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ONTOLOGY REPORT - ANNOTATIONS


Term:methotrexate binding
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Accession:GO:0051870 term browser browse the term
Definition:Interacting selectively and non-covalently with methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.


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methotrexate binding term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhfr dihydrofolate reductase enables ISO (PMID:2303423) RGD PMID:2303423 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453
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G Folr1 folate receptor alpha enables ISO (PMID:19116913) RGD PMID:19116913 NCBI chr 1:166,934,457...166,945,864
Ensembl chr 1:166,934,460...166,943,592
JBrowse link
G Folr2 folate receptor beta enables ISO (PMID:19116913) RGD PMID:19116913 NCBI chr 1:166,915,045...166,933,377
Ensembl chr 1:166,915,045...166,919,302
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 20509
    binding 17315
      drug binding 44
        methotrexate binding 3
Path 2
Term Annotations click to browse term
  molecular_function 20509
    binding 17315
      ion binding 5372
        anion binding 2415
          carboxylic acid binding 190
            methotrexate binding 3
paths to the root