Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of hydrolase activity
go back to main search page
Accession:GO:0051346 term browser browse the term
Definition:Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds.
Synonyms:exact_synonym: down regulation of hydrolase activity;   downregulation of hydrolase activity;   hydrolase inhibitor
 narrow_synonym: inhibition of hydrolase activity


show annotations for term's descendants           Sort by:
negative regulation of hydrolase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PRKCZ protein kinase C zeta ISO inhibition of acid sphingomyelinase translocation to cell surface and activation RGD PMID:17346242 RGD:1642658 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664 		JBrowse link
negative regulation of alkaline phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor ISO RGD PMID:12193573 RGD:625678 NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444 		JBrowse link
negative regulation of cyclic-nucleotide phosphodiesterase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIP aryl hydrocarbon receptor interacting protein ISO RGD PMID:12810716 RGD:632260 NCBI chr18:49,986,582...49,992,756
Ensembl chr18:49,986,587...49,992,676 		JBrowse link
G EGLN1 egl-9 family hypoxia inducible factor 1 ISO RGD PMID:22975349 RGD:8554232 NCBI chr 4:8,053,486...8,110,791
Ensembl chr 4:8,053,837...8,109,325 		JBrowse link
G RGN regucalcin ISO RGD PMID:1656206 RGD:9590243 NCBI chr  X:40,697,292...40,715,491
Ensembl chr  X:40,698,768...40,715,490 		JBrowse link
negative regulation of cysteine-type endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GRK2 G protein-coupled receptor kinase 2 ISO RGD PMID:23690069 RGD:13792722 NCBI chr18:50,148,566...50,167,422
Ensembl chr18:50,148,598...50,167,428 		JBrowse link
G HTT huntingtin ISO RGD PMID:17124493 RGD:6902918 NCBI chr 3:61,076,934...61,221,462
Ensembl chr 3:61,079,904...61,330,290 		JBrowse link
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2A adenosine A2a receptor ISO RGD PMID:15211592 RGD:1625666 NCBI chr26:28,141,076...28,150,600
Ensembl chr26:28,141,076...28,150,598 		JBrowse link
G AKT2 AKT serine/threonine kinase 2 ISO caspase 3 RGD PMID:18348079 RGD:2313324 NCBI chr 1:113,359,038...113,407,119
Ensembl chr 1:113,359,575...113,407,131 		JBrowse link
G ARRB2 arrestin beta 2 ISO RGD PMID:19171933 RGD:5510006 NCBI chr 5:31,831,208...31,838,875
Ensembl chr 5:31,829,864...31,839,454 		JBrowse link
G GPI glucose-6-phosphate isomerase ISO RGD PMID:12615053 RGD:1600634 NCBI chr 1:117,922,380...117,948,325
Ensembl chr 1:117,922,635...117,948,316 		JBrowse link
G HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 ISO RGD PMID:15102845 RGD:1304324 NCBI chr 2:59,388,492...59,400,028
Ensembl chr 2:59,388,494...59,400,003 		JBrowse link
G HNF1A HNF1 homeobox A ISO RGD PMID:21874357 RGD:150540304 NCBI chr26:16,805,690...16,826,065
Ensembl chr26:16,805,690...16,824,790 		JBrowse link
G HSP70 heat shock protein 70 ISO reduced cleavage of Casp8 and Casp9 in brain following hypoxic/ischemic injury RGD PMID:16397188 RGD:1626654 NCBI chr12:1,285,282...1,287,670 JBrowse link
G IL6 interleukin 6 ISO RGD PMID:19061939 RGD:2306937 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519 		JBrowse link
G MDM2 MDM2 proto-oncogene ISO caspase-2, caspase-3 RGD PMID:19850968 RGD:2317361 NCBI chr10:10,936,288...10,963,118
Ensembl chr10:10,893,719...10,962,596 		JBrowse link
G POR cytochrome p450 oxidoreductase ISO caspase-3 RGD PMID:19264869 RGD:2316785 NCBI chr 6:7,247,780...7,316,282
Ensembl chr 6:7,263,574...7,316,297 		JBrowse link
G PTMA prothymosin alpha ISO RGD PMID:12522243 RGD:734494 NCBI chr25:43,563,145...43,567,987
Ensembl chr25:43,562,395...43,675,699 		JBrowse link
G ZC3H7B zinc finger CCCH-type containing 7B ISO cardiac myocytes RGD PMID:22562121 RGD:7327216 NCBI chr10:23,882,379...23,944,850
Ensembl chr10:23,884,981...23,920,131 		JBrowse link
negative regulation of endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2M alpha-2-macroglobulin ISO RGD PMID:19240864 RGD:7411612 NCBI chr27:36,654,328...36,695,775 JBrowse link
G RENBP renin binding protein ISO RGD PMID:11926999 RGD:727355 NCBI chr  X:121,782,411...121,788,928
Ensembl chr  X:121,727,573...121,788,860 		JBrowse link
G SERPINE1 serpin family E member 1 ISO RGD PMID:10717410 RGD:8547889 NCBI chr 6:8,719,547...8,727,160
Ensembl chr 6:8,720,825...8,726,301 		JBrowse link
negative regulation of GTP cyclohydrolase I activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GCHFR GTP cyclohydrolase I feedback regulator ISO RGD PMID:8702680 RGD:728623 NCBI chr30:7,900,691...7,904,330
Ensembl chr30:7,897,975...7,904,328 		JBrowse link
negative regulation of GTPase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 ISO RGD PMID:15870074 RGD:2325307 NCBI chr 7:67,682,421...67,691,035 JBrowse link
G ARRB1 arrestin beta 1 ISO RGD PMID:1517224 RGD:631708 NCBI chr21:23,261,020...23,304,448
Ensembl chr21:23,235,711...23,297,786 		JBrowse link
G ARRB2 arrestin beta 2 ISO RGD PMID:1517224 RGD:631708 NCBI chr 5:31,831,208...31,838,875
Ensembl chr 5:31,829,864...31,839,454 		JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 ISO RGD PMID:17662049 RGD:7240703 NCBI chr 9:12,166,124...12,219,553
Ensembl chr 9:12,166,775...12,219,778 		JBrowse link
G PTPRN2 protein tyrosine phosphatase receptor type N2 ISO RGD PMID:16413169 RGD:1625628 NCBI chr16:19,904,468...20,562,585
Ensembl chr16:19,905,473...20,602,680 		JBrowse link
G RGN regucalcin ISO RGD PMID:11510494 RGD:9590205 NCBI chr  X:40,697,292...40,715,491
Ensembl chr  X:40,698,768...40,715,490 		JBrowse link
G TSC1 TSC complex subunit 1 ISO RGD PMID:15611338 RGD:1601406 NCBI chr 9:51,409,307...51,459,546
Ensembl chr 9:51,425,937...51,454,677 		JBrowse link
negative regulation of lipase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOA1 apolipoprotein A1 ISO RGD PMID:10419291 RGD:1626385 NCBI chr 5:16,740,071...16,742,081
Ensembl chr 5:16,740,130...16,741,943 		JBrowse link
G POR cytochrome p450 oxidoreductase ISO phospholipase D RGD PMID:18801337 RGD:4889814 NCBI chr 6:7,247,780...7,316,282
Ensembl chr 6:7,263,574...7,316,297 		JBrowse link
negative regulation of myosin-light-chain-phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MPRIP myosin phosphatase Rho interacting protein ISO RGD PMID:17661354 RGD:9685557 NCBI chr 5:42,216,938...42,338,572
Ensembl chr 5:42,210,790...42,338,566 		JBrowse link
negative regulation of phosphatidate phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LPIN1 lipin 1 ISO RGD PMID:21715287 RGD:38599010 NCBI chr17:8,348,860...8,480,447
Ensembl chr17:8,348,886...8,478,863 		JBrowse link
negative regulation of phospholipase A2 activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 ISO RGD PMID:2969352 RGD:7421659 NCBI chr 1:84,744,159...84,763,011
Ensembl chr 1:84,744,163...84,763,011 		JBrowse link
negative regulation of phospholipase C activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SNAP91 synaptosome associated protein 91 ISO RGD PMID:11779129 RGD:70605 NCBI chr12:43,919,925...44,058,315
Ensembl chr12:43,919,925...44,058,616 		JBrowse link
negative regulation of phospholipase D activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SNAP91 synaptosome associated protein 91 ISO RGD PMID:9188501 RGD:13506241 NCBI chr12:43,919,925...44,058,315
Ensembl chr12:43,919,925...44,058,616 		JBrowse link
negative regulation of phosphoprotein phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC403581 peptidylprolyl isomerase A (cyclophilin A) pseudogene ISO RGD PMID:19832699 RGD:7247324 NCBI chr 7:80,937,433...80,938,175 JBrowse link
G PPP1R9B protein phosphatase 1 regulatory subunit 9B ISO RGD PMID:10585469 PMID:12016225 RGD:625568 RGD:9999389 NCBI chr 9:26,135,982...26,152,303
Ensembl chr 9:26,137,464...26,151,810 		JBrowse link
G RGN regucalcin ISO RGD PMID:10922512 RGD:9590172 NCBI chr  X:40,697,292...40,715,491
Ensembl chr  X:40,698,768...40,715,490 		JBrowse link
negative regulation of protein tyrosine phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GNAI2 G protein subunit alpha i2 ISO RGD PMID:11500506 RGD:13508599 NCBI chr20:39,075,085...39,094,697
Ensembl chr20:39,075,085...39,094,697 		JBrowse link
negative regulation of serine-type endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SERPINA1 serpin family A member 1 ISO RGD PMID:19240864 RGD:7411612 NCBI chr 8:63,388,498...63,400,377
Ensembl chr 8:63,376,945...63,398,435 		JBrowse link
G SPINK1 serine peptidase inhibitor Kazal type 1 ISO RGD PMID:12771515 RGD:724699 NCBI chr 2:42,112,015...42,120,738
Ensembl chr 2:42,112,016...42,120,706 		JBrowse link
Term paths to the root