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ONTOLOGY REPORT - ANNOTATIONS

Term:membrane depolarization
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Accession:GO:0051899 term browser browse the term
Definition:The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential.

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membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2A adenosine A2a receptor ISO RGD PMID:16644907 RGD:1625443 NCBI chr19:7,691,678...7,706,781
Ensembl chr19:7,691,536...7,706,926 		JBrowse link
G ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 acts_upstream_of_or_within ISO (PMID:30819023) MGI PMID:30819023 NCBI chr20:3,801,044...3,828,680
Ensembl chr20:3,802,887...3,828,692 		JBrowse link
G ATP1A3 ATPase Na+/K+ transporting subunit alpha 3 acts_upstream_of_or_within ISO (PMID:30819023) MGI PMID:30819023 NCBI chr 6:36,166,586...36,195,343
Ensembl chr 6:36,166,262...36,195,363 		JBrowse link
G BEST2 bestrophin 2 involved_in ISO (MGI:3763293|PMID:16912113) HGNC-UCL PMID:16912113 MGI:3763293 NCBI chr 6:11,438,981...11,447,952
Ensembl chr 6:11,441,380...11,448,629 		JBrowse link
G CACNA1A calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO (PMID:11718712)
(PMID:8158221)
(PMID:10908603)		 MGI PMID:8158221 PMID:10908603 PMID:11718712 NCBI chr 6:11,883,353...12,307,023 JBrowse link
G CACNG2 calcium voltage-gated channel auxiliary subunit gamma 2 acts_upstream_of_or_within ISO (PMID:9065835) MGI PMID:9065835 NCBI chr19:19,263,950...19,406,952
Ensembl chr19:19,267,426...19,406,883 		JBrowse link
G CAV1 caveolin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17098833) Ensembl
MGI		 PMID:17098833 GO_REF:0000107 NCBI chr21:85,222,724...85,258,562
Ensembl chr21:85,222,879...85,258,627 		JBrowse link
G CHRNA10 cholinergic receptor nicotinic alpha 10 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:63,058,935...63,065,673
Ensembl chr 1:63,060,039...63,065,150 		JBrowse link
G CHRNA4 cholinergic receptor nicotinic alpha 4 subunit acts_upstream_of_or_within ISO (PMID:15741168)
(PMID:11226318)
(PMID:11222635), (PMID:12944511)		 MGI PMID:11222635 PMID:11226318 PMID:12944511 PMID:15741168 NCBI chr 2:851,790...862,685 JBrowse link
G CHRNA6 cholinergic receptor nicotinic alpha 6 subunit acts_upstream_of_or_within ISO (PMID:12944511) MGI PMID:12944511 NCBI chr 8:40,750,839...40,767,010
Ensembl chr 8:40,751,375...40,766,236 		JBrowse link
G CHRNA9 cholinergic receptor nicotinic alpha 9 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:9,952,344...9,979,638
Ensembl chr27:9,953,115...9,971,811 		JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit acts_upstream_of_or_within ISO (PMID:11222635) MGI PMID:11222635 NCBI chr20:9,245,803...9,255,430
Ensembl chr20:9,247,231...9,253,795 		JBrowse link
G CNGA2 cyclic nucleotide gated channel subunit alpha 2 involved_in ISO PMID:1697649 RGD
UniProt		 PMID:1697649 PMID:18048449 RGD:1298763 RGD:6902904 NCBI chr  X:126,277,931...126,302,167
Ensembl chr  X:126,295,236...126,301,141 		JBrowse link
G CNGA3 cyclic nucleotide gated channel subunit alpha 3 involved_in ISO PMID:15178415 UniProt PMID:15178415 RGD:405650286 NCBI chr14:2,039,281...2,124,527
Ensembl chr14:2,096,232...2,123,231 		JBrowse link
G CNGB1 cyclic nucleotide gated channel subunit beta 1 involved_in ISO (MGI:5817509|PMID:28053034) ARUK-UCL PMID:28053034 MGI:5817509 NCBI chr 5:43,814,500...43,903,323 JBrowse link
G EDN1 endothelin 1 ISO RGD PMID:15655307 RGD:1580292 NCBI chr17:59,854,186...59,861,319
Ensembl chr17:59,853,699...59,861,198 		JBrowse link
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 acts_upstream_of_or_within ISO (PMID:17245443) MGI PMID:17245443 NCBI chr 2:62,286,828...62,692,061 JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit ISO induced in pulmonary artery smooth muscle cells RGD PMID:11571252 RGD:2290591 NCBI chr20:74,204,481...74,207,835
Ensembl chr20:74,205,542...74,206,546 		JBrowse link
G KMT2A lysine methyltransferase 2A ISO RGD PMID:20211609 RGD:9588219 NCBI chr 1:109,819,748...109,912,763
Ensembl chr 1:109,853,758...109,908,113 		JBrowse link
G LOC103246137 cyclic nucleotide gated channel subunit alpha 1 ISO RGD PMID:18048449 RGD:6902904 NCBI chr27:2,273,540...2,313,083
Ensembl chr27:2,293,765...2,312,761 		JBrowse link
G P2RX4 purinergic receptor P2X 4 involved_in ISO (PMID:9016352) BHF-UCL PMID:9016352 NCBI chr11:116,585,276...116,609,401
Ensembl chr11:116,585,586...116,609,511 		JBrowse link
G P2RX7 purinergic receptor P2X 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:116,505,975...116,560,151
Ensembl chr11:116,529,346...116,563,059 		JBrowse link
G PARK7 Parkinsonism associated deglycase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16624565) Ensembl
MGI		 PMID:16624565 GO_REF:0000107 NCBI chr20:123,776,084...123,808,031
Ensembl chr20:123,776,297...123,798,434 		JBrowse link
G PHOX2B paired like homeobox 2B ISO RGD PMID:19036978 RGD:152025257 NCBI chr27:8,602,764...8,608,052
Ensembl chr27:8,603,484...8,606,299 		JBrowse link
G PRKCZ protein kinase C zeta ISO RGD PMID:15381257 RGD:1642699 NCBI chr20:129,367,309...129,502,681
Ensembl chr20:129,365,679...129,485,818 		JBrowse link
G SCN1B sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:29,962,993...29,972,845
Ensembl chr 6:29,962,843...29,973,325 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:115,031,634...115,057,829
Ensembl chr 1:115,034,508...115,057,787 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:767,854...869,787
Ensembl chr15:794,963...867,457 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 involved_in ISO PMID:14642278 UniProt PMID:14642278 RGD:8553687 NCBI chr16:23,929,196...23,969,665
Ensembl chr16:23,927,311...23,955,616 		JBrowse link
membrane depolarization during action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1G calcium voltage-gated channel subunit alpha1 G involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr16:42,710,640...42,776,736
Ensembl chr16:42,708,638...42,768,843 		JBrowse link
G CACNA1H calcium voltage-gated channel subunit alpha1 H involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 5:1,039,709...1,106,212
Ensembl chr 5:1,078,973...1,106,507 		JBrowse link
G CACNA1I calcium voltage-gated channel subunit alpha1 I involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr19:22,129,795...22,264,485
Ensembl chr19:22,143,980...22,261,098 		JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:119,123,601...119,156,985
Ensembl chr21:119,124,007...119,156,794 		JBrowse link
G SCN10A sodium voltage-gated channel alpha subunit 10 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr15:624,962...724,018
Ensembl chr15:625,742...721,963 		JBrowse link
G SCN11A sodium voltage-gated channel alpha subunit 11 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr15:466,295...575,460
Ensembl chr15:467,210...575,110 		JBrowse link
G SCN1A sodium voltage-gated channel alpha subunit 1 involved_in ISO (PMID:14672992)
(MGI:5796061|PMID:27281198)		 UniProt PMID:14672992 PMID:27281198 MGI:5796061 NCBI chr10:51,490,204...51,653,916 JBrowse link
G SCN1A sodium voltage-gated channel alpha subunit 1 involved_in IEA TreeGrafter GO_REF:0000118 Ensembl chr10:51,498,962...51,560,377 JBrowse link
G SCN1B sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:29,962,993...29,972,845
Ensembl chr 6:29,962,843...29,973,325 		JBrowse link
G SCN2A sodium voltage-gated channel alpha subunit 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr10:50,717,264...50,886,079
Ensembl chr10:50,717,271...50,888,145 		JBrowse link
G SCN2B sodium voltage-gated channel beta subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:109,538,694...109,552,745
Ensembl chr 1:109,538,652...109,552,740 		JBrowse link
G SCN3A sodium voltage-gated channel alpha subunit 3 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr10:50,563,560...50,679,179
Ensembl chr10:50,563,568...50,637,179 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:115,031,634...115,057,829
Ensembl chr 1:115,034,508...115,057,787 		JBrowse link
G SCN4A sodium voltage-gated channel alpha subunit 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr16:57,273,143...57,331,677
Ensembl chr16:57,282,252...57,331,035 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr15:767,854...869,787
Ensembl chr15:794,963...867,457 		JBrowse link
G SCN7A sodium voltage-gated channel alpha subunit 7 NOT|involved_in ISO
IEA		 PMID:9001394 UniProt
TreeGrafter		 PMID:9001394 GO_REF:0000118 RGD:61747 NCBI chr10:51,929,727...52,024,734
Ensembl chr10:51,927,523...52,004,720 		JBrowse link
G SCN8A sodium voltage-gated channel alpha subunit 8 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr11:47,770,513...47,983,843
Ensembl chr11:47,838,358...47,978,399 		JBrowse link
G SCN9A sodium voltage-gated channel alpha subunit 9 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr10:51,711,446...51,898,856
Ensembl chr10:51,714,931...51,829,621 		JBrowse link
G YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:14,825,963...14,839,668
Ensembl chr19:14,826,135...14,840,325 		JBrowse link
membrane depolarization during atrial cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1C calcium voltage-gated channel subunit alpha1 C involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:2,107,722...2,753,970
Ensembl chr11:2,508,705...2,752,991 		JBrowse link
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:18,075,436...18,470,985
Ensembl chr 9:18,332,165...18,469,617 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:767,854...869,787
Ensembl chr15:794,963...867,457 		JBrowse link
membrane depolarization during AV node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1C calcium voltage-gated channel subunit alpha1 C involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:2,107,722...2,753,970
Ensembl chr11:2,508,705...2,752,991 		JBrowse link
G CACNA1G calcium voltage-gated channel subunit alpha1 G involved_in ISO (MGI:3714901|PMID:16690884) BHF-UCL PMID:16690884 MGI:3714901 NCBI chr16:42,710,640...42,776,736
Ensembl chr16:42,708,638...42,768,843 		JBrowse link
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:18,075,436...18,470,985
Ensembl chr 9:18,332,165...18,469,617 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:767,854...869,787
Ensembl chr15:794,963...867,457 		JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:42,379,534...42,424,721
Ensembl chr 6:42,379,659...42,424,146 		JBrowse link
membrane depolarization during bundle of His cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:66,449,154...66,937,643
Ensembl chr21:66,770,578...66,934,898 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:767,854...869,787
Ensembl chr15:794,963...867,457 		JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:42,379,534...42,424,721
Ensembl chr 6:42,379,659...42,424,146 		JBrowse link
membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1C calcium voltage-gated channel subunit alpha1 C involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:2,107,722...2,753,970
Ensembl chr11:2,508,705...2,752,991 		JBrowse link
G SCN10A sodium voltage-gated channel alpha subunit 10 involved_in IEA GOC GO_REF:0000108 NCBI chr15:624,962...724,018
Ensembl chr15:625,742...721,963 		JBrowse link
G SCN1B sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:29,962,993...29,972,845
Ensembl chr 6:29,962,843...29,973,325 		JBrowse link
G SCN2B sodium voltage-gated channel beta subunit 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:109,538,694...109,552,745
Ensembl chr 1:109,538,652...109,552,740 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:115,031,634...115,057,829
Ensembl chr 1:115,034,508...115,057,787 		JBrowse link
G SCN4B sodium voltage-gated channel beta subunit 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:109,507,121...109,528,512
Ensembl chr 1:109,509,979...109,528,721 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:767,854...869,787
Ensembl chr15:794,963...867,457 		JBrowse link
membrane depolarization during Purkinje myocyte cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SCN1B sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:29,962,993...29,972,845
Ensembl chr 6:29,962,843...29,973,325 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:767,854...869,787
Ensembl chr15:794,963...867,457 		JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:42,379,534...42,424,721
Ensembl chr 6:42,379,659...42,424,146 		JBrowse link
membrane depolarization during SA node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1D calcium voltage-gated channel subunit alpha1 D involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12700358) Ensembl
MGI		 PMID:12700358 GO_REF:0000107 NCBI chr22:14,868,459...15,195,002
Ensembl chr22:15,027,565...15,197,101 		JBrowse link
G CACNA1G calcium voltage-gated channel subunit alpha1 G involved_in ISO (MGI:3714901|PMID:16690884) BHF-UCL PMID:16690884 MGI:3714901 NCBI chr16:42,710,640...42,776,736
Ensembl chr16:42,708,638...42,768,843 		JBrowse link
G HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:10,107,342...10,158,885
Ensembl chr26:10,110,579...10,156,292 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:767,854...869,787
Ensembl chr15:794,963...867,457 		JBrowse link
mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP5IF1 ATP synthase inhibitory factor subunit 1 involved_in ISO (PMID:24005319) ParkinsonsUK-UCL PMID:24005319 NCBI chr20:104,567,306...104,569,346 JBrowse link
G CASP1 caspase 1 acts_upstream_of_or_within ISO (PMID:23028046) MGI PMID:23028046 NCBI chr 1:96,389,697...96,400,610
Ensembl chr 1:96,389,657...96,400,849 		JBrowse link
G COL6A1 collagen type VI alpha 1 chain acts_upstream_of_or_within ISO (PMID:19519726), (PMID:24852368)
(PMID:19293339)		 MGI PMID:19293339 PMID:19519726 PMID:24852368 NCBI chr 2:89,608,525...89,649,823 JBrowse link
G KCNQ2 potassium voltage-gated channel subfamily Q member 2 acts_upstream_of_or_within ISO (PMID:20885443) MGI PMID:20885443 NCBI chr 2:739,965...803,575
Ensembl chr 2:761,952...802,999 		JBrowse link
G KCNQ3 potassium voltage-gated channel subfamily Q member 3 acts_upstream_of_or_within ISO (PMID:20885443) MGI PMID:20885443 NCBI chr 8:126,566,288...126,921,354
Ensembl chr 8:126,566,545...126,622,712 		JBrowse link
G P2RX7 purinergic receptor P2X 7 acts_upstream_of ISO (PMID:16198349) MGI PMID:16198349 NCBI chr11:116,505,975...116,560,151
Ensembl chr11:116,529,346...116,563,059 		JBrowse link
G PPIF peptidylprolyl isomerase F involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19293339) Ensembl
MGI		 PMID:19293339 GO_REF:0000107 NCBI chr 9:52,109,865...52,117,703
Ensembl chr 9:52,109,272...52,117,483 		JBrowse link
negative regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV3 caveolin 3 involved_in ISO (MGI:5613732|PMID:25257915) BHF-UCL PMID:25257915 MGI:5613732 NCBI chr22:44,726,597...44,740,456
Ensembl chr22:44,727,624...44,740,459 		JBrowse link
negative regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALB albumin involved_in ISO (PMID:16153637) UniProt PMID:16153637 NCBI chr 7:21,872,036...21,890,095
Ensembl chr 7:21,876,132...21,891,407 		JBrowse link
G BOK BCL2 family apoptosis regulator BOK involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:127,621,936...127,634,091
Ensembl chr10:127,622,149...127,635,833 		JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 ISO RGD PMID:29215467 RGD:13504824 NCBI chr 9:92,463,017...92,489,227
Ensembl chr 9:92,462,782...92,488,310 		JBrowse link
G HSH2D hematopoietic SH2 domain containing acts_upstream_of_or_within ISO (PMID:15569688) MGI PMID:15569688 NCBI chr 6:14,644,424...14,660,859
Ensembl chr 6:14,649,814...14,660,089 		JBrowse link
G IFI6 interferon alpha inducible protein 6 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr20:105,118,969...105,125,037
Ensembl chr20:105,118,645...105,125,151 		JBrowse link
G NGFR nerve growth factor receptor ISO RGD PMID:19457114 RGD:5508731 NCBI chr16:69,894,000...69,914,209
Ensembl chr16:69,894,139...69,912,189 		JBrowse link
G RBFOX2 RNA binding fox-1 homolog 2 ISO RGD PMID:34731606 RGD:329845875 NCBI chr19:18,507,184...18,801,535 JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:26,344,480...26,367,448
Ensembl chr 2:26,343,450...26,367,776 		JBrowse link
positive regulation of membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1C calcium voltage-gated channel subunit alpha1 C ISO RGD PMID:18562674 RGD:152177517 NCBI chr11:2,107,722...2,753,970
Ensembl chr11:2,508,705...2,752,991 		JBrowse link
G CACNA1D calcium voltage-gated channel subunit alpha1 D ISO RGD PMID:7760845 RGD:70680 NCBI chr22:14,868,459...15,195,002
Ensembl chr22:15,027,565...15,197,101 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 ISO RGD PMID:16641242 RGD:401959318 NCBI chr10:93,316,774...93,395,187
Ensembl chr10:93,316,840...93,388,832 		JBrowse link
positive regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK3 ankyrin 3 involved_in ISO PMID:18180363 BHF-UCL PMID:18180363 RGD:6767295 NCBI chr 9:70,549,665...71,253,928
Ensembl chr 9:70,893,260...71,254,245 		JBrowse link
positive regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCY10 adenylate cyclase 10 ISO RGD PMID:31172217 RGD:329403053 NCBI chr25:61,129,837...61,228,180
Ensembl chr25:61,140,293...61,230,117 		JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type ISO RGD PMID:15564577 RGD:2313870 NCBI chr16:6,355,795...6,370,051
Ensembl chr16:6,356,058...6,369,738 		JBrowse link
G CCK cholecystokinin ISO apoptotic RGD PMID:11964411 RGD:625521 NCBI chr22:3,698,192...3,705,443
Ensembl chr22:3,698,173...3,704,956 		JBrowse link
G DCN decorin acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23798385) MGI
Ensembl		 PMID:23798385 GO_REF:0000107 NCBI chr11:86,552,392...86,590,229
Ensembl chr11:86,551,072...86,586,891 		JBrowse link
G KDR kinase insert domain receptor acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23798385) MGI
Ensembl		 PMID:23798385 GO_REF:0000107 NCBI chr 7:13,435,059...13,482,236
Ensembl chr 7:13,435,096...13,482,771 		JBrowse link
G MLLT11 MLLT11 transcription factor 7 cofactor involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr20:12,625,224...12,635,589
Ensembl chr20:12,626,214...12,626,486 		JBrowse link
G MYOC myocilin involved_in ISO (PMID:17516541) UniProt PMID:17516541 NCBI chr25:57,458,615...57,475,329
Ensembl chr25:57,459,374...57,475,322 		JBrowse link
G OGA O-GlcNAcase ISO RGD PMID:19139380 RGD:2305938 NCBI chr 9:94,812,126...94,847,118 JBrowse link
G P2RX7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO (PMID:16198349) MGI PMID:16198349 NCBI chr11:116,505,975...116,560,151
Ensembl chr11:116,529,346...116,563,059 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 ISO protein:increased activity:brain: RGD PMID:21616968 RGD:10413888 NCBI chr25:3,350,798...3,405,040 JBrowse link
G RACK1 receptor for activated C kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:82,800,211...82,805,769
Ensembl chr23:82,798,085...82,805,936 		JBrowse link
G TSPO translocator protein ISO RGD PMID:15183124 RGD:2317155 NCBI chr19:25,678,602...25,690,556
Ensembl chr19:25,686,981...25,690,768 		JBrowse link
positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRPM4 transient receptor potential cation channel subfamily M member 4 ISO RGD PMID:20826763 RGD:10003037 NCBI chr 6:42,379,534...42,424,721
Ensembl chr 6:42,379,659...42,424,146 		JBrowse link
regulation of atrial cardiac muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1G calcium voltage-gated channel subunit alpha1 G involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16690884) Ensembl
MGI		 PMID:16690884 GO_REF:0000107 NCBI chr16:42,710,640...42,776,736
Ensembl chr16:42,708,638...42,768,843 		JBrowse link
G GJA1 gap junction protein alpha 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10969038) Ensembl
MGI		 PMID:10969038 GO_REF:0000107 NCBI chr13:52,397,291...52,410,341
Ensembl chr13:52,396,109...52,410,339 		JBrowse link
G GJA5 gap junction protein alpha 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10515563), (PMID:10969038), (PMID:9501070) Ensembl
MGI		 PMID:9501070 PMID:10515563 PMID:10969038 GO_REF:0000107
G SCN10A sodium voltage-gated channel alpha subunit 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20062061) Ensembl
TreeGrafter
MGI		 PMID:20062061 GO_REF:0000107 GO_REF:0000118 NCBI chr15:624,962...724,018
Ensembl chr15:625,742...721,963 		JBrowse link
G SCN1B sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:29,962,993...29,972,845
Ensembl chr 6:29,962,843...29,973,325 		JBrowse link
G SCN2B sodium voltage-gated channel beta subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:109,538,694...109,552,745
Ensembl chr 1:109,538,652...109,552,740 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:115,031,634...115,057,829
Ensembl chr 1:115,034,508...115,057,787 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr15:767,854...869,787
Ensembl chr15:794,963...867,457 		JBrowse link
G TBX5 T-box transcription factor 5 acts_upstream_of_positive_effect ISO (MGI:5449667|PMID:22728936) BHF-UCL PMID:22728936 MGI:5449667 NCBI chr11:109,638,694...109,696,619
Ensembl chr11:109,638,715...109,689,177 		JBrowse link
regulation of membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2M beta-2-microglobulin involved_in ISO (PMID:23144825) UniProt PMID:23144825 NCBI chr26:38,331,818...38,338,785
Ensembl chr26:38,331,442...38,338,809 		JBrowse link
G CAMK2D calcium/calmodulin dependent protein kinase II delta involved_in ISO (PMID:22514276) BHF-UCL PMID:22514276 NCBI chr 7:61,240,584...61,552,562 JBrowse link
G CFTR CF transmembrane conductance regulator NOT|involved_in ISO (MGI:5640937|PMID:24885604) UniProt PMID:24885604 MGI:5640937 NCBI chr21:86,154,313...86,332,436 JBrowse link
G FGF12 fibroblast growth factor 12 involved_in ISO PMID:12401812 BHF-UCL PMID:12401812 RGD:6484231 NCBI chr15:86,252,816...86,836,363 JBrowse link
G FHL1 four and a half LIM domains 1 involved_in ISO (PMID:18281375) BHF-UCL PMID:18281375 NCBI chr  X:111,160,389...111,226,713
Ensembl chr  X:111,211,911...111,226,841 		JBrowse link
G HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:20806410 GO_REF:0000118 RGD:9686372 NCBI chr 4:44,029,173...44,443,669 JBrowse link
G HCN2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 6:326,437...358,119
Ensembl chr 6:324,517...358,119 		JBrowse link
G HCN3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr20:8,546,609...8,558,911
Ensembl chr20:8,545,720...8,558,056 		JBrowse link
G HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr26:10,107,342...10,158,885
Ensembl chr26:10,110,579...10,156,292 		JBrowse link
G NEDD4L NEDD4 like E3 ubiquitin protein ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:21,326,276...21,683,817
Ensembl chr18:21,327,567...21,683,905 		JBrowse link
G NPFF neuropeptide FF-amide peptide precursor ISO RGD PMID:17289819 RGD:2316567 NCBI chr11:49,607,352...49,608,304
Ensembl chr11:49,607,443...49,608,139 		JBrowse link
G NTSR1 neurotensin receptor 1 ISO RGD PMID:15120846 RGD:9743930 NCBI chr 2:1,466,965...1,521,681
Ensembl chr 2:1,469,378...1,521,323 		JBrowse link
G RANGRF RAN guanine nucleotide release factor involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr16:7,654,235...7,655,851
Ensembl chr16:7,654,439...7,655,703 		JBrowse link
regulation of membrane depolarization during action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLCN2 chloride voltage-gated channel 2 involved_in ISO PMID:8816717 UniProt PMID:8816717 RGD:405650388 NCBI chr15:5,057,687...5,073,596
Ensembl chr15:5,057,900...5,073,184 		JBrowse link
G PTPN3 protein tyrosine phosphatase non-receptor type 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:30,048,941...30,168,816
Ensembl chr12:30,083,128...30,171,473 		JBrowse link
regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV3 caveolin 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr22:44,726,597...44,740,456
Ensembl chr22:44,727,624...44,740,459 		JBrowse link
G GJA5 gap junction protein alpha 5 acts_upstream_of_or_within ISO (PMID:9501070) MGI PMID:9501070
G RANGRF RAN guanine nucleotide release factor involved_in ISO (PMID:21621375) BHF-UCL PMID:21621375 NCBI chr16:7,654,235...7,655,851
Ensembl chr16:7,654,439...7,655,703 		JBrowse link
G SLMAP sarcolemma associated protein involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr22:19,054,322...19,231,037
Ensembl chr22:19,054,673...19,232,336 		JBrowse link
regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCD1 ATP binding cassette subfamily D member 1 involved_in ISO (MGI:5790173|PMID:25583114) UniProt PMID:25583114 MGI:5790173 NCBI chr  X:128,152,697...128,171,007 JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit acts_upstream_of_or_within ISO (PMID:15288121) MGI PMID:15288121 NCBI chr17:19,012,994...19,060,617
Ensembl chr17:19,013,026...19,060,659 		JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit acts_upstream_of_or_within ISO (PMID:15288121) MGI PMID:15288121 NCBI chr20:39,339,948...39,359,980
Ensembl chr20:39,339,908...39,359,430 		JBrowse link
G LRRK2 leucine rich repeat kinase 2 involved_in ISO (PMID:22736029) ParkinsonsUK-UCL PMID:22736029 NCBI chr11:36,490,775...36,634,215
Ensembl chr11:36,492,011...36,634,216 		JBrowse link
G PPP2R3C protein phosphatase 2 regulatory subunit B''gamma involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16129705) Ensembl
MGI		 PMID:16129705 GO_REF:0000107 NCBI chr24:11,901,522...11,935,764
Ensembl chr24:11,900,604...11,935,560 		JBrowse link
regulation of ventricular cardiac muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV3 caveolin 3 involved_in ISO (PMID:17060380) BHF-UCL PMID:17060380 NCBI chr22:44,726,597...44,740,456
Ensembl chr22:44,727,624...44,740,459 		JBrowse link
G GJA1 gap junction protein alpha 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10969038)
(PMID:10969038), (PMID:9109444)		 Ensembl
MGI		 PMID:9109444 PMID:10969038 GO_REF:0000107 NCBI chr13:52,397,291...52,410,341
Ensembl chr13:52,396,109...52,410,339 		JBrowse link
G GJA5 gap junction protein alpha 5 acts_upstream_of
acts_upstream_of_or_within		 ISO (MGI:6101691|PMID:26786475)
(PMID:10515563), (PMID:9501070)
(PMID:10969038)		 BHF-UCL
MGI		 PMID:9501070 PMID:10515563 PMID:10969038 PMID:26786475 MGI:6101691
G GPD1L glycerol-3-phosphate dehydrogenase 1 like involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:76,617,122...76,680,508
Ensembl chr15:76,617,441...76,677,713 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:115,031,634...115,057,829
Ensembl chr 1:115,034,508...115,057,787 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:767,854...869,787
Ensembl chr15:794,963...867,457 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17079
    biological regulation 11800
      regulation of biological quality 3144
        regulation of membrane potential 523
          membrane depolarization 104
            membrane depolarization during action potential + 33
            mitochondrial depolarization + 31
            negative regulation of membrane depolarization + 9
            positive regulation of membrane depolarization + 17
            regulation of membrane depolarization + 57
            regulation of vascular associated smooth muscle cell membrane depolarization + 1
paths to the root