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ONTOLOGY REPORT - ANNOTATIONS

Term:nitric-oxide synthase biosynthetic process
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Accession:GO:0051767 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of a nitric-oxide synthase, an enzyme which catalyzes the reaction L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+.
Synonyms:exact_synonym: NO synthase biosynthesis;   NO synthase biosynthetic process;   NOS biosynthesis;   NOS biosynthetic process
 narrow_synonym: NOS1 biosynthesis;   NOS2 biosynthesis;   NOS2 synthase biosynthesis;   NOS2 synthase biosynthetic process;   NOS3 biosynthesis;   brain nitric-oxide synthase biosynthetic process;   endothelial nitric-oxide synthase biosynthetic process;   inducible nitric-oxide synthase biosynthetic process;   nitric-oxide synthase (type 2) biosynthesis;   nitric-oxide synthase (type 2) biosynthetic process;   nitric-oxide synthase (type II) biosynthesis;   nitric-oxide synthase (type II) biosynthetic process;   nitric-oxide synthase 2 biosynthetic process;   nitric-oxide synthase-1 biosynthetic process;   nitric-oxide synthase-3 biosynthetic process
 alt_id: GO:0051768
 never_in_taxon: NCBITaxon:4751 ! Fungi


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negative regulation of nitric-oxide synthase biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:12,076,312...12,142,861
Ensembl chr 6:12,462,718...12,503,545 		JBrowse link
G FNTA farnesyltransferase, CAAX box, subunit alpha ISO RGD PMID:9153192 RGD:2302974 NCBI chr 8:42,303,987...42,333,743
Ensembl chr 8:39,743,768...39,774,031 		JBrowse link
G GSTP1 glutathione S-transferase pi 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:62,942,756...62,945,701
Ensembl chr11:66,253,421...66,256,472 		JBrowse link
G PGGT1B protein geranylgeranyltransferase type I subunit beta ISO RGD PMID:9153192 RGD:2302974 NCBI chr 5:110,558,684...110,622,175
Ensembl chr 5:116,366,984...116,419,069 		JBrowse link
G PTGER4 prostaglandin E receptor 4 ISO RGD PMID:11991626 RGD:10003093 NCBI chr 5:69,686,906...69,700,739
Ensembl chr 5:74,731,470...74,745,148 		JBrowse link
G SELENOS selenoprotein S involved_in ISO (PMID:18675776) BHF-UCL PMID:18675776 NCBI chr15:79,995,678...80,002,159
Ensembl chr15:99,279,203...99,285,682 		JBrowse link
positive regulation of nitric-oxide synthase biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKAP12 A-kinase anchoring protein 12 ISO RGD PMID:19937403 RGD:14348968 NCBI chr 6:149,058,350...149,176,710
Ensembl chr 6:153,757,081...153,873,925 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 involved_in ISO (MGI:4943659|PMID:19164781) BHF-UCL PMID:19164781 MGI:4943659 NCBI chr17:22,528,154...22,530,091
Ensembl chr17:22,820,890...22,823,384 		JBrowse link
G CCL20 C-C motif chemokine ligand 20 ISO RGD PMID:19428685 RGD:7488896 NCBI chr2B:115,052,768...115,056,479
Ensembl chr2B:233,862,505...233,866,225 		JBrowse link
G CPEB1 cytoplasmic polyadenylation element binding protein 1 ISO RGD PMID:21620800 RGD:9685153 NCBI chr15:62,949,264...63,053,994
Ensembl chr15:80,443,096...80,526,948 		JBrowse link
G FCER2 Fc epsilon receptor II involved_in IEA Ensembl GO_REF:0000107 NCBI chr19:6,978,116...6,989,986
Ensembl chr19:7,834,106...7,844,924 		JBrowse link
G FNTA farnesyltransferase, CAAX box, subunit alpha ISO RGD PMID:9153192 RGD:2302974 NCBI chr 8:42,303,987...42,333,743
Ensembl chr 8:39,743,768...39,774,031 		JBrowse link
G FNTB farnesyltransferase, CAAX box, subunit beta ISO RGD PMID:9153192 RGD:2302974 NCBI chr14:45,568,511...45,643,952
Ensembl chr14:64,448,170...64,522,632 		JBrowse link
G IFNG interferon gamma involved_in ISO (MGI:5776417|PMID:26227742)
(MGI:6304699|PMID:29061364)		 ARUK-UCL PMID:26227742 PMID:29061364 MGI:5776417 MGI:6304699 NCBI chr12:65,663,764...65,668,732
Ensembl chr12:68,448,861...68,453,829 		JBrowse link
G IL33 interleukin 33 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:6414704|PMID:26936882) ARUK-UCL
Ensembl		 PMID:26936882 GO_REF:0000107 MGI:6414704 NCBI chr 9:6,027,014...6,069,540
Ensembl chr 9:6,234,178...6,248,624 		JBrowse link
G JAK2 Janus kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:4,820,303...4,971,867
Ensembl chr 9:5,006,271...5,156,626 		JBrowse link
G JAK3 Janus kinase 3 ISO RGD PMID:22788969 RGD:11533941 NCBI chr19:17,299,129...17,330,700
Ensembl chr19:18,283,560...18,300,964 		JBrowse link
G KDR kinase insert domain receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:68,813,894...68,861,018
Ensembl chr 4:75,377,375...75,427,109 		JBrowse link
G LRRK2 leucine rich repeat kinase 2 ISO RGD PMID:22302802 RGD:13462052 NCBI chr12:48,343,621...48,488,337
Ensembl chr12:49,205,930...49,350,462 		JBrowse link
G MAP2K4 mitogen-activated protein kinase kinase 4 ISO RGD PMID:10593906 RGD:2304240 NCBI chr17:39,497,105...39,622,331
Ensembl chr17:44,248,857...44,359,909 		JBrowse link
G MAP2K6 mitogen-activated protein kinase kinase 6 ISO RGD PMID:10593906 RGD:2304240 NCBI chr17:63,342,720...63,483,926
Ensembl chr17:68,730,011...68,870,454 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 ISO RGD PMID:10593906 RGD:2304240 NCBI chr 5:175,437,167...175,495,469
Ensembl chr 5:182,748,381...182,795,135 		JBrowse link
G NAMPT nicotinamide phosphoribosyltransferase involved_in ISO (PMID:19727662) BHF-UCL PMID:19727662 NCBI chr 7:98,227,071...98,262,254
Ensembl chr 7:110,952,876...110,981,967 		JBrowse link
G NOD2 nucleotide binding oligomerization domain containing 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:30,955,976...30,995,451
Ensembl chr16:49,837,891...49,873,773 		JBrowse link
G STAT1 signal transducer and activator of transcription 1 ISO RGD PMID:22788969 RGD:11533941 NCBI chr2B:78,270,642...78,316,074
Ensembl chr2B:196,186,906...196,232,280 		JBrowse link
G TLR2 toll like receptor 2 involved_in ISO (MGI:4456948|PMID:15356140) BHF-UCL PMID:15356140 MGI:4456948 NCBI chr 4:146,024,653...146,091,388
Ensembl chr 4:157,866,977...157,869,331 		JBrowse link
G TLR4 toll like receptor 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:88,827,495...88,840,458
Ensembl chr 9:117,180,550...117,190,711 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16313
    metabolic process 10179
      organic substance metabolic process 9739
        macromolecule metabolic process 8210
          macromolecule biosynthetic process 6359
            nitric-oxide synthase biosynthetic process 26
              negative regulation of nitric-oxide synthase biosynthetic process 6
              positive regulation of nitric-oxide synthase biosynthetic process 21
              regulation of nitric-oxide synthase biosynthetic process + 26
paths to the root