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ONTOLOGY REPORT - ANNOTATIONS

Term:intracellular pH reduction
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Accession:GO:0051452 term browser browse the term
Definition:Any process that reduces the internal pH of a cell, measured by the concentration of the hydrogen ion.
Synonyms:exact_synonym: cell pH reduction;   cellular acidification;   reduction of cellular pH;   reduction of pH in cell
 related_synonym: intracellular acidification


show annotations for term's descendants           Sort by:
intracellular pH reduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpr89b G protein-coupled receptor 89B involved_in ISO
IBA		 (PMID:18794847)
GO_REF:0000033		 RGD
GO_Central		 PMID:18794847 GO_REF:0000033 NCBI chr 2:184,408,136...184,445,560
Ensembl chr 2:184,401,438...184,445,584 		JBrowse link
G Slc12a5 solute carrier family 12 member 5 IDA RGD PMID:16420452 RGD:2303953 NCBI chr 3:153,696,517...153,735,801
Ensembl chr 3:153,696,517...153,735,765 		JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 acts_upstream_of_or_within ISO (PMID:23908015) RGD PMID:23908015 NCBI chr 1:201,127,034...201,138,787
Ensembl chr 1:201,127,034...201,138,742 		JBrowse link
G Tpcn2 two pore segment channel 2 involved_in ISO (PMID:27140606)
(MGI:6219928|PMID:27231233)		 RGD PMID:27140606 PMID:27231233 MGI:6219928 NCBI chr 1:200,416,538...200,446,252
Ensembl chr 1:200,416,540...200,446,236 		JBrowse link
G Ttpa alpha tocopherol transfer protein IDA RGD PMID:22147702 RGD:7247589 NCBI chr 5:33,497,537...33,518,936
Ensembl chr 5:33,497,137...33,518,073 		JBrowse link
endosomal lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp11 aquaporin 11 acts_upstream_of_or_within ISO MGI:3528447 (PMID:16107722) RGD PMID:16107722 NCBI chr 1:152,046,515...152,056,675
Ensembl chr 1:152,046,517...152,056,725 		JBrowse link
G Faslg Fas ligand IDA RGD PMID:18045865 RGD:2315735 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Rnasek ribonuclease K involved_in ISO UniProtKB:Q15904 (PMID:26212330) RGD PMID:26212330 NCBI chr10:54,954,904...54,956,622
Ensembl chr10:54,951,991...54,956,601 		JBrowse link
G Tmem9 transmembrane protein 9 involved_in ISO (PMID:30374053) RGD PMID:30374053 NCBI chr13:47,458,486...47,475,832
Ensembl chr13:47,458,498...47,475,832 		JBrowse link
lysosomal lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp6ap2 ATPase H+ transporting accessory protein 2 involved_in ISO
IEA
ISS		 (PMID:32276428)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:32276428 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:10,183,983...10,210,948
Ensembl chr  X:10,183,068...10,210,918 		JBrowse link
G Ccdc115 coiled-coil domain containing 115 involved_in ISO (PMID:28296633) RGD PMID:28296633 NCBI chr 9:36,650,384...36,654,348
Ensembl chr 9:36,649,271...36,653,946 		JBrowse link
G Cln3 CLN3 lysosomal/endosomal transmembrane protein, battenin involved_in ISO
IBA		 (PMID:11722572)
GO_REF:0000033		 RGD
GO_Central		 PMID:11722572 GO_REF:0000033 NCBI chr 1:181,156,071...181,169,458
Ensembl chr 1:181,156,073...181,167,434 		JBrowse link
G Cln5 CLN5, intracellular trafficking protein involved_in ISO (PMID:11722572) RGD PMID:11722572 NCBI chr15:79,893,573...79,903,438
Ensembl chr15:79,893,548...79,903,438 		JBrowse link
G Cln6 CLN6, transmembrane ER protein involved_in ISO (PMID:11722572) RGD PMID:11722572 NCBI chr 8:63,303,356...63,318,360
Ensembl chr 8:63,303,029...63,318,360 		JBrowse link
G Creg1 cellular repressor of E1A-stimulated genes 1 acts_upstream_of_or_within ISO (PMID:33966596) RGD PMID:33966596 NCBI chr13:78,019,814...78,032,310
Ensembl chr13:78,019,843...78,032,308 		JBrowse link
G Grn granulin precursor involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:28073925)		 UniProt
Ensembl
RGD		 PMID:28073925 GO_REF:0000024 GO_REF:0000107 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Lamp1 lysosomal-associated membrane protein 1 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:37390818)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:37390818 GO_REF:0000024 GO_REF:0000107 NCBI chr16:76,355,982...76,380,700
Ensembl chr16:76,355,984...76,381,883 		JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:37390818)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:37390818 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522 		JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 involved_in ISO
ISS		 (PMID:11722572)
PMID:8895569		 RGD PMID:11722572 PMID:8895569 RGD:8553248 NCBI chr 5:135,121,164...135,142,048
Ensembl chr 5:135,121,163...135,142,048 		JBrowse link
G Snapin SNAP-associated protein acts_upstream_of_or_within ISO MGI:3608768 (PMID:20920792) RGD PMID:20920792 NCBI chr 2:175,971,575...175,974,164
Ensembl chr 2:175,971,257...175,974,231 		JBrowse link
G Tmem106b transmembrane protein 106B acts_upstream_of_or_within ISO MGI:5319917 (PMID:28728022) RGD PMID:28728022 NCBI chr 4:41,328,125...41,347,315
Ensembl chr 4:41,327,994...41,345,619 		JBrowse link
G Tmem199 transmembrane protein 199 involved_in ISO
IEA
ISS		 (PMID:28296633)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:28296633 GO_REF:0000024 GO_REF:0000107 NCBI chr10:63,402,493...63,407,065
Ensembl chr10:63,402,494...63,407,108 		JBrowse link
G Tmem9 transmembrane protein 9 involved_in ISO (PMID:30374053) RGD PMID:30374053 NCBI chr13:47,458,486...47,475,832
Ensembl chr13:47,458,498...47,475,832 		JBrowse link
negative regulation of cellular pH reduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator involved_in ISO
IEA		 (PMID:10506221)
GO_REF:0000107		 RGD
Ensembl		 PMID:10506221 GO_REF:0000107 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
phagosome acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rab20 RAB20, member RAS oncogene family involved_in ISO (PMID:21255211) RGD PMID:21255211 NCBI chr16:78,019,337...78,043,529
Ensembl chr16:78,019,337...78,043,529 		JBrowse link
G Rab38 RAB38, member RAS oncogene family involved_in ISO (PMID:21255211) RGD PMID:21255211 NCBI chr 1:142,182,566...142,262,923
Ensembl chr 1:142,182,556...142,262,924 		JBrowse link
G Rab39a RAB39A, member RAS oncogene family involved_in ISO (PMID:21255211) RGD PMID:21255211 NCBI chr 8:54,088,246...54,105,867
Ensembl chr 8:54,088,129...54,106,483 		JBrowse link
G Rab7a RAB7A, member RAS oncogene family involved_in ISO
ISS		 (PMID:21255211)
GO_REF:0000024		 RGD
UniProt		 PMID:21255211 GO_REF:0000024 NCBI chr 4:120,461,966...120,510,756
Ensembl chr 4:120,461,963...120,506,889 		JBrowse link
G Slamf8 SLAM family member 8 acts_upstream_of_or_within ISO MGI:5442794 (PMID:22593622) RGD PMID:22593622 NCBI chr13:85,047,729...85,057,571
Ensembl chr13:85,047,727...85,057,211 		JBrowse link
G Slc4a7 solute carrier family 4 member 7 involved_in ISO (PMID:29779931) RGD PMID:29779931 NCBI chr15:10,585,307...10,664,780
Ensembl chr15:10,588,979...10,664,781 		JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 acts_upstream_of_or_within ISO MGI:3852642 (PMID:19549681) RGD PMID:19549681 NCBI chr 1:201,127,034...201,138,787
Ensembl chr 1:201,127,034...201,138,742 		JBrowse link
positive regulation of cellular pH reduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avp arginine vasopressin IMP RGD PMID:17762181 RGD:2300343 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Avpr1a arginine vasopressin receptor 1A IMP RGD PMID:17762181 RGD:2300343 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215 		JBrowse link
G Avpr1b arginine vasopressin receptor 1B IMP RGD PMID:17762181 RGD:2300343 NCBI chr13:43,046,531...43,059,046
Ensembl chr13:43,046,267...43,057,792 		JBrowse link
G Car2 carbonic anhydrase 2 acts_upstream_of_or_within IMP
ISO		 MGI:2135646 (PMID:23881097) RGD PMID:23881097 PMID:9665810 RGD:1342423 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Car7 carbonic anhydrase 7 acts_upstream_of_or_within ISO MGI:5543604 (PMID:23881097) RGD PMID:23881097 NCBI chr19:429,063...438,478
Ensembl chr19:429,075...438,467 		JBrowse link
positive regulation of Golgi lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ube3a ubiquitin protein ligase E3A involved_in IMP
ISO		 PMID:23447592
(MGI:5486513|PMID:23447592)
(PMID:23447592)		 RGD PMID:23447592 PMID:23447592 MGI:5486513, RGD:15023469 NCBI chr 1:110,070,260...110,161,675
Ensembl chr 1:110,070,480...110,157,250 		JBrowse link
regulation of Golgi lumen acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc9a7 solute carrier family 9 member A7 involved_in ISO (PMID:30335141) RGD PMID:30335141 NCBI chr  X:2,214,064...2,395,052
Ensembl chr  X:2,214,441...2,388,012 		JBrowse link
G Slc9a8 solute carrier family 9 member A8 involved_in IEA
ISO		 GO_REF:0000107
(PMID:15522866)		 Ensembl
RGD		 PMID:15522866 GO_REF:0000107 NCBI chr 3:156,147,855...156,198,497
Ensembl chr 3:156,148,104...156,198,471 		JBrowse link
vacuolar acidification term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp6v0a1 ATPase H+ transporting V0 subunit a1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:85,935,802...85,989,901
Ensembl chr10:85,935,854...85,989,895 		JBrowse link
G Atp6v0a4 ATPase H+ transporting V0 subunit a4 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:66,760,163...66,842,126
Ensembl chr 4:66,760,159...66,842,110 		JBrowse link
G Atp6v0d1 ATPase H+ transporting V0 subunit D1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr19:33,403,352...33,447,357
Ensembl chr19:33,403,355...33,447,450 		JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354 		JBrowse link
G Atp6v1b1 ATPase H+ transporting V1 subunit B1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 4:116,223,799...116,242,475
Ensembl chr 4:116,223,799...116,242,475 		JBrowse link
G Atp6v1b2 ATPase H+ transporting V1 subunit B2 involved_in TAS
IBA		 GO_REF:0000033 GO_Central
RGD		 PMID:15013950 GO_REF:0000033, RGD:1304309 NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745 		JBrowse link
G Clic4 chloride intracellular channel 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:3838012 (PMID:19197003)		 Ensembl
RGD		 PMID:19197003 GO_REF:0000107 NCBI chr 5:147,453,702...147,513,455
Ensembl chr 5:147,453,712...147,513,452 		JBrowse link
G Dmxl1 Dmx-like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr18:42,993,292...43,163,457
Ensembl chr18:42,993,340...43,163,456 		JBrowse link
G Dmxl2 Dmx-like 2 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 8:54,741,164...54,884,948
Ensembl chr 8:54,741,160...54,885,161 		JBrowse link
G Slc11a1 solute carrier family 11 member 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2446573 (PMID:11067873), (PMID:18984740), (PMID:9670047)		 Ensembl
RGD		 PMID:9670047 PMID:11067873 PMID:18984740 GO_REF:0000107 NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101 		JBrowse link
G Tcirg1 T-cell immune regulator 1, ATPase H+ transporting V0 subunit A3 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:201,127,034...201,138,787
Ensembl chr 1:201,127,034...201,138,742 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20134
    biological regulation 13566
      regulation of biological quality 3390
        regulation of intracellular pH 82
          intracellular pH reduction 47
            Golgi lumen acidification + 3
            endosomal lumen acidification 4
            negative regulation of cellular pH reduction + 1
            phagosome acidification + 7
            positive regulation of cellular pH reduction + 6
            regulation of cellular pH reduction + 9
            vacuolar acidification + 25
Path 2
Term Annotations click to browse term
  biological_process 20134
    homeostatic process 1984
      chemical homeostasis 1208
        monoatomic ion homeostasis 669
          monoatomic cation homeostasis 656
            regulation of pH 106
              regulation of cellular pH 91
                regulation of intracellular pH 82
                  intracellular pH reduction 47
                    Golgi lumen acidification + 3
                    endosomal lumen acidification 4
                    negative regulation of cellular pH reduction + 1
                    phagosome acidification + 7
                    positive regulation of cellular pH reduction + 6
                    regulation of cellular pH reduction + 9
                    vacuolar acidification + 25
paths to the root