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ONTOLOGY REPORT - ANNOTATIONS

Term:membrane depolarization
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Accession:GO:0051899 term browser browse the term
Definition:The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential.

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membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor ISO RGD PMID:16644907 RGD:1625443 NCBI chrNW_004936619:597,970...618,564
Ensembl chrNW_004936619:608,441...616,779 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:30819023) Ensembl
MGI		 PMID:30819023 GO_REF:0000107 NCBI chrNW_004936740:489,357...514,235
Ensembl chrNW_004936740:488,154...514,308 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 acts_upstream_of_or_within ISO (PMID:30819023) MGI PMID:30819023 NCBI chrNW_004936706:476,473...494,659
Ensembl chrNW_004936706:477,107...495,525 		JBrowse link
G Best2 bestrophin 2 involved_in ISO (MGI:3763293|PMID:16912113) HGNC-UCL PMID:16912113 MGI:3763293 NCBI chrNW_004936659:1,862,075...1,867,021
Ensembl chrNW_004936659:1,861,021...1,867,642 		JBrowse link
G Cacng2 calcium voltage-gated channel auxiliary subunit gamma 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9065835) Ensembl
MGI		 PMID:9065835 GO_REF:0000107 NCBI chrNW_004936492:4,125,182...4,232,239
Ensembl chrNW_004936492:4,125,173...4,236,062 		JBrowse link
G Cav1 caveolin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17098833) Ensembl
MGI		 PMID:17098833 GO_REF:0000107 NCBI chrNW_004936589:2,504,235...2,536,778
Ensembl chrNW_004936589:2,504,224...2,537,170 		JBrowse link
G Chrna10 cholinergic receptor nicotinic alpha 10 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936498:1,224,123...1,230,640
Ensembl chrNW_004936498:1,225,636...1,230,884 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit acts_upstream_of_or_within ISO (PMID:15741168)
(PMID:11222635), (PMID:12944511)
(PMID:11226318)		 MGI PMID:11222635 PMID:11226318 PMID:12944511 PMID:15741168 NCBI chrNW_004936514:10,680,893...10,695,859
Ensembl chrNW_004936514:10,680,859...10,695,865 		JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12944511) Ensembl
MGI		 PMID:12944511 GO_REF:0000107 NCBI chrNW_004936785:17,588...28,565
Ensembl chrNW_004936785:18,147...27,409 		JBrowse link
G Chrna9 cholinergic receptor nicotinic alpha 9 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936482:7,792,292...7,801,152
Ensembl chrNW_004936482:7,792,292...7,801,152 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit acts_upstream_of_or_within ISO (PMID:11222635) MGI PMID:11222635 NCBI chrNW_004936580:4,165,255...4,179,285
Ensembl chrNW_004936580:4,166,619...4,186,443 		JBrowse link
G Cnga1 cyclic nucleotide gated channel subunit alpha 1 ISO RGD PMID:18048449 RGD:6902904 NCBI chrNW_004936482:14,091,343...14,107,793
Ensembl chrNW_004936482:14,091,913...14,107,787 		JBrowse link
G Cnga2 cyclic nucleotide gated channel subunit alpha 2 involved_in ISO PMID:1697649 RGD
UniProt		 PMID:1697649 PMID:18048449 RGD:1298763 RGD:6902904 NCBI chrNW_004936714:1,011,736...1,017,722
Ensembl chrNW_004936714:1,011,736...1,017,729 		JBrowse link
G Cnga3 cyclic nucleotide gated channel subunit alpha 3 involved_in ISO PMID:15178415 UniProt PMID:15178415 RGD:405650286 NCBI chrNW_004936744:1,499,431...1,537,784
Ensembl chrNW_004936744:1,514,821...1,540,580 		JBrowse link
G Cngb1 cyclic nucleotide gated channel subunit beta 1 involved_in ISO (MGI:5817509|PMID:28053034) ARUK-UCL PMID:28053034 MGI:5817509 NCBI chrNW_004936475:9,844,438...9,908,009 JBrowse link
G Edn1 endothelin 1 ISO RGD PMID:15655307 RGD:1580292 NCBI chrNW_004936534:885,489...892,292
Ensembl chrNW_004936534:885,287...891,772 		JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 acts_upstream_of_or_within ISO (PMID:17245443) MGI PMID:17245443 NCBI chrNW_004936500:12,157,215...12,536,555
Ensembl chrNW_004936500:12,157,765...12,536,224 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO induced in pulmonary artery smooth muscle cells RGD PMID:11571252 RGD:2290591 NCBI chrNW_004936522:3,034,364...3,037,632
Ensembl chrNW_004936522:3,035,346...3,036,350 		JBrowse link
G Kmt2a lysine methyltransferase 2A ISO RGD PMID:20211609 RGD:9588219 NCBI chrNW_004936542:3,480,071...3,566,823
Ensembl chrNW_004936542:3,391,774...3,562,147 		JBrowse link
G LOC101960999 voltage-dependent P/Q-type calcium channel subunit alpha-1A acts_upstream_of_or_within ISO (PMID:8158221)
(PMID:10908603)
(PMID:11718712)		 MGI PMID:8158221 PMID:10908603 PMID:11718712 NCBI chrNW_004936659:2,201,606...2,269,625
Ensembl chrNW_004936659:2,192,610...2,392,638 		JBrowse link
G P2rx4 purinergic receptor P2X 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936558:3,062,279...3,077,493
Ensembl chrNW_004936558:3,059,886...3,077,451 		JBrowse link
G P2rx7 purinergic receptor P2X 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936558:3,106,819...3,149,689
Ensembl chrNW_004936558:3,108,283...3,149,765 		JBrowse link
G Park7 Parkinsonism associated deglycase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16624565) Ensembl
MGI		 PMID:16624565 GO_REF:0000107 NCBI chrNW_004936623:2,422,780...2,436,817
Ensembl chrNW_004936623:2,422,833...2,436,817 		JBrowse link
G Phox2b paired like homeobox 2B ISO RGD PMID:19036978 RGD:152025257 NCBI chrNW_004936482:8,972,433...8,975,284
Ensembl chrNW_004936482:8,972,433...8,975,284 		JBrowse link
G Prkcz protein kinase C zeta ISO RGD PMID:15381257 RGD:1642699 NCBI chrNW_004936737:1,303,502...1,383,135
Ensembl chrNW_004936737:1,303,887...1,321,944 		JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936570:1,187,916...1,195,423
Ensembl chrNW_004936570:1,186,711...1,195,388 		JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936542:8,082,487...8,106,154
Ensembl chrNW_004936542:8,086,702...8,105,372 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:27,883,526...27,963,994
Ensembl chrNW_004936473:27,883,526...27,963,994 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 involved_in ISO PMID:14642278 UniProt PMID:14642278 RGD:8553687 NCBI chrNW_004936538:6,205,268...6,239,062
Ensembl chrNW_004936538:6,205,251...6,239,083 		JBrowse link
membrane depolarization during action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1g calcium voltage-gated channel subunit alpha1 G involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936490:11,093,600...11,157,756
Ensembl chrNW_004936490:11,093,595...11,157,563 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936694:2,702,224...2,724,574 JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936492:1,990,430...2,030,744
Ensembl chrNW_004936492:1,998,793...2,075,257 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936527:6,380,222...6,412,390
Ensembl chrNW_004936527:6,379,669...6,412,390 		JBrowse link
G LOC101967418 voltage-dependent T-type calcium channel subunit alpha-1H-like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936694:2,778,548...2,800,905 JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936473:28,010,123...28,102,124
Ensembl chrNW_004936473:28,010,123...28,102,124 		JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936473:28,162,528...28,248,474
Ensembl chrNW_004936473:28,162,528...28,248,474 		JBrowse link
G Scn1a sodium voltage-gated channel alpha subunit 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936469:13,194,769...13,345,979
Ensembl chrNW_004936469:13,256,925...13,345,978 		JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936570:1,187,916...1,195,423
Ensembl chrNW_004936570:1,186,711...1,195,388 		JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936469:13,872,701...14,019,170
Ensembl chrNW_004936469:13,872,701...13,971,005 		JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936542:3,262,161...3,274,545
Ensembl chrNW_004936542:3,261,533...3,274,623 		JBrowse link
G Scn3a sodium voltage-gated channel alpha subunit 3 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936469:14,072,182...14,180,552
Ensembl chrNW_004936469:14,101,868...14,179,998 		JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936542:8,082,487...8,106,154
Ensembl chrNW_004936542:8,086,702...8,105,372 		JBrowse link
G Scn4a sodium voltage-gated channel alpha subunit 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936541:4,541,061...4,570,212
Ensembl chrNW_004936541:4,543,102...4,569,862 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936473:27,883,526...27,963,994
Ensembl chrNW_004936473:27,883,526...27,963,994 		JBrowse link
G Scn7a sodium voltage-gated channel alpha subunit 7 NOT|involved_in ISO
IEA		 PMID:9001394 UniProt
TreeGrafter		 PMID:9001394 GO_REF:0000118 RGD:61747 NCBI chrNW_004936469:12,862,314...12,946,784
Ensembl chrNW_004936469:12,888,856...12,946,818 		JBrowse link
G Scn8a sodium voltage-gated channel alpha subunit 8 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936512:9,164,310...9,281,795
Ensembl chrNW_004936512:9,164,262...9,279,688 		JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936469:13,063,971...13,153,030
Ensembl chrNW_004936469:13,064,043...13,152,974 		JBrowse link
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936755:1,597,487...1,608,915
Ensembl chrNW_004936755:1,597,445...1,609,003 		JBrowse link
membrane depolarization during atrial cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936606:2,168,104...2,867,560
Ensembl chrNW_004936606:2,168,625...2,865,758 		JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936520:8,951,994...9,164,039
Ensembl chrNW_004936520:8,955,164...9,295,331 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:27,883,526...27,963,994
Ensembl chrNW_004936473:27,883,526...27,963,994 		JBrowse link
membrane depolarization during AV node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936606:2,168,104...2,867,560
Ensembl chrNW_004936606:2,168,625...2,865,758 		JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G involved_in ISO (MGI:3714901|PMID:16690884) BHF-UCL PMID:16690884 MGI:3714901 NCBI chrNW_004936490:11,093,600...11,157,756
Ensembl chrNW_004936490:11,093,595...11,157,563 		JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936520:8,951,994...9,164,039
Ensembl chrNW_004936520:8,955,164...9,295,331 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:27,883,526...27,963,994
Ensembl chrNW_004936473:27,883,526...27,963,994 		JBrowse link
G Trpm4 transient receptor potential cation channel subfamily M member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936664:3,093,258...3,124,473
Ensembl chrNW_004936664:3,093,367...3,124,117 		JBrowse link
membrane depolarization during bundle of His cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936734:577,656...1,027,412
Ensembl chrNW_004936734:581,538...1,027,018 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:27,883,526...27,963,994
Ensembl chrNW_004936473:27,883,526...27,963,994 		JBrowse link
G Trpm4 transient receptor potential cation channel subfamily M member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936664:3,093,258...3,124,473
Ensembl chrNW_004936664:3,093,367...3,124,117 		JBrowse link
membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936606:2,168,104...2,867,560
Ensembl chrNW_004936606:2,168,625...2,865,758 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 involved_in IEA GOC GO_REF:0000108 NCBI chrNW_004936473:28,010,123...28,102,124
Ensembl chrNW_004936473:28,010,123...28,102,124 		JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936570:1,187,916...1,195,423
Ensembl chrNW_004936570:1,186,711...1,195,388 		JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936542:3,262,161...3,274,545
Ensembl chrNW_004936542:3,261,533...3,274,623 		JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936542:8,082,487...8,106,154
Ensembl chrNW_004936542:8,086,702...8,105,372 		JBrowse link
G Scn4b sodium voltage-gated channel beta subunit 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936542:3,236,238...3,252,550
Ensembl chrNW_004936542:3,236,231...3,252,692 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl
GOC		 GO_REF:0000107 GO_REF:0000108 NCBI chrNW_004936473:27,883,526...27,963,994
Ensembl chrNW_004936473:27,883,526...27,963,994 		JBrowse link
membrane depolarization during Purkinje myocyte cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn1b sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936570:1,187,916...1,195,423
Ensembl chrNW_004936570:1,186,711...1,195,388 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:27,883,526...27,963,994
Ensembl chrNW_004936473:27,883,526...27,963,994 		JBrowse link
G Trpm4 transient receptor potential cation channel subfamily M member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936664:3,093,258...3,124,473
Ensembl chrNW_004936664:3,093,367...3,124,117 		JBrowse link
membrane depolarization during SA node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1d calcium voltage-gated channel subunit alpha1 D involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12700358) Ensembl
MGI		 PMID:12700358 GO_REF:0000107 NCBI chrNW_004936473:4,164,633...4,479,866
Ensembl chrNW_004936473:4,037,533...4,478,073 		JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G involved_in ISO (MGI:3714901|PMID:16690884) BHF-UCL PMID:16690884 MGI:3714901 NCBI chrNW_004936490:11,093,600...11,157,756
Ensembl chrNW_004936490:11,093,595...11,157,563 		JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936471:32,527,551...32,570,548
Ensembl chrNW_004936471:32,529,847...32,570,284 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:27,883,526...27,963,994
Ensembl chrNW_004936473:27,883,526...27,963,994 		JBrowse link
mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp5if1 ATP synthase inhibitory factor subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:12,396,416...12,399,760
Ensembl chrNW_004936474:12,396,023...12,401,023 		JBrowse link
G Col6a1 collagen type VI alpha 1 chain acts_upstream_of_or_within ISO (PMID:19519726), (PMID:24852368)
(PMID:19293339)		 MGI PMID:19293339 PMID:19519726 PMID:24852368 NCBI chrNW_004936778:515,600...530,828 JBrowse link
G Kcnq2 potassium voltage-gated channel subfamily Q member 2 acts_upstream_of_or_within ISO (PMID:20885443) MGI PMID:20885443 NCBI chrNW_004936514:10,735,247...10,787,682
Ensembl chrNW_004936514:10,735,809...10,787,678 		JBrowse link
G Kcnq3 potassium voltage-gated channel subfamily Q member 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20885443) Ensembl
MGI		 PMID:20885443 GO_REF:0000107 NCBI chrNW_004936470:16,712,508...17,009,648
Ensembl chrNW_004936470:16,712,703...17,009,397 		JBrowse link
G LOC101954543 caspase-1-like involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936551:3,230,060...3,240,496 JBrowse link
G P2rx7 purinergic receptor P2X 7 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:16198349) Ensembl
MGI		 PMID:16198349 GO_REF:0000107 NCBI chrNW_004936558:3,106,819...3,149,689
Ensembl chrNW_004936558:3,108,283...3,149,765 		JBrowse link
G Ppif peptidylprolyl isomerase F involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19293339) Ensembl
MGI		 PMID:19293339 GO_REF:0000107 NCBI chrNW_004936521:404,574...411,381
Ensembl chrNW_004936521:404,544...411,539 		JBrowse link
negative regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936602:4,264,896...4,278,160
Ensembl chrNW_004936602:4,264,889...4,278,161 		JBrowse link
negative regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bok BCL2 family apoptosis regulator BOK involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936745:344,837...350,950
Ensembl chrNW_004936745:345,635...351,749 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 ISO RGD PMID:29215467 RGD:13504824 NCBI chrNW_004936636:617,376...640,424
Ensembl chrNW_004936636:617,356...640,932 		JBrowse link
G Hsh2d hematopoietic SH2 domain containing acts_upstream_of_or_within ISO (PMID:15569688) MGI PMID:15569688 NCBI chrNW_004936596:4,371,480...4,376,985 JBrowse link
G Ngfr nerve growth factor receptor ISO RGD PMID:19457114 RGD:5508731 NCBI chrNW_004936490:12,038,500...12,057,257
Ensembl chrNW_004936490:12,035,769...12,057,263 		JBrowse link
G Rbfox2 RNA binding fox-1 homolog 2 ISO RGD PMID:34731606 RGD:329845875 NCBI chrNW_004936492:4,624,013...4,826,715
Ensembl chrNW_004936492:4,645,167...4,821,291 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936561:3,826,802...3,844,406
Ensembl chrNW_004936561:3,825,787...3,844,483 		JBrowse link
positive regulation of membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO RGD PMID:18562674 RGD:152177517 NCBI chrNW_004936606:2,168,104...2,867,560
Ensembl chrNW_004936606:2,168,625...2,865,758 		JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D ISO RGD PMID:7760845 RGD:70680 NCBI chrNW_004936473:4,164,633...4,479,866
Ensembl chrNW_004936473:4,037,533...4,478,073 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 ISO RGD PMID:16641242 RGD:401959318 NCBI chrNW_004936631:3,721,307...3,785,346
Ensembl chrNW_004936631:3,721,313...3,780,892 		JBrowse link
positive regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ank3 ankyrin 3 involved_in ISO PMID:18180363 BHF-UCL PMID:18180363 RGD:6767295 NCBI chrNW_004936614:2,664,594...2,976,174 JBrowse link
positive regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy10 adenylate cyclase 10 ISO RGD PMID:31172217 RGD:329403053 NCBI chrNW_004936481:18,274,158...18,330,136
Ensembl chrNW_004936481:18,274,154...18,330,173 		JBrowse link
G Cck cholecystokinin ISO apoptotic RGD PMID:11964411 RGD:625521 NCBI chrNW_004936695:2,776,705...2,782,280
Ensembl chrNW_004936695:2,776,831...2,782,061 		JBrowse link
G Dcn decorin acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23798385) MGI
Ensembl		 PMID:23798385 GO_REF:0000107 NCBI chrNW_004936507:7,887,259...7,923,055
Ensembl chrNW_004936507:7,884,654...7,922,961 		JBrowse link
G Kdr kinase insert domain receptor acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23798385) MGI
Ensembl		 PMID:23798385 GO_REF:0000107 NCBI chrNW_004936482:17,537,697...17,581,320
Ensembl chrNW_004936482:17,538,864...17,581,002 		JBrowse link
G Mllt11 MLLT11 transcription factor 7 cofactor involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936580:1,274,658...1,283,505 JBrowse link
G Myoc myocilin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936481:15,544,733...15,556,813
Ensembl chrNW_004936481:15,544,660...15,556,857 		JBrowse link
G Oga O-GlcNAcase ISO RGD PMID:19139380 RGD:2305938 NCBI chrNW_004936600:3,983,983...3,996,360 JBrowse link
G P2rx7 purinergic receptor P2X 7 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16198349) Ensembl
MGI		 PMID:16198349 GO_REF:0000107 NCBI chrNW_004936558:3,106,819...3,149,689
Ensembl chrNW_004936558:3,108,283...3,149,765 		JBrowse link
G Parp1 poly(ADP-ribose) polymerase 1 ISO protein:increased activity:brain: RGD PMID:21616968 RGD:10413888 NCBI chrNW_004936526:3,102,468...3,147,601
Ensembl chrNW_004936526:3,102,039...3,147,642 		JBrowse link
G Rack1 receptor for activated C kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936826:748,256...753,460
Ensembl chrNW_004936826:747,291...753,442 		JBrowse link
G Tspo translocator protein ISO RGD PMID:15183124 RGD:2317155 NCBI chrNW_004936718:992,301...995,172
Ensembl chrNW_004936718:992,301...995,995 		JBrowse link
positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trpm4 transient receptor potential cation channel subfamily M member 4 ISO RGD PMID:20826763 RGD:10003037 NCBI chrNW_004936664:3,093,258...3,124,473
Ensembl chrNW_004936664:3,093,367...3,124,117 		JBrowse link
regulation of atrial cardiac muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1g calcium voltage-gated channel subunit alpha1 G involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16690884) Ensembl
MGI		 PMID:16690884 GO_REF:0000107 NCBI chrNW_004936490:11,093,600...11,157,756
Ensembl chrNW_004936490:11,093,595...11,157,563 		JBrowse link
G Gja1 gap junction protein alpha 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10969038) Ensembl
MGI		 PMID:10969038 GO_REF:0000107 NCBI chrNW_004936658:3,920,043...3,932,987
Ensembl chrNW_004936658:3,920,043...3,932,987 		JBrowse link
G Gja5 gap junction protein alpha 5 involved_in
acts_upstream_of_or_within		 ISO (PMID:22247482), (PMID:23348765)
(PMID:10515563), (PMID:10969038), (PMID:9501070)		 BHF-UCL
MGI		 PMID:9501070 PMID:10515563 PMID:10969038 PMID:22247482 PMID:23348765 NCBI chrNW_004936867:269,477...279,549 JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20062061) Ensembl
TreeGrafter
MGI		 PMID:20062061 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936473:28,010,123...28,102,124
Ensembl chrNW_004936473:28,010,123...28,102,124 		JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936570:1,187,916...1,195,423
Ensembl chrNW_004936570:1,186,711...1,195,388 		JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936542:3,262,161...3,274,545
Ensembl chrNW_004936542:3,261,533...3,274,623 		JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936542:8,082,487...8,106,154
Ensembl chrNW_004936542:8,086,702...8,105,372 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936473:27,883,526...27,963,994
Ensembl chrNW_004936473:27,883,526...27,963,994 		JBrowse link
G Tbx5 T-box transcription factor 5 involved_in
acts_upstream_of_positive_effect		 IEA
ISO		 (MGI:5449667|PMID:22728936) Ensembl
BHF-UCL		 PMID:22728936 GO_REF:0000107 MGI:5449667 NCBI chrNW_004936558:7,408,229...7,454,897
Ensembl chrNW_004936558:7,408,222...7,454,901 		JBrowse link
regulation of membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2m beta-2-microglobulin involved_in ISO (PMID:23144825) UniProt PMID:23144825 NCBI chrNW_004936471:7,646,504...7,655,656
Ensembl chrNW_004936471:7,646,373...7,655,778 		JBrowse link
G Camk2d calcium/calmodulin dependent protein kinase II delta involved_in ISO (PMID:22514276) BHF-UCL PMID:22514276 NCBI chrNW_004936563:4,226,412...4,526,139
Ensembl chrNW_004936563:4,227,986...4,526,118 		JBrowse link
G Cftr CF transmembrane conductance regulator NOT|involved_in ISO (MGI:5640937|PMID:24885604) UniProt PMID:24885604 MGI:5640937 NCBI chrNW_004936589:1,565,933...1,719,208 JBrowse link
G Fgf12 fibroblast growth factor 12 involved_in ISO PMID:12401812 BHF-UCL PMID:12401812 RGD:6484231 NCBI chrNW_004936711:1,873,030...2,378,028
Ensembl chrNW_004936711:2,045,080...2,375,896 		JBrowse link
G Fhl1 four and a half LIM domains 1 involved_in ISO (PMID:18281375) BHF-UCL PMID:18281375 NCBI chrNW_004936513:11,025,753...11,064,312
Ensembl chrNW_004936513:11,025,715...11,064,312 		JBrowse link
G Hcn1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:20806410 GO_REF:0000118 RGD:9686372 NCBI chrNW_004936480:17,051,902...17,416,335
Ensembl chrNW_004936480:17,051,898...17,413,657 		JBrowse link
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936588:202,101...209,255
Ensembl chrNW_004936588:142,786...208,606 		JBrowse link
G Hcn3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936580:4,760,289...4,770,571
Ensembl chrNW_004936580:4,760,241...4,772,583 		JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936471:32,527,551...32,570,548
Ensembl chrNW_004936471:32,529,847...32,570,284 		JBrowse link
G Nedd4l NEDD4 like E3 ubiquitin protein ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936497:6,106,284...6,318,339
Ensembl chrNW_004936497:6,106,268...6,318,354 		JBrowse link
G Npff neuropeptide FF-amide peptide precursor ISO RGD PMID:17289819 RGD:2316567 NCBI chrNW_004936512:10,780,277...10,782,219
Ensembl chrNW_004936512:10,780,354...10,780,930 		JBrowse link
G Ntsr1 neurotensin receptor 1 ISO RGD PMID:15120846 RGD:9743930 NCBI chrNW_004936514:10,240,990...10,272,859
Ensembl chrNW_004936514:10,241,020...10,272,816 		JBrowse link
G Rangrf RAN guanine nucleotide release factor involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936595:1,513,855...1,515,300
Ensembl chrNW_004936595:1,513,180...1,517,270 		JBrowse link
regulation of membrane depolarization during action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcn2 chloride voltage-gated channel 2 involved_in ISO PMID:8816717 UniProt PMID:8816717 RGD:405650388 NCBI chrNW_004936578:5,525,461...5,539,351
Ensembl chrNW_004936578:5,525,601...5,539,472 		JBrowse link
G Ptpn3 protein tyrosine phosphatase non-receptor type 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936559:3,436,114...3,547,316
Ensembl chrNW_004936559:3,436,651...3,547,275 		JBrowse link
regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936602:4,264,896...4,278,160
Ensembl chrNW_004936602:4,264,889...4,278,161 		JBrowse link
G Gja5 gap junction protein alpha 5 acts_upstream_of_or_within ISO (PMID:9501070) MGI PMID:9501070 NCBI chrNW_004936867:269,477...279,549 JBrowse link
G Rangrf RAN guanine nucleotide release factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936595:1,513,855...1,515,300
Ensembl chrNW_004936595:1,513,180...1,517,270 		JBrowse link
G Slmap sarcolemma associated protein involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936473:8,057,236...8,208,564
Ensembl chrNW_004936473:8,057,042...8,209,087 		JBrowse link
regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd1 ATP binding cassette subfamily D member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936809:615,133...634,618
Ensembl chrNW_004936809:615,139...635,990 		JBrowse link
G Gclc glutamate-cysteine ligase catalytic subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15288121) Ensembl
MGI		 PMID:15288121 GO_REF:0000107 NCBI chrNW_004936476:7,371,270...7,418,756
Ensembl chrNW_004936476:7,371,149...7,418,958 		JBrowse link
G LOC101977655 glutamate--cysteine ligase regulatory subunit acts_upstream_of_or_within ISO (PMID:15288121) MGI PMID:15288121 NCBI chrNW_004936537:5,356,914...5,378,998 JBrowse link
G Lrrk2 leucine rich repeat kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936607:628,469...761,117
Ensembl chrNW_004936607:626,991...761,123 		JBrowse link
G Ppp2r3c protein phosphatase 2 regulatory subunit B''gamma involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16129705) Ensembl
MGI		 PMID:16129705 GO_REF:0000107 NCBI chrNW_004936494:9,247,600...9,283,019
Ensembl chrNW_004936494:9,244,588...9,283,019 		JBrowse link
regulation of ventricular cardiac muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936602:4,264,896...4,278,160
Ensembl chrNW_004936602:4,264,889...4,278,161 		JBrowse link
G Gja1 gap junction protein alpha 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10969038)
(PMID:10969038), (PMID:9109444)		 Ensembl
MGI		 PMID:9109444 PMID:10969038 GO_REF:0000107 NCBI chrNW_004936658:3,920,043...3,932,987
Ensembl chrNW_004936658:3,920,043...3,932,987 		JBrowse link
G Gja5 gap junction protein alpha 5 acts_upstream_of
acts_upstream_of_or_within		 ISO (MGI:6101691|PMID:26786475)
(PMID:10969038)
(PMID:10515563), (PMID:9501070)		 BHF-UCL
MGI		 PMID:9501070 PMID:10515563 PMID:10969038 PMID:26786475 MGI:6101691 NCBI chrNW_004936867:269,477...279,549 JBrowse link
G Gpd1l glycerol-3-phosphate dehydrogenase 1 like involved_in ISO (PMID:17967977), (PMID:19666841) BHF-UCL PMID:17967977 PMID:19666841 NCBI chrNW_004936473:22,649,107...22,774,719
Ensembl chrNW_004936473:22,649,133...22,696,959 		JBrowse link
G LOC101971485 glycerol-3-phosphate dehydrogenase 1-like protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004937472:61,719...62,288 JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936542:8,082,487...8,106,154
Ensembl chrNW_004936542:8,086,702...8,105,372 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:27,883,526...27,963,994
Ensembl chrNW_004936473:27,883,526...27,963,994 		JBrowse link
G Smad7 SMAD family member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936497:13,894,586...13,921,978
Ensembl chrNW_004936497:13,894,580...13,922,065 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16121
    biological regulation 11335
      regulation of biological quality 3037
        regulation of membrane potential 512
          membrane depolarization 103
            membrane depolarization during action potential + 33
            mitochondrial depolarization + 28
            negative regulation of membrane depolarization + 7
            positive regulation of membrane depolarization + 16
            regulation of membrane depolarization + 56
            regulation of vascular associated smooth muscle cell membrane depolarization + 1
paths to the root