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ONTOLOGY REPORT - ANNOTATIONS

Term:membrane depolarization
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Accession:GO:0051899 term browser browse the term
Definition:The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential.

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membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor ISO RGD PMID:16644907 RGD:1625443 NCBI chrNW_004955455:7,886,720...7,906,214
Ensembl chrNW_004955455:7,895,974...7,906,505 		JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 acts_upstream_of_or_within ISO (PMID:30819023) MGI PMID:30819023 NCBI chrNW_004955468:11,898,786...11,924,341
Ensembl chrNW_004955468:11,898,915...11,922,400 		JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 acts_upstream_of_or_within ISO (PMID:30819023) MGI PMID:30819023 NCBI chrNW_004955555:869,508...892,510
Ensembl chrNW_004955555:869,325...893,542 		JBrowse link
G Best2 bestrophin 2 involved_in ISO (MGI:3763293|PMID:16912113) HGNC-UCL PMID:16912113 MGI:3763293 NCBI chrNW_004955415:31,846,053...31,851,628
Ensembl chrNW_004955415:31,846,047...31,851,962 		JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO (PMID:8158221)
(PMID:10908603)
(PMID:11718712)		 MGI PMID:8158221 PMID:10908603 PMID:11718712 NCBI chrNW_004955415:32,182,536...32,457,511
Ensembl chrNW_004955415:32,183,442...32,400,595 		JBrowse link
G Cacng2 calcium voltage-gated channel auxiliary subunit gamma 2 acts_upstream_of_or_within ISO (PMID:9065835) MGI PMID:9065835 NCBI chrNW_004955413:23,136,369...23,248,231
Ensembl chrNW_004955413:23,132,896...23,248,231 		JBrowse link
G Cav1 caveolin 1 acts_upstream_of_or_within ISO (PMID:17098833) MGI PMID:17098833 NCBI chrNW_004955432:22,258,262...22,292,403
Ensembl chrNW_004955432:22,258,250...22,292,403 		JBrowse link
G Chrna10 cholinergic receptor nicotinic alpha 10 subunit involved_in ISO (MGI:3771935|PMID:18077337) ComplexPortal PMID:18077337 MGI:3771935 NCBI chrNW_004955414:19,487,840...19,495,368
Ensembl chrNW_004955414:19,487,862...19,493,034 		JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit acts_upstream_of_or_within ISO (PMID:11222635), (PMID:12944511)
(PMID:15741168)
(PMID:11226318)		 MGI PMID:11222635 PMID:11226318 PMID:12944511 PMID:15741168 NCBI chrNW_004955528:825,314...840,994
Ensembl chrNW_004955528:825,308...841,270 		JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit acts_upstream_of_or_within ISO (PMID:12944511) MGI PMID:12944511 NCBI chrNW_004955536:166,212...172,551
Ensembl chrNW_004955536:166,212...172,551 		JBrowse link
G Chrna9 cholinergic receptor nicotinic alpha 9 subunit involved_in ISO (MGI:3771935|PMID:18077337) ComplexPortal PMID:18077337 MGI:3771935 NCBI chrNW_004955443:7,148,604...7,157,824
Ensembl chrNW_004955443:7,148,604...7,157,824 		JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit acts_upstream_of_or_within ISO (PMID:11222635) MGI PMID:11222635 NCBI chrNW_004955545:1,065,457...1,077,056
Ensembl chrNW_004955545:1,065,457...1,077,526 		JBrowse link
G Cnga1 cyclic nucleotide gated channel subunit alpha 1 ISO RGD PMID:18048449 RGD:6902904 NCBI chrNW_004955443:615,061...649,693
Ensembl chrNW_004955443:639,096...649,606 		JBrowse link
G Cnga2 cyclic nucleotide gated channel subunit alpha 2 involved_in ISO PMID:1697649 RGD
UniProt		 PMID:1697649 PMID:18048449 RGD:1298763 RGD:6902904 NCBI chrNW_004955498:7,250,514...7,257,701
Ensembl chrNW_004955498:7,250,514...7,257,701 		JBrowse link
G Cnga3 cyclic nucleotide gated channel subunit alpha 3 involved_in ISO PMID:15178415 UniProt PMID:15178415 RGD:405650286 NCBI chrNW_004955470:4,884,054...4,907,151
Ensembl chrNW_004955470:4,884,309...4,906,902 		JBrowse link
G Cngb1 cyclic nucleotide gated channel subunit beta 1 involved_in ISO (MGI:5817509|PMID:28053034) ARUK-UCL PMID:28053034 MGI:5817509 NCBI chrNW_004955433:15,467,042...15,556,471 JBrowse link
G Edn1 endothelin 1 ISO RGD PMID:15655307 RGD:1580292 NCBI chrNW_004955465:2,287,906...2,314,945
Ensembl chrNW_004955465:2,287,798...2,314,753 		JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 acts_upstream_of_or_within ISO (PMID:17245443) MGI PMID:17245443 NCBI chrNW_004955407:28,899,643...29,308,936
Ensembl chrNW_004955407:28,899,899...29,308,470 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit ISO induced in pulmonary artery smooth muscle cells RGD PMID:11571252 RGD:2290591 NCBI chrNW_004955464:1,107,598...1,110,326 JBrowse link
G Kmt2a lysine methyltransferase 2A ISO RGD PMID:20211609 RGD:9588219 NCBI chrNW_004955412:19,586,435...19,670,149
Ensembl chrNW_004955412:19,586,141...19,665,527 		JBrowse link
G P2rx4 purinergic receptor P2X 4 involved_in ISO (PMID:9016352) BHF-UCL PMID:9016352 NCBI chrNW_004955482:7,031,874...7,039,026
Ensembl chrNW_004955482:7,031,874...7,039,220 		JBrowse link
G P2rx7 purinergic receptor P2X 7 involved_in ISO (PMID:9038151)
PMID:8614837		 BHF-UCL PMID:8614837 PMID:9038151 RGD:69918 NCBI chrNW_004955482:7,048,674...7,087,525
Ensembl chrNW_004955482:7,048,776...7,086,926 		JBrowse link
G Park7 Parkinsonism associated deglycase acts_upstream_of_or_within ISO (PMID:16624565) MGI PMID:16624565 NCBI chrNW_004955486:4,974,130...4,985,927
Ensembl chrNW_004955486:4,969,497...4,985,885 		JBrowse link
G Phox2b paired like homeobox 2B ISO RGD PMID:19036978 RGD:152025257 NCBI chrNW_004955443:5,935,975...5,938,747
Ensembl chrNW_004955443:5,935,975...5,938,747 		JBrowse link
G Prkcz protein kinase C zeta ISO RGD PMID:15381257 RGD:1642699 NCBI chrNW_004955486:8,947,579...9,021,702
Ensembl chrNW_004955486:8,947,579...9,021,702 		JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 involved_in ISO (PMID:21051419) BHF-UCL PMID:21051419 NCBI chrNW_004955468:4,375,517...4,383,383
Ensembl chrNW_004955468:4,375,157...4,383,502 		JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in ISO (PMID:21051419) BHF-UCL PMID:21051419 NCBI chrNW_004955412:24,391,764...24,412,912
Ensembl chrNW_004955412:24,388,366...24,412,604 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO (PMID:14500339), (PMID:21051419), (PMID:21895525) BHF-UCL PMID:14500339 PMID:21051419 PMID:21895525 NCBI chrNW_004955427:25,295,517...25,371,419
Ensembl chrNW_004955427:25,295,514...25,371,552 		JBrowse link
G Slc6a4 solute carrier family 6 member 4 involved_in ISO PMID:14642278 UniProt PMID:14642278 RGD:8553687 NCBI chrNW_004955481:3,088,440...3,122,421
Ensembl chrNW_004955481:3,088,416...3,125,711 		JBrowse link
membrane depolarization during action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 involved_in ISO (PMID:7604285) BHF-UCL PMID:7604285 NCBI chrNW_004955491:5,391,444...5,422,241
Ensembl chrNW_004955491:5,391,384...5,422,241 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 involved_in ISO (PMID:23115331) UniProt PMID:23115331 NCBI chrNW_004955427:25,157,179...25,244,020
Ensembl chrNW_004955427:25,157,179...25,243,473 		JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 involved_in ISO (PMID:12384689)
(MGI:5553040|PMID:24036948)
PMID:10196578
(PMID:24036948), (PMID:24776970)		 UniProt PMID:10196578 PMID:12384689 PMID:24036948 PMID:24776970 MGI:5553040 RGD:69980 NCBI chrNW_004955427:24,917,709...25,109,499
Ensembl chrNW_004955427:24,989,615...25,109,550 		JBrowse link
G Scn1a sodium voltage-gated channel alpha subunit 1 involved_in ISO (PMID:14672992)
(MGI:5796061|PMID:27281198)		 UniProt PMID:14672992 PMID:27281198 MGI:5796061 NCBI chrNW_004955449:8,072,910...8,220,763
Ensembl chrNW_004955449:8,160,986...8,221,951 		JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 involved_in ISO (PMID:35277491) UniProt PMID:35277491 NCBI chrNW_004955468:4,375,517...4,383,383
Ensembl chrNW_004955468:4,375,157...4,383,502 		JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 involved_in ISO (PMID:35277491) UniProt PMID:35277491 NCBI chrNW_004955412:19,341,008...19,353,563
Ensembl chrNW_004955412:19,340,947...19,354,062 		JBrowse link
G Scn3a sodium voltage-gated channel alpha subunit 3 involved_in ISO (PMID:35277491) UniProt PMID:35277491 NCBI chrNW_004955449:8,896,454...9,009,304
Ensembl chrNW_004955449:8,896,454...9,009,304 		JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in ISO (PMID:20042427), (PMID:20226894)
(PMID:21051419)		 BHF-UCL PMID:20042427 PMID:20226894 PMID:21051419 NCBI chrNW_004955412:24,391,764...24,412,912
Ensembl chrNW_004955412:24,388,366...24,412,604 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO (PMID:14500339), (PMID:18065446), (PMID:22529811) BHF-UCL PMID:14500339 PMID:18065446 PMID:22529811 NCBI chrNW_004955427:25,295,517...25,371,419
Ensembl chrNW_004955427:25,295,514...25,371,552 		JBrowse link
G Scn7a sodium voltage-gated channel alpha subunit 7 NOT|involved_in ISO PMID:9001394 UniProt PMID:9001394 RGD:61747 NCBI chrNW_004955449:7,714,424...7,798,383
Ensembl chrNW_004955449:7,736,502...7,796,626 		JBrowse link
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta involved_in ISO (PMID:16728661) BHF-UCL PMID:16728661 NCBI chrNW_004955455:6,045,919...6,057,729
Ensembl chrNW_004955455:6,045,919...6,057,729 		JBrowse link
membrane depolarization during atrial cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C involved_in ISO (PMID:17224476) BHF-UCL PMID:17224476 NCBI chrNW_004955454:4,573,647...5,199,046
Ensembl chrNW_004955454:4,490,923...5,198,506 		JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in ISO (PMID:17224476) BHF-UCL PMID:17224476 NCBI chrNW_004955429:9,642,725...9,966,175
Ensembl chrNW_004955429:9,644,053...9,966,175 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO (PMID:18065446) BHF-UCL PMID:18065446 NCBI chrNW_004955427:25,295,517...25,371,419
Ensembl chrNW_004955427:25,295,514...25,371,552 		JBrowse link
membrane depolarization during AV node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C involved_in ISO (PMID:26253506) BHF-UCL PMID:26253506 NCBI chrNW_004955454:4,573,647...5,199,046
Ensembl chrNW_004955454:4,490,923...5,198,506 		JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G involved_in ISO (MGI:3714901|PMID:16690884) BHF-UCL PMID:16690884 MGI:3714901 NCBI chrNW_004955451:11,136,885...11,194,321
Ensembl chrNW_004955451:11,137,214...11,194,036 		JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in ISO (PMID:17224476) BHF-UCL PMID:17224476 NCBI chrNW_004955429:9,642,725...9,966,175
Ensembl chrNW_004955429:9,644,053...9,966,175 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO (PMID:18616619) BHF-UCL PMID:18616619 NCBI chrNW_004955427:25,295,517...25,371,419
Ensembl chrNW_004955427:25,295,514...25,371,552 		JBrowse link
G Trpm4 transient receptor potential cation channel subfamily M member 4 involved_in ISO (PMID:27207958) BHF-UCL PMID:27207958 NCBI chrNW_004955559:1,539,036...1,581,800
Ensembl chrNW_004955559:1,546,365...1,581,712 		JBrowse link
membrane depolarization during bundle of His cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 involved_in ISO (PMID:21383000) BHF-UCL PMID:21383000 NCBI chrNW_004955410:3,544,398...3,963,582
Ensembl chrNW_004955410:3,619,740...3,964,239 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO (PMID:18065446) BHF-UCL PMID:18065446 NCBI chrNW_004955427:25,295,517...25,371,419
Ensembl chrNW_004955427:25,295,514...25,371,552 		JBrowse link
G Trpm4 transient receptor potential cation channel subfamily M member 4 involved_in ISO (PMID:27207958) BHF-UCL PMID:27207958 NCBI chrNW_004955559:1,539,036...1,581,800
Ensembl chrNW_004955559:1,546,365...1,581,712 		JBrowse link
membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C involved_in ISO (PMID:15454078) BHF-UCL PMID:15454078 NCBI chrNW_004955454:4,573,647...5,199,046
Ensembl chrNW_004955454:4,490,923...5,198,506 		JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 involved_in ISO (MGI:3763979|PMID:17884088)
(PMID:19808477)		 BHF-UCL PMID:17884088 PMID:19808477 MGI:3763979 NCBI chrNW_004955468:4,375,517...4,383,383
Ensembl chrNW_004955468:4,375,157...4,383,502 		JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 involved_in ISO (PMID:19808477) BHF-UCL PMID:19808477 NCBI chrNW_004955412:19,341,008...19,353,563
Ensembl chrNW_004955412:19,340,947...19,354,062 		JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in ISO (PMID:21051419) BHF-UCL PMID:21051419 NCBI chrNW_004955412:24,391,764...24,412,912
Ensembl chrNW_004955412:24,388,366...24,412,604 		JBrowse link
G Scn4b sodium voltage-gated channel beta subunit 4 involved_in ISO (PMID:17592081) BHF-UCL PMID:17592081 NCBI chrNW_004955412:19,312,697...19,330,913
Ensembl chrNW_004955412:19,311,797...19,331,201 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO (PMID:21895525)
PMID:29457789		 BHF-UCL PMID:21895525 PMID:29457789 RGD:126781740 NCBI chrNW_004955427:25,295,517...25,371,419
Ensembl chrNW_004955427:25,295,514...25,371,552 		JBrowse link
membrane depolarization during Purkinje myocyte cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn1b sodium voltage-gated channel beta subunit 1 involved_in ISO (PMID:18464934) BHF-UCL PMID:18464934 NCBI chrNW_004955468:4,375,517...4,383,383
Ensembl chrNW_004955468:4,375,157...4,383,502 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO (PMID:22766342) BHF-UCL PMID:22766342 NCBI chrNW_004955427:25,295,517...25,371,419
Ensembl chrNW_004955427:25,295,514...25,371,552 		JBrowse link
G Trpm4 transient receptor potential cation channel subfamily M member 4 involved_in ISO (PMID:27207958) BHF-UCL PMID:27207958 NCBI chrNW_004955559:1,539,036...1,581,800
Ensembl chrNW_004955559:1,546,365...1,581,712 		JBrowse link
membrane depolarization during SA node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1d calcium voltage-gated channel subunit alpha1 D involved_in
acts_upstream_of_or_within		 ISO (PMID:21131953)
(PMID:12700358)		 BHF-UCL
MGI		 PMID:12700358 PMID:21131953 NCBI chrNW_004955430:3,450,151...3,796,983
Ensembl chrNW_004955430:3,268,953...3,794,592 		JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G involved_in ISO (MGI:3714901|PMID:16690884) BHF-UCL PMID:16690884 MGI:3714901 NCBI chrNW_004955451:11,136,885...11,194,321
Ensembl chrNW_004955451:11,137,214...11,194,036 		JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 involved_in ISO (PMID:16407510) BHF-UCL PMID:16407510 NCBI chrNW_004955450:4,139,852...4,181,377
Ensembl chrNW_004955450:4,139,852...4,181,377 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO (PMID:18616619) BHF-UCL PMID:18616619 NCBI chrNW_004955427:25,295,517...25,371,419
Ensembl chrNW_004955427:25,295,514...25,371,552 		JBrowse link
mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp5if1 ATP synthase inhibitory factor subunit 1 involved_in ISO (PMID:24005319) ParkinsonsUK-UCL PMID:24005319 NCBI chrNW_004955452:7,372,917...7,375,072
Ensembl chrNW_004955452:7,373,001...7,375,856 		JBrowse link
G Col6a1 collagen type VI alpha 1 chain acts_upstream_of_or_within ISO (PMID:19519726), (PMID:24852368)
(PMID:19293339)		 MGI PMID:19293339 PMID:19519726 PMID:24852368 NCBI chrNW_004955407:42,461,837...42,479,048
Ensembl chrNW_004955407:42,461,952...42,478,261 		JBrowse link
G Kcnq2 potassium voltage-gated channel subfamily Q member 2 acts_upstream_of_or_within ISO (PMID:20885443) MGI PMID:20885443 NCBI chrNW_004955528:737,416...792,885
Ensembl chrNW_004955528:737,416...791,321 		JBrowse link
G Kcnq3 potassium voltage-gated channel subfamily Q member 3 acts_upstream_of_or_within ISO (PMID:20885443) MGI PMID:20885443 NCBI chrNW_004955461:6,793,877...7,119,859
Ensembl chrNW_004955461:6,797,018...7,119,569 		JBrowse link
G P2rx7 purinergic receptor P2X 7 acts_upstream_of ISO (PMID:16198349) MGI PMID:16198349 NCBI chrNW_004955482:7,048,674...7,087,525
Ensembl chrNW_004955482:7,048,776...7,086,926 		JBrowse link
G Ppif peptidylprolyl isomerase F acts_upstream_of_or_within ISO (PMID:19293339) MGI PMID:19293339 NCBI chrNW_004955437:13,295,766...13,301,918
Ensembl chrNW_004955437:13,295,663...13,302,175 		JBrowse link
negative regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 involved_in ISO (MGI:5613732|PMID:25257915) BHF-UCL PMID:25257915 MGI:5613732 NCBI chrNW_004955561:326,008...335,911
Ensembl chrNW_004955561:325,944...335,914 		JBrowse link
negative regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin involved_in ISO (PMID:16153637) UniProt PMID:16153637 NCBI chrNW_004955447:9,327...21,212 JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISO (MGI:5796062|PMID:27098698) UniProt PMID:27098698 MGI:5796062 NCBI chrNW_004955542:224,471...232,401
Ensembl chrNW_004955542:224,471...232,428 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 ISO RGD PMID:29215467 RGD:13504824 NCBI chrNW_004955507:5,346,937...5,370,072
Ensembl chrNW_004955507:5,346,838...5,370,072 		JBrowse link
G Hsh2d hematopoietic SH2 domain containing acts_upstream_of_or_within ISO (PMID:15569688) MGI PMID:15569688 NCBI chrNW_004955524:1,392,805...1,399,662
Ensembl chrNW_004955524:1,393,325...1,397,490 		JBrowse link
G Ngfr nerve growth factor receptor ISO RGD PMID:19457114 RGD:5508731 NCBI chrNW_004955451:12,030,303...12,047,305
Ensembl chrNW_004955451:12,030,252...12,047,305 		JBrowse link
G Rbfox2 RNA binding fox-1 homolog 2 ISO RGD PMID:34731606 RGD:329845875 NCBI chrNW_004955413:22,034,048...22,288,430
Ensembl chrNW_004955413:22,035,837...22,287,763 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO (PMID:19767770) UniProt PMID:19767770 NCBI chrNW_004955445:19,213,210...19,227,670
Ensembl chrNW_004955445:19,215,161...19,228,695 		JBrowse link
positive regulation of membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C ISO RGD PMID:18562674 RGD:152177517 NCBI chrNW_004955454:4,573,647...5,199,046
Ensembl chrNW_004955454:4,490,923...5,198,506 		JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D ISO RGD PMID:7760845 RGD:70680 NCBI chrNW_004955430:3,450,151...3,796,983
Ensembl chrNW_004955430:3,268,953...3,794,592 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 ISO RGD PMID:16641242 RGD:401959318 NCBI chrNW_004955457:7,424,403...7,490,630
Ensembl chrNW_004955457:7,431,736...7,491,149 		JBrowse link
positive regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ank3 ankyrin 3 involved_in ISO PMID:18180363 BHF-UCL PMID:18180363 RGD:6767295 NCBI chrNW_004955425:13,522,233...13,851,286 JBrowse link
positive regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy10 adenylate cyclase 10 ISO RGD PMID:31172217 RGD:329403053 NCBI chrNW_004955462:9,196,984...9,278,850
Ensembl chrNW_004955462:9,207,314...9,278,621 		JBrowse link
G Cck cholecystokinin ISO apoptotic RGD PMID:11964411 RGD:625521 NCBI chrNW_004955420:28,438,806...28,443,458
Ensembl chrNW_004955420:28,438,806...28,443,458 		JBrowse link
G Dcn decorin acts_upstream_of_or_within ISO (PMID:23798385) MGI PMID:23798385 NCBI chrNW_004955405:28,335,493...28,371,912
Ensembl chrNW_004955405:28,332,545...28,372,323 		JBrowse link
G Kdr kinase insert domain receptor acts_upstream_of_or_within ISO (PMID:23798385) MGI PMID:23798385 NCBI chrNW_004955447:15,810,816...15,851,702
Ensembl chrNW_004955447:15,810,815...15,853,583 		JBrowse link
G Mllt11 MLLT11 transcription factor 7 cofactor involved_in ISO (PMID:18852119) UniProt PMID:18852119 NCBI chrNW_004955588:427,102...438,578 JBrowse link
G Myoc myocilin involved_in ISO (PMID:17516541) UniProt PMID:17516541 NCBI chrNW_004955406:12,182,115...12,194,683
Ensembl chrNW_004955406:12,182,046...12,199,669 		JBrowse link
G Oga O-GlcNAcase ISO RGD PMID:19139380 RGD:2305938 NCBI chrNW_004955485:8,477,615...8,509,386
Ensembl chrNW_004955485:8,478,060...8,507,420 		JBrowse link
G P2rx7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO (PMID:16198349) MGI PMID:16198349 NCBI chrNW_004955482:7,048,674...7,087,525
Ensembl chrNW_004955482:7,048,776...7,086,926 		JBrowse link
G Parp1 poly(ADP-ribose) polymerase 1 ISO protein:increased activity:brain: RGD PMID:21616968 RGD:10413888 NCBI chrNW_004955489:520,875...557,609
Ensembl chrNW_004955489:520,875...557,615 		JBrowse link
G Rack1 receptor for activated C kinase 1 involved_in ISO (PMID:19767770) UniProt PMID:19767770 NCBI chrNW_004955530:78,488...83,297
Ensembl chrNW_004955530:78,426...83,297 		JBrowse link
G Tspo translocator protein ISO RGD PMID:15183124 RGD:2317155 NCBI chrNW_004955413:28,309,105...28,315,075
Ensembl chrNW_004955413:28,308,658...28,315,075 		JBrowse link
positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trpm4 transient receptor potential cation channel subfamily M member 4 ISO RGD PMID:20826763 RGD:10003037 NCBI chrNW_004955559:1,539,036...1,581,800
Ensembl chrNW_004955559:1,546,365...1,581,712 		JBrowse link
regulation of atrial cardiac muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1g calcium voltage-gated channel subunit alpha1 G acts_upstream_of_or_within ISO (PMID:16690884) MGI PMID:16690884 NCBI chrNW_004955451:11,136,885...11,194,321
Ensembl chrNW_004955451:11,137,214...11,194,036 		JBrowse link
G Gja1 gap junction protein alpha 1 acts_upstream_of_or_within ISO (PMID:10969038) MGI PMID:10969038 NCBI chrNW_004955436:3,612,533...3,618,095
Ensembl chrNW_004955436:3,612,533...3,618,095 		JBrowse link
G Gja5 gap junction protein alpha 5 involved_in
acts_upstream_of_or_within		 ISO (PMID:22247482), (PMID:23348765)
(PMID:10515563), (PMID:10969038), (PMID:9501070)		 BHF-UCL
MGI		 PMID:9501070 PMID:10515563 PMID:10969038 PMID:22247482 PMID:23348765 NCBI chrNW_004955568:635,319...652,692
Ensembl chrNW_004955568:635,042...653,349 		JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 involved_in
acts_upstream_of_or_within		 ISO (PMID:20062061), (PMID:21041692) BHF-UCL
MGI		 PMID:20062061 PMID:21041692 NCBI chrNW_004955427:25,157,179...25,244,020
Ensembl chrNW_004955427:25,157,179...25,243,473 		JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 involved_in ISO (PMID:19808477), (PMID:22247482) BHF-UCL PMID:19808477 PMID:22247482 NCBI chrNW_004955468:4,375,517...4,383,383
Ensembl chrNW_004955468:4,375,157...4,383,502 		JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 involved_in ISO (PMID:19808477) BHF-UCL PMID:19808477 NCBI chrNW_004955412:19,341,008...19,353,563
Ensembl chrNW_004955412:19,340,947...19,354,062 		JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in ISO (PMID:21051419)
(MGI:5294533|PMID:19796257)		 BHF-UCL PMID:19796257 PMID:21051419 MGI:5294533 NCBI chrNW_004955412:24,391,764...24,412,912
Ensembl chrNW_004955412:24,388,366...24,412,604 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO (PMID:19167345), (PMID:22247482) BHF-UCL PMID:19167345 PMID:22247482 NCBI chrNW_004955427:25,295,517...25,371,419
Ensembl chrNW_004955427:25,295,514...25,371,552 		JBrowse link
G Tbx5 T-box transcription factor 5 acts_upstream_of_positive_effect ISO (MGI:5449667|PMID:22728936) BHF-UCL PMID:22728936 MGI:5449667 NCBI chrNW_004955455:16,133,130...16,217,894
Ensembl chrNW_004955455:16,132,975...16,217,953 		JBrowse link
regulation of membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2m beta-2-microglobulin involved_in ISO (PMID:23144825) UniProt PMID:23144825 NCBI chrNW_004955416:11,205,503...11,211,325
Ensembl chrNW_004955416:11,204,849...11,215,568 		JBrowse link
G Camk2d calcium/calmodulin dependent protein kinase II delta involved_in ISO (PMID:22514276) BHF-UCL PMID:22514276 NCBI chrNW_004955428:25,583,501...25,880,395 JBrowse link
G Cftr CF transmembrane conductance regulator NOT|involved_in ISO (MGI:5640937|PMID:24885604) UniProt PMID:24885604 MGI:5640937 NCBI chrNW_004955432:23,179,645...23,328,347
Ensembl chrNW_004955432:23,178,866...23,328,382 		JBrowse link
G Fgf12 fibroblast growth factor 12 involved_in ISO PMID:12401812 BHF-UCL PMID:12401812 RGD:6484231 NCBI chrNW_004955420:15,783,184...16,310,743
Ensembl chrNW_004955420:16,070,096...16,306,103 		JBrowse link
G Fhl1 four and a half LIM domains 1 involved_in ISO (PMID:18281375) BHF-UCL PMID:18281375 NCBI chrNW_004955489:8,888,845...8,944,778
Ensembl chrNW_004955489:8,888,779...8,901,970 		JBrowse link
G Hcn1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 ISO RGD PMID:20806410 RGD:9686372 NCBI chrNW_004955446:17,146,915...17,457,843
Ensembl chrNW_004955446:17,151,311...17,457,888 		JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 involved_in ISO (PMID:12750403) BHF-UCL PMID:12750403 NCBI chrNW_004955450:4,139,852...4,181,377
Ensembl chrNW_004955450:4,139,852...4,181,377 		JBrowse link
G Nedd4l NEDD4 like E3 ubiquitin protein ligase involved_in ISO (PMID:15217910) BHF-UCL PMID:15217910 NCBI chrNW_004955402:42,339,380...42,688,661
Ensembl chrNW_004955402:42,339,380...42,688,714 		JBrowse link
G Npff neuropeptide FF-amide peptide precursor ISO RGD PMID:17289819 RGD:2316567 NCBI chrNW_004955458:799,072...799,745
Ensembl chrNW_004955458:799,072...799,745 		JBrowse link
G Ntsr1 neurotensin receptor 1 ISO RGD PMID:15120846 RGD:9743930 NCBI chrNW_004955528:1,348,616...1,394,798
Ensembl chrNW_004955528:1,348,555...1,394,868 		JBrowse link
G Rangrf RAN guanine nucleotide release factor involved_in ISO (PMID:23420830)
(MGI:5508678|PMID:23420830)
(PMID:18184654)		 BHF-UCL PMID:18184654 PMID:23420830 MGI:5508678 NCBI chrNW_004955467:8,622,843...8,624,401
Ensembl chrNW_004955467:8,622,843...8,624,401 		JBrowse link
regulation of membrane depolarization during action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clcn2 chloride voltage-gated channel 2 involved_in ISO PMID:8816717 UniProt PMID:8816717 RGD:405650388 NCBI chrNW_004955420:23,138,558...23,152,462
Ensembl chrNW_004955420:23,138,605...23,152,311 		JBrowse link
G Ptpn3 protein tyrosine phosphatase non-receptor type 3 involved_in ISO (PMID:16930557) BHF-UCL PMID:16930557 NCBI chrNW_004955419:17,560,664...17,645,420
Ensembl chrNW_004955419:17,493,518...17,645,477 		JBrowse link
regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 involved_in ISO (PMID:17275750) BHF-UCL PMID:17275750 NCBI chrNW_004955561:326,008...335,911
Ensembl chrNW_004955561:325,944...335,914 		JBrowse link
G Gja5 gap junction protein alpha 5 acts_upstream_of_or_within ISO (PMID:9501070) MGI PMID:9501070 NCBI chrNW_004955568:635,319...652,692
Ensembl chrNW_004955568:635,042...653,349 		JBrowse link
G Rangrf RAN guanine nucleotide release factor involved_in ISO (PMID:21621375) BHF-UCL PMID:21621375 NCBI chrNW_004955467:8,622,843...8,624,401
Ensembl chrNW_004955467:8,622,843...8,624,401 		JBrowse link
G Slmap sarcolemma associated protein involved_in ISO (PMID:23064965) BHF-UCL PMID:23064965 NCBI chrNW_004955430:7,470,823...7,620,101
Ensembl chrNW_004955430:7,471,400...7,622,459 		JBrowse link
regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd1 ATP binding cassette subfamily D member 1 involved_in ISO (MGI:5790173|PMID:25583114) UniProt PMID:25583114 MGI:5790173 NCBI chrNW_004955580:459,715...475,363
Ensembl chrNW_004955580:459,715...475,774 		JBrowse link
G Gclc glutamate-cysteine ligase catalytic subunit acts_upstream_of_or_within ISO (PMID:15288121) MGI PMID:15288121 NCBI chrNW_004955411:2,593,523...2,617,553
Ensembl chrNW_004955411:2,593,541...2,616,539 		JBrowse link
G Gclm glutamate-cysteine ligase modifier subunit acts_upstream_of_or_within ISO (PMID:15288121) MGI PMID:15288121 NCBI chrNW_004955423:782,468...805,384
Ensembl chrNW_004955423:782,468...805,384 		JBrowse link
G Lrrk2 leucine rich repeat kinase 2 involved_in ISO (PMID:22736029) ParkinsonsUK-UCL PMID:22736029 NCBI chrNW_004955505:84,324...216,923
Ensembl chrNW_004955505:81,796...216,923 		JBrowse link
G Ppp2r3c protein phosphatase 2 regulatory subunit B''gamma acts_upstream_of_or_within ISO (PMID:16129705) MGI PMID:16129705 NCBI chrNW_004955409:25,920,973...25,943,985 JBrowse link
regulation of ventricular cardiac muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 involved_in ISO (PMID:17060380) BHF-UCL PMID:17060380 NCBI chrNW_004955561:326,008...335,911
Ensembl chrNW_004955561:325,944...335,914 		JBrowse link
G Gja1 gap junction protein alpha 1 acts_upstream_of_or_within ISO (PMID:10969038)
(PMID:10969038), (PMID:9109444)		 MGI PMID:9109444 PMID:10969038 NCBI chrNW_004955436:3,612,533...3,618,095
Ensembl chrNW_004955436:3,612,533...3,618,095 		JBrowse link
G Gja5 gap junction protein alpha 5 acts_upstream_of
acts_upstream_of_or_within		 ISO (MGI:6101691|PMID:26786475)
(PMID:10515563), (PMID:9501070)
(PMID:10969038)		 BHF-UCL
MGI		 PMID:9501070 PMID:10515563 PMID:10969038 PMID:26786475 MGI:6101691 NCBI chrNW_004955568:635,319...652,692
Ensembl chrNW_004955568:635,042...653,349 		JBrowse link
G Gpd1l glycerol-3-phosphate dehydrogenase 1 like involved_in ISO (PMID:17967977), (PMID:19666841) BHF-UCL PMID:17967977 PMID:19666841 NCBI chrNW_004955430:23,481,957...23,536,407
Ensembl chrNW_004955430:23,481,957...23,539,495 		JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in ISO (PMID:20042427) BHF-UCL PMID:20042427 NCBI chrNW_004955412:24,391,764...24,412,912
Ensembl chrNW_004955412:24,388,366...24,412,604 		JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO (PMID:18065446), (PMID:22529811), (PMID:7889574) BHF-UCL PMID:7889574 PMID:18065446 PMID:22529811 NCBI chrNW_004955427:25,295,517...25,371,419
Ensembl chrNW_004955427:25,295,514...25,371,552 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12483
    biological regulation 9026
      regulation of biological quality 2672
        regulation of membrane potential 452
          membrane depolarization 92
            membrane depolarization during action potential + 26
            mitochondrial depolarization + 28
            negative regulation of membrane depolarization + 8
            positive regulation of membrane depolarization + 16
            regulation of membrane depolarization + 53
            regulation of vascular associated smooth muscle cell membrane depolarization + 1
paths to the root