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ONTOLOGY REPORT - ANNOTATIONS


Term:methotrexate binding
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Accession:GO:0051870 term browser browse the term
Definition:Binding to methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.



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  molecular_function 19910
    binding 16997
      organic cyclic compound binding 5704
        methotrexate binding 0
Path 2
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  molecular_function 19910
    binding 16997
      ion binding 5265
        anion binding 2362
          carboxylic acid binding 187
            methotrexate binding 0
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