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ONTOLOGY REPORT - ANNOTATIONS


Term:membrane depolarization
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Accession:GO:0051899 term browser browse the term
Definition:The process in which membrane potential decreases with respect to its steady-state potential, usually from negative potential to a more positive potential. For example, the initial depolarization during the rising phase of an action potential is in the direction from the negative steady-state resting potential towards the positive membrane potential that will be the peak of the action potential.


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membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor IMP RGD PMID:16644907 RGD:1625443 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
JBrowse link
G Best2 bestrophin 2 involved_in ISO (MGI:3763293|PMID:16912113) RGD PMID:16912113 MGI:3763293 NCBI chr19:23,141,602...23,148,351
Ensembl chr19:23,141,602...23,148,339
JBrowse link
G Cacna1a calcium voltage-gated channel subunit alpha1 A acts_upstream_of_or_within ISO MGI:1856209|MGI:1856210|MGI:1856211 (MGI:1861319|PMID:10908603), (MGI:2153687|PMID:11718712), (MGI:66121|PMID:8158221) RGD PMID:8158221 PMID:10908603 PMID:11718712 MGI:1861319 MGI:2153687 MGI:66121 NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225
JBrowse link
G Cacng2 calcium voltage-gated channel auxiliary subunit gamma 2 acts_upstream_of_or_within ISO MGI:1856548 (MGI:708065|PMID:9065835) RGD PMID:9065835 MGI:708065 NCBI chr 7:109,572,838...109,698,516
Ensembl chr 7:109,574,459...109,697,227
JBrowse link
G Cav1 caveolin 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2180364 (MGI:3707284|PMID:17098833)
Ensembl
RGD
PMID:17098833 GO_REF:0000107 MGI:3707284 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit acts_upstream_of_or_within ISO MGI:1926251|MGI:2158758|MGI:87891 (MGI:1931636|PMID:11226318), (MGI:2673776|PMID:12944511), (MGI:3581093|PMID:15741168), (MGI:3628837|PMID:11222635) RGD PMID:11222635 PMID:11226318 PMID:12944511 PMID:15741168 MGI:1931636 MGI:2673776 MGI:3581093 MGI:3628837 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2179133 (MGI:2673776|PMID:12944511)
Ensembl
RGD
PMID:12944511 GO_REF:0000107 MGI:2673776 NCBI chr16:64,697,741...64,704,441
Ensembl chr16:64,697,741...64,704,441
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit acts_upstream_of_or_within ISO MGI:1926253 (MGI:3628837|PMID:11222635) RGD PMID:11222635 MGI:3628837 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Cnga1 cyclic nucleotide gated channel subunit alpha 1 IDA RGD PMID:18048449 RGD:6902904 NCBI chr14:35,566,947...35,605,065
Ensembl chr14:35,567,125...35,605,065
JBrowse link
G Cnga2 cyclic nucleotide gated channel subunit alpha 2 IDA RGD PMID:18048449 RGD:6902904 NCBI chr  X:149,696,999...149,715,051 JBrowse link
G Cngb1 cyclic nucleotide gated channel subunit beta 1 involved_in ISO
IEA
(MGI:5817509|PMID:28053034)
GO_REF:0000107
RGD
Ensembl
PMID:28053034 GO_REF:0000107 MGI:5817509 NCBI chr19:9,726,595...9,791,111
Ensembl chr19:9,726,595...9,791,173
JBrowse link
G Edn1 endothelin 1 IMP RGD PMID:15655307 RGD:1580292 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 acts_upstream_of_or_within ISO MGI:2176347 (MGI:3769099|PMID:17245443) RGD PMID:17245443 MGI:3769099 NCBI chr11:27,169,739...27,571,131
Ensembl chr11:27,169,740...27,570,645
JBrowse link
G Grm1 glutamate metabotropic receptor 1 involved_in TAS PMID:12514208 UniProt PMID:12514208 RGD:728711 NCBI chr 1:5,058,285...5,453,170
Ensembl chr 1:5,058,292...5,453,170
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit IDA induced in pulmonary artery smooth muscle cells RGD PMID:11571252 RGD:2290591 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kmt2a lysine methyltransferase 2A IEP RGD PMID:20211609 RGD:9588219 NCBI chr 8:45,116,771...45,193,320
Ensembl chr 8:45,118,814...45,193,181
JBrowse link
G P2rx4 purinergic receptor P2X 4 involved_in ISO (PMID:9016352) RGD PMID:9016352 NCBI chr12:33,844,609...33,862,265
Ensembl chr12:33,844,396...33,862,253
JBrowse link
G P2rx7 purinergic receptor P2X 7 involved_in IEA
IDA
ISO
GO_REF:0000107
PMID:8614837
(PMID:9038151)
Ensembl
RGD
PMID:9038151 PMID:8614837 GO_REF:0000107, RGD:69918 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
JBrowse link
G Park7 Parkinsonism associated deglycase acts_upstream_of_or_within ISO MGI:3579140 (MGI:3653054|PMID:16624565) RGD PMID:16624565 MGI:3653054 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Prkcz protein kinase C, zeta IMP RGD PMID:15381257 RGD:1642699 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 involved_in ISO (PMID:21051419) RGD PMID:21051419 NCBI chr 1:86,353,917...86,363,836
Ensembl chr 1:86,353,917...86,363,739
JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in ISO (PMID:21051419) RGD PMID:21051419 NCBI chr 8:40,630,372...40,652,869
Ensembl chr 8:40,630,455...40,652,868
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISS
ISO
GO_REF:0000024
(PMID:14500339), (PMID:21051419), (PMID:21895525)
BHF-UCL
RGD
PMID:14500339 PMID:21051419 PMID:21895525 GO_REF:0000024 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Snap91 synaptosome associated protein 91 IEP RGD PMID:11779129 RGD:70605 NCBI chr 8:87,738,056...87,852,690
Ensembl chr 8:87,738,824...87,852,367
JBrowse link
membrane depolarization during action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1g calcium voltage-gated channel subunit alpha1 G involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
JBrowse link
G Cacna1i calcium voltage-gated channel subunit alpha1 I involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 involved_in ISO
IEA
(PMID:7604285)
GO_REF:0000107
RGD
Ensembl
PMID:7604285 GO_REF:0000107 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614
JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:119,495,550...119,567,044
Ensembl chr 8:119,496,769...119,567,044
JBrowse link
G Scn1a sodium voltage-gated channel alpha subunit 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:50,952,790...51,071,804
Ensembl chr 3:50,952,791...51,071,699
JBrowse link
G Scn2a sodium voltage-gated channel alpha subunit 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:50,302,781...50,437,504
Ensembl chr 3:50,302,877...50,437,214
JBrowse link
G Scn3a sodium voltage-gated channel alpha subunit 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:50,146,411...50,258,119
Ensembl chr 3:50,148,139...50,258,119
JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in ISO (PMID:20042427), (PMID:20226894), (PMID:21051419) RGD PMID:20042427 PMID:20226894 PMID:21051419 NCBI chr 8:40,630,372...40,652,869
Ensembl chr 8:40,630,455...40,652,868
JBrowse link
G Scn4a sodium voltage-gated channel alpha subunit 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:91,246,936...91,296,670
Ensembl chr10:91,246,936...91,296,545
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:14500339), (PMID:18065446), (PMID:22529811)
BHF-UCL
RGD
PMID:14500339 PMID:18065446 PMID:22529811 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Scn7a sodium voltage-gated channel alpha subunit 7 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:51,335,841...51,438,308
Ensembl chr 3:51,335,841...51,438,256
JBrowse link
G Scn8a sodium voltage-gated channel alpha subunit 8 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:131,982,152...132,156,075
Ensembl chr 7:131,982,480...132,151,292
JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:51,145,148...51,293,342
Ensembl chr 3:51,145,146...51,293,516
JBrowse link
G Ywhah tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:16728661)
BHF-UCL
Ensembl
RGD
PMID:16728661 GO_REF:0000024 GO_REF:0000107 NCBI chr14:77,696,332...77,705,715
Ensembl chr14:77,696,333...77,705,741
JBrowse link
membrane depolarization during atrial cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C involved_in ISO
IEA
ISS
(PMID:17224476)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
BHF-UCL
PMID:17224476 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in ISS
ISO
IEA
GO_REF:0000024
(PMID:17224476)
GO_REF:0000107
BHF-UCL
RGD
Ensembl
PMID:17224476 GO_REF:0000024 GO_REF:0000107 NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO
IEA
(PMID:18065446)
GO_REF:0000107
RGD
Ensembl
PMID:18065446 GO_REF:0000107 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
membrane depolarization during AV node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:26253506)
BHF-UCL
Ensembl
RGD
PMID:26253506 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G involved_in ISS
ISO
GO_REF:0000024
(MGI:3714901|PMID:16690884)
BHF-UCL
RGD
PMID:16690884 GO_REF:0000024 MGI:3714901 NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752
JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:17224476)
BHF-UCL
Ensembl
RGD
PMID:17224476 GO_REF:0000024 GO_REF:0000107 NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO
IEA
ISS
(PMID:18616619)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
BHF-UCL
PMID:18616619 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 involved_in IEA
ISO
GO_REF:0000107
(PMID:27207958)
Ensembl
RGD
PMID:27207958 GO_REF:0000107 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532
JBrowse link
membrane depolarization during bundle of His cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 involved_in ISO
IEA
(PMID:21383000)
GO_REF:0000107
RGD
Ensembl
PMID:21383000 GO_REF:0000107 NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO
IEA
ISS
(PMID:18065446)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
BHF-UCL
PMID:18065446 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 involved_in IEA
ISO
GO_REF:0000107
(PMID:27207958)
Ensembl
RGD
PMID:27207958 GO_REF:0000107 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532
JBrowse link
membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1c calcium voltage-gated channel subunit alpha1 C involved_in ISO
ISS
(PMID:15454078)
GO_REF:0000024
RGD
BHF-UCL
PMID:15454078 GO_REF:0000024 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D involved_in IC PMID:21859974 BHF-UCL PMID:21859974 RGD:6767284 NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215
JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 involved_in ISO (MGI:3763979|PMID:17884088) RGD PMID:17884088 MGI:3763979 NCBI chr 1:86,353,917...86,363,836
Ensembl chr 1:86,353,917...86,363,739
JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 involved_in ISO
IBA
(PMID:19808477)
PMID:21873635
RGD PMID:19808477 PMID:21873635 RGD:13792537 NCBI chr 8:45,425,629...45,437,765
Ensembl chr 8:45,425,629...45,437,765
JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in ISO (PMID:21051419) RGD PMID:21051419 NCBI chr 8:40,630,372...40,652,869
Ensembl chr 8:40,630,455...40,652,868
JBrowse link
G Scn4b sodium voltage-gated channel beta subunit 4 involved_in ISO (PMID:17592081) RGD PMID:17592081 NCBI chr 8:45,446,580...45,462,294
Ensembl chr 8:45,446,215...45,462,292
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO
IMP
ISS
(PMID:21895525)
PMID:29457789
GO_REF:0000024
RGD
BHF-UCL
PMID:21895525 PMID:29457789 GO_REF:0000024, RGD:126781740 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
membrane depolarization during Purkinje myocyte cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Scn1b sodium voltage-gated channel beta subunit 1 involved_in ISO (PMID:18464934) RGD PMID:18464934 NCBI chr 1:86,353,917...86,363,836
Ensembl chr 1:86,353,917...86,363,739
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:22766342)
BHF-UCL
Ensembl
RGD
PMID:22766342 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 involved_in IEA
ISO
GO_REF:0000107
(PMID:27207958)
Ensembl
RGD
PMID:27207958 GO_REF:0000107 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532
JBrowse link
membrane depolarization during SA node cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1d calcium voltage-gated channel subunit alpha1 D involved_in
acts_upstream_of_or_within
ISO
IEA
(PMID:21131953)
GO_REF:0000107
MGI:2180141 (MGI:3583874|PMID:12700358)
RGD
Ensembl
PMID:12700358 PMID:21131953 GO_REF:0000107 MGI:3583874 NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215
JBrowse link
G Cacna1g calcium voltage-gated channel subunit alpha1 G involved_in ISS
ISO
GO_REF:0000024
(MGI:3714901|PMID:16690884)
BHF-UCL
RGD
PMID:16690884 GO_REF:0000024 MGI:3714901 NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752
JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 involved_in IEA
ISO
GO_REF:0000107
(PMID:16407510)
Ensembl
RGD
PMID:16407510 GO_REF:0000107 NCBI chr 8:59,222,206...59,259,626
Ensembl chr 8:59,221,653...59,259,639
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:18616619)
BHF-UCL
Ensembl
RGD
PMID:18616619 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp5if1 ATP synthase inhibitory factor subunit 1 involved_in ISO (PMID:24005319) RGD PMID:24005319 NCBI chr 5:144,738,950...144,742,668
Ensembl chr 5:144,738,950...144,742,668
JBrowse link
G Casp1 caspase 1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:5466421|PMID:23028046)
Ensembl
RGD
PMID:23028046 GO_REF:0000107 MGI:5466421 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A involved_in ISO (PMID:25217637) RGD PMID:25217637 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
negative regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 involved_in ISO (MGI:5613732|PMID:25257915) RGD PMID:25257915 MGI:5613732 NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137
JBrowse link
negative regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bok BCL2 family apoptosis regulator BOK involved_in ISO (MGI:5796062|PMID:27098698) RGD PMID:27098698 MGI:5796062 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 IMP RGD PMID:29215467 RGD:13504824 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
JBrowse link
G Hsh2d hematopoietic SH2 domain containing acts_upstream_of_or_within ISO (MGI:3574118|PMID:15569688) RGD PMID:15569688 MGI:3574118 NCBI chr16:17,630,519...17,649,932
Ensembl chr16:17,635,322...17,647,991
JBrowse link
G Ngfr nerve growth factor receptor IMP RGD PMID:19457114 RGD:5508731 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase involved_in ISO (PMID:19767770) RGD PMID:19767770 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
positive regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ank3 ankyrin 3 involved_in IMP PMID:18180363 BHF-UCL PMID:18180363 RGD:6767295 NCBI chr20:18,602,267...19,225,831
Ensembl chr20:18,602,786...19,086,300
JBrowse link
positive regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox12 arachidonate 12-lipoxygenase, 12S type IMP RGD PMID:15564577 RGD:2313870 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542
JBrowse link
G Cck cholecystokinin IDA apoptotic RGD PMID:11964411 RGD:625521 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Dcn decorin acts_upstream_of_or_within ISO UniProtKB:P35968 (PMID:23798385) RGD PMID:23798385 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
JBrowse link
G Kdr kinase insert domain receptor acts_upstream_of_or_within
involved_in
ISO
IEA
UniProtKB:P07585 (PMID:23798385)
GO_REF:0000107
RGD
Ensembl
PMID:23798385 GO_REF:0000107 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Mllt11 MLLT11, transcription factor 7 cofactor involved_in IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:18852119)
UniProt
RGD
PMID:18852119 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 2:182,795,790...182,804,960
Ensembl chr 2:182,795,790...182,797,199
JBrowse link
G Myoc myocilin involved_in ISO
IEA
ISS
(PMID:17516541)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:17516541 GO_REF:0000024 GO_REF:0000107 NCBI chr13:74,976,730...74,987,128
Ensembl chr13:74,976,730...74,987,127
JBrowse link
G Oga O-GlcNAcase IMP RGD PMID:19139380 RGD:2305938 NCBI chr 1:244,598,285...244,633,835
Ensembl chr 1:244,598,292...244,634,359
JBrowse link
G P2rx7 purinergic receptor P2X 7 acts_upstream_of_or_within ISO MGI:2386080 (MGI:3607437|PMID:16198349) RGD PMID:16198349 MGI:3607437 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 IMP protein:increased activity:brain: RGD PMID:21616968 RGD:10413888 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Rack1 receptor for activated C kinase 1 involved_in ISO (PMID:19767770) RGD PMID:19767770 NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975
JBrowse link
G Tspo translocator protein IDA RGD PMID:15183124 RGD:2317155 NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450
JBrowse link
positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trpm4 transient receptor potential cation channel, subfamily M, member 4 IMP RGD PMID:20826763 RGD:10003037 NCBI chr 1:95,781,805...95,812,095
Ensembl chr 1:95,782,000...95,812,532
JBrowse link
regulation of atrial cardiac muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cacna1g calcium voltage-gated channel subunit alpha1 G involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:2182962 (MGI:3714901|PMID:16690884)
Ensembl
RGD
PMID:16690884 GO_REF:0000107 MGI:3714901 NCBI chr10:79,354,998...79,422,960
Ensembl chr10:79,355,008...79,422,752
JBrowse link
G Gja1 gap junction protein, alpha 1 acts_upstream_of_or_within ISO MGI:1857177 (MGI:3639795|PMID:10969038) RGD PMID:10969038 MGI:3639795 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gja5 gap junction protein, alpha 5 involved_in
acts_upstream_of_or_within
ISO (PMID:22247482), (PMID:23348765)
MGI:2445238 (MGI:1197846|PMID:9501070), (MGI:3639795|PMID:10969038), (MGI:3696497|PMID:10515563)
RGD PMID:9501070 PMID:10515563 PMID:10969038 PMID:22247482 PMID:23348765 MGI:1197846 MGI:3639795 MGI:3696497 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952
JBrowse link
G Scn10a sodium voltage-gated channel alpha subunit 10 involved_in
acts_upstream_of_or_within
ISO (PMID:20062061), (PMID:21041692)
MGI:2180183 (MGI:4848026|PMID:20062061)
RGD PMID:20062061 PMID:21041692 MGI:4848026 NCBI chr 8:119,350,723...119,462,882
Ensembl chr 8:119,350,724...119,462,614
JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 involved_in ISO (PMID:19808477), (PMID:22247482) RGD PMID:19808477 PMID:22247482 NCBI chr 1:86,353,917...86,363,836
Ensembl chr 1:86,353,917...86,363,739
JBrowse link
G Scn2b sodium voltage-gated channel beta subunit 2 involved_in ISO (PMID:19808477) RGD PMID:19808477 NCBI chr 8:45,425,629...45,437,765
Ensembl chr 8:45,425,629...45,437,765
JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in ISO (PMID:21051419)
(MGI:5294533|PMID:19796257)
RGD PMID:19796257 PMID:21051419 MGI:5294533 NCBI chr 8:40,630,372...40,652,869
Ensembl chr 8:40,630,455...40,652,868
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in IBA
IEA
ISS
ISO
PMID:21873635
GO_REF:0000107
GO_REF:0000024
(PMID:19167345), (PMID:22247482)
Ensembl
BHF-UCL
RGD
PMID:19167345 PMID:22247482 PMID:21873635 GO_REF:0000024 GO_REF:0000107, RGD:13792537 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Tbx5 T-box transcription factor 5 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
UniProtKB:Q9JJV9 (MGI:5449667|PMID:22728936)
Ensembl
RGD
PMID:22728936 GO_REF:0000107 MGI:5449667 NCBI chr12:36,686,344...36,739,253
Ensembl chr12:36,688,014...36,734,885
JBrowse link
regulation of membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B2m beta-2 microglobulin involved_in ISO (PMID:23144825) RGD PMID:23144825 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
JBrowse link
G Camk2d calcium/calmodulin-dependent protein kinase II delta involved_in ISO (PMID:22514276) RGD PMID:22514276 NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178
JBrowse link
G Cftr CF transmembrane conductance regulator NOT|involved_in ISO (MGI:5640937|PMID:24885604) RGD PMID:24885604 MGI:5640937 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Fgf12 fibroblast growth factor 12 involved_in IDA PMID:12401812 BHF-UCL PMID:12401812 RGD:6484231 NCBI chr11:71,997,049...72,564,965
Ensembl chr11:71,997,099...72,562,607
JBrowse link
G Fhl1 four and a half LIM domains 1 involved_in ISO (PMID:18281375) RGD PMID:18281375 NCBI chr  X:134,555,399...134,614,930
Ensembl chr  X:134,555,479...134,614,928
JBrowse link
G Hcn1 hyperpolarization-activated cyclic nucleotide-gated potassium channel 1 IDA RGD PMID:20806410 RGD:9686372 NCBI chr 2:49,495,771...49,899,702
Ensembl chr 2:49,495,771...49,899,774
JBrowse link
G Hcn4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 involved_in IEA
ISO
GO_REF:0000107
(PMID:12750403)
Ensembl
RGD
PMID:12750403 GO_REF:0000107 NCBI chr 8:59,222,206...59,259,626
Ensembl chr 8:59,221,653...59,259,639
JBrowse link
G Nedd4l NEDD4 like E3 ubiquitin protein ligase involved_in ISO (PMID:15217910) RGD PMID:15217910 NCBI chr18:58,393,759...58,726,709
Ensembl chr18:58,393,509...58,723,137
JBrowse link
G Npff neuropeptide FF-amide peptide precursor IDA RGD PMID:17289819 RGD:2316567 NCBI chr 7:133,654,530...133,655,319 JBrowse link
G Ntsr1 neurotensin receptor 1 IMP RGD PMID:15120846 RGD:9743930 NCBI chr 3:167,606,215...167,656,377
Ensembl chr 3:167,606,215...167,656,377
JBrowse link
G Rangrf RAN guanine nucleotide release factor involved_in ISO (PMID:18184654), (PMID:23420830)
(MGI:5508678|PMID:23420830)
RGD PMID:18184654 PMID:23420830 MGI:5508678 NCBI chr10:53,677,467...53,678,880
Ensembl chr10:53,677,467...53,678,840
JBrowse link
regulation of membrane depolarization during action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptpn3 protein tyrosine phosphatase, non-receptor type 3 involved_in ISO (PMID:16930557) RGD PMID:16930557 NCBI chr 5:71,908,520...72,027,323
Ensembl chr 5:71,911,135...72,065,443
JBrowse link
regulation of membrane depolarization during cardiac muscle cell action potential term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 involved_in ISO
IBA
(PMID:17275750)
PMID:21873635
RGD PMID:17275750 PMID:21873635 RGD:13792537 NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137
JBrowse link
G Gja5 gap junction protein, alpha 5 acts_upstream_of_or_within ISO MGI:2445238 (MGI:1197846|PMID:9501070) RGD PMID:9501070 MGI:1197846 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952
JBrowse link
G Rangrf RAN guanine nucleotide release factor involved_in ISO (PMID:21621375) RGD PMID:21621375 NCBI chr10:53,677,467...53,678,880
Ensembl chr10:53,677,467...53,678,840
JBrowse link
G Slmap sarcolemma associated protein involved_in ISO
IBA
(PMID:23064965)
PMID:21873635
RGD PMID:23064965 PMID:21873635 RGD:13792537 NCBI chr16:1,667,205...1,785,200
Ensembl chr16:1,667,208...1,785,149
JBrowse link
regulation of mitochondrial depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd1 ATP binding cassette subfamily D member 1 involved_in ISO (MGI:5790173|PMID:25583114) RGD PMID:25583114 MGI:5790173 NCBI chr  X:151,428,334...151,450,115
Ensembl chr  X:151,428,578...151,450,115
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit acts_upstream_of_or_within ISO MGI:104995 (MGI:3047441|PMID:15288121) RGD PMID:15288121 MGI:3047441 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit acts_upstream_of_or_within ISO MGI:104990 (MGI:3047441|PMID:15288121) RGD PMID:15288121 MGI:3047441 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 involved_in ISO (PMID:22736029) RGD PMID:22736029 NCBI chr 7:122,826,712...122,987,711
Ensembl chr 7:122,826,696...122,987,703
JBrowse link
G Ppp2r3c protein phosphatase 2, regulatory subunit B'', gamma acts_upstream_of_or_within ISO MGI:3759678 (MGI:3589325|PMID:16129705) RGD PMID:16129705 MGI:3589325 NCBI chr 6:72,647,025...72,670,885
Ensembl chr 6:72,647,025...72,672,491
JBrowse link
regulation of ventricular cardiac muscle cell membrane depolarization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cav3 caveolin 3 involved_in ISO (PMID:17060380) RGD PMID:17060380 NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137
JBrowse link
G Gja1 gap junction protein, alpha 1 acts_upstream_of_or_within ISO MGI:1857177|MGI:95716 (MGI:3639795|PMID:10969038), (MGI:86953|PMID:9109444) RGD PMID:9109444 PMID:10969038 MGI:3639795 MGI:86953 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gja5 gap junction protein, alpha 5 acts_upstream_of_or_within ISO MGI:2445238|MGI:95713 (MGI:1197846|PMID:9501070), (MGI:3639795|PMID:10969038), (MGI:3696497|PMID:10515563)
(MGI:6101691|PMID:26786475)
RGD PMID:9501070 PMID:10515563 PMID:10969038 PMID:26786475 MGI:1197846 MGI:3639795 MGI:3696497 MGI:6101691 NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952
JBrowse link
G Gpd1l glycerol-3-phosphate dehydrogenase 1-like involved_in ISO (PMID:17967977), (PMID:19666841) RGD PMID:17967977 PMID:19666841 NCBI chr 8:114,591,103...114,620,771
Ensembl chr 8:114,588,487...114,620,723
JBrowse link
G Scn3b sodium voltage-gated channel beta subunit 3 involved_in ISO (PMID:20042427) RGD PMID:20042427 NCBI chr 8:40,630,372...40,652,869
Ensembl chr 8:40,630,455...40,652,868
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 involved_in ISO
IEA
ISS
(PMID:18065446), (PMID:22529811), (PMID:7889574)
GO_REF:0000107
GO_REF:0000024
RGD
Ensembl
BHF-UCL
PMID:7889574 PMID:18065446 PMID:22529811 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19492
    biological regulation 13513
      regulation of biological quality 4181
        regulation of membrane potential 488
          membrane depolarization 87
            membrane depolarization during action potential + 31
            mitochondrial depolarization + 24
            negative regulation of membrane depolarization + 6
            positive regulation of membrane depolarization + 13
            regulation of membrane depolarization + 47
            regulation of vascular associated smooth muscle cell membrane depolarization + 1
paths to the root