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ONTOLOGY REPORT - ANNOTATIONS


Term:nitric-oxide synthase biosynthetic process
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Accession:GO:0051767 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of a nitric-oxide synthase, an enzyme which catalyzes the reaction L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+.
Synonyms:exact_synonym: NO synthase biosynthesis;   NO synthase biosynthetic process;   NOS biosynthesis;   NOS biosynthetic process
 narrow_synonym: NOS1 biosynthesis;   NOS2 biosynthesis;   NOS2 synthase biosynthesis;   NOS2 synthase biosynthetic process;   NOS3 biosynthesis;   brain nitric-oxide synthase biosynthetic process;   endothelial nitric-oxide synthase biosynthetic process;   inducible nitric-oxide synthase biosynthetic process;   nitric-oxide synthase (type 2) biosynthesis;   nitric-oxide synthase (type 2) biosynthetic process;   nitric-oxide synthase (type II) biosynthesis;   nitric-oxide synthase (type II) biosynthetic process;   nitric-oxide synthase 2 biosynthetic process;   nitric-oxide synthase-1 biosynthetic process;   nitric-oxide synthase-3 biosynthetic process
 alt_id: GO:0051768



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negative regulation of nitric-oxide synthase biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 involved_in ISO (PMID:16820593) RGD PMID:16820593 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Fnta farnesyltransferase, CAAX box, alpha IMP RGD PMID:9153192 RGD:2302974 NCBI chr16:66,065,131...66,083,460
Ensembl chr16:66,065,132...66,083,460
JBrowse link
G Gstp1 glutathione S-transferase pi 1 involved_in ISO
ISS
(PMID:18962899)
(MGI:5009376|PMID:18962899), (MGI:5009411|PMID:16023107)
GO_REF:0000024
RGD
BHF-UCL
PMID:16023107 PMID:18962899 GO_REF:0000024 MGI:5009376 MGI:5009411 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Pggt1b protein geranylgeranyltransferase type I subunit beta IMP RGD PMID:9153192 RGD:2302974 NCBI chr18:38,952,147...38,995,656
Ensembl chr18:38,952,914...38,995,503
JBrowse link
G Ptger4 prostaglandin E receptor 4 IMP RGD PMID:11991626 RGD:10003093 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670
JBrowse link
G Selenos selenoprotein S involved_in ISO
IEA
(PMID:18675776)
GO_REF:0000107
RGD
Ensembl
PMID:18675776 GO_REF:0000107 NCBI chr 1:119,659,779...119,669,546
Ensembl chr 1:119,659,751...119,669,833
JBrowse link
positive regulation of nitric-oxide synthase biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akap12 A-kinase anchoring protein 12 IMP RGD PMID:19937403 RGD:14348968 NCBI chr 1:40,730,123...40,819,863
Ensembl chr 1:40,730,123...40,819,886
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 involved_in ISO (MGI:4943659|PMID:19164781) RGD PMID:19164781 MGI:4943659 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 IDA RGD PMID:19428685 RGD:7488896 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Cpeb1 cytoplasmic polyadenylation element binding protein 1 IMP RGD PMID:21620800 RGD:9685153 NCBI chr 1:135,300,048...135,407,688
Ensembl chr 1:135,300,461...135,409,760
JBrowse link
G Fcer2 Fc epsilon receptor II involved_in ISO (PMID:7544003) RGD PMID:7544003 NCBI chr12:1,742,809...1,754,476
Ensembl chr12:1,742,815...1,754,476
JBrowse link
G Fnta farnesyltransferase, CAAX box, alpha IMP RGD PMID:9153192 RGD:2302974 NCBI chr16:66,065,131...66,083,460
Ensembl chr16:66,065,132...66,083,460
JBrowse link
G Fntb farnesyltransferase, CAAX box, beta IMP RGD PMID:9153192 RGD:2302974 NCBI chr 6:95,536,540...95,619,587
Ensembl chr 6:95,470,683...95,619,586
JBrowse link
G Ifng interferon gamma involved_in ISO UniProtKB:P05067|UniProtKB:P49768 (MGI:5776417|PMID:26227742), (MGI:6304699|PMID:29061364) RGD PMID:26227742 PMID:29061364 MGI:5776417 MGI:6304699 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il33 interleukin 33 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:6414704|PMID:26936882)
Ensembl
RGD
PMID:26936882 GO_REF:0000107 MGI:6414704 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
JBrowse link
G Jak2 Janus kinase 2 involved_in IDA
ISO
PMID:11536325
UniProtKB:P01580 (MGI:5009182|PMID:12426001), (MGI:5009205|PMID:10600756), (MGI:5776417|PMID:26227742)
RGD PMID:10600756 PMID:12426001 PMID:26227742 PMID:11536325 MGI:5009182 MGI:5009205 MGI:5776417, RGD:8553830 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Jak3 Janus kinase 3 IMP RGD PMID:22788969 RGD:11533941 NCBI chr16:18,386,330...18,398,542
Ensembl chr16:18,386,405...18,398,536
JBrowse link
G Kdr kinase insert domain receptor involved_in IEA
ISO
ISS
GO_REF:0000107
(PMID:10600473), (PMID:9837777)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:9837777 PMID:10600473 GO_REF:0000024 GO_REF:0000107 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 IMP RGD PMID:22302802 RGD:13462052 NCBI chr 7:122,826,712...122,987,711
Ensembl chr 7:122,826,696...122,987,703
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 IMP RGD PMID:10593906 RGD:2304240 NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492
JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 IMP RGD PMID:10593906 RGD:2304240 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 IMP RGD PMID:10593906 RGD:2304240 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 IMP RGD PMID:10593906 RGD:2304240 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase involved_in ISO (PMID:19727662) RGD PMID:19727662 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 involved_in ISO (MGI:4946442|PMID:21156799) RGD PMID:21156799 MGI:4946442 NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177
JBrowse link
G Stat1 signal transducer and activator of transcription 1 IMP RGD PMID:22788969 RGD:11533941 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Tlr2 toll-like receptor 2 involved_in ISO (MGI:4456948|PMID:15356140) RGD PMID:15356140 MGI:4456948 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tlr4 toll-like receptor 4 involved_in IEA
ISO
GO_REF:0000107
(MGI:4456948|PMID:15356140)
Ensembl
RGD
PMID:15356140 GO_REF:0000107 MGI:4456948 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tlr9 toll-like receptor 9 involved_in ISO (MGI:4456948|PMID:15356140) RGD PMID:15356140 MGI:4456948 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
JBrowse link

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  biological_process 19497
    metabolic process 11824
      organic substance metabolic process 11355
        macromolecule metabolic process 9812
          macromolecule biosynthetic process 5042
            nitric-oxide synthase biosynthetic process 28
              negative regulation of nitric-oxide synthase biosynthetic process 6
              positive regulation of nitric-oxide synthase biosynthetic process 23
              regulation of nitric-oxide synthase biosynthetic process + 28
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