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ONTOLOGY REPORT - ANNOTATIONS

Term:membrane depolarization
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Accession:GO:0051899 term browser browse the term
Definition:The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential.

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membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor ISO RGD PMID:16644907 RGD:1625443 NCBI chrNW_004624747:9,846,254...9,860,938
Ensembl chrNW_004624747:9,851,153...9,860,094 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 acts_upstream_of_or_within ISO (PMID:30819023) MGI PMID:30819023 NCBI chrNW_004624907:715,109...736,040
Ensembl chrNW_004624907:715,094...736,432 		JBrowse link
G Best2 bestrophin 2 involved_in ISO (MGI:3763293|PMID:16912113) HGNC-UCL PMID:16912113 MGI:3763293 NCBI chrNW_004624901:372,181...377,411
Ensembl chrNW_004624901:372,205...376,958 		JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO (PMID:10908603)
(PMID:8158221)
(PMID:11718712)		 MGI PMID:8158221 PMID:10908603 PMID:11718712 NCBI chrNW_004624901:707,322...932,658
Ensembl chrNW_004624901:708,234...932,643 		JBrowse link
G Cacng2 calcium voltage-gated channel auxiliary subunit gamma 2 acts_upstream_of_or_within ISO (PMID:9065835) MGI PMID:9065835 NCBI chrNW_004624752:11,062,059...11,172,357
Ensembl chrNW_004624752:11,062,002...11,170,406 		JBrowse link
G Cav1 caveolin 1 acts_upstream_of_or_within ISO (PMID:17098833) MGI PMID:17098833 NCBI chrNW_004624827:2,844,855...2,878,367
Ensembl chrNW_004624827:2,844,115...2,879,179 		JBrowse link
G Chrna10 cholinergic receptor nicotinic alpha 10 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624817:5,109,448...5,125,469
Ensembl chrNW_004624817:5,109,452...5,116,528 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit acts_upstream_of_or_within ISO (PMID:11222635), (PMID:12944511)
(PMID:15741168)
(PMID:11226318)		 MGI PMID:11222635 PMID:11226318 PMID:12944511 PMID:15741168 NCBI chrNW_004624741:29,024,668...29,039,684
Ensembl chrNW_004624741:29,026,908...29,044,464 		JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit acts_upstream_of_or_within ISO (PMID:12944511) MGI PMID:12944511 NCBI chrNW_004624780:462,195...477,568 JBrowse link
G Chrna9 cholinergic receptor nicotinic alpha 9 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624761:26,636,242...26,646,072
Ensembl chrNW_004624761:26,636,506...26,645,471 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit acts_upstream_of_or_within ISO (PMID:11222635) MGI PMID:11222635 NCBI chrNW_004624885:2,839,607...2,851,934
Ensembl chrNW_004624885:2,843,899...2,848,522 		JBrowse link
G Cnga1 cyclic nucleotide gated channel subunit alpha 1 ISO RGD PMID:18048449 RGD:6902904 NCBI chrNW_004624761:18,992,372...19,004,247
Ensembl chrNW_004624761:18,992,384...19,004,202 		JBrowse link
G Cnga2 cyclic nucleotide gated channel subunit alpha 2 involved_in ISO PMID:1697649 RGD
UniProt		 PMID:1697649 PMID:18048449 RGD:1298763 RGD:6902904 NCBI chrNW_004624883:3,043,661...3,051,420
Ensembl chrNW_004624883:3,043,666...3,049,801 		JBrowse link
G Cnga3 cyclic nucleotide gated channel subunit alpha 3 involved_in ISO PMID:15178415 UniProt PMID:15178415 RGD:405650286 NCBI chrNW_004624749:3,458,997...3,482,697
Ensembl chrNW_004624749:3,458,991...3,483,003 		JBrowse link
G Cngb1 cyclic nucleotide gated channel subunit beta 1 involved_in ISO (MGI:5817509|PMID:28053034) ARUK-UCL PMID:28053034 MGI:5817509 NCBI chrNW_004624746:28,198,324...28,268,280 JBrowse link
G Edn1 endothelin 1 ISO RGD PMID:15655307 RGD:1580292 NCBI chrNW_004624756:13,842,482...13,849,003
Ensembl chrNW_004624756:13,842,164...13,849,029 		JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 acts_upstream_of_or_within ISO (PMID:17245443) MGI PMID:17245443 NCBI chrNW_004624745:17,592,587...17,986,863
Ensembl chrNW_004624745:17,592,874...17,986,759 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO induced in pulmonary artery smooth muscle cells RGD PMID:11571252 RGD:2290591 NCBI chrNW_004624862:1,537,886...1,540,633
Ensembl chrNW_004624862:1,538,455...1,539,426 		JBrowse link
G Kmt2a lysine methyltransferase 2A ISO RGD PMID:20211609 RGD:9588219 NCBI chrNW_004624784:13,824,507...13,912,672
Ensembl chrNW_004624784:13,824,541...13,908,077 		JBrowse link
G P2rx4 purinergic receptor P2X 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624747:21,783,445...21,796,501
Ensembl chrNW_004624747:21,783,381...21,796,260 		JBrowse link
G P2rx7 purinergic receptor P2X 7 involved_in ISO (PMID:9038151)
PMID:8614837		 BHF-UCL PMID:8614837 PMID:9038151 RGD:69918 NCBI chrNW_004624747:21,725,813...21,768,123
Ensembl chrNW_004624747:21,725,395...21,759,453 		JBrowse link
G Park7 Parkinsonism associated deglycase acts_upstream_of_or_within ISO (PMID:16624565) MGI PMID:16624565 NCBI chrNW_004624818:3,900,917...3,915,457
Ensembl chrNW_004624818:3,900,917...3,911,042 		JBrowse link
G Phox2b paired like homeobox 2B ISO RGD PMID:19036978 RGD:152025257 NCBI chrNW_004624761:25,234,048...25,238,725
Ensembl chrNW_004624761:25,234,372...25,237,102 		JBrowse link
G Prkcz protein kinase C zeta ISO RGD PMID:15381257 RGD:1642699 NCBI chrNW_004624818:7,758,192...7,846,950
Ensembl chrNW_004624818:7,759,770...7,847,208 		JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624794:8,439,609...8,449,731
Ensembl chrNW_004624794:8,439,600...8,450,179 		JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624880:1,496,571...1,519,728
Ensembl chrNW_004624880:1,496,634...1,516,684 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO (PMID:14500339), (PMID:21051419), (PMID:21895525) BHF-UCL PMID:14500339 PMID:21051419 PMID:21895525 NCBI chrNW_004624731:2,401,358...2,498,212
Ensembl chrNW_004624731:2,401,380...2,498,211 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 involved_in ISO PMID:14642278 UniProt PMID:14642278 RGD:8553687 NCBI chrNW_004624786:2,673,285...2,711,432
Ensembl chrNW_004624786:2,672,552...2,710,914 		JBrowse link
membrane depolarization during action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1g calcium voltage-gated channel subunit alpha1 G involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624795:6,443,322...6,501,673
Ensembl chrNW_004624795:6,443,781...6,501,050 		JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624913:1,926,405...1,952,426
Ensembl chrNW_004624913:1,891,156...1,949,633 		JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624752:8,702,320...8,795,192
Ensembl chrNW_004624752:8,705,149...8,785,272 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 involved_in ISO (PMID:7604285) BHF-UCL PMID:7604285 NCBI chrNW_004624800:5,633,060...5,663,700
Ensembl chrNW_004624800:5,632,726...5,663,771 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624731:2,254,445...2,356,174
Ensembl chrNW_004624731:2,254,445...2,355,738 		JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 involved_in ISO (PMID:24036948), (PMID:24776970)
(MGI:5553040|PMID:24036948)
PMID:10196578
(PMID:12384689)		 UniProt PMID:10196578 PMID:12384689 PMID:24036948 PMID:24776970 MGI:5553040 RGD:69980 NCBI chrNW_004624731:2,065,228...2,203,215 JBrowse link
G Scn1a sodium voltage-gated channel alpha subunit 1 involved_in ISO (PMID:14672992)
(MGI:5796061|PMID:27281198)		 UniProt PMID:14672992 PMID:27281198 MGI:5796061 NCBI chrNW_004624787:3,767,405...3,939,065
Ensembl chrNW_004624787:3,768,120...3,908,889 		JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624794:8,439,609...8,449,731
Ensembl chrNW_004624794:8,439,600...8,450,179 		JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 involved_in ISO (PMID:35277491) UniProt PMID:35277491 NCBI chrNW_004624784:13,580,427...13,593,055
Ensembl chrNW_004624784:13,580,313...13,593,169 		JBrowse link
G Scn3a sodium voltage-gated channel alpha subunit 3 involved_in ISO (PMID:35277491) UniProt PMID:35277491 NCBI chrNW_004624732:222,657...330,959
Ensembl chrNW_004624732:251,860...328,917 		JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624880:1,496,571...1,519,728
Ensembl chrNW_004624880:1,496,634...1,516,684 		JBrowse link
G Scn4a sodium voltage-gated channel alpha subunit 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624849:1,436,372...1,483,531
Ensembl chrNW_004624849:1,436,047...1,483,531 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624731:2,401,358...2,498,212
Ensembl chrNW_004624731:2,401,380...2,498,211 		JBrowse link
G Scn7a sodium voltage-gated channel alpha subunit 7 NOT|involved_in ISO PMID:9001394 UniProt PMID:9001394 RGD:61747 NCBI chrNW_004624787:4,198,048...4,284,985
Ensembl chrNW_004624787:4,197,782...4,284,991 		JBrowse link
G Scn8a sodium voltage-gated channel alpha subunit 8 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624816:498,737...631,850
Ensembl chrNW_004624816:499,179...631,936 		JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624787:3,995,319...4,148,230
Ensembl chrNW_004624787:3,997,887...4,085,449 		JBrowse link
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta involved_in ISO (PMID:16728661) BHF-UCL PMID:16728661 NCBI chrNW_004624747:8,350,552...8,362,610
Ensembl chrNW_004624747:8,350,474...8,363,576 		JBrowse link
membrane depolarization during atrial cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C involved_in ISO (PMID:17224476) BHF-UCL PMID:17224476 NCBI chrNW_004624735:10,201,030...10,927,349
Ensembl chrNW_004624735:10,201,526...10,432,896 		JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in ISO (PMID:17224476) BHF-UCL PMID:17224476 NCBI chrNW_004624796:9,502,132...9,858,836
Ensembl chrNW_004624796:9,503,452...9,859,019 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO (PMID:18065446) BHF-UCL PMID:18065446 NCBI chrNW_004624731:2,401,358...2,498,212
Ensembl chrNW_004624731:2,401,380...2,498,211 		JBrowse link
membrane depolarization during AV node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C involved_in ISO (PMID:26253506) BHF-UCL PMID:26253506 NCBI chrNW_004624735:10,201,030...10,927,349
Ensembl chrNW_004624735:10,201,526...10,432,896 		JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G involved_in ISO (MGI:3714901|PMID:16690884) BHF-UCL PMID:16690884 MGI:3714901 NCBI chrNW_004624795:6,443,322...6,501,673
Ensembl chrNW_004624795:6,443,781...6,501,050 		JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in ISO (PMID:17224476) BHF-UCL PMID:17224476 NCBI chrNW_004624796:9,502,132...9,858,836
Ensembl chrNW_004624796:9,503,452...9,859,019 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO (PMID:18616619) BHF-UCL PMID:18616619 NCBI chrNW_004624731:2,401,358...2,498,212
Ensembl chrNW_004624731:2,401,380...2,498,211 		JBrowse link
G Trpm4 transient receptor potential cation channel subfamily M member 4 involved_in ISO (PMID:27207958) BHF-UCL PMID:27207958 NCBI chrNW_004624832:4,902,335...4,937,806
Ensembl chrNW_004624832:4,902,659...4,936,926 		JBrowse link
membrane depolarization during bundle of His cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 involved_in ISO (PMID:21383000) BHF-UCL PMID:21383000 NCBI chrNW_004624739:30,436,662...30,864,482
Ensembl chrNW_004624739:30,436,568...30,864,468 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO (PMID:18065446) BHF-UCL PMID:18065446 NCBI chrNW_004624731:2,401,358...2,498,212
Ensembl chrNW_004624731:2,401,380...2,498,211 		JBrowse link
G Trpm4 transient receptor potential cation channel subfamily M member 4 involved_in ISO (PMID:27207958) BHF-UCL PMID:27207958 NCBI chrNW_004624832:4,902,335...4,937,806
Ensembl chrNW_004624832:4,902,659...4,936,926 		JBrowse link
membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C involved_in ISO (PMID:15454078) BHF-UCL PMID:15454078 NCBI chrNW_004624735:10,201,030...10,927,349
Ensembl chrNW_004624735:10,201,526...10,432,896 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 involved_in IEA GOC GO_REF:0000108 NCBI chrNW_004624731:2,254,445...2,356,174
Ensembl chrNW_004624731:2,254,445...2,355,738 		JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624794:8,439,609...8,449,731
Ensembl chrNW_004624794:8,439,600...8,450,179 		JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624784:13,580,427...13,593,055
Ensembl chrNW_004624784:13,580,313...13,593,169 		JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624880:1,496,571...1,519,728
Ensembl chrNW_004624880:1,496,634...1,516,684 		JBrowse link
G Scn4b sodium voltage-gated channel beta subunit 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624784:13,550,950...13,569,937
Ensembl chrNW_004624784:13,549,815...13,570,026 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in IEA GOC GO_REF:0000108 NCBI chrNW_004624731:2,401,358...2,498,212
Ensembl chrNW_004624731:2,401,380...2,498,211 		JBrowse link
membrane depolarization during Purkinje myocyte cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn1b sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624794:8,439,609...8,449,731
Ensembl chrNW_004624794:8,439,600...8,450,179 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO (PMID:22766342) BHF-UCL PMID:22766342 NCBI chrNW_004624731:2,401,358...2,498,212
Ensembl chrNW_004624731:2,401,380...2,498,211 		JBrowse link
G Trpm4 transient receptor potential cation channel subfamily M member 4 involved_in ISO (PMID:27207958) BHF-UCL PMID:27207958 NCBI chrNW_004624832:4,902,335...4,937,806
Ensembl chrNW_004624832:4,902,659...4,936,926 		JBrowse link
membrane depolarization during SA node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1d calcium voltage-gated channel subunit alpha1 D involved_in
acts_upstream_of_or_within		 ISO (PMID:21131953)
(PMID:12700358)		 BHF-UCL
MGI		 PMID:12700358 PMID:21131953 NCBI chrNW_004624822:3,391,045...3,734,258
Ensembl chrNW_004624822:3,392,044...3,919,415 		JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G involved_in ISO (MGI:3714901|PMID:16690884) BHF-UCL PMID:16690884 MGI:3714901 NCBI chrNW_004624795:6,443,322...6,501,673
Ensembl chrNW_004624795:6,443,781...6,501,050 		JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 involved_in ISO (PMID:16407510) BHF-UCL PMID:16407510 NCBI chrNW_004624781:968,608...1,007,969
Ensembl chrNW_004624781:968,748...1,008,200 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO (PMID:18616619) BHF-UCL PMID:18616619 NCBI chrNW_004624731:2,401,358...2,498,212
Ensembl chrNW_004624731:2,401,380...2,498,211 		JBrowse link
mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp5if1 ATP synthase inhibitory factor subunit 1 involved_in ISO (PMID:24005319) ParkinsonsUK-UCL PMID:24005319 NCBI chrNW_004624764:12,068,518...12,070,542
Ensembl chrNW_004624764:12,068,638...12,072,190 		JBrowse link
G Col6a1 collagen type VI alpha 1 chain acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:19293339)
(PMID:19519726), (PMID:24852368)		 MGI
Ensembl		 PMID:19293339 PMID:19519726 PMID:24852368 GO_REF:0000107 NCBI chrNW_004624745:31,125,136...31,140,126
Ensembl chrNW_004624745:31,125,265...31,139,318 		JBrowse link
G Kcnq2 potassium voltage-gated channel subfamily Q member 2 acts_upstream_of_or_within ISO (PMID:20885443) MGI PMID:20885443 NCBI chrNW_004624741:29,089,894...29,143,681
Ensembl chrNW_004624741:29,091,119...29,143,589 		JBrowse link
G Kcnq3 potassium voltage-gated channel subfamily Q member 3 acts_upstream_of_or_within ISO (PMID:20885443) MGI PMID:20885443 NCBI chrNW_004624735:23,441,042...23,752,197
Ensembl chrNW_004624735:23,441,042...23,751,247 		JBrowse link
G P2rx7 purinergic receptor P2X 7 acts_upstream_of ISO (PMID:16198349) MGI PMID:16198349 NCBI chrNW_004624747:21,725,813...21,768,123
Ensembl chrNW_004624747:21,725,395...21,759,453 		JBrowse link
G Ppif peptidylprolyl isomerase F acts_upstream_of_or_within ISO (PMID:19293339) MGI PMID:19293339 NCBI chrNW_004624754:12,336,474...12,342,687
Ensembl chrNW_004624754:12,336,427...12,342,687 		JBrowse link
negative regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624731:3,348,172...3,363,772
Ensembl chrNW_004624731:3,347,984...3,364,581 		JBrowse link
negative regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin involved_in ISO (PMID:16153637) UniProt PMID:16153637 NCBI chrNW_004624735:34,105,237...34,123,479
Ensembl chrNW_004624735:34,104,537...34,123,624 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISO (MGI:5796062|PMID:27098698) UniProt PMID:27098698 MGI:5796062 NCBI chrNW_004624847:5,564,671...5,573,459
Ensembl chrNW_004624847:5,564,979...5,573,459 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 ISO RGD PMID:29215467 RGD:13504824 NCBI chrNW_004624737:11,114,818...11,153,209
Ensembl chrNW_004624737:11,115,066...11,153,211 		JBrowse link
G Hsh2d hematopoietic SH2 domain containing acts_upstream_of_or_within ISO (PMID:15569688) MGI PMID:15569688 NCBI chrNW_004624908:1,108,552...1,116,615 JBrowse link
G Ngfr nerve growth factor receptor ISO RGD PMID:19457114 RGD:5508731 NCBI chrNW_004624795:5,623,686...5,639,545
Ensembl chrNW_004624795:5,623,700...5,639,655 		JBrowse link
G Rbfox2 RNA binding fox-1 homolog 2 ISO RGD PMID:34731606 RGD:329845875 NCBI chrNW_004624752:11,766,033...12,027,804
Ensembl chrNW_004624752:11,765,679...12,022,320 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO (PMID:19767770) UniProt PMID:19767770 NCBI chrNW_004624842:2,212,561...2,260,514
Ensembl chrNW_004624842:2,211,020...2,230,132 		JBrowse link
positive regulation of membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO RGD PMID:18562674 RGD:152177517 NCBI chrNW_004624735:10,201,030...10,927,349
Ensembl chrNW_004624735:10,201,526...10,432,896 		JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D ISO RGD PMID:7760845 RGD:70680 NCBI chrNW_004624822:3,391,045...3,734,258
Ensembl chrNW_004624822:3,392,044...3,919,415 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 ISO RGD PMID:16641242 RGD:401959318 NCBI chrNW_004624765:8,374,160...8,436,969 JBrowse link
positive regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ank3 ankyrin 3 involved_in ISO PMID:18180363 BHF-UCL PMID:18180363 RGD:6767295 NCBI chrNW_004624791:3,299,287...3,633,631 JBrowse link
positive regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy10 adenylate cyclase 10 ISO RGD PMID:31172217 RGD:329403053 NCBI chrNW_004624826:5,844,868...5,897,541
Ensembl chrNW_004624826:5,845,001...5,897,497 		JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type ISO RGD PMID:15564577 RGD:2313870 NCBI chrNW_004624786:9,542,966...9,555,235
Ensembl chrNW_004624786:9,542,970...9,555,214 		JBrowse link
G Cck cholecystokinin ISO apoptotic RGD PMID:11964411 RGD:625521 NCBI chrNW_004624730:77,310,080...77,314,258
Ensembl chrNW_004624730:77,309,633...77,314,384 		JBrowse link
G Dcn decorin acts_upstream_of_or_within ISO (PMID:23798385) MGI PMID:23798385 NCBI chrNW_004624750:15,466,938...15,517,475
Ensembl chrNW_004624750:15,470,968...15,516,365 		JBrowse link
G Kdr kinase insert domain receptor acts_upstream_of_or_within ISO (PMID:23798385) MGI PMID:23798385 NCBI chrNW_004624761:14,330,224...14,380,680
Ensembl chrNW_004624761:14,330,489...14,379,051 		JBrowse link
G LOC101704728 protein AF1q involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624731:39,307,512...39,307,956 JBrowse link
G Mllt11 MLLT11 transcription factor 7 cofactor involved_in IEA
ISS		 TreeGrafter
UniProt		 GO_REF:0000024 GO_REF:0000118 NCBI chrNW_004624772:18,762,099...18,768,629 JBrowse link
G Myoc myocilin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624771:10,066,170...10,080,257
Ensembl chrNW_004624771:10,065,788...10,080,680 		JBrowse link
G Oga O-GlcNAcase ISO RGD PMID:19139380 RGD:2305938 NCBI chrNW_004624831:1,264,612...1,297,406
Ensembl chrNW_004624831:1,264,616...1,297,378 		JBrowse link
G P2rx7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO (PMID:16198349) MGI PMID:16198349 NCBI chrNW_004624747:21,725,813...21,768,123
Ensembl chrNW_004624747:21,725,395...21,759,453 		JBrowse link
G Parp1 poly(ADP-ribose) polymerase 1 ISO protein:increased activity:brain: RGD PMID:21616968 RGD:10413888 NCBI chrNW_004624807:446,662...478,571
Ensembl chrNW_004624807:446,647...479,069 		JBrowse link
G Rack1 receptor for activated C kinase 1 involved_in ISO (PMID:19767770) UniProt PMID:19767770 NCBI chrNW_004624958:181,325...185,620
Ensembl chrNW_004624958:181,273...185,620 		JBrowse link
G Tspo translocator protein ISO RGD PMID:15183124 RGD:2317155 NCBI chrNW_004624752:5,814,784...5,820,250
Ensembl chrNW_004624752:5,814,784...5,820,141 		JBrowse link
positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trpm4 transient receptor potential cation channel subfamily M member 4 ISO RGD PMID:20826763 RGD:10003037 NCBI chrNW_004624832:4,902,335...4,937,806
Ensembl chrNW_004624832:4,902,659...4,936,926 		JBrowse link
regulation of atrial cardiac muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1g calcium voltage-gated channel subunit alpha1 G acts_upstream_of_or_within ISO (PMID:16690884) MGI PMID:16690884 NCBI chrNW_004624795:6,443,322...6,501,673
Ensembl chrNW_004624795:6,443,781...6,501,050 		JBrowse link
G Gja1 gap junction protein alpha 1 acts_upstream_of_or_within ISO (PMID:10969038) MGI PMID:10969038 NCBI chrNW_004624798:9,358,996...9,364,413
Ensembl chrNW_004624798:9,359,004...9,364,313 		JBrowse link
G Gja5 gap junction protein alpha 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10515563), (PMID:10969038), (PMID:9501070) Ensembl
MGI		 PMID:9501070 PMID:10515563 PMID:10969038 GO_REF:0000107 NCBI chrNW_004624772:16,810,723...16,828,328
Ensembl chrNW_004624772:16,813,011...16,814,084 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20062061) TreeGrafter
MGI		 PMID:20062061 GO_REF:0000118 NCBI chrNW_004624731:2,254,445...2,356,174
Ensembl chrNW_004624731:2,254,445...2,355,738 		JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624794:8,439,609...8,449,731
Ensembl chrNW_004624794:8,439,600...8,450,179 		JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 involved_in ISO (PMID:19808477) BHF-UCL PMID:19808477 NCBI chrNW_004624784:13,580,427...13,593,055
Ensembl chrNW_004624784:13,580,313...13,593,169 		JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624880:1,496,571...1,519,728
Ensembl chrNW_004624880:1,496,634...1,516,684 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624731:2,401,358...2,498,212
Ensembl chrNW_004624731:2,401,380...2,498,211 		JBrowse link
G Tbx5 T-box transcription factor 5 involved_in
acts_upstream_of_positive_effect		 IEA
ISO		 (MGI:5449667|PMID:22728936) Ensembl
BHF-UCL		 PMID:22728936 GO_REF:0000107 MGI:5449667 NCBI chrNW_004624747:18,307,294...18,348,040
Ensembl chrNW_004624747:18,307,294...18,348,040 		JBrowse link
regulation of membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2m beta-2-microglobulin involved_in ISO (PMID:23144825) UniProt PMID:23144825 NCBI chrNW_004624804:11,514,728...11,521,625 JBrowse link
G Cftr CF transmembrane conductance regulator NOT|involved_in ISO (MGI:5640937|PMID:24885604) UniProt PMID:24885604 MGI:5640937 NCBI chrNW_004624827:1,704,733...1,893,579 JBrowse link
G Fgf12 fibroblast growth factor 12 involved_in ISO PMID:12401812 BHF-UCL PMID:12401812 RGD:6484231 NCBI chrNW_004624730:64,743,724...65,288,816
Ensembl chrNW_004624730:65,038,077...65,284,083 		JBrowse link
G Fhl1 four and a half LIM domains 1 involved_in ISO (PMID:18281375) BHF-UCL PMID:18281375 NCBI chrNW_004624808:10,924,606...10,984,422
Ensembl chrNW_004624808:10,924,248...10,965,164 		JBrowse link
G Hcn1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 ISO RGD PMID:20806410 RGD:9686372 NCBI chrNW_004624759:9,636,380...10,044,832
Ensembl chrNW_004624759:9,636,457...10,049,403 		JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624781:968,608...1,007,969
Ensembl chrNW_004624781:968,748...1,008,200 		JBrowse link
G Nedd4l NEDD4 like E3 ubiquitin protein ligase involved_in ISO (PMID:15217910) BHF-UCL PMID:15217910 NCBI chrNW_004624792:3,553,185...3,903,288
Ensembl chrNW_004624792:3,553,004...3,902,468 		JBrowse link
G Npff neuropeptide FF-amide peptide precursor ISO RGD PMID:17289819 RGD:2316567 NCBI chrNW_004624904:1,603,743...1,606,141
Ensembl chrNW_004624904:1,603,743...1,605,519 		JBrowse link
G Ntsr1 neurotensin receptor 1 ISO RGD PMID:15120846 RGD:9743930 NCBI chrNW_004624741:28,504,814...28,543,592
Ensembl chrNW_004624741:28,505,037...28,544,122 		JBrowse link
G Rangrf RAN guanine nucleotide release factor involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624786:10,866,724...10,868,136
Ensembl chrNW_004624786:10,866,834...10,867,983 		JBrowse link
regulation of membrane depolarization during action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcn2 chloride voltage-gated channel 2 involved_in ISO PMID:8816717 UniProt PMID:8816717 RGD:405650388 NCBI chrNW_004624730:72,228,912...72,242,636
Ensembl chrNW_004624730:72,228,189...72,244,332 		JBrowse link
G Ptpn3 protein tyrosine phosphatase non-receptor type 3 involved_in ISO (PMID:16930557) BHF-UCL PMID:16930557 NCBI chrNW_004624758:2,011,998...2,170,096
Ensembl chrNW_004624758:2,011,732...2,170,348 		JBrowse link
regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004624731:3,348,172...3,363,772
Ensembl chrNW_004624731:3,347,984...3,364,581 		JBrowse link
G Gja5 gap junction protein alpha 5 acts_upstream_of_or_within ISO (PMID:9501070) MGI PMID:9501070 NCBI chrNW_004624772:16,810,723...16,828,328
Ensembl chrNW_004624772:16,813,011...16,814,084 		JBrowse link
G Rangrf RAN guanine nucleotide release factor involved_in ISO (PMID:21621375) BHF-UCL PMID:21621375 NCBI chrNW_004624786:10,866,724...10,868,136
Ensembl chrNW_004624786:10,866,834...10,867,983 		JBrowse link
G Slmap sarcolemma associated protein involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004624821:493,902...638,553
Ensembl chrNW_004624821:493,735...639,801 		JBrowse link
regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd1 ATP binding cassette subfamily D member 1 involved_in ISO (MGI:5790173|PMID:25583114) UniProt PMID:25583114 MGI:5790173 NCBI chrNW_004624946:421,113...439,961
Ensembl chrNW_004624946:421,132...440,075 		JBrowse link
G Gclc glutamate-cysteine ligase catalytic subunit acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:15288121) MGI
Ensembl		 PMID:15288121 GO_REF:0000107 NCBI chrNW_004624850:749,046...793,654
Ensembl chrNW_004624850:749,050...793,959 		JBrowse link
G Gclm glutamate-cysteine ligase modifier subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15288121) Ensembl
MGI		 PMID:15288121 GO_REF:0000107 NCBI chrNW_004624742:3,713,275...3,746,219
Ensembl chrNW_004624742:3,713,250...3,743,290 		JBrowse link
G Lrrk2 leucine rich repeat kinase 2 involved_in ISO (PMID:22736029) ParkinsonsUK-UCL PMID:22736029 NCBI chrNW_004624778:106,594...279,325
Ensembl chrNW_004624778:108,761...279,230 		JBrowse link
G Ppp2r3c protein phosphatase 2 regulatory subunit B''gamma acts_upstream_of_or_within ISO (PMID:16129705) MGI PMID:16129705 NCBI chrNW_004624838:1,627,632...1,655,079
Ensembl chrNW_004624838:1,627,873...1,657,475 		JBrowse link
regulation of ventricular cardiac muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624731:3,348,172...3,363,772
Ensembl chrNW_004624731:3,347,984...3,364,581 		JBrowse link
G Gja1 gap junction protein alpha 1 acts_upstream_of_or_within ISO (PMID:10969038)
(PMID:10969038), (PMID:9109444)		 MGI PMID:9109444 PMID:10969038 NCBI chrNW_004624798:9,358,996...9,364,413
Ensembl chrNW_004624798:9,359,004...9,364,313 		JBrowse link
G Gja5 gap junction protein alpha 5 acts_upstream_of
acts_upstream_of_or_within		 ISO (MGI:6101691|PMID:26786475)
(PMID:10969038)
(PMID:10515563), (PMID:9501070)		 BHF-UCL
MGI		 PMID:9501070 PMID:10515563 PMID:10969038 PMID:26786475 MGI:6101691 NCBI chrNW_004624772:16,810,723...16,828,328
Ensembl chrNW_004624772:16,813,011...16,814,084 		JBrowse link
G Gpd1l glycerol-3-phosphate dehydrogenase 1 like involved_in ISO (PMID:17967977), (PMID:19666841) BHF-UCL PMID:17967977 PMID:19666841 NCBI chrNW_004624788:10,173,629...10,240,200
Ensembl chrNW_004624788:10,173,551...10,240,704 		JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004624880:1,496,571...1,519,728
Ensembl chrNW_004624880:1,496,634...1,516,684 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO (PMID:18065446), (PMID:22529811), (PMID:7889574) BHF-UCL PMID:7889574 PMID:18065446 PMID:22529811 NCBI chrNW_004624731:2,401,358...2,498,212
Ensembl chrNW_004624731:2,401,380...2,498,211 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15225
    biological regulation 10771
      regulation of biological quality 2932
        regulation of membrane potential 491
          membrane depolarization 97
            membrane depolarization during action potential + 31
            mitochondrial depolarization + 30
            negative regulation of membrane depolarization + 8
            positive regulation of membrane depolarization + 18
            regulation of membrane depolarization + 54
            regulation of vascular associated smooth muscle cell membrane depolarization + 1
paths to the root