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ONTOLOGY REPORT - ANNOTATIONS


Term:serotonin uptake
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Accession:GO:0051610 term browser browse the term
Definition:The directed movement of serotonin into a cell, typically presynaptic neurons or glial cells. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems.
Synonyms:exact_synonym: 5-HT uptake;   5-hydroxytryptamine uptake;   5HT uptake;   serotonin import


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serotonin uptake term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc18a1 solute carrier family 18 member A1 IDA RGD PMID:19008227 RGD:5131091 NCBI chr16:22,358,646...22,395,183
Ensembl chr16:22,361,998...22,395,183
JBrowse link
G Slc18a2 solute carrier family 18 member A2 IEA
IMP
GO_REF:0000108 GOC PMID:20007701 GO_REF:0000108, RGD:5130957 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148
JBrowse link
G Slc22a1 solute carrier family 22 member 1 ISO (PMID:24688079) RGD PMID:24688079 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 ISO
IEA
(PMID:9687576)
GO_REF:0000107
RGD
Ensembl
PMID:9687576 GO_REF:0000107 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a3 solute carrier family 22 member 3 ISO (PMID:20858707) RGD PMID:20858707 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc29a4 solute carrier family 29 member 4 ISO (PMID:20858707)
(MGI:5484979|PMID:23255610), (MGI:6436398|PMID:20858707)
RGD PMID:20858707, PMID:23255610 MGI:5484979, MGI:6436398 NCBI chr12:13,914,114...13,924,511
Ensembl chr12:13,914,114...13,924,531
JBrowse link
G Slc6a4 solute carrier family 6 member 4 IMP
ISO
IDA
IBA
(MGI:2178281|PMID:9547354), (MGI:3710710|PMID:17452640), (MGI:6436398|PMID:20858707)
PMID:10716733
PMID:21873635
(PMID:16870614), (PMID:17506858), (PMID:7681602), (PMID:8987735)
PMID:15627510
PMID:14642278
RGD PMID:7681602, PMID:8987735, PMID:9547354, PMID:16870614, PMID:17452640, PMID:17506858, PMID:20858707, PMID:12944413, PMID:10716733, PMID:21873635, PMID:15627510, PMID:14642278 MGI:2178281, MGI:3710710, MGI:6436398, RGD:1580638, RGD:8554226, RGD:13792537, RGD:8553308, RGD:8553687 NCBI chr10:63,153,656...63,188,377
Ensembl chr10:63,153,651...63,176,463
JBrowse link
negative regulation of serotonin uptake term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpm6b glycoprotein m6b ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(MGI:5426133|PMID:18581270)
UniProt
RGD
PMID:18581270, PMID:21873635 GO_REF:0000024, MGI:5426133, RGD:13792537 NCBI chr  X:29,604,607...29,751,174
Ensembl chr  X:29,607,075...29,648,403
JBrowse link
G Nos1 nitric oxide synthase 1 IEA
ISO
GO_REF:0000107
(MGI:3710710|PMID:17452640)
Ensembl
RGD
PMID:17452640 GO_REF:0000107, MGI:3710710 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Slc18a1 solute carrier family 18 member A1 IMP G-protein mediated uptake inhibition RGD PMID:16926160 RGD:5130998 NCBI chr16:22,358,646...22,395,183
Ensembl chr16:22,361,998...22,395,183
JBrowse link
G Snca synuclein alpha ISO (PMID:16882008) RGD PMID:16882008 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
regulation of serotonin uptake term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgb3 integrin subunit beta 3 ISS
ISO
GO_REF:0000024
(MGI:6101340|PMID:29038237)
UniProt
RGD
PMID:29038237 GO_REF:0000024, MGI:6101340 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    cellular process 18792
      cellular localization 2966
        establishment of localization in cell 2177
          neurotransmitter reuptake 31
            serotonin uptake 11
              negative regulation of serotonin uptake + 4
              positive regulation of serotonin uptake 0
              regulation of serotonin uptake + 5
Path 2
Term Annotations click to browse term
  biological_process 20020
    localization 6478
      establishment of localization 4886
        transport 4734
          ion transport 3500
            anion transport 2681
              organic substance transport 2558
                monoamine transport 106
                  serotonin transport 27
                    serotonin uptake 11
                      negative regulation of serotonin uptake + 4
                      positive regulation of serotonin uptake 0
                      regulation of serotonin uptake + 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.