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ONTOLOGY REPORT - ANNOTATIONS

Term:nitric-oxide synthase biosynthetic process
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Accession:GO:0051767 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of a nitric-oxide synthase, an enzyme which catalyzes the reaction L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+.
Synonyms:exact_synonym: NO synthase biosynthesis;   NO synthase biosynthetic process;   NOS biosynthesis;   NOS biosynthetic process
 narrow_synonym: NOS1 biosynthesis;   NOS2 biosynthesis;   NOS2 synthase biosynthesis;   NOS2 synthase biosynthetic process;   NOS3 biosynthesis;   brain nitric-oxide synthase biosynthetic process;   endothelial nitric-oxide synthase biosynthetic process;   inducible nitric-oxide synthase biosynthetic process;   nitric-oxide synthase (type 2) biosynthesis;   nitric-oxide synthase (type 2) biosynthetic process;   nitric-oxide synthase (type II) biosynthesis;   nitric-oxide synthase (type II) biosynthetic process;   nitric-oxide synthase 2 biosynthetic process;   nitric-oxide synthase-1 biosynthetic process;   nitric-oxide synthase-3 biosynthetic process
 alt_id: GO:0051768

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negative regulation of nitric-oxide synthase biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 ISO (PMID:16820593) RGD PMID:16820593 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Fnta farnesyltransferase, CAAX box, alpha IMP RGD PMID:9153192 RGD:2302974 NCBI chr16:70,834,957...70,854,724
Ensembl chr16:70,834,957...70,854,724 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO
ISS		 (PMID:18962899)
(MGI:5009376|PMID:18962899), (MGI:5009411|PMID:16023107)
GO_REF:0000024		 RGD
BHF-UCL		 PMID:16023107 PMID:18962899 GO_REF:0000024 MGI:5009376 MGI:5009411 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147 		JBrowse link
G Pggt1b protein geranylgeranyltransferase type I subunit beta IMP RGD PMID:9153192 RGD:2302974 NCBI chr18:40,173,236...40,218,225
Ensembl chr18:40,175,951...40,218,225 		JBrowse link
G Ptger4 prostaglandin E receptor 4 IMP RGD PMID:11991626 RGD:10003093 NCBI chr 2:54,951,625...54,966,470
Ensembl chr 2:54,952,821...54,963,448 		JBrowse link
G Selenos selenoprotein S ISO (PMID:18675776) RGD PMID:18675776 NCBI chr 1:126,979,579...126,989,344
Ensembl chr 1:126,979,575...126,989,344 		JBrowse link
positive regulation of nitric-oxide synthase biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap12 A-kinase anchoring protein 12 IMP RGD PMID:19937403 RGD:14348968 NCBI chr 1:40,816,130...40,906,582
Ensembl chr 1:40,816,107...40,906,581 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 ISO (MGI:4943659|PMID:19164781) RGD PMID:19164781 MGI:4943659 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 IDA RGD PMID:19428685 RGD:7488896 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001 		JBrowse link
G Cpeb1 cytoplasmic polyadenylation element binding protein 1 IMP RGD PMID:21620800 RGD:9685153 NCBI chr 1:143,171,457...143,278,485
Ensembl chr 1:143,171,264...143,278,485 		JBrowse link
G Fcer2 Fc fragment of IgE receptor II ISO (PMID:7544003) RGD PMID:7544003 NCBI chr12:2,233,772...2,245,324
Ensembl chr12:2,233,778...2,245,324 		JBrowse link
G Fnta farnesyltransferase, CAAX box, alpha IMP RGD PMID:9153192 RGD:2302974 NCBI chr16:70,834,957...70,854,724
Ensembl chr16:70,834,957...70,854,724 		JBrowse link
G Fntb farnesyltransferase, CAAX box, beta IMP RGD PMID:9153192 RGD:2302974 NCBI chr 6:99,883,959...99,966,988
Ensembl chr 6:99,883,959...99,966,988 		JBrowse link
G Ifng interferon gamma ISO UniProtKB:P05067|UniProtKB:P49768 (MGI:5776417|PMID:26227742), (MGI:6304699|PMID:29061364) RGD PMID:26227742 PMID:29061364 MGI:5776417 MGI:6304699 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il33 interleukin 33 IEA
ISO		 GO_REF:0000107
(MGI:6414704|PMID:26936882)		 Ensembl
RGD		 PMID:26936882 GO_REF:0000107 MGI:6414704 NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029 		JBrowse link
G Jak2 Janus kinase 2 IDA
ISO		 PMID:11536325
UniProtKB:P01580 (MGI:5009182|PMID:12426001), (MGI:5009205|PMID:10600756), (MGI:5776417|PMID:26227742)		 RGD PMID:10600756 PMID:12426001 PMID:26227742, PMID:11536325 MGI:5009182 MGI:5009205 MGI:5776417, RGD:8553830 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509 		JBrowse link
G Jak3 Janus kinase 3 IMP RGD PMID:22788969 RGD:11533941 NCBI chr16:20,107,471...20,120,678
Ensembl chr16:20,109,200...20,120,668 		JBrowse link
G Kdr kinase insert domain receptor ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:10600473), (PMID:9837777)		 UniProt
Ensembl
RGD		 PMID:9837777 PMID:10600473 GO_REF:0000024 GO_REF:0000107 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183 		JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 IMP RGD PMID:22302802 RGD:13462052 NCBI chr 7:132,857,311...133,018,549
Ensembl chr 7:132,857,628...133,018,584 		JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 IMP RGD PMID:10593906 RGD:2304240 NCBI chr10:45,089,455...45,110,802
Ensembl chr10:47,182,433...47,203,753 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 IMP RGD PMID:10593906 RGD:2304240 NCBI chr10:52,196,121...52,301,887
Ensembl chr10:52,196,124...52,290,657 		JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 IMP RGD PMID:10593906 RGD:2304240 NCBI chr10:98,707,160...98,823,054
Ensembl chr10:98,706,960...98,823,287 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 IMP RGD PMID:10593906 RGD:2304240 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase ISO (PMID:19727662) RGD PMID:19727662 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 ISO (MGI:4946442|PMID:21156799) RGD PMID:21156799 MGI:4946442 NCBI chr19:19,342,061...19,389,366
Ensembl chr19:19,332,594...19,377,492 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 IMP RGD PMID:22788969 RGD:11533941 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533 		JBrowse link
G Tlr2 toll-like receptor 2 ISO (MGI:4456948|PMID:15356140) RGD PMID:15356140 MGI:4456948 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061 		JBrowse link
G Tlr4 toll-like receptor 4 IEA
ISO		 GO_REF:0000107
(MGI:4456948|PMID:15356140)		 Ensembl
RGD		 PMID:15356140 GO_REF:0000107 MGI:4456948 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
G Tlr9 toll-like receptor 9 ISO (MGI:4456948|PMID:15356140) RGD PMID:15356140 MGI:4456948 NCBI chr 8:114,916,122...114,920,171
Ensembl chr 8:114,916,122...114,920,171 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20045
    metabolic process 12101
      organic substance metabolic process 11622
        macromolecule metabolic process 10033
          macromolecule biosynthetic process 5161
            nitric-oxide synthase biosynthetic process 28
              negative regulation of nitric-oxide synthase biosynthetic process 6
              positive regulation of nitric-oxide synthase biosynthetic process 23
              regulation of nitric-oxide synthase biosynthetic process + 28
paths to the root