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ONTOLOGY REPORT - ANNOTATIONS

Term:membrane depolarization
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Accession:GO:0051899 term browser browse the term
Definition:The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential.


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membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2A adenosine A2a receptor ISO RGD PMID:16644907 RGD:1625443 NCBI chr26:28,141,076...28,150,600
Ensembl chr26:28,141,076...28,150,598 		JBrowse link
G ATP1A3 ATPase Na+/K+ transporting subunit alpha 3 acts_upstream_of_or_within ISO (PMID:30819023) MGI PMID:30819023 NCBI chr 1:112,325,988...112,346,056
Ensembl chr 1:112,325,289...112,346,916 		JBrowse link
G ATP1A4 ATPase Na+/K+ transporting subunit alpha 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr38:22,023,176...22,080,656
Ensembl chr38:22,023,221...22,080,604 		JBrowse link
G BEST2 bestrophin 2 involved_in ISO (MGI:3763293|PMID:16912113) HGNC-UCL PMID:16912113 MGI:3763293 NCBI chr20:49,384,595...49,388,758
Ensembl chr20:49,384,966...49,388,755 		JBrowse link
G CACNA1A calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO (PMID:10908603)
(PMID:8158221)
(PMID:11718712)		 MGI PMID:8158221 PMID:10908603 PMID:11718712 NCBI chr20:48,747,087...49,036,627
Ensembl chr20:48,821,025...49,036,032 		JBrowse link
G CACNG2 calcium voltage-gated channel auxiliary subunit gamma 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9065835) Ensembl
MGI		 PMID:9065835 GO_REF:0000107 NCBI chr10:27,750,314...27,862,646
Ensembl chr10:27,750,935...27,862,885 		JBrowse link
G CAV1 caveolin 1 acts_upstream_of_or_within ISO (PMID:17098833) MGI PMID:17098833 NCBI chr14:55,458,934...55,494,563
Ensembl chr14:55,461,048...55,492,935 		JBrowse link
G CHRNA10 cholinergic receptor nicotinic alpha 10 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:26,216,862...26,233,226 JBrowse link
G CHRNA4 cholinergic receptor nicotinic alpha 4 subunit acts_upstream_of_or_within ISO (PMID:15741168)
(PMID:11226318)
(PMID:11222635), (PMID:12944511)		 MGI PMID:11222635 PMID:11226318 PMID:12944511 PMID:15741168 NCBI chr24:47,024,948...47,036,507
Ensembl chr24:47,025,187...47,042,266 		JBrowse link
G CHRNA6 cholinergic receptor nicotinic alpha 6 subunit acts_upstream_of_or_within ISO (PMID:12944511) MGI PMID:12944511 NCBI chr16:22,990,377...23,009,257
Ensembl chr16:22,990,167...23,009,106 		JBrowse link
G CHRNA9 cholinergic receptor nicotinic alpha 9 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:72,190,431...72,204,092
Ensembl chr 3:72,190,555...72,203,404 		JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit acts_upstream_of_or_within ISO (PMID:11222635) MGI PMID:11222635 NCBI chr 7:42,786,505...42,797,976
Ensembl chr 7:42,789,600...42,795,722 		JBrowse link
G CNGA1 cyclic nucleotide gated channel subunit alpha 1 ISO RGD PMID:18048449 RGD:6902904 NCBI chr13:43,831,159...43,864,276
Ensembl chr13:43,831,163...43,864,276 		JBrowse link
G CNGA2 cyclic nucleotide gated channel subunit alpha 2 involved_in ISO PMID:1697649 RGD
UniProt		 PMID:1697649 PMID:18048449 RGD:1298763 RGD:6902904 NCBI chr  X:119,695,898...119,702,791
Ensembl chr  X:119,695,898...119,702,446 		JBrowse link
G CNGA3 cyclic nucleotide gated channel subunit alpha 3 involved_in ISO PMID:15178415 UniProt PMID:15178415 RGD:405650286 NCBI chr10:44,232,716...44,278,555
Ensembl chr10:44,234,004...44,260,746 		JBrowse link
G CNGB1 cyclic nucleotide gated channel subunit beta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:58,574,552...58,641,631
Ensembl chr 2:58,574,552...58,640,812 		JBrowse link
G EDN1 endothelin 1 ISO RGD PMID:15655307 RGD:1580292 NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383 		JBrowse link
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 acts_upstream_of_or_within ISO (PMID:17245443) MGI PMID:17245443 NCBI chr31:24,477,319...24,839,502
Ensembl chr31:24,478,696...24,839,434 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit ISO induced in pulmonary artery smooth muscle cells RGD PMID:11571252 RGD:2290591 NCBI chr 5:50,966,698...50,968,939 JBrowse link
G KMT2A lysine methyltransferase 2A ISO RGD PMID:20211609 RGD:9588219 NCBI chr 5:15,212,559...15,302,825
Ensembl chr 5:15,217,348...15,270,971 		JBrowse link
G P2RX4 purinergic receptor P2X 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:7,897,528...7,914,279
Ensembl chr26:7,898,015...7,914,234 		JBrowse link
G P2RX7 purinergic receptor P2X 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:7,928,863...7,983,956
Ensembl chr26:7,940,985...7,983,740 		JBrowse link
G PARK7 Parkinsonism associated deglycase acts_upstream_of_or_within ISO (PMID:16624565) MGI PMID:16624565 NCBI chr 5:61,576,219...61,592,325
Ensembl chr 5:61,576,069...61,592,303 		JBrowse link
G PHOX2B paired like homeobox 2B ISO RGD PMID:19036978 RGD:152025257 NCBI chr13:38,865,963...38,869,912
Ensembl chr13:38,865,995...38,869,854 		JBrowse link
G PRKCZ protein kinase C zeta ISO RGD PMID:15381257 RGD:1642699 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664 		JBrowse link
G SCN1B sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:117,504,428...117,510,666
Ensembl chr 1:117,503,828...117,511,727 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:10,783,235...10,808,342
Ensembl chr 5:10,783,325...10,804,242 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:8,278,844...8,374,614
Ensembl chr23:8,280,793...8,358,560 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 involved_in ISO PMID:14642278 UniProt PMID:14642278 RGD:8553687 NCBI chr 9:44,224,026...44,259,655
Ensembl chr 9:44,224,229...44,259,736 		JBrowse link
membrane depolarization during action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNH2 potassium voltage-gated channel subfamily H member 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:15,009,031...15,041,786
Ensembl chr16:15,009,031...15,041,504 		JBrowse link
G SCN10A sodium voltage-gated channel alpha subunit 10 involved_in IEA
IBA
ISS		 Ensembl
GO_Central
UniProt		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr23:8,420,468...8,527,414
Ensembl chr23:8,420,472...8,527,383 		JBrowse link
G SCN11A sodium voltage-gated channel alpha subunit 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:8,559,804...8,651,448
Ensembl chr23:8,559,952...8,651,500 		JBrowse link
G SCN1A sodium voltage-gated channel alpha subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr36:11,105,936...11,245,978
Ensembl chr36:11,108,050...11,183,496 		JBrowse link
G SCN1B sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:117,504,428...117,510,666
Ensembl chr 1:117,503,828...117,511,727 		JBrowse link
G SCN2B sodium voltage-gated channel beta subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:15,514,760...15,534,179
Ensembl chr 5:15,521,481...15,534,179 		JBrowse link
G SCN3A sodium voltage-gated channel alpha subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr36:10,300,091...10,405,361
Ensembl chr36:10,302,191...10,377,923 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:10,783,235...10,808,342
Ensembl chr 5:10,783,325...10,804,242 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:8,278,844...8,374,614
Ensembl chr23:8,280,793...8,358,560 		JBrowse link
G SCN7A sodium voltage-gated channel alpha subunit 7 NOT|involved_in ISO PMID:9001394 UniProt PMID:9001394 RGD:61747 NCBI chr36:11,482,840...11,590,394
Ensembl chr36:11,482,899...11,561,845 		JBrowse link
G YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta involved_in ISO (PMID:16728661) BHF-UCL PMID:16728661 NCBI chr26:24,785,374...24,796,603
Ensembl chr26:24,785,368...24,795,778 		JBrowse link
membrane depolarization during atrial cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1C calcium voltage-gated channel subunit alpha1 C involved_in ISO (PMID:17224476) BHF-UCL PMID:17224476 NCBI chr27:44,007,363...44,748,251
Ensembl chr27:44,008,020...44,746,429 		JBrowse link
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:18,537,100...18,787,728
Ensembl chr 2:18,538,620...18,902,286 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:8,278,844...8,374,614
Ensembl chr23:8,280,793...8,358,560 		JBrowse link
membrane depolarization during AV node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1C calcium voltage-gated channel subunit alpha1 C involved_in ISO (PMID:26253506) BHF-UCL PMID:26253506 NCBI chr27:44,007,363...44,748,251
Ensembl chr27:44,008,020...44,746,429 		JBrowse link
G CACNA1G calcium voltage-gated channel subunit alpha1 G involved_in ISO (MGI:3714901|PMID:16690884) BHF-UCL PMID:16690884 MGI:3714901 NCBI chr 9:26,481,148...26,544,511
Ensembl chr 9:26,481,652...26,544,845 		JBrowse link
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:18,537,100...18,787,728
Ensembl chr 2:18,538,620...18,902,286 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:8,278,844...8,374,614
Ensembl chr23:8,280,793...8,358,560 		JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:107,261,760...107,304,157
Ensembl chr 1:107,261,756...107,303,346 		JBrowse link
membrane depolarization during bundle of His cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:21,561,091...21,949,970
Ensembl chr18:21,564,676...21,949,544 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:8,278,844...8,374,614
Ensembl chr23:8,280,793...8,358,560 		JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:107,261,760...107,304,157
Ensembl chr 1:107,261,756...107,303,346 		JBrowse link
membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1C calcium voltage-gated channel subunit alpha1 C involved_in ISO (PMID:15454078) BHF-UCL PMID:15454078 NCBI chr27:44,007,363...44,748,251
Ensembl chr27:44,008,020...44,746,429 		JBrowse link
G SCN10A sodium voltage-gated channel alpha subunit 10 involved_in IEA GOC GO_REF:0000108 NCBI chr23:8,420,468...8,527,414
Ensembl chr23:8,420,472...8,527,383 		JBrowse link
G SCN1B sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:117,504,428...117,510,666
Ensembl chr 1:117,503,828...117,511,727 		JBrowse link
G SCN2B sodium voltage-gated channel beta subunit 2 involved_in IEA
IBA		 Ensembl
GO_Central		 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:15,514,760...15,534,179
Ensembl chr 5:15,521,481...15,534,179 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:10,783,235...10,808,342
Ensembl chr 5:10,783,325...10,804,242 		JBrowse link
G SCN4B sodium voltage-gated channel beta subunit 4 involved_in ISO (PMID:17592081) BHF-UCL PMID:17592081 NCBI chr 5:15,552,347...15,564,085
Ensembl chr 5:15,543,632...15,563,486 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:8,278,844...8,374,614
Ensembl chr23:8,280,793...8,358,560 		JBrowse link
membrane depolarization during Purkinje myocyte cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SCN1B sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:117,504,428...117,510,666
Ensembl chr 1:117,503,828...117,511,727 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:8,278,844...8,374,614
Ensembl chr23:8,280,793...8,358,560 		JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:107,261,760...107,304,157
Ensembl chr 1:107,261,756...107,303,346 		JBrowse link
membrane depolarization during SA node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1D calcium voltage-gated channel subunit alpha1 D involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12700358) Ensembl
MGI		 PMID:12700358 GO_REF:0000107 NCBI chr20:36,189,986...36,488,460
Ensembl chr20:36,191,810...36,613,686 		JBrowse link
G CACNA1G calcium voltage-gated channel subunit alpha1 G involved_in ISO (MGI:3714901|PMID:16690884) BHF-UCL PMID:16690884 MGI:3714901 NCBI chr 9:26,481,148...26,544,511
Ensembl chr 9:26,481,652...26,544,845 		JBrowse link
G HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:36,637,492...36,656,194
Ensembl chr30:36,639,908...36,656,406 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:8,278,844...8,374,614
Ensembl chr23:8,280,793...8,358,560 		JBrowse link
mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP5IF1 ATP synthase inhibitory factor subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:72,188,562...72,191,344
Ensembl chr 2:72,188,266...72,191,326 		JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A involved_in ISO (PMID:25217637) ParkinsonsUK-UCL PMID:25217637 NCBI chr11:41,223,316...41,226,056
Ensembl chr11:41,223,315...41,264,379 		JBrowse link
G COL6A1 collagen type VI alpha 1 chain involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19293339)
(PMID:19519726), (PMID:24852368)		 Ensembl
MGI		 PMID:19293339 PMID:19519726 PMID:24852368 GO_REF:0000107 NCBI chr31:39,301,718...39,319,895
Ensembl chr31:39,301,748...39,448,062 		JBrowse link
G KCNQ2 potassium voltage-gated channel subfamily Q member 2 acts_upstream_of_or_within ISO (PMID:20885443) MGI PMID:20885443 NCBI chr24:47,060,527...47,089,077
Ensembl chr24:47,060,245...47,089,711 		JBrowse link
G KCNQ3 potassium voltage-gated channel subfamily Q member 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20885443) Ensembl
MGI		 PMID:20885443 GO_REF:0000107 NCBI chr13:28,765,472...29,062,371
Ensembl chr13:28,773,738...29,062,370 		JBrowse link
G P2RX7 purinergic receptor P2X 7 involved_in
acts_upstream_of		 IEA
ISO		 (PMID:16198349) Ensembl
MGI		 PMID:16198349 GO_REF:0000107 NCBI chr26:7,928,863...7,983,956
Ensembl chr26:7,940,985...7,983,740 		JBrowse link
G PPIF peptidylprolyl isomerase F involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19293339) Ensembl
MGI		 PMID:19293339 GO_REF:0000107 NCBI chr 4:29,074,806...29,080,487 JBrowse link
negative regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV3 caveolin 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:9,384,901...9,398,055
Ensembl chr20:9,384,901...9,401,196 		JBrowse link
negative regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALB albumin involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr13:62,133,747...62,169,349
Ensembl chr13:62,053,814...62,294,709 		JBrowse link
G BOK BCL2 family apoptosis regulator BOK involved_in ISO (MGI:5796062|PMID:27098698) UniProt PMID:27098698 MGI:5796062 NCBI chr25:51,449,700...51,450,967 JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 ISO RGD PMID:29215467 RGD:13504824 NCBI chr28:12,352,658...12,377,960
Ensembl chr28:12,352,659...12,414,579 		JBrowse link
G HSH2D hematopoietic SH2 domain containing acts_upstream_of_or_within ISO (PMID:15569688) MGI PMID:15569688 NCBI chr20:46,319,410...46,329,997
Ensembl chr20:46,319,315...46,326,600 		JBrowse link
G IFI6 interferon alpha inducible protein 6 involved_in ISO (PMID:15685448) HGNC-UCL PMID:15685448 NCBI chr 2:72,638,657...72,642,648
Ensembl chr 2:72,638,705...72,642,648 		JBrowse link
G NGFR nerve growth factor receptor ISO RGD PMID:19457114 RGD:5508731 NCBI chr 9:25,598,468...25,621,021
Ensembl chr 9:25,601,074...25,623,274 		JBrowse link
G RBFOX2 RNA binding fox-1 homolog 2 ISO RGD PMID:34731606 RGD:329845875 NCBI chr10:28,284,836...28,494,618
Ensembl chr10:28,192,683...28,489,114 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:25,982,499...26,019,748
Ensembl chr24:25,999,048...26,018,077 		JBrowse link
positive regulation of membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1C calcium voltage-gated channel subunit alpha1 C ISO RGD PMID:18562674 RGD:152177517 NCBI chr27:44,007,363...44,748,251
Ensembl chr27:44,008,020...44,746,429 		JBrowse link
G CACNA1D calcium voltage-gated channel subunit alpha1 D ISO RGD PMID:7760845 RGD:70680 NCBI chr20:36,189,986...36,488,460
Ensembl chr20:36,191,810...36,613,686 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 ISO RGD PMID:16641242 RGD:401959318 NCBI chr37:15,921,214...15,978,492
Ensembl chr37:15,939,138...15,977,556 		JBrowse link
positive regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK3 ankyrin 3 involved_in ISO PMID:18180363 BHF-UCL PMID:18180363 RGD:6767295 NCBI chr 4:12,166,275...12,827,175
Ensembl chr 4:12,167,550...12,827,037 		JBrowse link
positive regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCY10 adenylate cyclase 10 ISO RGD PMID:31172217 RGD:329403053 NCBI chr 7:30,576,445...30,660,926
Ensembl chr 7:30,577,591...30,660,926 		JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type ISO RGD PMID:15564577 RGD:2313870 NCBI chr 5:32,026,193...32,038,698
Ensembl chr 5:31,882,501...32,038,119 		JBrowse link
G CCK cholecystokinin ISO apoptotic RGD PMID:11964411 RGD:625521 NCBI chr23:11,414,254...11,419,990
Ensembl chr23:11,414,249...11,454,198 		JBrowse link
G DCN decorin acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23798385) MGI
Ensembl		 PMID:23798385 GO_REF:0000107 NCBI chr15:31,833,492...31,887,699
Ensembl chr15:31,833,746...31,877,417 		JBrowse link
G KDR kinase insert domain receptor acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23798385) MGI
Ensembl		 PMID:23798385 GO_REF:0000107 NCBI chr13:47,442,861...47,484,574
Ensembl chr13:47,442,764...47,485,042 		JBrowse link
G MLLT11 MLLT11 transcription factor 7 cofactor involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:60,142,411...60,153,650
Ensembl chr17:60,152,378...60,152,650 		JBrowse link
G MYOC myocilin involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:27,335,314...27,346,821
Ensembl chr 7:27,335,314...27,346,820 		JBrowse link
G OGA O-GlcNAcase ISO RGD PMID:19139380 RGD:2305938 NCBI chr28:14,376,824...14,405,409
Ensembl chr28:14,373,452...14,404,541 		JBrowse link
G P2RX7 purinergic receptor P2X 7 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16198349) Ensembl
MGI		 PMID:16198349 GO_REF:0000107 NCBI chr26:7,928,863...7,983,956
Ensembl chr26:7,940,985...7,983,740 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 ISO protein:increased activity:brain: RGD PMID:21616968 RGD:10413888 NCBI chr 7:38,503,072...38,542,556
Ensembl chr 7:38,503,067...38,542,127 		JBrowse link
G RACK1 receptor for activated C kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:426,734...431,087
Ensembl chr11:426,215...431,089 		JBrowse link
G TSPO translocator protein ISO RGD PMID:15183124 RGD:2317155 NCBI chr10:22,388,498...22,399,329
Ensembl chr10:22,274,405...22,399,297 		JBrowse link
positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRPM4 transient receptor potential cation channel subfamily M member 4 ISO RGD PMID:20826763 RGD:10003037 NCBI chr 1:107,261,760...107,304,157
Ensembl chr 1:107,261,756...107,303,346 		JBrowse link
regulation of atrial cardiac muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1G calcium voltage-gated channel subunit alpha1 G involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16690884) Ensembl
MGI		 PMID:16690884 GO_REF:0000107 NCBI chr 9:26,481,148...26,544,511
Ensembl chr 9:26,481,652...26,544,845 		JBrowse link
G GJA1 gap junction protein alpha 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10969038) Ensembl
MGI		 PMID:10969038 GO_REF:0000107 NCBI chr 1:60,941,772...60,944,694
Ensembl chr 1:60,929,097...60,942,936 		JBrowse link
G GJA5 gap junction protein alpha 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10515563), (PMID:10969038), (PMID:9501070) Ensembl
MGI		 PMID:9501070 PMID:10515563 PMID:10969038 GO_REF:0000107 NCBI chr17:58,289,327...58,305,315
Ensembl chr17:58,289,327...58,305,315 		JBrowse link
G SCN10A sodium voltage-gated channel alpha subunit 10 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 (PMID:20062061) Ensembl
MGI
GO_Central		 PMID:20062061 GO_REF:0000033 GO_REF:0000107 NCBI chr23:8,420,468...8,527,414
Ensembl chr23:8,420,472...8,527,383 		JBrowse link
G SCN1B sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:117,504,428...117,510,666
Ensembl chr 1:117,503,828...117,511,727 		JBrowse link
G SCN2B sodium voltage-gated channel beta subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:15,514,760...15,534,179
Ensembl chr 5:15,521,481...15,534,179 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:10,783,235...10,808,342
Ensembl chr 5:10,783,325...10,804,242 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:8,278,844...8,374,614
Ensembl chr23:8,280,793...8,358,560 		JBrowse link
G TBX5 T-box transcription factor 5 involved_in
acts_upstream_of_positive_effect		 IEA
ISO		 (MGI:5449667|PMID:22728936) Ensembl
BHF-UCL		 PMID:22728936 GO_REF:0000107 MGI:5449667 NCBI chr26:11,462,541...11,549,699
Ensembl chr26:11,463,653...11,506,446 		JBrowse link
regulation of membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2M beta-2-microglobulin involved_in ISO (PMID:23144825) UniProt PMID:23144825 NCBI chr30:11,331,574...11,337,991
Ensembl chr30:11,331,569...11,337,997 		JBrowse link
G CAMK2D calcium/calmodulin dependent protein kinase II delta involved_in ISO (PMID:22514276) BHF-UCL PMID:22514276 NCBI chr32:33,223,093...33,525,783
Ensembl chr32:33,224,716...33,525,371 		JBrowse link
G CFTR CF transmembrane conductance regulator NOT|involved_in ISO (MGI:5640937|PMID:24885604) UniProt PMID:24885604 MGI:5640937 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977 		JBrowse link
G FGF12 fibroblast growth factor 12 involved_in ISO PMID:12401812 BHF-UCL PMID:12401812 RGD:6484231 NCBI chr34:23,818,445...24,357,825
Ensembl chr34:23,819,686...24,357,373 		JBrowse link
G FHL1 four and a half LIM domains 1 involved_in ISO (PMID:18281375) BHF-UCL PMID:18281375 NCBI chr  X:106,542,450...106,604,494
Ensembl chr  X:106,590,988...106,604,029 		JBrowse link
G HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 ISO RGD PMID:20806410 RGD:9686372 NCBI chr 4:64,777,069...65,162,603
Ensembl chr 4:64,775,577...65,160,444 		JBrowse link
G HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:36,637,492...36,656,194
Ensembl chr30:36,639,908...36,656,406 		JBrowse link
G NEDD4L NEDD4 like E3 ubiquitin protein ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:17,629,163...17,858,471
Ensembl chr 1:17,633,591...17,950,072 		JBrowse link
G NTSR1 neurotensin receptor 1 ISO RGD PMID:15120846 RGD:9743930 NCBI chr24:46,576,690...46,615,192
Ensembl chr24:46,576,501...46,615,206 		JBrowse link
G RANGRF RAN guanine nucleotide release factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:33,084,355...33,085,810
Ensembl chr 5:33,084,397...33,085,812 		JBrowse link
regulation of membrane depolarization during action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLCN2 chloride voltage-gated channel 2 involved_in ISO PMID:8816717 UniProt PMID:8816717 RGD:405650388 NCBI chr34:17,224,136...17,238,755
Ensembl chr34:17,223,215...17,239,621 		JBrowse link
G PTPN3 protein tyrosine phosphatase non-receptor type 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:64,486,293...64,595,416
Ensembl chr11:64,489,446...64,630,004 		JBrowse link
regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV3 caveolin 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:9,384,901...9,398,055
Ensembl chr20:9,384,901...9,401,196 		JBrowse link
G GJA5 gap junction protein alpha 5 acts_upstream_of_or_within ISO (PMID:9501070) MGI PMID:9501070 NCBI chr17:58,289,327...58,305,315
Ensembl chr17:58,289,327...58,305,315 		JBrowse link
G RANGRF RAN guanine nucleotide release factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:33,084,355...33,085,810
Ensembl chr 5:33,084,397...33,085,812 		JBrowse link
G SLMAP sarcolemma associated protein involved_in ISO (PMID:23064965) BHF-UCL PMID:23064965 NCBI chr20:32,592,576...32,738,515
Ensembl chr20:32,594,417...32,738,823 		JBrowse link
regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCD1 ATP binding cassette subfamily D member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:121,545,690...121,564,117
Ensembl chr  X:121,545,586...121,563,186 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15288121) Ensembl
MGI		 PMID:15288121 GO_REF:0000107 NCBI chr12:20,999,815...21,047,779
Ensembl chr12:21,000,792...21,047,779 		JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15288121) Ensembl
MGI		 PMID:15288121 GO_REF:0000107 NCBI chr 6:55,204,602...55,244,217 JBrowse link
G LRRK2 leucine rich repeat kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:13,282,824...13,420,917
Ensembl chr27:13,283,756...13,420,870 		JBrowse link
G PPP2R3C protein phosphatase 2 regulatory subunit B''gamma involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16129705) Ensembl
MGI		 PMID:16129705 GO_REF:0000107 NCBI chr 8:13,863,017...13,885,245
Ensembl chr 8:13,863,380...13,885,130 		JBrowse link
regulation of ventricular cardiac muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV3 caveolin 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:9,384,901...9,398,055
Ensembl chr20:9,384,901...9,401,196 		JBrowse link
G GJA1 gap junction protein alpha 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10969038)
(PMID:10969038), (PMID:9109444)		 Ensembl
MGI		 PMID:9109444 PMID:10969038 GO_REF:0000107 NCBI chr 1:60,941,772...60,944,694
Ensembl chr 1:60,929,097...60,942,936 		JBrowse link
G GJA5 gap junction protein alpha 5 acts_upstream_of
acts_upstream_of_or_within		 ISO (MGI:6101691|PMID:26786475)
(PMID:10515563), (PMID:9501070)
(PMID:10969038)		 BHF-UCL
MGI		 PMID:9501070 PMID:10515563 PMID:10969038 PMID:26786475 MGI:6101691 NCBI chr17:58,289,327...58,305,315
Ensembl chr17:58,289,327...58,305,315 		JBrowse link
G GPD1L glycerol-3-phosphate dehydrogenase 1 like involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:12,568,914...12,631,903
Ensembl chr23:12,522,398...12,632,447 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:10,783,235...10,808,342
Ensembl chr 5:10,783,325...10,804,242 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:8,278,844...8,374,614
Ensembl chr23:8,280,793...8,358,560 		JBrowse link
G SMAD7 SMAD family member 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:79,706,485...79,734,673
Ensembl chr 7:79,706,705...79,734,749 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17068
    biological regulation 11812
      regulation of biological quality 3150
        regulation of membrane potential 494
          membrane depolarization 95
            membrane depolarization during action potential + 26
            mitochondrial depolarization + 31
            negative regulation of membrane depolarization + 9
            positive regulation of membrane depolarization + 17
            regulation of membrane depolarization + 55
            regulation of vascular associated smooth muscle cell membrane depolarization + 1
paths to the root