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ONTOLOGY REPORT - ANNOTATIONS

Term:membrane depolarization
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Accession:GO:0051899 term browser browse the term
Definition:The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential.


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membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2A adenosine A2a receptor ISO RGD PMID:16644907 RGD:1625443 NCBI chr14:49,467,186...49,485,845
Ensembl chr14:49,468,877...49,485,850 		JBrowse link
G ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:30819023) Ensembl
MGI		 PMID:30819023 GO_REF:0000107 NCBI chr 4:90,341,316...90,371,040
Ensembl chr 4:90,341,322...90,370,996 		JBrowse link
G ATP1A3 ATPase Na+/K+ transporting subunit alpha 3 acts_upstream_of_or_within ISO (PMID:30819023) MGI PMID:30819023 NCBI chr 6:49,905,851...49,927,437
Ensembl chr 6:49,905,847...49,927,633 		JBrowse link
G BEST2 bestrophin 2 involved_in ISO (MGI:3763293|PMID:16912113) HGNC-UCL PMID:16912113 MGI:3763293 NCBI chr 2:66,242,820...66,248,908
Ensembl chr 2:66,242,999...66,248,784 		JBrowse link
G CACNA1A calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO (PMID:8158221)
(PMID:10908603)
(PMID:11718712)		 MGI PMID:8158221 PMID:10908603 PMID:11718712 NCBI chr 2:65,491,784...65,871,068
Ensembl chr 2:65,514,509...65,871,182 		JBrowse link
G CACNG2 calcium voltage-gated channel auxiliary subunit gamma 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9065835) Ensembl
MGI		 PMID:9065835 GO_REF:0000107 NCBI chr 5:11,067,016...11,185,480
Ensembl chr 5:11,067,692...11,185,480 		JBrowse link
G CAV1 caveolin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17098833) Ensembl
MGI		 PMID:17098833 GO_REF:0000107 NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465 		JBrowse link
G CHRNA10 cholinergic receptor nicotinic alpha 10 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:6,427,832...6,431,881
Ensembl chr 9:6,427,191...6,432,875 		JBrowse link
G CHRNA2 cholinergic receptor nicotinic alpha 2 subunit involved_in IBA GO_Central GO_REF:0000033 NCBI chr14:11,193,732...11,204,334
Ensembl chr14:11,195,228...11,207,650 		JBrowse link
G CHRNA3 cholinergic receptor nicotinic alpha 3 subunit involved_in IBA GO_Central GO_REF:0000033 NCBI chr 7:47,361,710...47,382,743
Ensembl chr 7:47,361,899...47,384,303 		JBrowse link
G CHRNA4 cholinergic receptor nicotinic alpha 4 subunit involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:11222635), (PMID:12944511)
(PMID:15741168)
(PMID:11226318)		 GO_Central
MGI		 PMID:11222635 PMID:11226318 PMID:12944511 PMID:15741168 GO_REF:0000033 NCBI chr17:62,424,672...62,436,646
Ensembl chr17:62,423,878...62,435,728 		JBrowse link
G CHRNA5 cholinergic receptor nicotinic alpha 5 subunit involved_in IBA GO_Central GO_REF:0000033 NCBI chr 7:47,382,860...47,425,871
Ensembl chr 7:47,383,792...47,425,841 		JBrowse link
G CHRNA6 cholinergic receptor nicotinic alpha 6 subunit acts_upstream_of_or_within ISO (PMID:12944511) MGI PMID:12944511 NCBI chr17:11,725,880...11,739,949
Ensembl chr17:11,725,880...11,739,747 		JBrowse link
G CHRNA9 cholinergic receptor nicotinic alpha 9 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:31,430,933...31,456,385
Ensembl chr 8:31,443,043...31,456,384 		JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit involved_in
acts_upstream_of_or_within		 IBA
ISO		 (PMID:11222635) GO_Central
MGI		 PMID:11222635 GO_REF:0000033 NCBI chr 4:95,196,992...95,211,084
Ensembl chr 4:95,198,717...95,211,037 		JBrowse link
G CHRNB3 cholinergic receptor nicotinic beta 3 subunit involved_in IBA GO_Central GO_REF:0000033 NCBI chr17:11,687,646...11,714,357
Ensembl chr17:11,687,557...11,722,183 		JBrowse link
G CHRNG cholinergic receptor nicotinic gamma subunit involved_in IBA GO_Central GO_REF:0000033 NCBI chr15:133,051,668...133,059,935
Ensembl chr15:133,052,031...133,058,544 		JBrowse link
G CNGA1 cyclic nucleotide gated channel subunit alpha 1 ISO RGD PMID:18048449 RGD:6902904 NCBI chr 8:37,896,460...37,968,935
Ensembl chr 8:37,896,459...37,969,344 		JBrowse link
G CNGA2 cyclic nucleotide gated channel subunit alpha 2 involved_in ISO PMID:1697649 RGD
UniProt		 PMID:1697649 PMID:18048449 RGD:1298763 RGD:6902904 NCBI chr  X:123,115,980...123,130,043
Ensembl chr  X:123,115,975...123,129,840 		JBrowse link
G CNGA3 cyclic nucleotide gated channel subunit alpha 3 involved_in ISO PMID:15178415 UniProt PMID:15178415 RGD:405650286 NCBI chr 3:55,872,607...55,936,516
Ensembl chr 3:55,874,250...55,922,979 		JBrowse link
G CNGB1 cyclic nucleotide gated channel subunit beta 1 involved_in ISO (MGI:5817509|PMID:28053034) ARUK-UCL PMID:28053034 MGI:5817509 NCBI chr 6:19,752,734...19,865,830 JBrowse link
G EDN1 endothelin 1 ISO RGD PMID:15655307 RGD:1580292 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348 		JBrowse link
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 acts_upstream_of_or_within ISO (PMID:17245443) MGI PMID:17245443 NCBI chr13:192,877,707...193,296,954
Ensembl chr13:192,877,606...193,294,952 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit ISO induced in pulmonary artery smooth muscle cells RGD PMID:11571252 RGD:2290591 NCBI chr 6:153,686,425...153,687,635
Ensembl chr 6:153,685,682...153,687,636 		JBrowse link
G KMT2A lysine methyltransferase 2A ISO RGD PMID:20211609 RGD:9588219 NCBI chr 9:45,743,566...45,828,559
Ensembl chr 9:45,743,397...45,824,884 		JBrowse link
G P2RX4 purinergic receptor P2X 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:31,368,542...31,387,960
Ensembl chr14:31,368,303...31,387,905 		JBrowse link
G P2RX7 purinergic receptor P2X 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:31,415,188...31,476,502
Ensembl chr14:31,415,193...31,476,472 		JBrowse link
G PARK7 Parkinsonism associated deglycase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16624565) Ensembl
MGI		 PMID:16624565 GO_REF:0000107 NCBI chr 6:68,629,327...68,645,147
Ensembl chr 6:68,629,214...68,645,516 		JBrowse link
G PHOX2B paired like homeobox 2B ISO RGD PMID:19036978 RGD:152025257 NCBI chr 8:32,841,425...32,846,133
Ensembl chr 8:32,842,145...32,846,127 		JBrowse link
G PRKCZ protein kinase C zeta ISO RGD PMID:15381257 RGD:1642699 NCBI chr 6:64,073,343...64,159,187
Ensembl chr 6:64,068,577...64,163,472 		JBrowse link
G SCN1B sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:44,597,461...44,607,488
Ensembl chr 6:44,597,482...44,607,481 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:50,508,194...50,532,432
Ensembl chr 9:50,508,880...50,583,712 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:23,336,143...23,424,755
Ensembl chr13:23,336,153...23,424,755 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 involved_in ISO PMID:14642278 UniProt PMID:14642278 RGD:8553687 NCBI chr12:46,285,995...46,328,377
Ensembl chr12:46,285,997...46,314,378 		JBrowse link
membrane depolarization during action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1B calcium voltage-gated channel subunit alpha1 B involved_in IBA GO_Central GO_REF:0000033
G CACNA1F calcium voltage-gated channel subunit alpha1 F involved_in IBA GO_Central GO_REF:0000033 NCBI chr  X:43,250,449...43,284,458
Ensembl chr  X:43,251,370...43,283,990 		JBrowse link
G CACNA1G calcium voltage-gated channel subunit alpha1 G involved_in IBA GO_Central GO_REF:0000033 NCBI chr12:26,838,633...26,912,344
Ensembl chr12:26,844,079...26,912,110 		JBrowse link
G CACNA1I calcium voltage-gated channel subunit alpha1 I involved_in IBA GO_Central GO_REF:0000033 NCBI chr 5:8,593,014...8,702,734
Ensembl chr 5:8,595,909...8,701,367 		JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:6,242,826...6,279,154
Ensembl chr18:6,243,524...6,279,111 		JBrowse link
G SCN10A sodium voltage-gated channel alpha subunit 10 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr13:23,481,537...23,570,454
Ensembl chr13:23,481,255...23,570,379 		JBrowse link
G SCN11A sodium voltage-gated channel alpha subunit 11 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr13:23,602,378...23,692,281
Ensembl chr13:23,602,977...23,692,220 		JBrowse link
G SCN1A sodium voltage-gated channel alpha subunit 1 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr15:72,529,866...72,696,715
Ensembl chr15:72,529,875...72,678,066 		JBrowse link
G SCN1B sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:44,597,461...44,607,488
Ensembl chr 6:44,597,482...44,607,481 		JBrowse link
G SCN2A sodium voltage-gated channel alpha subunit 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr15:71,864,753...71,999,219
Ensembl chr15:71,864,784...71,999,211 		JBrowse link
G SCN2B sodium voltage-gated channel beta subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:45,484,994...45,502,578
Ensembl chr 9:45,484,998...45,498,465 		JBrowse link
G SCN3A sodium voltage-gated channel alpha subunit 3 involved_in IBA
IEA		 GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr15:71,717,330...71,824,190
Ensembl chr15:71,717,334...71,824,160 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:50,508,194...50,532,432
Ensembl chr 9:50,508,880...50,583,712 		JBrowse link
G SCN4A sodium voltage-gated channel alpha subunit 4 involved_in IBA GO_Central GO_REF:0000033 NCBI chr12:15,001,356...15,048,092
Ensembl chr12:15,002,175...15,047,582 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr13:23,336,143...23,424,755
Ensembl chr13:23,336,153...23,424,755 		JBrowse link
G SCN7A sodium voltage-gated channel alpha subunit 7 NOT|involved_in ISO PMID:9001394 UniProt PMID:9001394 RGD:61747 NCBI chr15:72,946,147...73,026,656
Ensembl chr15:72,945,288...73,026,656 		JBrowse link
G SCN8A sodium voltage-gated channel alpha subunit 8 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 5:16,977,468...17,173,831
Ensembl chr 5:16,977,700...17,169,543 		JBrowse link
G SCN9A sodium voltage-gated channel alpha subunit 9 involved_in IBA GO_Central GO_REF:0000033 NCBI chr15:72,745,706...72,912,352
Ensembl chr15:72,748,705...72,912,382 		JBrowse link
G YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:48,544,031...48,556,496
Ensembl chr14:48,544,173...48,556,490 		JBrowse link
membrane depolarization during atrial cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1C calcium voltage-gated channel subunit alpha1 C involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:69,016,954...69,448,428
Ensembl chr 5:69,275,176...69,448,430 		JBrowse link
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:44,321,954...44,887,410
Ensembl chr10:44,421,485...44,886,425 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:23,336,143...23,424,755
Ensembl chr13:23,336,153...23,424,755 		JBrowse link
membrane depolarization during AV node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1C calcium voltage-gated channel subunit alpha1 C involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:69,016,954...69,448,428
Ensembl chr 5:69,275,176...69,448,430 		JBrowse link
G CACNA1G calcium voltage-gated channel subunit alpha1 G involved_in ISO (MGI:3714901|PMID:16690884) BHF-UCL PMID:16690884 MGI:3714901 NCBI chr12:26,838,633...26,912,344
Ensembl chr12:26,844,079...26,912,110 		JBrowse link
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:44,321,954...44,887,410
Ensembl chr10:44,421,485...44,886,425 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:23,336,143...23,424,755
Ensembl chr13:23,336,153...23,424,755 		JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:54,342,774...54,377,557
Ensembl chr 6:54,342,784...54,377,155 		JBrowse link
membrane depolarization during bundle of His cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:97,781,057...98,265,925
Ensembl chr 9:97,781,090...98,266,969 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:23,336,143...23,424,755
Ensembl chr13:23,336,153...23,424,755 		JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:54,342,774...54,377,557
Ensembl chr 6:54,342,784...54,377,155 		JBrowse link
membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1C calcium voltage-gated channel subunit alpha1 C involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:69,016,954...69,448,428
Ensembl chr 5:69,275,176...69,448,430 		JBrowse link
G SCN10A sodium voltage-gated channel alpha subunit 10 involved_in IEA GOC GO_REF:0000108 NCBI chr13:23,481,537...23,570,454
Ensembl chr13:23,481,255...23,570,379 		JBrowse link
G SCN1B sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:44,597,461...44,607,488
Ensembl chr 6:44,597,482...44,607,481 		JBrowse link
G SCN2B sodium voltage-gated channel beta subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:45,484,994...45,502,578
Ensembl chr 9:45,484,998...45,498,465 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:50,508,194...50,532,432
Ensembl chr 9:50,508,880...50,583,712 		JBrowse link
G SCN4B sodium voltage-gated channel beta subunit 4 involved_in ISO (PMID:17592081) BHF-UCL PMID:17592081 NCBI chr 9:45,451,473...45,475,606 JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:23,336,143...23,424,755
Ensembl chr13:23,336,153...23,424,755 		JBrowse link
membrane depolarization during Purkinje myocyte cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SCN1B sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:44,597,461...44,607,488
Ensembl chr 6:44,597,482...44,607,481 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:23,336,143...23,424,755
Ensembl chr13:23,336,153...23,424,755 		JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:54,342,774...54,377,557
Ensembl chr 6:54,342,784...54,377,155 		JBrowse link
membrane depolarization during SA node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1D calcium voltage-gated channel subunit alpha1 D involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12700358) Ensembl
MGI		 PMID:12700358 GO_REF:0000107 NCBI chr13:35,568,534...35,911,483
Ensembl chr13:35,436,519...35,909,662 		JBrowse link
G CACNA1G calcium voltage-gated channel subunit alpha1 G involved_in ISO (MGI:3714901|PMID:16690884) BHF-UCL PMID:16690884 MGI:3714901 NCBI chr12:26,838,633...26,912,344
Ensembl chr12:26,844,079...26,912,110 		JBrowse link
G HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:60,010,396...60,052,258
Ensembl chr 7:60,010,283...60,050,689 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:23,336,143...23,424,755
Ensembl chr13:23,336,153...23,424,755 		JBrowse link
mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP5IF1 ATP synthase inhibitory factor subunit 1 involved_in ISO (PMID:24005319) ParkinsonsUK-UCL PMID:24005319 NCBI chr 6:85,307,242...85,309,211
Ensembl chr 6:85,307,189...85,309,215 		JBrowse link
G CASP1 caspase 1, apoptosis-related cysteine peptidase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23028046) Ensembl
MGI		 PMID:23028046 GO_REF:0000107 NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328 		JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A involved_in ISO (PMID:25217637) ParkinsonsUK-UCL PMID:25217637 NCBI chr 1:200,774,496...200,799,149
Ensembl chr 1:200,792,469...200,798,854 		JBrowse link
G KCNQ2 potassium voltage-gated channel subfamily Q member 2 acts_upstream_of_or_within ISO (PMID:20885443) MGI PMID:20885443 NCBI chr17:62,459,277...62,506,403
Ensembl chr17:62,459,281...62,506,424 		JBrowse link
G KCNQ3 potassium voltage-gated channel subfamily Q member 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20885443) Ensembl
MGI		 PMID:20885443 GO_REF:0000107 NCBI chr 4:8,669,969...8,978,656
Ensembl chr 4:8,669,121...8,970,342 		JBrowse link
G LOC100623720 collagen alpha-1(VI) chain acts_upstream_of_or_within ISO (PMID:19519726), (PMID:24852368)
(PMID:19293339)		 MGI PMID:19293339 PMID:19519726 PMID:24852368 NCBI chr13:208,295,245...208,321,789
Ensembl chr13:208,295,451...208,313,127 		JBrowse link
G P2RX7 purinergic receptor P2X 7 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:16198349) Ensembl
MGI		 PMID:16198349 GO_REF:0000107 NCBI chr14:31,415,188...31,476,502
Ensembl chr14:31,415,193...31,476,472 		JBrowse link
G PPIF peptidylprolyl isomerase F involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19293339) Ensembl
MGI		 PMID:19293339 GO_REF:0000107 NCBI chr14:81,674,671...81,681,977
Ensembl chr14:81,667,672...81,689,495 		JBrowse link
negative regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV3 caveolin 3 involved_in ISO (MGI:5613732|PMID:25257915) BHF-UCL PMID:25257915 MGI:5613732 NCBI chr13:65,117,868...65,130,886
Ensembl chr13:65,117,795...65,131,273 		JBrowse link
negative regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALB albumin involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,721,696 		JBrowse link
G BOK BCL2 family apoptosis regulator BOK involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:140,171,134...140,184,126
Ensembl chr15:140,171,143...140,184,121 		JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 ISO RGD PMID:29215467 RGD:13504824 NCBI chr14:110,608,422...110,635,825
Ensembl chr14:110,608,430...110,635,874 		JBrowse link
G HSH2D hematopoietic SH2 domain containing acts_upstream_of_or_within ISO (PMID:15569688) MGI PMID:15569688 NCBI chr 2:61,418,042...61,430,795
Ensembl chr 2:61,418,055...61,427,144 		JBrowse link
G IFI6 interferon alpha inducible protein 6 involved_in IEA
IBA
ISS		 Ensembl
GO_Central
HGNC-UCL		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 6:84,852,782...84,858,072
Ensembl chr 6:84,852,793...84,857,982 		JBrowse link
G NGFR nerve growth factor receptor ISO RGD PMID:19457114 RGD:5508731 NCBI chr12:25,699,410...25,720,355
Ensembl chr12:25,699,427...25,720,356 		JBrowse link
G RBFOX2 RNA binding fox-1 homolog 2 ISO RGD PMID:34731606 RGD:329845875 NCBI chr 5:11,633,523...11,905,325
Ensembl chr 5:11,633,541...11,903,094 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:40,470,970...40,524,862
Ensembl chr17:40,471,009...40,524,860 		JBrowse link
positive regulation of membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1C calcium voltage-gated channel subunit alpha1 C ISO RGD PMID:18562674 RGD:152177517 NCBI chr 5:69,016,954...69,448,428
Ensembl chr 5:69,275,176...69,448,430 		JBrowse link
G CACNA1D calcium voltage-gated channel subunit alpha1 D ISO RGD PMID:7760845 RGD:70680 NCBI chr13:35,568,534...35,911,483
Ensembl chr13:35,436,519...35,909,662 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 ISO RGD PMID:16641242 RGD:401959318 NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,705,496...110,771,728 		JBrowse link
positive regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK3 ankyrin 3 involved_in ISO PMID:18180363 BHF-UCL PMID:18180363 RGD:6767295 NCBI chr14:63,416,154...63,809,220 JBrowse link
positive regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCY10 adenylate cyclase 10 ISO RGD PMID:31172217 RGD:329403053 NCBI chr 4:83,103,768...83,205,015
Ensembl chr 4:83,098,290...83,205,454 		JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type ISO RGD PMID:15564577 RGD:2313870 NCBI chr12:52,401,861...52,414,913
Ensembl chr12:52,401,810...52,414,903 		JBrowse link
G CCK cholecystokinin ISO apoptotic RGD PMID:11964411 RGD:625521 NCBI chr13:25,940,674...25,945,879
Ensembl chr13:25,937,645...25,945,793 		JBrowse link
G DCN decorin acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23798385) MGI
Ensembl		 PMID:23798385 GO_REF:0000107 NCBI chr 5:91,678,601...91,713,925
Ensembl chr 5:91,682,658...91,714,235 		JBrowse link
G KDR kinase insert domain receptor acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23798385) MGI
Ensembl		 PMID:23798385 GO_REF:0000107 NCBI chr 8:41,809,116...41,856,379
Ensembl chr 8:41,809,122...41,856,336 		JBrowse link
G MLLT11 MLLT11 transcription factor 7 cofactor involved_in ISS
IBA
IEA		 UniProt
GO_Central
Ensembl		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 4:98,165,990...98,171,674
Ensembl chr 4:98,164,676...98,171,674 		JBrowse link
G MYOC myocilin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:114,087,370...114,098,765
Ensembl chr 9:114,087,378...114,098,745 		JBrowse link
G OGA O-GlcNAcase ISO RGD PMID:19139380 RGD:2305938 NCBI chr14:112,822,494...112,851,215
Ensembl chr14:112,822,499...112,851,203 		JBrowse link
G P2RX7 purinergic receptor P2X 7 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16198349) Ensembl
MGI		 PMID:16198349 GO_REF:0000107 NCBI chr14:31,415,188...31,476,502
Ensembl chr14:31,415,193...31,476,472 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 ISO protein:increased activity:brain: RGD PMID:21616968 RGD:10413888 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,160...14,241,196 		JBrowse link
G RACK1 receptor for activated C kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:57,280,192...57,284,846
Ensembl chr 2:57,279,857...57,284,849 		JBrowse link
G TSPO translocator protein ISO RGD PMID:15183124 RGD:2317155 NCBI chr 5:5,723,190...5,735,097
Ensembl chr 5:5,723,190...5,735,131 		JBrowse link
positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRPM4 transient receptor potential cation channel subfamily M member 4 ISO RGD PMID:20826763 RGD:10003037 NCBI chr 6:54,342,774...54,377,557
Ensembl chr 6:54,342,784...54,377,155 		JBrowse link
regulation of atrial cardiac muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1G calcium voltage-gated channel subunit alpha1 G involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16690884) Ensembl
MGI		 PMID:16690884 GO_REF:0000107 NCBI chr12:26,838,633...26,912,344
Ensembl chr12:26,844,079...26,912,110 		JBrowse link
G GJA1 gap junction protein alpha 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10969038) Ensembl
MGI		 PMID:10969038 GO_REF:0000107 NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,528...41,002,156 		JBrowse link
G GJA5 gap junction protein alpha 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10515563), (PMID:10969038), (PMID:9501070) Ensembl
MGI		 PMID:9501070 PMID:10515563 PMID:10969038 GO_REF:0000107 NCBI chr 4:99,854,129...99,871,288
Ensembl chr 4:99,854,392...99,871,286 		JBrowse link
G SCN10A sodium voltage-gated channel alpha subunit 10 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:20062061) Ensembl
MGI
GO_Central		 PMID:20062061 GO_REF:0000033 GO_REF:0000107 NCBI chr13:23,481,537...23,570,454
Ensembl chr13:23,481,255...23,570,379 		JBrowse link
G SCN1B sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:44,597,461...44,607,488
Ensembl chr 6:44,597,482...44,607,481 		JBrowse link
G SCN2B sodium voltage-gated channel beta subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:45,484,994...45,502,578
Ensembl chr 9:45,484,998...45,498,465 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:50,508,194...50,532,432
Ensembl chr 9:50,508,880...50,583,712 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr13:23,336,143...23,424,755
Ensembl chr13:23,336,153...23,424,755 		JBrowse link
G TBX5 T-box transcription factor 5 involved_in
acts_upstream_of_positive_effect		 IEA
ISO		 (MGI:5449667|PMID:22728936) Ensembl
BHF-UCL		 PMID:22728936 GO_REF:0000107 MGI:5449667 NCBI chr14:37,772,205...37,826,015
Ensembl chr14:37,774,171...37,825,401 		JBrowse link
regulation of membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2M beta-2-microglobulin involved_in ISO (PMID:23144825) UniProt PMID:23144825 NCBI chr 1:126,837,721...126,844,043
Ensembl chr 1:126,835,143...126,981,582 		JBrowse link
G CAMK2D calcium/calmodulin dependent protein kinase II delta involved_in ISO (PMID:22514276) BHF-UCL PMID:22514276 NCBI chr 8:108,916,019...109,221,317
Ensembl chr 8:108,915,572...109,222,905 		JBrowse link
G CFTR CF transmembrane conductance regulator NOT|involved_in ISO (MGI:5640937|PMID:24885604) UniProt PMID:24885604 MGI:5640937 NCBI chr18:28,627,717...28,818,209
Ensembl chr18:28,627,728...28,817,950 		JBrowse link
G FGF12 fibroblast growth factor 12 involved_in ISO PMID:12401812 BHF-UCL PMID:12401812 RGD:6484231 NCBI chr13:129,237,500...129,817,992
Ensembl chr13:129,240,083...129,817,911 		JBrowse link
G FHL1 four and a half LIM domains 1 involved_in ISO (PMID:18281375) BHF-UCL PMID:18281375 NCBI chr  X:111,309,989...111,367,900
Ensembl chr  X:111,356,011...111,367,903 		JBrowse link
G HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 involved_in ISO
IBA		 RGD
GO_Central		 PMID:20806410 GO_REF:0000033 RGD:9686372 NCBI chr16:29,439,294...29,808,855
Ensembl chr16:29,439,264...29,808,993 		JBrowse link
G HCN2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 2:77,708,159...77,730,881
Ensembl chr 2:77,708,162...77,730,881 		JBrowse link
G HCN3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 4:94,545,919...94,560,105
Ensembl chr 4:94,547,416...94,560,106 		JBrowse link
G HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 7:60,010,396...60,052,258
Ensembl chr 7:60,010,283...60,050,689 		JBrowse link
G NEDD4L NEDD4 like E3 ubiquitin protein ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:162,364,053...162,736,515
Ensembl chr 1:162,364,057...162,513,718 		JBrowse link
G NPFF neuropeptide FF-amide peptide precursor ISO RGD PMID:17289819 RGD:2316567 NCBI chr 5:18,724,078...18,724,844
Ensembl chr 5:18,723,784...18,724,826 		JBrowse link
G NTSR1 neurotensin receptor 1 ISO RGD PMID:15120846 RGD:9743930 NCBI chr17:61,989,601...62,038,299
Ensembl chr17:61,989,402...62,033,548 		JBrowse link
G RANGRF RAN guanine nucleotide release factor involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr12:53,484,584...53,486,716
Ensembl chr12:53,485,265...53,486,713 		JBrowse link
regulation of membrane depolarization during action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLCN2 chloride voltage-gated channel 2 involved_in ISO PMID:8816717 UniProt PMID:8816717 RGD:405650388 NCBI chr13:122,234,731...122,249,889
Ensembl chr13:122,234,736...122,249,867 		JBrowse link
G PTPN3 protein tyrosine phosphatase non-receptor type 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:250,418,131...250,583,148
Ensembl chr 1:250,418,133...250,540,480 		JBrowse link
regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV3 caveolin 3 involved_in ISO (PMID:17275750) BHF-UCL PMID:17275750 NCBI chr13:65,117,868...65,130,886
Ensembl chr13:65,117,795...65,131,273 		JBrowse link
G GJA5 gap junction protein alpha 5 acts_upstream_of_or_within ISO (PMID:9501070) MGI PMID:9501070 NCBI chr 4:99,854,129...99,871,288
Ensembl chr 4:99,854,392...99,871,286 		JBrowse link
G RANGRF RAN guanine nucleotide release factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:53,484,584...53,486,716
Ensembl chr12:53,485,265...53,486,713 		JBrowse link
G SLMAP sarcolemma associated protein involved_in IBA GO_Central GO_REF:0000033 NCBI chr13:39,571,930...39,720,229
Ensembl chr13:39,571,981...39,719,923 		JBrowse link
regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCD1 ATP binding cassette subfamily D member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:124,485,076...124,501,742
Ensembl chr  X:124,485,076...124,501,741 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit acts_upstream_of_or_within ISO (PMID:15288121) MGI PMID:15288121 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,565...27,253,530 		JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15288121) Ensembl
MGI		 PMID:15288121 GO_REF:0000107 NCBI chr 4:123,371,198...123,390,130
Ensembl chr 4:123,371,193...123,390,131 		JBrowse link
G LRRK2 leucine rich repeat kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:71,800,337...71,945,828
Ensembl chr 5:71,800,225...71,945,828 		JBrowse link
G PPP2R3C protein phosphatase 2 regulatory subunit B''gamma involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16129705) Ensembl
MGI		 PMID:16129705 GO_REF:0000107 NCBI chr 7:64,762,863...64,789,919
Ensembl chr 7:64,763,050...64,789,921 		JBrowse link
regulation of ventricular cardiac muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV3 caveolin 3 involved_in ISO (PMID:17060380) BHF-UCL PMID:17060380 NCBI chr13:65,117,868...65,130,886
Ensembl chr13:65,117,795...65,131,273 		JBrowse link
G GJA1 gap junction protein alpha 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10969038)
(PMID:10969038), (PMID:9109444)		 Ensembl
MGI		 PMID:9109444 PMID:10969038 GO_REF:0000107 NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,528...41,002,156 		JBrowse link
G GJA5 gap junction protein alpha 5 acts_upstream_of
acts_upstream_of_or_within		 ISO (MGI:6101691|PMID:26786475)
(PMID:10969038)
(PMID:10515563), (PMID:9501070)		 BHF-UCL
MGI		 PMID:9501070 PMID:10515563 PMID:10969038 PMID:26786475 MGI:6101691 NCBI chr 4:99,854,129...99,871,288
Ensembl chr 4:99,854,392...99,871,286 		JBrowse link
G GPD1L glycerol-3-phosphate dehydrogenase 1 like involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:18,126,471...18,176,669
Ensembl chr13:18,127,088...18,176,666 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:50,508,194...50,532,432
Ensembl chr 9:50,508,880...50,583,712 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr13:23,336,143...23,424,755
Ensembl chr13:23,336,153...23,424,755 		JBrowse link
G SMAD7 SMAD family member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:98,512,800...98,543,924
Ensembl chr 1:98,514,267...98,542,382 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17634
    biological regulation 12790
      regulation of biological quality 3195
        regulation of membrane potential 533
          membrane depolarization 111
            membrane depolarization during action potential + 33
            mitochondrial depolarization + 32
            negative regulation of membrane depolarization + 9
            positive regulation of membrane depolarization + 17
            regulation of membrane depolarization + 58
            regulation of vascular associated smooth muscle cell membrane depolarization + 1
paths to the root