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ONTOLOGY REPORT - ANNOTATIONS

Term:methotrexate binding
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Accession:GO:0051870 term browser browse the term
Definition:Binding to methotrexate, an antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of tetrahydrofolate reductase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.


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  molecular_function 21091
    binding 18088
      amide binding 243
        methotrexate binding 0
Path 2
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  molecular_function 21091
    binding 18088
      small molecule binding 6429
        ion binding 6155
          anion binding 2611
            carboxylic acid binding 205
              methotrexate binding 0
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