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ONTOLOGY REPORT - ANNOTATIONS

Term:membrane depolarization
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Accession:GO:0051899 term browser browse the term
Definition:The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential.


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membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2A adenosine A2a receptor ISO RGD PMID:16644907 RGD:1625443 NCBI chr22:5,233,876...5,248,622
Ensembl chr22:22,104,253...22,114,189 		JBrowse link
G ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:30819023) Ensembl
MGI		 PMID:30819023 GO_REF:0000107 NCBI chr 1:135,469,495...135,497,303
Ensembl chr 1:139,390,549...139,418,303 		JBrowse link
G ATP1A3 ATPase Na+/K+ transporting subunit alpha 3 acts_upstream_of_or_within ISO (PMID:30819023) MGI PMID:30819023 NCBI chr19:38,854,243...38,882,034
Ensembl chr19:47,358,281...47,384,716 		JBrowse link
G BEST2 bestrophin 2 involved_in ISO (MGI:3763293|PMID:16912113) HGNC-UCL PMID:16912113 MGI:3763293 NCBI chr19:12,314,252...12,321,051
Ensembl chr19:13,060,133...13,066,033 		JBrowse link
G CACNA1A calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO (PMID:8158221)
(PMID:11718712)
(PMID:10908603)		 MGI PMID:8158221 PMID:10908603 PMID:11718712 NCBI chr19:12,769,586...13,189,022
Ensembl chr19:13,507,102...13,804,729 		JBrowse link
G CACNG2 calcium voltage-gated channel auxiliary subunit gamma 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9065835) Ensembl
MGI		 PMID:9065835 GO_REF:0000107 NCBI chr22:17,475,693...17,618,299
Ensembl chr22:35,317,121...35,454,850 		JBrowse link
G CAV1 caveolin 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17098833) Ensembl
MGI		 PMID:17098833 GO_REF:0000107 NCBI chr 7:108,497,125...108,533,090
Ensembl chr 7:121,193,424...121,229,655 		JBrowse link
G CHRNA10 cholinergic receptor nicotinic alpha 10 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:3,543,450...3,552,036
Ensembl chr11:3,651,580...3,656,780 		JBrowse link
G CHRNA4 cholinergic receptor nicotinic alpha 4 subunit acts_upstream_of_or_within ISO (PMID:11226318)
(PMID:11222635), (PMID:12944511)
(PMID:15741168)		 MGI PMID:11222635 PMID:11226318 PMID:12944511 PMID:15741168 NCBI chr20:59,730,759...59,748,678
Ensembl chr20:61,270,631...61,283,005 		JBrowse link
G CHRNA6 cholinergic receptor nicotinic alpha 6 subunit acts_upstream_of_or_within ISO (PMID:12944511) MGI PMID:12944511 NCBI chr 8:42,000,748...42,016,913
Ensembl chr 8:39,444,447...39,460,569 		JBrowse link
G CHRNA9 cholinergic receptor nicotinic alpha 9 subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:34,654,043...34,675,984
Ensembl chr 4:40,509,475...40,528,869 		JBrowse link
G CHRNB2 cholinergic receptor nicotinic beta 2 subunit acts_upstream_of_or_within ISO (PMID:11222635) MGI PMID:11222635 NCBI chr 1:129,922,740...129,931,582
Ensembl chr 1:133,535,023...133,547,361 		JBrowse link
G CNGA1 cyclic nucleotide gated channel subunit alpha 1 ISO RGD PMID:18048449 RGD:6902904 NCBI chr 4:74,196,877...74,213,563
Ensembl chr 4:84,910,653...84,945,248 		JBrowse link
G CNGA2 cyclic nucleotide gated channel subunit alpha 2 involved_in ISO PMID:1697649 RGD
UniProt		 PMID:1697649 PMID:18048449 RGD:1298763 RGD:6902904 NCBI chr  X:141,315,052...141,324,754
Ensembl chr  X:151,275,800...151,281,909 		JBrowse link
G CNGA3 cyclic nucleotide gated channel subunit alpha 3 involved_in ISO PMID:15178415 UniProt PMID:15178415 RGD:405650286 NCBI chr2A:100,911,053...100,962,278
Ensembl chr2A:99,259,808...99,308,517 		JBrowse link
G CNGB1 cyclic nucleotide gated channel subunit beta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:38,160,056...38,249,474
Ensembl chr16:57,292,093...57,375,460 		JBrowse link
G EDN1 endothelin 1 ISO RGD PMID:15655307 RGD:1580292 NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545 		JBrowse link
G GRIK1 glutamate ionotropic receptor kainate type subunit 1 acts_upstream_of_or_within ISO (PMID:17245443) MGI PMID:17245443 NCBI chr21:15,976,931...16,357,578
Ensembl chr21:29,364,269...29,743,379 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit ISO induced in pulmonary artery smooth muscle cells RGD PMID:11571252 RGD:2290591 NCBI chr 1:58,042,794...58,045,536 JBrowse link
G KMT2A lysine methyltransferase 2A ISO RGD PMID:20211609 RGD:9588219 NCBI chr11:113,273,198...113,364,404
Ensembl chr11:117,204,820...117,290,100 		JBrowse link
G P2RX4 purinergic receptor P2X 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:118,807,961...118,832,267
Ensembl chr12:122,178,672...122,202,959 		JBrowse link
G P2RX7 purinergic receptor P2X 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:118,731,761...118,786,039
Ensembl chr12:122,102,888...122,154,068 		JBrowse link
G PARK7 Parkinsonism associated deglycase acts_upstream_of_or_within ISO (PMID:16624565) MGI PMID:16624565 NCBI chr 1:6,722,260...6,745,915
Ensembl chr 1:7,969,280...7,993,271 		JBrowse link
G PHOX2B paired like homeobox 2B ISO RGD PMID:19036978 RGD:152025257 NCBI chr 4:36,070,924...36,074,532
Ensembl chr 4:41,919,742...41,922,449 		JBrowse link
G PRKCZ protein kinase C zeta ISO RGD PMID:15381257 RGD:1642699 NCBI chr 1:763,942...901,531
Ensembl chr 1:1,920,219...2,045,855 		JBrowse link
G SCN1B sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:31,974,499...31,984,488
Ensembl chr19:40,711,281...40,724,052 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:118,460,860...118,486,563
Ensembl chr11:122,377,643...122,403,063 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:38,444,421...38,546,364
Ensembl chr 3:38,728,897...38,812,202 		JBrowse link
G SLC6A4 solute carrier family 6 member 4 involved_in ISO PMID:14642278 UniProt PMID:14642278 RGD:8553687 NCBI chr17:26,546,177...26,572,301
Ensembl chr17:27,050,900...27,092,882 		JBrowse link
membrane depolarization during action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1G calcium voltage-gated channel subunit alpha1 G involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:44,654,558...44,786,037
Ensembl chr17:49,529,402...49,595,166 		JBrowse link
G CACNA1H calcium voltage-gated channel subunit alpha1 H involved_in IEA TreeGrafter GO_REF:0000118 Ensembl chr16:1,195,364...1,222,917 JBrowse link
G CACNA1I calcium voltage-gated channel subunit alpha1 I involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr22:20,463,511...20,595,253
Ensembl chr22:38,296,436...38,414,963 		JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 involved_in ISO (PMID:7604285) BHF-UCL PMID:7604285 NCBI chr 7:142,528,979...142,562,074 JBrowse link
G SCN10A sodium voltage-gated channel alpha subunit 10 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:38,593,765...38,691,172
Ensembl chr 3:38,876,068...38,972,247 		JBrowse link
G SCN11A sodium voltage-gated channel alpha subunit 11 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:38,741,485...38,948,400
Ensembl chr 3:39,024,921...39,128,015 		JBrowse link
G SCN1A sodium voltage-gated channel alpha subunit 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr2B:53,258,614...53,348,131
Ensembl chr2B:170,736,651...170,822,014 		JBrowse link
G SCN1B sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:31,974,499...31,984,488
Ensembl chr19:40,711,281...40,724,052 		JBrowse link
G SCN2A sodium voltage-gated channel alpha subunit 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr2B:52,514,918...52,667,225
Ensembl chr2B:169,928,323...170,027,509 		JBrowse link
G SCN2B sodium voltage-gated channel beta subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:112,996,609...113,010,412
Ensembl chr11:116,928,676...116,942,500 		JBrowse link
G SCN3A sodium voltage-gated channel alpha subunit 3 involved_in IEA TreeGrafter
Ensembl		 GO_REF:0000107 GO_REF:0000118 NCBI chr2B:52,363,020...52,479,818
Ensembl chr2B:169,722,134...169,838,590 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:118,460,860...118,486,563
Ensembl chr11:122,377,643...122,403,063 		JBrowse link
G SCN4A sodium voltage-gated channel alpha subunit 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr17:58,034,146...58,066,644
Ensembl chr17:63,128,550...63,161,043 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:38,444,421...38,546,364
Ensembl chr 3:38,728,897...38,812,202 		JBrowse link
G SCN7A sodium voltage-gated channel alpha subunit 7 NOT|involved_in ISO
IEA		 PMID:9001394 UniProt
TreeGrafter		 PMID:9001394 GO_REF:0000118 RGD:61747 NCBI chr2B:53,676,298...53,768,289
Ensembl chr2B:171,151,969...171,243,717 		JBrowse link
G SCN8A sodium voltage-gated channel alpha subunit 8 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr12:36,950,057...37,172,235
Ensembl chr12:37,730,900...37,876,357 		JBrowse link
G SCN9A sodium voltage-gated channel alpha subunit 9 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr2B:53,468,290...53,643,747
Ensembl chr2B:170,944,974...171,054,013 		JBrowse link
G YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta involved_in IEA Ensembl GO_REF:0000107 NCBI chr22:12,966,653...12,979,695
Ensembl chr22:30,819,821...30,831,804 		JBrowse link
membrane depolarization during atrial cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1C calcium voltage-gated channel subunit alpha1 C involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:2,166,672...2,817,827
Ensembl chr12:2,114,140...2,744,826 		JBrowse link
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:18,459,528...18,862,495
Ensembl chr10:18,795,832...19,195,226 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:38,444,421...38,546,364
Ensembl chr 3:38,728,897...38,812,202 		JBrowse link
membrane depolarization during AV node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1C calcium voltage-gated channel subunit alpha1 C involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:2,166,672...2,817,827
Ensembl chr12:2,114,140...2,744,826 		JBrowse link
G CACNA1G calcium voltage-gated channel subunit alpha1 G involved_in ISO (MGI:3714901|PMID:16690884) BHF-UCL PMID:16690884 MGI:3714901 NCBI chr17:44,654,558...44,786,037
Ensembl chr17:49,529,402...49,595,166 		JBrowse link
G CACNB2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:18,459,528...18,862,495
Ensembl chr10:18,795,832...19,195,226 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:38,444,421...38,546,364
Ensembl chr 3:38,728,897...38,812,202 		JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:46,168,301...46,224,726
Ensembl chr19:55,095,029...55,150,464 		JBrowse link
membrane depolarization during bundle of His cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:73,917,439...74,410,627
Ensembl chr 7:87,579,004...88,068,482 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:38,444,421...38,546,364
Ensembl chr 3:38,728,897...38,812,202 		JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:46,168,301...46,224,726
Ensembl chr19:55,095,029...55,150,464 		JBrowse link
membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1C calcium voltage-gated channel subunit alpha1 C involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:2,166,672...2,817,827
Ensembl chr12:2,114,140...2,744,826 		JBrowse link
G SCN10A sodium voltage-gated channel alpha subunit 10 involved_in IEA GOC GO_REF:0000108 NCBI chr 3:38,593,765...38,691,172
Ensembl chr 3:38,876,068...38,972,247 		JBrowse link
G SCN1B sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:31,974,499...31,984,488
Ensembl chr19:40,711,281...40,724,052 		JBrowse link
G SCN2B sodium voltage-gated channel beta subunit 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr11:112,996,609...113,010,412
Ensembl chr11:116,928,676...116,942,500 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:118,460,860...118,486,563
Ensembl chr11:122,377,643...122,403,063 		JBrowse link
G SCN4B sodium voltage-gated channel beta subunit 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:112,967,190...112,986,727
Ensembl chr11:116,899,268...116,918,892 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl
GOC		 GO_REF:0000107 GO_REF:0000108 NCBI chr 3:38,444,421...38,546,364
Ensembl chr 3:38,728,897...38,812,202 		JBrowse link
membrane depolarization during Purkinje myocyte cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SCN1B sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:31,974,499...31,984,488
Ensembl chr19:40,711,281...40,724,052 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:38,444,421...38,546,364
Ensembl chr 3:38,728,897...38,812,202 		JBrowse link
G TRPM4 transient receptor potential cation channel subfamily M member 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:46,168,301...46,224,726
Ensembl chr19:55,095,029...55,150,464 		JBrowse link
membrane depolarization during SA node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1D calcium voltage-gated channel subunit alpha1 D involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12700358) Ensembl
MGI		 PMID:12700358 GO_REF:0000107 NCBI chr 3:53,432,189...53,751,347
Ensembl chr 3:54,495,952...54,970,444 		JBrowse link
G CACNA1G calcium voltage-gated channel subunit alpha1 G involved_in ISO (MGI:3714901|PMID:16690884) BHF-UCL PMID:16690884 MGI:3714901 NCBI chr17:44,654,558...44,786,037
Ensembl chr17:49,529,402...49,595,166 		JBrowse link
G HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:52,231,906...52,285,220
Ensembl chr15:70,997,020...71,042,285 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:38,444,421...38,546,364
Ensembl chr 3:38,728,897...38,812,202 		JBrowse link
mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP5IF1 ATP synthase inhibitory factor subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:27,495,250...27,497,255
Ensembl chr 1:28,532,091...28,542,607 		JBrowse link
G CASP1 caspase 1 acts_upstream_of_or_within ISO (PMID:23028046) MGI PMID:23028046 NCBI chr11:99,965,964...99,975,640
Ensembl chr11:103,448,497...103,458,149
Ensembl chr11:103,448,497...103,458,149 		JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A involved_in ISO (PMID:25217637) ParkinsonsUK-UCL PMID:25217637 NCBI chr 9:21,803,862...21,831,322 JBrowse link
G COL6A1 collagen type VI alpha 1 chain involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19519726), (PMID:24852368)
(PMID:19293339)		 Ensembl
MGI		 PMID:19293339 PMID:19519726 PMID:24852368 GO_REF:0000107 NCBI chr21:32,322,185...32,346,850
Ensembl chr21:45,584,096...45,607,240 		JBrowse link
G KCNQ2 potassium voltage-gated channel subfamily Q member 2 acts_upstream_of_or_within ISO (PMID:20885443) MGI PMID:20885443 Ensembl chr20:61,325,365...61,395,266 JBrowse link
G KCNQ3 potassium voltage-gated channel subfamily Q member 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20885443) Ensembl
MGI		 PMID:20885443 GO_REF:0000107 NCBI chr 8:128,769,930...129,134,671
Ensembl chr 8:131,755,454...131,815,237 		JBrowse link
G P2RX7 purinergic receptor P2X 7 acts_upstream_of ISO (PMID:16198349) MGI PMID:16198349 NCBI chr12:118,731,761...118,786,039
Ensembl chr12:122,102,888...122,154,068 		JBrowse link
G PPIF peptidylprolyl isomerase F involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19293339) Ensembl
MGI		 PMID:19293339 GO_REF:0000107 NCBI chr10:75,860,197...75,868,098
Ensembl chr10:78,521,642...78,530,202 		JBrowse link
negative regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV3 caveolin 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:8,684,829...8,697,731
Ensembl chr 3:8,928,069...8,940,942 		JBrowse link
negative regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALB albumin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:50,773,244...50,790,474
Ensembl chr 4:56,605,322...56,622,418 		JBrowse link
G BOK BCL2 family apoptosis regulator BOK involved_in IEA Ensembl GO_REF:0000107 NCBI chr2B:128,832,458...128,847,918
Ensembl chr2B:247,626,494...247,640,238 		JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 ISO RGD PMID:29215467 RGD:13504824 NCBI chr10:96,012,345...96,046,266
Ensembl chr10:99,506,205...99,540,178 		JBrowse link
G HSH2D hematopoietic SH2 domain containing acts_upstream_of_or_within ISO (PMID:15569688) MGI PMID:15569688 NCBI chr19:15,629,688...15,643,636
Ensembl chr19:16,611,500...16,624,500 		JBrowse link
G IFI6 interferon alpha inducible protein 6 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:26,929,129...26,935,205
Ensembl chr 1:27,972,866...27,978,890 		JBrowse link
G NGFR nerve growth factor receptor ISO RGD PMID:19457114 RGD:5508731 NCBI chr17:8,089,600...8,109,361
Ensembl chr17:8,075,316...8,094,966 		JBrowse link
G RBFOX2 RNA binding fox-1 homolog 2 ISO RGD PMID:34731606 RGD:329845875 NCBI chr22:16,740,707...17,031,415
Ensembl chr22:34,586,044...34,870,257 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:33,667,614...33,727,126
Ensembl chr20:34,822,271...34,839,634 		JBrowse link
positive regulation of membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1C calcium voltage-gated channel subunit alpha1 C ISO RGD PMID:18562674 RGD:152177517 NCBI chr12:2,166,672...2,817,827
Ensembl chr12:2,114,140...2,744,826 		JBrowse link
G CACNA1D calcium voltage-gated channel subunit alpha1 D ISO RGD PMID:7760845 RGD:70680 NCBI chr 3:53,432,189...53,751,347
Ensembl chr 3:54,495,952...54,970,444 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 ISO RGD PMID:16641242 RGD:401959318 NCBI chr2B:94,762,796...94,836,304
Ensembl chr2B:212,891,261...212,958,130 		JBrowse link
positive regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANK3 ankyrin 3 involved_in ISO PMID:18180363 BHF-UCL PMID:18180363 RGD:6767295 NCBI chr10:56,560,589...57,269,952
Ensembl chr10:58,790,696...59,602,954 		JBrowse link
positive regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCY10 adenylate cyclase 10 ISO RGD PMID:31172217 RGD:329403053 NCBI chr 1:143,239,576...143,404,038
Ensembl chr 1:147,023,671...147,129,705 		JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type ISO RGD PMID:15564577 RGD:2313870 NCBI chr17:7,026,839...7,041,598
Ensembl chr17:7,014,591...7,029,602 		JBrowse link
G CCK cholecystokinin ISO apoptotic RGD PMID:11964411 RGD:625521 NCBI chr 3:42,168,012...42,176,358
Ensembl chr 3:42,431,022...42,439,396 		JBrowse link
G DCN decorin acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23798385) MGI
Ensembl		 PMID:23798385 GO_REF:0000107 NCBI chr12:88,678,791...88,715,677
Ensembl chr12:91,994,129...92,031,413 		JBrowse link
G KDR kinase insert domain receptor acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:23798385) MGI
Ensembl		 PMID:23798385 GO_REF:0000107 NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109 		JBrowse link
G MLLT11 MLLT11 transcription factor 7 cofactor involved_in ISO (PMID:18852119) UniProt PMID:18852119 NCBI chr 1:126,408,533...126,417,624 JBrowse link
G MYOC myocilin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:147,128,541...147,146,227
Ensembl chr 1:150,841,630...150,858,628 		JBrowse link
G OGA O-GlcNAcase ISO RGD PMID:19139380 RGD:2305938 NCBI chr10:98,387,144...98,421,105
Ensembl chr10:101,858,879...101,892,479 		JBrowse link
G P2RX7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO (PMID:16198349) MGI PMID:16198349 NCBI chr12:118,731,761...118,786,039
Ensembl chr12:122,102,888...122,154,068 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 ISO protein:increased activity:brain: RGD PMID:21616968 RGD:10413888 NCBI chr 1:201,820,355...201,867,673
Ensembl chr 1:206,812,981...206,860,356 		JBrowse link
G RACK1 receptor for activated C kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:176,462,991...176,470,153
Ensembl chr 5:183,712,665...183,720,128 		JBrowse link
G TSPO translocator protein ISO RGD PMID:15183124 RGD:2317155 NCBI chr22:24,034,918...24,046,370
Ensembl chr22:42,233,619...42,244,930 		JBrowse link
positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRPM4 transient receptor potential cation channel subfamily M member 4 ISO RGD PMID:20826763 RGD:10003037 NCBI chr19:46,168,301...46,224,726
Ensembl chr19:55,095,029...55,150,464 		JBrowse link
regulation of atrial cardiac muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CACNA1G calcium voltage-gated channel subunit alpha1 G involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16690884) Ensembl
MGI		 PMID:16690884 GO_REF:0000107 NCBI chr17:44,654,558...44,786,037
Ensembl chr17:49,529,402...49,595,166 		JBrowse link
G GJA1 gap junction protein alpha 1 acts_upstream_of_or_within ISO (PMID:10969038) MGI PMID:10969038 NCBI chr 6:119,213,513...119,227,617 JBrowse link
G GJA5 gap junction protein alpha 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10515563), (PMID:10969038), (PMID:9501070) Ensembl
MGI		 PMID:9501070 PMID:10515563 PMID:10969038 GO_REF:0000107 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
G SCN10A sodium voltage-gated channel alpha subunit 10 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20062061) Ensembl
TreeGrafter
MGI		 PMID:20062061 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:38,593,765...38,691,172
Ensembl chr 3:38,876,068...38,972,247 		JBrowse link
G SCN1B sodium voltage-gated channel beta subunit 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:31,974,499...31,984,488
Ensembl chr19:40,711,281...40,724,052 		JBrowse link
G SCN2B sodium voltage-gated channel beta subunit 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:112,996,609...113,010,412
Ensembl chr11:116,928,676...116,942,500 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:118,460,860...118,486,563
Ensembl chr11:122,377,643...122,403,063 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:38,444,421...38,546,364
Ensembl chr 3:38,728,897...38,812,202 		JBrowse link
G TBX5 T-box transcription factor 5 involved_in
acts_upstream_of_positive_effect		 IEA
ISO		 (MGI:5449667|PMID:22728936) Ensembl
BHF-UCL		 PMID:22728936 GO_REF:0000107 MGI:5449667 NCBI chr12:111,954,222...112,009,261
Ensembl chr12:115,333,609...115,389,739 		JBrowse link
regulation of membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2M beta-2-microglobulin involved_in ISO (PMID:23144825) UniProt PMID:23144825 NCBI chr15:23,668,108...23,674,791
Ensembl chr15:41,836,345...41,842,991 		JBrowse link
G CAMK2D calcium/calmodulin dependent protein kinase II delta involved_in ISO (PMID:22514276) BHF-UCL PMID:22514276 NCBI chr 4:105,957,773...106,271,887
Ensembl chr 4:116,523,850...116,835,387 		JBrowse link
G CFTR CF transmembrane conductance regulator NOT|involved_in ISO (MGI:5640937|PMID:24885604) UniProt PMID:24885604 MGI:5640937 NCBI chr 7:109,449,847...109,633,023
Ensembl chr 7:122,129,798...122,327,864 		JBrowse link
G FGF12 fibroblast growth factor 12 involved_in ISO PMID:12401812 BHF-UCL PMID:12401812 RGD:6484231 NCBI chr 3:189,430,811...190,017,254
Ensembl chr 3:199,778,545...200,358,744 		JBrowse link
G FHL1 four and a half LIM domains 1 involved_in ISO (PMID:18281375) BHF-UCL PMID:18281375 NCBI chr  X:125,270,340...125,334,961
Ensembl chr  X:135,559,321...135,602,375 		JBrowse link
G HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 involved_in ISO
IEA		 RGD
TreeGrafter		 PMID:20806410 GO_REF:0000118 RGD:9686372 NCBI chr 5:64,673,392...65,116,259
Ensembl chr 5:69,724,767...70,158,761 		JBrowse link
G HCN2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr19:521,348...528,203 JBrowse link
G HCN3 hyperpolarization activated cyclic nucleotide gated potassium channel 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 1:130,621,991...130,634,402
Ensembl chr 1:134,227,404...134,240,120 		JBrowse link
G HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr15:52,231,906...52,285,220
Ensembl chr15:70,997,020...71,042,285 		JBrowse link
G NEDD4L NEDD4 like E3 ubiquitin protein ligase involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:51,428,077...51,792,995
Ensembl chr18:54,867,149...55,123,423 		JBrowse link
G NPFF neuropeptide FF-amide peptide precursor ISO RGD PMID:17289819 RGD:2316567 NCBI chr12:35,245,172...35,246,710
Ensembl chr12:36,030,805...36,031,591 		JBrowse link
G NTSR1 neurotensin receptor 1 ISO RGD PMID:15120846 RGD:9743930 NCBI chr20:59,100,110...59,151,563
Ensembl chr20:60,392,736...60,446,056 		JBrowse link
G RANGRF RAN guanine nucleotide release factor involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr17:43,369,556...43,371,025
Ensembl chr17:48,101,744...48,103,394 		JBrowse link
regulation of membrane depolarization during action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLCN2 chloride voltage-gated channel 2 involved_in ISO PMID:8816717 UniProt PMID:8816717 RGD:405650388 NCBI chr 3:181,383,608...181,399,200
Ensembl chr 3:189,862,489...189,881,049 		JBrowse link
G PTPN3 protein tyrosine phosphatase non-receptor type 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:80,528,896...80,651,629
Ensembl chr 9:108,699,761...108,787,464 		JBrowse link
regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV3 caveolin 3 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 3:8,684,829...8,697,731
Ensembl chr 3:8,928,069...8,940,942 		JBrowse link
G GJA5 gap junction protein alpha 5 acts_upstream_of_or_within ISO (PMID:9501070) MGI PMID:9501070 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
G RANGRF RAN guanine nucleotide release factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:43,369,556...43,371,025
Ensembl chr17:48,101,744...48,103,394 		JBrowse link
G SLMAP sarcolemma associated protein involved_in IEA TreeGrafter GO_REF:0000118 NCBI chr 3:57,688,669...57,864,355
Ensembl chr 3:59,108,247...59,280,713 		JBrowse link
regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCD1 ATP binding cassette subfamily D member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:143,275,165...143,295,283
Ensembl chr  X:153,162,412...153,182,424 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15288121) Ensembl
MGI		 PMID:15288121 GO_REF:0000107 NCBI chr 6:53,052,145...53,102,794
Ensembl chr 6:54,687,315...54,734,994 		JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15288121) Ensembl
MGI		 PMID:15288121 GO_REF:0000107 NCBI chr 1:96,548,850...96,573,273
Ensembl chr 1:95,278,665...95,297,893 		JBrowse link
G LRRK2 leucine rich repeat kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:48,343,621...48,488,337
Ensembl chr12:49,205,930...49,350,462 		JBrowse link
G PPP2R3C protein phosphatase 2 regulatory subunit B''gamma involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16129705) Ensembl
MGI		 PMID:16129705 GO_REF:0000107 NCBI chr14:15,834,603...15,871,741
Ensembl chr14:34,020,893...34,056,842 		JBrowse link
regulation of ventricular cardiac muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAV3 caveolin 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:8,684,829...8,697,731
Ensembl chr 3:8,928,069...8,940,942 		JBrowse link
G GJA1 gap junction protein alpha 1 acts_upstream_of_or_within ISO (PMID:10969038)
(PMID:10969038), (PMID:9109444)		 MGI PMID:9109444 PMID:10969038 NCBI chr 6:119,213,513...119,227,617 JBrowse link
G GJA5 gap junction protein alpha 5 acts_upstream_of
acts_upstream_of_or_within		 ISO (MGI:6101691|PMID:26786475)
(PMID:10969038)
(PMID:10515563), (PMID:9501070)		 BHF-UCL
MGI		 PMID:9501070 PMID:10515563 PMID:10969038 PMID:26786475 MGI:6101691 NCBI chr 1:123,200,111...123,224,626
Ensembl chr 1:112,328,337...112,329,413 		JBrowse link
G GPD1L glycerol-3-phosphate dehydrogenase 1 like involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:32,026,586...32,088,512
Ensembl chr 3:32,342,776...32,404,172 		JBrowse link
G SCN3B sodium voltage-gated channel beta subunit 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:118,460,860...118,486,563
Ensembl chr11:122,377,643...122,403,063 		JBrowse link
G SCN5A sodium voltage-gated channel alpha subunit 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:38,444,421...38,546,364
Ensembl chr 3:38,728,897...38,812,202 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16768
    biological regulation 11715
      regulation of biological quality 3140
        regulation of membrane potential 523
          membrane depolarization 104
            membrane depolarization during action potential + 32
            mitochondrial depolarization + 32
            negative regulation of membrane depolarization + 9
            positive regulation of membrane depolarization + 17
            regulation of membrane depolarization + 57
            regulation of vascular associated smooth muscle cell membrane depolarization + 1
paths to the root