...132,189,388
JBrowse link
regulation of synaptic transmission, GABAergic term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Baiap3 BAI1-associated protein 3 involved_in ISO (MGI:5638520|PMID:23698091) RGD PMID:23698091 MGI:5638520 NCBI chr10:14,601,133...14,613,881
Ensembl chr10:14,599,197...14,613,878
JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in ISO (MGI:6111006|PMID:29135436) RGD PMID:29135436 MGI:6111006 NCBI chr 1:197,986,384...197,999,726
Ensembl chr 1:197,986,385...197,997,664
JBrowse link
G Cnr1 cannabinoid receptor 1 IMP RGD PMID:19725112 RGD:2314643 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Cntnap4 contactin associated protein family member 4 involved_in ISO (MGI:5574524|PMID:24870235) RGD PMID:24870235 MGI:5574524 NCBI chr19:44,817,727...45,118,133
Ensembl chr19:44,908,905...45,117,309
JBrowse link
G Dbi diazepam binding inhibitor, acyl-CoA binding protein acts_upstream_of_or_within IDA PMID:3456171 MGI PMID:3456171 RGD:8554715 NCBI chr13:36,147,667...36,156,076
Ensembl chr13:36,117,119...36,174,908
JBrowse link
G Drd2 dopamine receptor D2 acts_upstream_of_or_within ISO MGI:2387895|MGI:99402 (MGI:3050921|PMID:15080900), (MGI:3655944|PMID:10934242)
MGI:2387895|MGI:2675755 (MGI:3628700|PMID:15489038)
RGD PMID:10934242 PMID:15080900 PMID:15489038 MGI:3050921 MGI:3628700 MGI:3655944 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Kras KRAS proto-oncogene, GTPase acts_upstream_of_or_within ISO MGI:97306 (MGI:2157992|PMID:11793011) RGD PMID:11793011 MGI:2157992 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Nf1 neurofibromin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:96680 (MGI:2157992|PMID:11793011)
Ensembl
RGD
PMID:11793011 GO_REF:0000107 MGI:2157992 NCBI chr10:66,732,460...66,928,706
Ensembl chr10:66,690,133...66,928,903
JBrowse link
G Nisch nischarin IMP RGD PMID:16467528 RGD:1582692 NCBI chr16:7,254,372...7,290,670
Ensembl chr16:7,254,974...7,290,561
JBrowse link
G Npas4 neuronal PAS domain protein 4 involved_in ISS
ISO
GO_REF:0000024
(MGI:3826741|PMID:18815592)
UniProt
RGD
PMID:18815592 GO_REF:0000024 MGI:3826741 NCBI chr 1:220,260,310...220,278,177
Ensembl chr 1:220,261,008...220,265,772
JBrowse link
G Phf24 PHD finger protein 24 acts_upstream_of_or_within ISO MGI:5706936 (MGI:5616490|PMID:25242222) RGD PMID:25242222 MGI:5616490 NCBI chr 5:58,359,744...58,387,446
Ensembl chr 5:58,359,498...58,383,070
JBrowse link
G Plcl1 phospholipase C-like 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1352756|MGI:3526123 (MGI:3055253|PMID:15464766), (MGI:3694324|PMID:16754670)
GO_REF:0000002
Ensembl
RGD
InterPro
PMID:15464766 PMID:16754670 GO_REF:0000002 GO_REF:0000107 MGI:3055253 MGI:3694324 NCBI chr 9:62,016,112...62,349,244
Ensembl chr 9:62,291,405...62,349,309
JBrowse link
G Plcl2 phospholipase C-like 2 acts_upstream_of_or_within ISO MGI:3036262 (MGI:3694324|PMID:16754670) RGD PMID:16754670 MGI:3694324 NCBI chr 9:1,782,536...1,984,654
Ensembl chr 9:1,782,536...1,984,654
JBrowse link
G Pten phosphatase and tensin homolog acts_upstream_of_or_within ISO MGI:2156086 (MGI:5584033|PMID:24875179) RGD PMID:24875179 MGI:5584033 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Usp46 ubiquitin specific peptidase 46 involved_in ISO (MGI:3850588|PMID:19465912) RGD PMID:19465912 MGI:3850588 NCBI chr14:36,687,134...36,755,360
Ensembl chr14:36,687,134...36,755,360
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    signaling 7458
      cell-cell signaling 1731
        synaptic signaling 916
          trans-synaptic signaling 889
            anterograde trans-synaptic signaling 880
              chemical synaptic transmission 880
                synaptic transmission, GABAergic 64
                  gamma-aminobutyric acid secretion, neurotransmission 2
                  negative regulation of synaptic transmission, GABAergic 8
                  positive regulation of synaptic transmission, GABAergic 18
                  regulation of synaptic transmission, GABAergic + 40
Path 2
Term Annotations click to browse term
  biological_process 19491
    cellular process 18343
      cell communication 7539
        cell-cell signaling 1731
          synaptic signaling 916
            trans-synaptic signaling 889
              anterograde trans-synaptic signaling 880
                chemical synaptic transmission 880
                  synaptic transmission, GABAergic 64
                    gamma-aminobutyric acid secretion, neurotransmission 2
                    negative regulation of synaptic transmission, GABAergic 8
                    positive regulation of synaptic transmission, GABAergic 18
                    regulation of synaptic transmission, GABAergic + 40
paths to the root