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ONTOLOGY REPORT - ANNOTATIONS


Term:intracellular pH reduction
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Accession:GO:0051452 term browser browse the term
Definition:Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion.
Synonyms:exact_synonym: cell pH reduction;   cellular acidification;   reduction of cellular pH;   reduction of pH in cell
 related_synonym: intracellular acidification



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intracellular pH reduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpr89b G protein-coupled receptor 89B involved_in IBA
ISO
PMID:21873635
(PMID:18794847)
RGD PMID:18794847 PMID:21873635 RGD:13792537 NCBI chr 2:184,408,136...184,445,560
Ensembl chr 2:184,401,438...184,445,584
JBrowse link
G Slc12a5 solute carrier family 12 member 5 IDA RGD PMID:16420452 RGD:2303953 NCBI chr 3:153,696,522...153,735,801
Ensembl chr 3:153,696,517...153,735,765
JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 acts_upstream_of_or_within ISO (MGI:6296816|PMID:23908015) RGD PMID:23908015 MGI:6296816 NCBI chr 1:201,127,034...201,138,787
Ensembl chr 1:201,127,034...201,138,742
JBrowse link
G Tpcn2 two pore segment channel 2 involved_in ISO (PMID:27140606)
(MGI:6219928|PMID:27231233)
RGD PMID:27140606 PMID:27231233 MGI:6219928 NCBI chr 1:200,416,538...200,446,252
Ensembl chr 1:200,416,540...200,446,236
JBrowse link
G Ttpa alpha tocopherol transfer protein IDA RGD PMID:22147702 RGD:7247589 NCBI chr 5:33,497,537...33,518,936
Ensembl chr 5:33,497,137...33,518,073
JBrowse link
endosomal lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp11 aquaporin 11 acts_upstream_of_or_within ISO MGI:3528447 (MGI:3588799|PMID:16107722) RGD PMID:16107722 MGI:3588799 NCBI chr 1:152,046,515...152,056,675
Ensembl chr 1:152,046,517...152,056,725
JBrowse link
G Faslg Fas ligand IDA RGD PMID:18045865 RGD:2315735 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Rnasek ribonuclease K involved_in ISO UniProtKB:Q15904 (PMID:26212330) RGD PMID:26212330 NCBI chr10:54,954,904...54,956,622
Ensembl chr10:54,951,991...54,956,601
JBrowse link
G Tmem9 transmembrane protein 9 involved_in ISO (PMID:30374053) RGD PMID:30374053 NCBI chr13:47,458,486...47,475,832
Ensembl chr13:47,458,498...47,475,832
JBrowse link
lysosomal lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp6ap2 ATPase H+ transporting accessory protein 2 involved_in ISO
ISS
(PMID:32276428)
GO_REF:0000024
RGD
UniProt
PMID:32276428 GO_REF:0000024 NCBI chr  X:10,183,983...10,210,948
Ensembl chr  X:10,183,068...10,210,918
JBrowse link
G Ccdc115 coiled-coil domain containing 115 involved_in ISO (PMID:28296633) RGD PMID:28296633 NCBI chr 9:36,650,384...36,654,348
Ensembl chr 9:36,649,271...36,653,946
JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in ISO
IBA
(PMID:11722572)
PMID:21873635
RGD PMID:11722572 PMID:21873635 RGD:13792537 NCBI chr 1:181,156,071...181,169,458
Ensembl chr 1:181,156,073...181,167,434
JBrowse link
G Cln5 CLN5, intracellular trafficking protein involved_in ISO (PMID:11722572) RGD PMID:11722572 NCBI chr15:79,893,573...79,903,438
Ensembl chr15:79,893,548...79,903,438
JBrowse link
G Cln6 CLN6, transmembrane ER protein involved_in ISO (PMID:11722572) RGD PMID:11722572 NCBI chr 8:63,303,356...63,318,360
Ensembl chr 8:63,303,029...63,318,360
JBrowse link
G Creg1 cellular repressor of E1A-stimulated genes 1 acts_upstream_of_or_within ISO (MGI:6854654|PMID:33966596) RGD PMID:33966596 MGI:6854654 NCBI chr13:78,019,814...78,032,310
Ensembl chr13:78,019,843...78,032,308
JBrowse link
G Grn granulin precursor involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(PMID:28073925)
UniProt
Ensembl
RGD
PMID:28073925 GO_REF:0000024 GO_REF:0000107 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 involved_in ISO
ISS
(PMID:11722572)
PMID:8895569
RGD PMID:11722572 PMID:8895569 RGD:8553248 NCBI chr 5:135,121,176...135,141,076
Ensembl chr 5:135,121,163...135,142,048
JBrowse link
G Snapin SNAP-associated protein acts_upstream_of_or_within ISO MGI:3608768 (MGI:4879078|PMID:20920792) RGD PMID:20920792 MGI:4879078 NCBI chr 2:175,971,575...175,974,164
Ensembl chr 2:175,971,257...175,974,231
JBrowse link
G Tmem106b transmembrane protein 106B acts_upstream_of_or_within ISO MGI:5319917 (MGI:6101836|PMID:28728022) RGD PMID:28728022 MGI:6101836 NCBI chr 4:41,328,125...41,347,315
Ensembl chr 4:41,327,994...41,345,619
JBrowse link
G Tmem199 transmembrane protein 199 involved_in ISO
ISS
(PMID:28296633)
GO_REF:0000024
RGD
UniProt
PMID:28296633 GO_REF:0000024 NCBI chr10:63,402,493...63,407,065
Ensembl chr10:63,402,494...63,407,108
JBrowse link
G Tmem9 transmembrane protein 9 involved_in ISO (PMID:30374053) RGD PMID:30374053 NCBI chr13:47,458,486...47,475,832
Ensembl chr13:47,458,498...47,475,832
JBrowse link
negative regulation of cellular pH reduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator involved_in ISO (PMID:10506221) RGD PMID:10506221 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
phagosome acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab20 RAB20, member RAS oncogene family involved_in ISO (PMID:21255211) RGD PMID:21255211 NCBI chr16:78,019,337...78,043,529
Ensembl chr16:78,019,337...78,043,529
JBrowse link
G Rab38 RAB38, member RAS oncogene family involved_in ISO (PMID:21255211) RGD PMID:21255211 NCBI chr 1:142,182,566...142,262,923
Ensembl chr 1:142,182,556...142,262,924
JBrowse link
G Rab39a RAB39A, member RAS oncogene family involved_in ISO (PMID:21255211) RGD PMID:21255211 NCBI chr 8:54,088,744...54,105,756
Ensembl chr 8:54,088,129...54,106,483
JBrowse link
G Rab7a RAB7A, member RAS oncogene family involved_in ISO
ISS
(PMID:21255211)
GO_REF:0000024
RGD
UniProt
PMID:21255211 GO_REF:0000024 NCBI chr 4:120,461,966...120,510,756
Ensembl chr 4:120,461,963...120,506,889
JBrowse link
G Slamf8 SLAM family member 8 acts_upstream_of_or_within ISO MGI:5442794 (MGI:5442671|PMID:22593622) RGD PMID:22593622 MGI:5442671 NCBI chr13:85,047,729...85,057,571
Ensembl chr13:85,047,727...85,057,211
JBrowse link
G Slc4a7 solute carrier family 4 member 7 involved_in ISO (PMID:29779931) RGD PMID:29779931 NCBI chr15:10,585,307...10,664,781
Ensembl chr15:10,588,979...10,664,781
JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 acts_upstream_of_or_within ISO MGI:3852642 (MGI:3850356|PMID:19549681) RGD PMID:19549681 MGI:3850356 NCBI chr 1:201,127,034...201,138,787
Ensembl chr 1:201,127,034...201,138,742
JBrowse link
positive regulation of cellular pH reduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avp arginine vasopressin IMP RGD PMID:17762181 RGD:2300343 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Avpr1a arginine vasopressin receptor 1A IMP RGD PMID:17762181 RGD:2300343 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
JBrowse link
G Avpr1b arginine vasopressin receptor 1B IMP RGD PMID:17762181 RGD:2300343 NCBI chr13:43,046,960...43,057,110
Ensembl chr13:43,046,267...43,057,792
JBrowse link
G Car2 carbonic anhydrase 2 acts_upstream_of_or_within IMP
ISO
MGI:2135646 (MGI:5506965|PMID:23881097) RGD PMID:23881097 PMID:9665810 MGI:5506965, RGD:1342423 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Car7 carbonic anhydrase 7 acts_upstream_of_or_within ISO MGI:5543604 (MGI:5506965|PMID:23881097) RGD PMID:23881097 MGI:5506965 NCBI chr19:429,063...438,478
Ensembl chr19:429,075...438,467
JBrowse link
positive regulation of Golgi lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ube3a ubiquitin protein ligase E3A involved_in IMP
ISO
PMID:23447592
(MGI:5486513|PMID:23447592)
RGD PMID:23447592 PMID:23447592 MGI:5486513, RGD:15023469 NCBI chr 1:110,070,260...110,161,675
Ensembl chr 1:110,070,480...110,157,250
JBrowse link
regulation of Golgi lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc9a7 solute carrier family 9 member A7 involved_in ISO (PMID:30335141) RGD PMID:30335141 NCBI chr  X:2,214,064...2,395,052
Ensembl chr  X:2,214,441...2,388,012
JBrowse link
G Slc9a8 solute carrier family 9 member A8 involved_in IEA
ISO
GO_REF:0000107
(PMID:15522866)
Ensembl
RGD
PMID:15522866 GO_REF:0000107 NCBI chr 3:156,147,855...156,198,497
Ensembl chr 3:156,148,104...156,198,471
JBrowse link
vacuolar acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp6v0a1 ATPase H+ transporting V0 subunit a1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:85,935,802...85,989,901
Ensembl chr10:85,935,854...85,989,895
JBrowse link
G Atp6v0a4 ATPase H+ transporting V0 subunit a4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:66,760,159...66,842,110
Ensembl chr 4:66,760,159...66,842,110
JBrowse link
G Atp6v0d1 ATPase H+ transporting V0 subunit D1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:33,403,352...33,447,357
Ensembl chr19:33,403,355...33,447,450
JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354
JBrowse link
G Atp6v1b1 ATPase H+ transporting V1 subunit B1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:116,223,799...116,242,475
Ensembl chr 4:116,223,799...116,242,475
JBrowse link
G Atp6v1b2 ATPase H+ transporting V1 subunit B2 involved_in TAS
IBA
PMID:21873635 RGD
GO_Central
PMID:15013950 PMID:21873635 RGD:1304309, RGD:13792537 NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745
JBrowse link
G Clic4 chloride intracellular channel 4 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3838012 (MGI:3837628|PMID:19197003)
Ensembl
RGD
PMID:19197003 GO_REF:0000107 MGI:3837628 NCBI chr 5:147,456,819...147,513,278
Ensembl chr 5:147,453,712...147,513,452
JBrowse link
G Dmxl1 Dmx-like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr18:42,993,292...43,163,457
Ensembl chr18:42,993,340...43,163,456
JBrowse link
G Dmxl2 Dmx-like 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:54,741,164...54,884,948
Ensembl chr 8:54,741,160...54,885,161
JBrowse link
G Slc11a1 solute carrier family 11 member 1 acts_upstream_of_or_within ISO MGI:2446573 (MGI:3654884|PMID:11067873), (MGI:3690711|PMID:9670047), (MGI:3839054|PMID:18984740) RGD PMID:9670047 PMID:11067873 PMID:18984740 MGI:3654884 MGI:3690711 MGI:3839054 NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101
JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:201,127,034...201,138,787
Ensembl chr 1:201,127,034...201,138,742
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19876
    biological regulation 13525
      regulation of pH 102
        regulation of cellular pH 89
          regulation of intracellular pH 80
            intracellular pH reduction 45
              Golgi lumen acidification + 3
              endosomal lumen acidification 4
              negative regulation of cellular pH reduction + 1
              phagosome acidification + 7
              positive regulation of cellular pH reduction + 6
              regulation of cellular pH reduction + 9
              vacuolar acidification + 23
Path 2
Term Annotations click to browse term
  biological_process 19876
    homeostatic process 1925
      chemical homeostasis 1196
        ion homeostasis 702
          cation homeostasis 676
            monovalent inorganic cation homeostasis 173
              regulation of pH 102
                regulation of cellular pH 89
                  regulation of intracellular pH 80
                    intracellular pH reduction 45
                      Golgi lumen acidification + 3
                      endosomal lumen acidification 4
                      negative regulation of cellular pH reduction + 1
                      phagosome acidification + 7
                      positive regulation of cellular pH reduction + 6
                      regulation of cellular pH reduction + 9
                      vacuolar acidification + 23
paths to the root