cytosine C-5 DNA demethylase activity - Ontology Report

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Term:	cytosine C-5 DNA demethylase activity	go back to main search page
Accession:	GO:0051747	browse the term
Definition:	Catalysis of the reaction: methyl-dCpdG DNA + H2O = dCpdG DNA + methanol. This reaction is the hydrolytic removal of the methyl group on the 5 position of cytosine in DNA.
Synonyms:	exact_synonym:	DNA methyltransferase activity acting on cytosine C-5
	broad_synonym:	DNA demethylase activity; hydrolytic DNA demethylase activity

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Genes (2)

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

ALKBH2

alkB homolog 2, alpha-ketoglutarate dependent dioxygenase

enables

GO_REF:0000033

NCBI chr26:17,911,892...17,918,911
Ensembl chr26:17,911,763...17,917,788

alkB homolog 3, alpha-ketoglutarate dependent dioxygenase

enables

(PMID:16174769)

NCBI chr18:25,864,041...25,899,226
Ensembl chr18:25,824,877...25,899,079

Term paths to the root

Path 1
Term	Annotations
molecular_function	21949
catalytic activity	5721
hydrolase activity	2453
cytosine C-5 DNA demethylase activity	2
Path 2
Term	Annotations
molecular_function	21949
catalytic activity	5721
catalytic activity, acting on a nucleic acid	613
catalytic activity, acting on DNA	240
DNA demethylase activity	5
cytosine C-5 DNA demethylase activity	2

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