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ONTOLOGY REPORT - ANNOTATIONS


Term:methotrexate binding
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Accession:GO:0051870 term browser browse the term
Definition:Interacting selectively and non-covalently with methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.


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methotrexate binding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dhfr dihydrofolate reductase JBrowse link 2 21,931,887 21,958,927 RGD:1624291
G Folr1 folate receptor alpha JBrowse link 1 166,934,457 166,945,864 RGD:1624291
G Folr2 folate receptor beta JBrowse link 1 166,915,045 166,933,377 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  molecular_function 19527
    binding 15910
      organic cyclic compound binding 5784
        methotrexate binding 3
Path 2
Term Annotations click to browse term
  molecular_function 19527
    binding 15910
      small molecule binding 2591
        organic acid binding 252
          carboxylic acid binding 238
            methotrexate binding 3
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.