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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
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Accession:GO:0051898 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase/protein kinase B signal transduction.
Synonyms:exact_synonym: negative regulation of PI3K-PKB/Akt pathway;   negative regulation of PI3K/Akt signal transduction;   negative regulation of PI3K/PKB signal transduction;   negative regulation of phosphatidylinositol 3-kinase signaling/protein kinase B signal transduction
 narrow_synonym: inhibition of protein kinase B signaling cascade
 related_synonym: down regulation of protein kinase B signaling cascade;   downregulation of protein kinase B signaling cascade;   negative regulation of AKT signaling cascade;   negative regulation of AKT signalling cascade;   negative regulation of PKB signaling cascade;   negative regulation of PKB signalling cascade;   negative regulation of protein kinase B signaling;   negative regulation of protein kinase B signaling cascade;   negative regulation of protein kinase B signalling cascade


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negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aim2 absent in melanoma 2 involved_in ISO (PMID:26095253), (PMID:26107252), (PMID:33505023) RGD PMID:26095253 PMID:26107252 PMID:33505023 NCBI chr13:88,397,516...88,439,325
Ensembl chr13:85,866,284...85,906,975 		JBrowse link
G Bank1 B-cell scaffold protein with ankyrin repeats 1 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:88336 (PMID:16546095)		 GO_Central
RGD		 PMID:16546095 GO_REF:0000033 NCBI chr 2:227,203,998...227,474,008
Ensembl chr 2:224,530,475...224,800,405 		JBrowse link
G Btn2a2 butyrophilin, subfamily 2, member A2 acts_upstream_of_or_within ISO MGI:88327 (PMID:23589618) RGD PMID:23589618 NCBI chr17:41,620,807...41,632,621
Ensembl chr17:41,620,839...41,632,618 		JBrowse link
G Cavin3 caveolae associated protein 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:5518819 (PMID:24069528)		 Ensembl
RGD		 PMID:24069528 GO_REF:0000107 NCBI chr 1:159,826,549...159,828,138
Ensembl chr 1:159,826,549...159,828,161 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A involved_in ISO (PMID:19057511) RGD PMID:19057511 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cib1 calcium and integrin binding 1 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:22128142)		 UniProt
Ensembl
RGD		 PMID:22128142 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:143,587,591...143,593,153
Ensembl chr 1:134,178,331...134,213,423 		JBrowse link
G Cntnap2 contactin associated protein 2 involved_in ISO MGI:2677631 (PMID:30816216), (PMID:31874168) RGD PMID:30816216 PMID:31874168 NCBI chr 4:74,109,455...76,366,434
Ensembl chr 4:74,109,472...76,362,027 		JBrowse link
G Cryba1 crystallin, beta A1 IMP RGD PMID:21993393 RGD:10059647 NCBI chr10:62,608,373...62,614,726
Ensembl chr10:62,608,383...62,614,726 		JBrowse link
G Dab2ip DAB2 interacting protein involved_in ISO
ISS
IEA		 (PMID:19903888)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:19903888 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280 		JBrowse link
G Dag1 dystroglycan 1 involved_in ISO (PMID:19587235) RGD PMID:19587235 NCBI chr 8:117,769,517...117,834,347
Ensembl chr 8:108,890,929...108,952,325 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 involved_in ISO
IEA		 (PMID:22761832)
GO_REF:0000107		 RGD
Ensembl		 PMID:22761832 GO_REF:0000107 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:20448149)		 Ensembl
RGD		 PMID:20448149 GO_REF:0000107 NCBI chr11:82,416,853...82,607,797
Ensembl chr11:68,911,883...69,102,689 		JBrowse link
G Drd2 dopamine receptor D2 acts_upstream_of_or_within ISO MGI:2387895|MGI:2675755 (PMID:17251429) RGD PMID:17251429 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Drd3 dopamine receptor D3 acts_upstream_of_or_within ISO MGI:3698033 (PMID:17251429) RGD PMID:17251429 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596 		JBrowse link
G Epha7 Eph receptor A7 involved_in ISO (PMID:19036963) RGD PMID:19036963 NCBI chr 5:42,975,353...43,128,703
Ensembl chr 5:42,975,405...43,127,112 		JBrowse link
G Flcn folliculin involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
MGI:3774416 (PMID:19850877)		 UniProt
RGD		 PMID:19850877 GO_REF:0000024 NCBI chr10:45,088,164...45,107,581
Ensembl chr10:44,588,624...44,607,769 		JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 involved_in ISO
IEA		 (PMID:23840305)
GO_REF:0000107		 RGD
Ensembl		 PMID:23840305 GO_REF:0000107 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889 		JBrowse link
G Hyal2 hyaluronidase 2 involved_in ISO
ISS
IEA		 (PMID:12676986)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:12676986 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:108,241,895...108,246,853
Ensembl chr 8:108,243,133...108,246,850 		JBrowse link
G Igf1r insulin-like growth factor 1 receptor acts_upstream_of_or_within ISO MGI:2386328 (PMID:18451178) RGD PMID:18451178 NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:121,550,743...121,831,777 		JBrowse link
G Inpp5e inositol polyphosphate-5-phosphatase E IDA RGD PMID:21436142 RGD:12911213 NCBI chr 3:29,614,868...29,627,542
Ensembl chr 3:9,216,776...9,229,450 		JBrowse link
G Inpp5f inositol polyphosphate-5-phosphatase F involved_in IC PMID:26908121 ParkinsonsUK-UCL PMID:26908121 RGD:11059577 NCBI chr 1:183,190,480...183,270,276
Ensembl chr 1:183,190,480...183,270,276 		JBrowse link
G Inpp5k inositol polyphosphate-5-phosphatase K involved_in ISO
IBA		 (PMID:12556481)
GO_REF:0000033
(PMID:19250614)		 RGD
GO_Central		 PMID:12556481 PMID:19250614 GO_REF:0000033 NCBI chr10:60,474,262...60,495,813
Ensembl chr10:60,475,897...60,496,773 		JBrowse link
G Klf4 KLF transcription factor 4 involved_in IMP PMID:19531492 UniProt PMID:19531492 RGD:8553301 NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:70,278,972...70,283,602 		JBrowse link
G Lemd2 LEM domain nuclear envelope protein 2 involved_in ISO (PMID:25790465) RGD PMID:25790465 NCBI chr20:5,282,397...5,296,621
Ensembl chr20:5,282,397...5,296,626 		JBrowse link
G Lingo1 leucine rich repeat and Ig domain containing 1 acts_upstream_of_or_within ISO (PMID:17726113) RGD PMID:17726113 NCBI chr 8:57,011,272...57,193,496
Ensembl chr 8:57,010,007...57,196,544 		JBrowse link
G Lox lysyl oxidase acts_upstream_of_or_within ISO MGI:2657016 (PMID:28538980) RGD PMID:28538980 NCBI chr18:48,162,889...48,175,640
Ensembl chr18:45,967,343...46,041,477 		JBrowse link
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 involved_in ISO
ISS
IEA		 (PMID:10760291)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:10760291 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:14,386,389...15,870,036
Ensembl chr 4:14,386,399...15,870,240 		JBrowse link
G Mir143 microRNA 143 acts_upstream_of_or_within ISO (PMID:21441927) RGD PMID:21441927 NCBI chr18:55,101,006...55,101,110
Ensembl chr18:55,101,006...55,101,110 		JBrowse link
G Mir146a microRNA 146a acts_upstream_of ISO UniProtKB:P05067-PRO_0000000092|UniProtKB:P98164 (PMID:27241555) RGD PMID:27241555 NCBI chr10:28,349,996...28,350,090
Ensembl chr10:27,848,516...27,848,610 		JBrowse link
G Mir206 microRNA 206 involved_in ISO (PMID:26175229) RGD PMID:26175229 NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332 		JBrowse link
G Mir20a microRNA 20a acts_upstream_of ISO (PMID:28972028) RGD PMID:28972028 NCBI chr15:98,588,303...98,588,387
Ensembl chr15:92,181,084...92,181,168 		JBrowse link
G Mir29a microRNA 29a involved_in ISO (PMID:25428377) RGD PMID:25428377 NCBI chr 4:60,617,955...60,618,042 JBrowse link
G Mir29b1 microRNA 29b-1 involved_in ISO (PMID:25428377) RGD PMID:25428377 NCBI chr 4:60,618,334...60,618,414
Ensembl chr 4:59,650,986...59,651,067 		JBrowse link
G Mir29b2 microRNA 29b-2 involved_in ISO (PMID:25428377) RGD PMID:25428377 NCBI chr13:106,570,371...106,570,451
Ensembl chr13:106,570,367...106,570,456 		JBrowse link
G Mir423 microRNA 423 acts_upstream_of_or_within_negative_effect ISO (PMID:28411267) RGD PMID:28411267 NCBI chr10:62,412,272...62,412,350
Ensembl chr10:61,914,133...61,914,226 		JBrowse link
G Mir449a microRNA 449a acts_upstream_of ISO (PMID:25487955) RGD PMID:25487955 NCBI chr 2:44,670,714...44,670,804
Ensembl chr 2:44,670,714...44,670,804 		JBrowse link
G Mirlet7f-1 microRNA let7f-1 involved_in ISO (PMID:21962509) RGD PMID:21962509 NCBI chr17:16,114,130...16,114,226
Ensembl chr17:16,114,130...16,114,226 		JBrowse link
G Mirlet7f2 microRNA let-7f-2 involved_in ISO (PMID:21962509) RGD PMID:21962509 NCBI chr  X:20,980,632...20,980,714
Ensembl chr  X:20,980,632...20,980,714 		JBrowse link
G Mmp3 matrix metallopeptidase 3 involved_in IEA
ISO		 GO_REF:0000107
(PMID:20969476)		 Ensembl
RGD		 PMID:20969476 GO_REF:0000107 NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:4,640,416...4,653,961 		JBrowse link
G Mstn myostatin involved_in ISO (PMID:19357233) RGD PMID:19357233 NCBI chr 9:55,944,513...55,950,913
Ensembl chr 9:48,452,533...48,458,933 		JBrowse link
G Mtm1 myotubularin 1 acts_upstream_of_or_within ISO MGI:2450997 (PMID:23695157) RGD PMID:23695157 NCBI chr 6:6,234,917...6,252,874
Ensembl chr 6:488,969...506,860 		JBrowse link
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 involved_in ISO (PMID:22410793) RGD PMID:22410793 NCBI chr 5:155,936,112...155,945,163
Ensembl chr 5:150,652,812...150,661,863 		JBrowse link
G Ncor1 nuclear receptor co-repressor 1 acts_upstream_of_or_within ISO (PMID:17606624) RGD PMID:17606624 NCBI chr10:46,999,536...47,142,294
Ensembl chr10:46,999,536...47,141,032 		JBrowse link
G Nherf1 NHERF family PDZ scaffold protein 1 involved_in
acts_upstream_of_or_within		 ISO
ISS		 (PMID:20736378)
GO_REF:0000024
MGI:97528 (PMID:16456542)
(PMID:16456542), (PMID:18190691)		 RGD
UniProt		 PMID:16456542 PMID:18190691 PMID:20736378 GO_REF:0000024 NCBI chr10:100,403,189...100,420,290
Ensembl chr10:100,403,069...100,420,598 		JBrowse link
G Nherf2 NHERF family PDZ scaffold protein 2 acts_upstream_of_or_within ISO MGI:97528 (PMID:16456542) RGD PMID:16456542 NCBI chr10:13,662,461...13,672,975
Ensembl chr10:13,662,461...13,673,049 		JBrowse link
G Nlrc3 NLR family, CARD domain containing 3 involved_in ISO (PMID:27951586) RGD PMID:27951586 NCBI chr10:11,551,378...11,585,027
Ensembl chr10:11,551,356...11,584,398 		JBrowse link
G Nop53 NOP53 ribosome biogenesis factor involved_in ISO (PMID:16971513), (PMID:27729611) RGD PMID:16971513 PMID:27729611 NCBI chr 1:76,629,084...76,636,902
Ensembl chr 1:76,629,069...76,636,902 		JBrowse link
G Obscn obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF involved_in ISO (PMID:28826662) RGD PMID:28826662 NCBI chr10:43,774,113...43,919,718
Ensembl chr10:43,789,293...43,919,723 		JBrowse link
G Otud3 OTU deubiquitinase 3 acts_upstream_of_or_within ISO (PMID:26280536) RGD PMID:26280536 NCBI chr 5:151,135,826...151,162,207
Ensembl chr 5:151,140,059...151,163,560 		JBrowse link
G Pdcd6 programmed cell death 6 involved_in ISO (PMID:21893193) RGD PMID:21893193 NCBI chr 1:28,966,518...28,982,188
Ensembl chr 1:28,966,518...28,982,189 		JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 involved_in ISO
ISS
IBA		 (PMID:19203586)
GO_REF:0000024
GO_REF:0000033		 RGD
UniProt
GO_Central		 PMID:19203586 GO_REF:0000024 GO_REF:0000033 NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335 		JBrowse link
G Phlpp1 PH domain and leucine rich repeat protein phosphatase 1 involved_in IMP
ISO
IEA		 (PMID:17386267)
PMID:20819118
GO_REF:0000107		 RGD
Ensembl		 PMID:17386267 PMID:20819118 PMID:20819118 GO_REF:0000107, RGD:8693633, RGD:8693633 NCBI chr13:22,308,532...22,530,978
Ensembl chr13:22,308,548...22,530,977 		JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:P15692 (PMID:30496354)		 Ensembl
RGD		 PMID:30496354 GO_REF:0000107 NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:99,594,644...99,699,663 		JBrowse link
G Pik3ip1 phosphoinositide-3-kinase interacting protein 1 involved_in ISO
IEA
IBA		 (PMID:17475214)
GO_REF:0000107
GO_REF:0000033		 RGD
Ensembl
GO_Central		 PMID:17475214 GO_REF:0000033 GO_REF:0000107 NCBI chr14:78,204,668...78,216,616
Ensembl chr14:78,204,053...78,216,608 		JBrowse link
G Pip5kl1 phosphatidylinositol-4-phosphate 5-kinase-like 1 involved_in ISO (PMID:19680787) RGD PMID:19680787 NCBI chr 3:15,860,493...15,869,264
Ensembl chr 3:15,855,946...15,869,165 		JBrowse link
G Pkhd1 PKHD1 ciliary IPT domain containing fibrocystin/polyductin involved_in ISO (PMID:21300060) RGD PMID:21300060 NCBI chr 9:22,547,396...23,037,443
Ensembl chr 9:22,549,513...23,037,381 		JBrowse link
G Plekha1 pleckstrin homology domain containing A1 involved_in ISO
IBA		 (PMID:14516276)
GO_REF:0000033		 RGD
GO_Central		 PMID:14516276 GO_REF:0000033 NCBI chr 1:194,858,239...194,909,418
Ensembl chr 1:185,428,048...185,479,156 		JBrowse link
G Plk3 polo-like kinase 3 involved_in ISS
ISO		 GO_REF:0000024
(PMID:20940307)		 UniProt
RGD		 PMID:20940307 GO_REF:0000024 NCBI chr 5:135,843,725...135,848,900
Ensembl chr 5:130,607,142...130,612,317 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha acts_upstream_of_or_within ISO (PMID:31574452) RGD PMID:31574452 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha acts_upstream_of_or_within
involved_in		 ISO
ISS		 (PMID:21806946)
GO_REF:0000024
(PMID:26974206)		 RGD
UniProt		 PMID:21806946 PMID:26974206 GO_REF:0000024 NCBI chr10:36,856,534...36,878,789
Ensembl chr10:36,358,101...36,377,862 		JBrowse link
G Ppp2r1a protein phosphatase 2 scaffold subunit A alpha involved_in ISO (PMID:26974206) RGD PMID:26974206 NCBI chr 1:69,213,198...69,232,441
Ensembl chr 1:60,540,194...60,560,129 		JBrowse link
G Pten phosphatase and tensin homolog acts_upstream_of_or_within
involved_in		 ISO (PMID:26280536)
(PMID:10760291), (PMID:21573166), (PMID:22879939), (PMID:31492966)
MGI:2156086|MGI:5051834 (PMID:20448149), (PMID:25512490)
(PMID:10339565), (PMID:16675393), (PMID:19147652), (PMID:20940307)		 RGD PMID:10339565 PMID:10760291 PMID:16675393 PMID:19147652 PMID:20448149 More... NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 IMP RGD PMID:31502193 RGD:401976382 NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:156,638,769...156,687,504 		JBrowse link
G Ptprj protein tyrosine phosphatase, receptor type, J involved_in ISO (PMID:19922411) RGD PMID:19922411 NCBI chr 3:76,405,917...76,561,842
Ensembl chr 3:76,405,927...76,562,260 		JBrowse link
G Rack1 receptor for activated C kinase 1 involved_in ISO (PMID:19767770) RGD PMID:19767770 NCBI chr10:33,668,560...33,676,031
Ensembl chr10:33,169,169...33,174,975 		JBrowse link
G Rapgef1 Rap guanine nucleotide exchange factor 1 acts_upstream_of_or_within ISO MGI:95516 (PMID:16858399) RGD PMID:16858399 NCBI chr 3:33,296,211...33,414,119
Ensembl chr 3:12,898,266...13,013,984 		JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 involved_in ISO (PMID:24453251) RGD PMID:24453251 NCBI chr20:1,329,227...1,333,394
Ensembl chr20:1,287,521...1,328,117 		JBrowse link
G Rubcn rubicon autophagy regulator involved_in ISO (PMID:21062745) RGD PMID:21062745 NCBI chr11:81,420,261...81,469,415
Ensembl chr11:67,907,516...67,964,314 		JBrowse link
G Sco1 synthesis of cytochrome C oxidase 1 acts_upstream_of_or_within ISO (PMID:28647369) RGD PMID:28647369 NCBI chr10:51,744,656...51,757,246
Ensembl chr10:51,744,656...51,757,237 		JBrowse link
G Serpine2 serpin family E member 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:88380 (PMID:18398001)		 Ensembl
RGD		 PMID:18398001 GO_REF:0000107 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826 		JBrowse link
G Sfrp5 secreted frizzled-related protein 5 involved_in ISO (PMID:19957335) RGD PMID:19957335 NCBI chr 1:241,006,762...241,011,224
Ensembl chr 1:241,006,762...241,011,224 		JBrowse link
G Sh2b3 SH2B adaptor protein 3 involved_in ISO
IEA		 (PMID:15337790)
GO_REF:0000107		 RGD
Ensembl		 PMID:15337790 GO_REF:0000107 NCBI chr12:40,391,755...40,414,336
Ensembl chr12:34,731,911...34,753,616 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO
IEA		 (PMID:21149730)
GO_REF:0000107		 RGD
Ensembl		 PMID:21149730 GO_REF:0000107 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sirt7 sirtuin 7 involved_in ISO (PMID:28147277) RGD PMID:28147277 NCBI chr10:106,394,802...106,401,627
Ensembl chr10:105,896,476...105,903,172 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:24505141)		 Ensembl
RGD		 PMID:24505141 GO_REF:0000107 NCBI chr19:34,162,337...34,245,786
Ensembl chr19:34,162,341...34,245,749 		JBrowse link
G Stambp Stam binding protein involved_in ISO (PMID:23542699) RGD PMID:23542699 NCBI chr 4:116,055,563...116,083,563
Ensembl chr 4:116,056,057...116,080,543 		JBrowse link
G Them4 thioesterase superfamily member 4 involved_in ISO
ISS		 (PMID:19168129)
GO_REF:0000024		 RGD
UniProt		 PMID:19168129 GO_REF:0000024 NCBI chr 2:181,953,550...181,974,708
Ensembl chr 2:181,953,550...181,974,708 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (PMID:30683932)
(PMID:29663649)		 RGD PMID:29663649 PMID:30683932 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170 		JBrowse link
G Tsc2 TSC complex subunit 2 involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
MGI:109583|MGI:1857938 (PMID:16027169)		 GO_Central
RGD		 PMID:16027169 GO_REF:0000033 NCBI chr10:14,125,679...14,160,317
Ensembl chr10:13,621,136...13,655,951 		JBrowse link
G Tsc2_v1 TSC complex subunit 2, variant 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Tsc2_v2 TSC complex subunit 2, variant 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033
G Twist1 twist family bHLH transcription factor 1 involved_in ISO (PMID:17003487) RGD PMID:17003487 NCBI chr 6:56,402,309...56,404,303
Ensembl chr 6:50,674,678...50,677,653 		JBrowse link
G Usp49 ubiquitin specific peptidase 49 involved_in ISO (PMID:28363942) RGD PMID:28363942 NCBI chr 9:13,305,640...13,366,132
Ensembl chr 9:13,308,178...13,366,132 		JBrowse link
G Wdr91 WD repeat domain 91 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:63,554,364...63,591,733
Ensembl chr 4:63,554,364...63,591,733 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20546
    negative regulation of biological process 5818
      negative regulation of signaling 1652
        negative regulation of signal transduction 1504
          negative regulation of intracellular signal transduction 787
            negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 84
Path 2
Term Annotations click to browse term
  biological_process 20546
    biological regulation 13834
      regulation of biological process 13389
        signaling 7822
          signal transduction 7262
            intracellular signal transduction 3154
              intracellular signaling cassette 2026
                phosphatidylinositol 3-kinase/protein kinase B signal transduction 353
                  regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 309
                    negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction 84
paths to the root