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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of intracellular pH
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Accession:GO:0051453 term browser browse the term
Definition:Any process that modulates the internal pH of a cell, measured by the concentration of the hydrogen ion.
Synonyms:exact_synonym: cell pH regulation;   cellular pH regulation;   pH regulation in cell;   regulation of cell pH

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regulation of intracellular pH term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp5f1b ATP synthase F1 subunit beta involved_in ISO (PMID:17510399) UniProt PMID:17510399 NCBI chrNW_004955458:4,188,167...4,195,575
Ensembl chrNW_004955458:4,186,461...4,195,494 		JBrowse link
G Ca2 carbonic anhydrase 2 involved_in ISO (MGI:4442131|PMID:20150244) UniProt PMID:20150244 MGI:4442131 NCBI chrNW_004955417:3,388,110...3,402,798
Ensembl chrNW_004955417:3,386,087...3,402,363 		JBrowse link
G Chp1 calcineurin like EF-hand protein 1 involved_in ISO (PMID:15035633), (PMID:8901634) UniProt PMID:8901634 PMID:15035633 NCBI chrNW_004955416:8,090,034...8,131,605
Ensembl chrNW_004955416:8,090,034...8,132,870 		JBrowse link
G Hvcn1 hydrogen voltage gated channel 1 involved_in ISO (MGI:6843609|PMID:24415791)
(PMID:20548053)		 RGD
UniProt		 PMID:20548053 PMID:24415791 PMID:24935944 MGI:6843609 RGD:14985214 NCBI chrNW_004955482:7,529,009...7,563,273
Ensembl chrNW_004955482:7,529,277...7,538,363 		JBrowse link
G Slc26a6 solute carrier family 26 member 6 involved_in ISO (PMID:15990874)
(MGI:4442131|PMID:20150244)
(PMID:20501439)		 UniProt PMID:15990874 PMID:20150244 PMID:20501439 MGI:4442131 NCBI chrNW_004955532:713,725...723,190
Ensembl chrNW_004955532:713,215...722,817 		JBrowse link
G Slc4a2 solute carrier family 4 member 2 ISO RGD PMID:16440368 RGD:9999231 NCBI chrNW_004955491:5,498,472...5,513,389
Ensembl chrNW_004955491:5,499,033...5,517,319 		JBrowse link
G Slc4a3 solute carrier family 4 member 3 acts_upstream_of_or_within ISO (PMID:2686841) MGI PMID:2686841 NCBI chrNW_004955453:13,846,444...13,859,707
Ensembl chrNW_004955453:13,843,556...13,859,705 		JBrowse link
G Slc4a4 solute carrier family 4 member 4 acts_upstream_of
involved_in		 ISO (PMID:21976511)
(MGI:5295108|PMID:21976511)
(MGI:5553185|PMID:24453308)
(PMID:10069984)
(PMID:24453308)		 ARUK-UCL PMID:10069984 PMID:21976511 PMID:24453308 MGI:5295108 MGI:5553185 NCBI chrNW_004955447:1,599,986...1,900,791
Ensembl chrNW_004955447:1,599,929...1,900,791 		JBrowse link
G Slc4a7 solute carrier family 4 member 7 involved_in ISO (MGI:3700901|PMID:16439691), (MGI:5506872|PMID:22586225), (MGI:5562523|PMID:23401617) UniProt PMID:16439691 PMID:22586225 PMID:23401617 MGI:3700901 MGI:5506872 MGI:5562523 NCBI chrNW_004955430:18,991,615...19,059,590
Ensembl chrNW_004955430:18,991,301...19,067,754 		JBrowse link
G Slc4a8 solute carrier family 4 member 8 acts_upstream_of_or_within
involved_in		 ISO (PMID:11133997), (PMID:18577713)
PMID:8189393
(MGI:5013899|PMID:21593314)		 ARUK-UCL
UniProt		 PMID:8189393 PMID:11133997 PMID:18577713 PMID:21593314 MGI:5013899 RGD:155230769 NCBI chrNW_004955547:1,896,597...1,975,285
Ensembl chrNW_004955547:1,896,862...1,969,975 		JBrowse link
G Slc9a1 solute carrier family 9 member A1 involved_in ISO (PMID:15035633), (PMID:24840010) RGD
BHF-UCL		 PMID:15035633 PMID:22387884 PMID:24840010 RGD:6771326 NCBI chrNW_004955452:6,409,833...6,467,841
Ensembl chrNW_004955452:6,409,833...6,467,841 		JBrowse link
G Slc9a2 solute carrier family 9 member A2 involved_in ISO (MGI:7434531|PMID:34985202) UniProt PMID:34985202 MGI:7434531 NCBI chrNW_004955470:8,083,737...8,137,372
Ensembl chrNW_004955470:8,083,641...8,137,372 		JBrowse link
G Slc9a3 solute carrier family 9 member A3 involved_in ISO (PMID:35613257) UniProt PMID:35613257 NCBI chrNW_004955504:226,192...260,632
Ensembl chrNW_004955504:228,049...260,650 		JBrowse link
G Slc9a5 solute carrier family 9 member A5 involved_in ISO (PMID:24936055) UniProt PMID:24936055 NCBI chrNW_004955484:9,359,468...9,379,959
Ensembl chrNW_004955484:9,359,468...9,379,697 		JBrowse link
G Slc9a6 solute carrier family 9 member A6 involved_in ISO (PMID:30296617)
(MGI:7387161|PMID:17005858)
(PMID:28635961)		 UniProt PMID:17005858 PMID:28635961 PMID:30296617 MGI:7387161 NCBI chrNW_004955489:9,020,719...9,078,375
Ensembl chrNW_004955489:9,019,425...9,078,705 		JBrowse link
G Slc9a8 solute carrier family 9 member A8 involved_in ISO (PMID:34288721)
(MGI:6844626|PMID:29958869)
PMID:22088432		 UniProt PMID:22088432 PMID:29958869 PMID:34288721 MGI:6844626 RGD:155663543 NCBI chrNW_004955445:8,308,847...8,384,146
Ensembl chrNW_004955445:8,312,477...8,383,969 		JBrowse link
G Slc9a9 solute carrier family 9 member A9 involved_in ISO (PMID:15522866), (PMID:24065030)
(MGI:7315838|PMID:35716776), (MGI:7387161|PMID:17005858)		 UniProt PMID:15522866 PMID:17005858 PMID:24065030 PMID:35716776 MGI:7315838 MGI:7387161 NCBI chrNW_004955508:2,060,078...2,671,792
Ensembl chrNW_004955508:2,090,609...2,670,240 		JBrowse link
G Slc9b1 solute carrier family 9 member B1 involved_in ISO (MGI:5883207|PMID:20036903) UniProt PMID:20036903 MGI:5883207 NCBI chrNW_004955496:5,586,836...5,637,550
Ensembl chrNW_004955496:5,601,578...5,641,594 		JBrowse link
G Tm9sf4 transmembrane 9 superfamily member 4 involved_in ISO (PMID:19893578) UniProt PMID:19893578 NCBI chrNW_004955422:28,871,977...28,929,246
Ensembl chrNW_004955422:28,871,977...28,926,938 		JBrowse link
G Tp53 tumor protein p53 ISO RGD PMID:16688778 RGD:1598619 NCBI chrNW_004955467:9,241,391...9,256,716
Ensembl chrNW_004955467:9,252,130...9,255,928 		JBrowse link
endosomal lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp11 aquaporin 11 acts_upstream_of_or_within ISO (PMID:16107722) MGI PMID:16107722 NCBI chrNW_004955414:14,245,682...14,260,717
Ensembl chrNW_004955414:14,245,682...14,260,717 		JBrowse link
G Faslg Fas ligand ISO RGD PMID:18045865 RGD:2315735 NCBI chrNW_004955406:13,098,479...13,107,045
Ensembl chrNW_004955406:13,098,662...13,107,389 		JBrowse link
G Rnasek ribonuclease K involved_in ISO (PMID:26212330) UniProt PMID:26212330 NCBI chrNW_004955467:9,914,907...9,917,051
Ensembl chrNW_004955467:9,914,907...9,917,051 		JBrowse link
G Tmem9 transmembrane protein 9 involved_in ISO (PMID:30374053) UniProt PMID:30374053 NCBI chrNW_004955406:37,279,885...37,299,196
Ensembl chrNW_004955406:37,279,694...37,314,251 		JBrowse link
intracellular pH elevation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cftr CF transmembrane conductance regulator involved_in ISO (MGI:5429843|PMID:21976599) UniProt PMID:21976599 MGI:5429843 NCBI chrNW_004955432:23,179,645...23,328,347
Ensembl chrNW_004955432:23,178,866...23,328,382 		JBrowse link
G Slc26a3 solute carrier family 26 member 3 involved_in ISO (MGI:5429843|PMID:21976599) UniProt PMID:21976599 MGI:5429843 NCBI chrNW_004955410:12,102,356...12,128,620
Ensembl chrNW_004955410:12,102,356...12,128,620 		JBrowse link
G Slc26a6 solute carrier family 26 member 6 involved_in ISO (MGI:5429843|PMID:21976599) UniProt PMID:21976599 MGI:5429843 NCBI chrNW_004955532:713,725...723,190
Ensembl chrNW_004955532:713,215...722,817 		JBrowse link
intracellular pH reduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpr89a G protein-coupled receptor 89A involved_in ISO (PMID:18794847) UniProt PMID:18794847 NCBI chrNW_004955568:436,817...493,188 JBrowse link
G Slc12a5 solute carrier family 12 member 5 ISO RGD PMID:16420452 RGD:2303953 NCBI chrNW_004955445:11,252,732...11,290,890
Ensembl chrNW_004955445:11,252,732...11,291,501 		JBrowse link
G Tcirg1 T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 acts_upstream_of_or_within ISO (PMID:23908015) MGI PMID:23908015 NCBI chrNW_004955422:17,768,469...17,778,976
Ensembl chrNW_004955422:17,768,469...17,779,003 		JBrowse link
G Tpcn2 two pore segment channel 2 involved_in ISO (PMID:27140606)
(MGI:6219928|PMID:27231233)		 UniProt PMID:27140606 PMID:27231233 MGI:6219928 NCBI chrNW_004955422:16,899,730...16,923,962
Ensembl chrNW_004955422:16,900,239...16,923,978 		JBrowse link
G Ttpa alpha tocopherol transfer protein ISO RGD PMID:22147702 RGD:7247589 NCBI chrNW_004955444:15,877,972...15,891,949
Ensembl chrNW_004955444:15,869,940...15,894,544 		JBrowse link
lysosomal lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp6ap2 ATPase H+ transporting accessory protein 2 involved_in ISO (PMID:32276428) UniProt PMID:32276428 NCBI chrNW_004955565:2,006,154...2,029,921 JBrowse link
G Ccdc115 coiled-coil domain containing 115 involved_in ISO (PMID:28296633) UniProt PMID:28296633 NCBI chrNW_004955459:25,649...30,215
Ensembl chrNW_004955459:25,649...30,215 		JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in ISO (PMID:11722572) UniProt PMID:11722572 NCBI chrNW_004955493:6,696,520...6,707,849
Ensembl chrNW_004955493:6,696,241...6,707,849 		JBrowse link
G Cln5 CLN5 intracellular trafficking protein involved_in ISO (PMID:11722572) UniProt PMID:11722572 NCBI chrNW_004955404:30,229,632...30,235,677
Ensembl chrNW_004955404:30,229,632...30,235,679 		JBrowse link
G Cln6 CLN6 transmembrane ER protein involved_in ISO (PMID:11722572) UniProt PMID:11722572 NCBI chrNW_004955450:7,876,572...7,885,305
Ensembl chrNW_004955450:7,876,522...7,886,581 		JBrowse link
G Creg1 cellular repressor of E1A stimulated genes 1 acts_upstream_of_or_within ISO (PMID:33966596) MGI PMID:33966596 NCBI chrNW_004955462:9,440,019...9,451,875
Ensembl chrNW_004955462:9,439,987...9,455,268 		JBrowse link
G Grn granulin precursor involved_in ISO (PMID:28073925) UniProt PMID:28073925 NCBI chrNW_004955451:17,368,600...17,371,981
Ensembl chrNW_004955451:17,368,428...17,372,377 		JBrowse link
G Lamp1 lysosomal associated membrane protein 1 involved_in ISO (PMID:37390818) UniProt PMID:37390818 NCBI chrNW_004955404:557,090...573,532
Ensembl chrNW_004955404:557,862...573,379 		JBrowse link
G Lamp2 lysosomal associated membrane protein 2 involved_in ISO (PMID:37390818) UniProt PMID:37390818 NCBI chrNW_004955572:1,423,048...1,464,443
Ensembl chrNW_004955572:1,422,981...1,462,622 		JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 involved_in ISO (PMID:11722572) UniProt PMID:11722572 NCBI chrNW_004955452:17,518,345...17,549,112
Ensembl chrNW_004955452:17,529,115...17,549,664 		JBrowse link
G Snapin SNAP associated protein acts_upstream_of_or_within ISO (PMID:20920792) MGI PMID:20920792 NCBI chrNW_004955545:306,546...308,229
Ensembl chrNW_004955545:306,546...308,229 		JBrowse link
G Tmem106b transmembrane protein 106B acts_upstream_of_or_within ISO (PMID:28728022) MGI PMID:28728022 NCBI chrNW_004955432:18,619,418...18,644,876
Ensembl chrNW_004955432:18,619,413...18,639,151 		JBrowse link
G Tmem199 transmembrane protein 199 involved_in ISO (PMID:28296633) UniProt PMID:28296633 NCBI chrNW_004955481:4,772,394...4,776,524
Ensembl chrNW_004955481:4,772,401...4,776,524 		JBrowse link
G Tmem9 transmembrane protein 9 involved_in ISO (PMID:30374053) UniProt PMID:30374053 NCBI chrNW_004955406:37,279,885...37,299,196
Ensembl chrNW_004955406:37,279,694...37,314,251 		JBrowse link
lysosomal lumen pH elevation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in ISO (PMID:10924275) UniProt PMID:10924275 NCBI chrNW_004955493:6,696,520...6,707,849
Ensembl chrNW_004955493:6,696,241...6,707,849 		JBrowse link
G Oca2 OCA2 melanosomal transmembrane protein involved_in ISO (PMID:25513726), (PMID:32966160) UniProt PMID:25513726 PMID:32966160 NCBI chrNW_004955533:1,522,878...1,796,673
Ensembl chrNW_004955533:1,522,795...1,797,116 		JBrowse link
G Slc45a2 solute carrier family 45 member 2 involved_in ISO (PMID:32966160)
(MGI:7338895|PMID:35469906)		 UniProt PMID:32966160 PMID:35469906 MGI:7338895 NCBI chrNW_004955426:19,498,942...19,530,628
Ensembl chrNW_004955426:19,498,942...19,530,628 		JBrowse link
G Tmem175 transmembrane protein 175 involved_in ISO (PMID:35333573), (PMID:35750034), (PMID:37390818) UniProt PMID:35333573 PMID:35750034 PMID:37390818 NCBI chrNW_004955514:434,283...453,239
Ensembl chrNW_004955514:434,285...453,239 		JBrowse link
negative regulation of cellular pH reduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2 apoptosis regulator involved_in ISO (PMID:10506221) UniProt PMID:10506221 NCBI chrNW_004955402:46,911,125...47,084,214
Ensembl chrNW_004955402:46,916,266...47,084,485 		JBrowse link
phagosome acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab20 RAB20, member RAS oncogene family involved_in ISO (PMID:21255211) UniProt PMID:21255211 NCBI chrNW_004955404:2,087,580...2,088,545 JBrowse link
G Rab38 RAB38, member RAS oncogene family involved_in ISO (PMID:21255211) UniProt PMID:21255211 NCBI chrNW_004955414:5,158,860...5,214,108
Ensembl chrNW_004955414:5,158,261...5,215,698 		JBrowse link
G Rab39a RAB39A, member RAS oncogene family involved_in ISO (PMID:21255211) UniProt PMID:21255211 NCBI chrNW_004955412:10,224,074...10,240,270
Ensembl chrNW_004955412:10,224,074...10,240,270 		JBrowse link
G Rab7a RAB7A, member RAS oncogene family involved_in ISO (PMID:21255211) UniProt PMID:21255211 NCBI chrNW_004955429:15,103,792...15,167,498 JBrowse link
G Slamf8 SLAM family member 8 acts_upstream_of_or_within ISO (PMID:22593622) MGI PMID:22593622 NCBI chrNW_004955468:11,623,092...11,632,566
Ensembl chrNW_004955468:11,623,197...11,632,573 		JBrowse link
G Slc4a7 solute carrier family 4 member 7 involved_in ISO (PMID:29779931) UniProt PMID:29779931 NCBI chrNW_004955430:18,991,615...19,059,590
Ensembl chrNW_004955430:18,991,301...19,067,754 		JBrowse link
G Tcirg1 T cell immune regulator 1, ATPase H+ transporting V0 subunit a3 acts_upstream_of_or_within ISO (PMID:19549681) MGI PMID:19549681 NCBI chrNW_004955422:17,768,469...17,778,976
Ensembl chrNW_004955422:17,768,469...17,779,003 		JBrowse link
positive regulation of cellular pH reduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avpr1a arginine vasopressin receptor 1A ISO RGD PMID:17762181 RGD:2300343 NCBI chrNW_004955458:10,245,325...10,253,209
Ensembl chrNW_004955458:10,245,111...10,253,209 		JBrowse link
G Avpr1b arginine vasopressin receptor 1B ISO RGD PMID:17762181 RGD:2300343 NCBI chrNW_004955406:41,706,088...41,716,173
Ensembl chrNW_004955406:41,705,305...41,716,173 		JBrowse link
G Ca2 carbonic anhydrase 2 acts_upstream_of_or_within ISO (PMID:23881097) RGD
MGI		 PMID:9665810 PMID:23881097 RGD:1342423 NCBI chrNW_004955417:3,388,110...3,402,798
Ensembl chrNW_004955417:3,386,087...3,402,363 		JBrowse link
G Ca7 carbonic anhydrase 7 acts_upstream_of_or_within ISO (PMID:23881097) MGI PMID:23881097 NCBI chrNW_004955433:23,365,832...23,374,517
Ensembl chrNW_004955433:23,365,718...23,374,548 		JBrowse link
positive regulation of Golgi lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ube3a ubiquitin protein ligase E3A involved_in ISO PMID:23447592
(MGI:5486513|PMID:23447592)		 CACAO PMID:23447592 MGI:5486513 RGD:15023469 NCBI chrNW_004955533:3,733,148...3,828,353
Ensembl chrNW_004955533:3,733,148...3,821,577 		JBrowse link
regulation of Golgi lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc9a7 solute carrier family 9 member A7 involved_in ISO (PMID:30335141) UniProt PMID:30335141 NCBI chrNW_004955516:1,286,070...1,428,789
Ensembl chrNW_004955516:1,286,070...1,428,789 		JBrowse link
G Slc9a8 solute carrier family 9 member A8 involved_in ISO (PMID:15522866) UniProt PMID:15522866 NCBI chrNW_004955445:8,308,847...8,384,146
Ensembl chrNW_004955445:8,312,477...8,383,969 		JBrowse link
regulation of lysosomal lumen pH term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrk2 leucine rich repeat kinase 2 involved_in ISO (PMID:22012985) ParkinsonsUK-UCL PMID:22012985 NCBI chrNW_004955505:84,324...216,923
Ensembl chrNW_004955505:81,796...216,923 		JBrowse link
G Spns1 SPNS lysolipid transporter 1, lysophospholipid acts_upstream_of_or_within ISO (PMID:36161949) MGI PMID:36161949 NCBI chrNW_004955493:6,506,449...6,514,308
Ensembl chrNW_004955493:6,505,230...6,514,307 		JBrowse link
G Tasl TLR adaptor interacting with endolysosomal SLC15A4 involved_in ISO (PMID:31001245) UniProt PMID:31001245 NCBI chrNW_004955531:207,614...293,127
Ensembl chrNW_004955531:267,216...293,127 		JBrowse link
G Tmem165 transmembrane protein 165 involved_in ISO (PMID:23569283) UniProt PMID:23569283 NCBI chrNW_004955447:15,538,958...15,543,885
Ensembl chrNW_004955447:15,538,958...15,543,892 		JBrowse link
G Tmem175 transmembrane protein 175 involved_in ISO (MGI:5693670|PMID:26317472)
(PMID:35750034)		 UniProt PMID:26317472 PMID:35750034 MGI:5693670 NCBI chrNW_004955514:434,283...453,239
Ensembl chrNW_004955514:434,285...453,239 		JBrowse link
G Vps33a VPS33A core subunit of CORVET and HOPS complexes involved_in ISO (PMID:28013294) UniProt PMID:28013294 NCBI chrNW_004955482:6,333,282...6,352,369
Ensembl chrNW_004955482:6,332,366...6,353,834 		JBrowse link
vacuolar acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clic4 chloride intracellular channel 4 acts_upstream_of_or_within ISO (PMID:19197003) MGI PMID:19197003 NCBI chrNW_004955452:4,479,783...4,534,115
Ensembl chrNW_004955452:4,479,783...4,534,115 		JBrowse link
G Slc11a1 solute carrier family 11 member 1 acts_upstream_of_or_within ISO (PMID:11067873), (PMID:18984740)
(PMID:9670047)		 MGI PMID:9670047 PMID:11067873 PMID:18984740 NCBI chrNW_004955453:14,980,562...14,995,118
Ensembl chrNW_004955453:14,980,562...14,995,608 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12346
    biological regulation 8880
      regulation of biological quality 2623
        regulation of intracellular pH 65
          intracellular pH elevation + 7
          intracellular pH reduction + 38
          regulation of cellular pH reduction + 8
          regulation of lysosomal lumen pH + 22
Path 2
Term Annotations click to browse term
  biological_process 12346
    homeostatic process 1655
      chemical homeostasis 974
        monoatomic ion homeostasis 529
          monoatomic cation homeostasis 517
            regulation of pH 88
              regulation of cellular pH 71
                regulation of intracellular pH 65
                  intracellular pH elevation + 7
                  intracellular pH reduction + 38
                  regulation of cellular pH reduction + 8
                  regulation of lysosomal lumen pH + 22
paths to the root