Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Community Projects (beta) QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:positive regulation of hydrolase activity
go back to main search page
Accession:GO:0051345 term browser browse the term
Definition:Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds.
Synonyms:exact_synonym: hydrolase activator;   up regulation of hydrolase activity;   upregulation of hydrolase activity
 narrow_synonym: activation of hydrolase activity;   stimulation of hydrolase activity


show annotations for term's descendants           Sort by:
positive regulation of hydrolase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fabp1 fatty acid binding protein 1 IDA peroxisomal medium- and long-chain acyl-CoA thioesterases RGD PMID:16262600 RGD:1626442 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788 		JBrowse link
G Gm2a ganglioside GM2 activator IDA Phospholipase D RGD PMID:9770472 RGD:1598995 NCBI chr10:39,219,221...39,231,756
Ensembl chr10:39,219,243...39,231,757 		JBrowse link
activation of cysteine-type endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pawr pro-apoptotic WT1 regulator IMP RGD PMID:10349840 RGD:9835366 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028 		JBrowse link
activation of cysteine-type endopeptidase activity involved in apoptotic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp4 caspase 4 TAS RGD PMID:11684090 RGD:632459 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092 		JBrowse link
G Cck cholecystokinin IDA RGD PMID:11964411 RGD:625521 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084 		JBrowse link
G Tnfsf15 TNF superfamily member 15 IDA RGD PMID:11911831 RGD:634236 NCBI chr 5:77,134,885...77,156,171
Ensembl chr 5:77,139,878...77,156,228 		JBrowse link
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Smad3 SMAD family member 3 IMP TGF-beta1-induced cleavage of BAD to its more active 15 kD form RGD PMID:11839804 RGD:2301029 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
activation of GTPase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif5 eukaryotic translation initiation factor 5 IDA RGD PMID:10805737 RGD:10755758 NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta IMP RGD PMID:15158121 RGD:1642626 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Rasa1 RAS p21 protein activator 1 IDA RGD PMID:8226805 RGD:9999452 NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854 		JBrowse link
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 IMP RGD PMID:1379346 RGD:10003125 NCBI chr 8:90,445,154...90,574,274
Ensembl chr 8:90,445,154...90,574,269 		JBrowse link
G Tiam1 TIAM Rac1 associated GEF 1 IMP RGD PMID:18930714 RGD:10043296 NCBI chr11:29,031,347...29,380,153
Ensembl chr11:29,031,348...29,159,901 		JBrowse link
activation of phospholipase C activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1r1 ADCYAP receptor type I IDA RGD PMID:8396727 RGD:631732 NCBI chr 4:84,593,558...84,642,700
Ensembl chr 4:84,593,892...84,642,700 		JBrowse link
G Adra1a adrenoceptor alpha 1A IDA RGD PMID:7935320 RGD:69745 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500 		JBrowse link
G Agt angiotensinogen IMP RGD PMID:11100981 RGD:1582152 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Dlc1 DLC1 Rho GTPase activating protein IDA RGD PMID:7835339 RGD:68218 NCBI chr16:55,246,716...55,671,441
Ensembl chr16:55,291,584...55,671,439 		JBrowse link
G Gnaq G protein subunit alpha q IMP RGD PMID:14981460 RGD:1598489 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672 		JBrowse link
G Ms4a2 membrane spanning 4-domains A2 IDA RGD PMID:11388899 RGD:1599963 NCBI chr 1:208,440,179...208,448,716
Ensembl chr 1:208,440,361...208,448,310 		JBrowse link
activation of phospholipase D activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gna13 G protein subunit alpha 13 IMP RGD PMID:12435801 RGD:1598460 NCBI chr10:94,337,939...94,370,774
Ensembl chr10:94,337,725...94,370,774 		JBrowse link
G Hpca hippocalcin IDA RGD PMID:11211872 RGD:9686445 NCBI chr 5:141,455,616...141,466,252
Ensembl chr 5:141,455,613...141,463,841 		JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate IDA RGD PMID:16341931 RGD:9685306 NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012 		JBrowse link
G Prkcz protein kinase C, zeta IMP RGD PMID:16113073 RGD:1642674 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
positive regulation of alkaline phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itga2 integrin subunit alpha 2 IMP RGD PMID:10867645 RGD:2307406 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481 		JBrowse link
G Smad3 SMAD family member 3 IDA rat gene expressed in mouse osteoblastic cell line MC3T3-E1; TGF-beta down-regulates this activity RGD PMID:12096832 RGD:727387 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
positive regulation of cyclic-nucleotide phosphodiesterase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gnat1 G protein subunit alpha transducin 1 IDA RGD PMID:7878085 RGD:1599022 NCBI chr 8:108,350,935...108,355,671
Ensembl chr 8:108,350,935...108,355,671 		JBrowse link
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox12 arachidonate 12-lipoxygenase, 12S type IMP RGD PMID:15105833 RGD:2313858 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542 		JBrowse link
G Arrb1 arrestin, beta 1 IMP RGD PMID:19171933 RGD:5510006 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061 		JBrowse link
G Casp12 caspase 12 IMP RGD PMID:17083921 RGD:2311464 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Ccn2 cellular communication network factor 2 IMP caspase 3/7 RGD PMID:19625611 RGD:2314487 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Fas Fas cell surface death receptor IMP RGD PMID:15519734 RGD:8662904 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Hsf1 heat shock transcription factor 1 IMP RGD PMID:21192280 RGD:10403035 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 IMP RGD PMID:14522843 RGD:2304239 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha IMP RGD PMID:18322138 RGD:8693423 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862 		JBrowse link
G Pycard PYD and CARD domain containing IMP RGD PMID:19401709 RGD:5491174 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rhoa ras homolog family member A IMP RGD PMID:17425560 RGD:1642961 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Wdr35 WD repeat domain 35 IMP RGD PMID:20193664 RGD:11553917 NCBI chr 6:31,771,315...31,831,450
Ensembl chr 6:31,771,360...31,831,029 		JBrowse link
positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnf tumor necrosis factor IMP RGD PMID:12131680 RGD:14995454 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
positive regulation of dUTP diphosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rgn regucalcin IDA RGD PMID:1315924 RGD:2301218 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450 		JBrowse link
positive regulation of endopeptidase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akirin2 akirin 2 IMP MMP-9 RGD PMID:18460465 RGD:2306009 NCBI chr 5:49,108,231...49,122,566
Ensembl chr 5:49,108,220...49,122,568 		JBrowse link
positive regulation of exoribonuclease activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tcea1 transcription elongation factor A1 IDA RGD PMID:16046193 RGD:9693728 NCBI chr 5:14,631,454...14,668,769
Ensembl chr 5:14,631,454...14,668,745
Ensembl chr15:14,631,454...14,668,745 		JBrowse link
positive regulation of GTPase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amph amphiphysin IDA RGD PMID:9348539 RGD:631926 NCBI chr17:45,739,385...45,982,905
Ensembl chr17:45,739,395...45,983,315 		JBrowse link
G Bin1 bridging integrator 1 IDA RGD PMID:9348539 RGD:631926 NCBI chr18:24,009,731...24,067,267
Ensembl chr18:24,009,653...24,067,263 		JBrowse link
G Gnao1 G protein subunit alpha o1 IMP RGD PMID:7544301 RGD:2302012 NCBI chr19:11,034,874...11,192,531
Ensembl chr19:11,035,956...11,192,493 		JBrowse link
G Icam1 intercellular adhesion molecule 1 IDA RGD PMID:17662049 RGD:7240703 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 IMP basal and EGF-activated Rac1 RGD PMID:17183546 RGD:2292641 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Rap1gds1 Rap1 GTPase-GDP dissociation stimulator 1 IMP RGD PMID:18348285 RGD:2314690 NCBI chr 2:227,500,366...227,645,213
Ensembl chr 2:227,500,367...227,645,169 		JBrowse link
G Rasa1 RAS p21 protein activator 1 IMP RGD PMID:14707121 RGD:9999423 NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854 		JBrowse link
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 IMP RGD PMID:15798216 RGD:10003119 NCBI chr 8:90,445,154...90,574,274
Ensembl chr 8:90,445,154...90,574,269 		JBrowse link
G Rgn regucalcin IDA RGD PMID:11693188 RGD:9590216 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450 		JBrowse link
G Rgs4 regulator of G-protein signaling 4 IMP RGD PMID:20530129 PMID:9430692 RGD:7207369, RGD:7207375 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 IDA RGD PMID:14711826 RGD:1304283 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681 		JBrowse link
positive regulation of phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rgn regucalcin IMP RGD PMID:9671264 RGD:9590174 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450 		JBrowse link
G Rpl5 ribosomal protein L5 IDA RGD PMID:7649987 RGD:2316860 NCBI chr14:1,843,856...1,850,301
Ensembl chr14:1,843,770...1,850,290 		JBrowse link
positive regulation of phospholipase A2 activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Camk2b calcium/calmodulin-dependent protein kinase II beta IDA RGD PMID:15576376 RGD:6482753 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994 		JBrowse link
positive regulation of phospholipase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hpca hippocalcin IDA RGD PMID:11211872 RGD:9686445 NCBI chr 5:141,455,616...141,466,252
Ensembl chr 5:141,455,613...141,463,841 		JBrowse link
positive regulation of phospholipase C activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptafr platelet-activating factor receptor IDA RGD PMID:8798508 RGD:9999203 NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251 		JBrowse link
positive regulation of phosphoprotein phosphatase activity term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Jak2 Janus kinase 2 IMP Ptpn11 activity RGD PMID:17021051 RGD:1641809 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Pawr pro-apoptotic WT1 regulator IMP RGD PMID:23219599 RGD:9835413 NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028 		JBrowse link
G Ppp2ca protein phosphatase 2 catalytic subunit alpha IMP RGD PMID:24265448 RGD:8693600 NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19553
    biological regulation 13187
      regulation of molecular function 323
        positive regulation of molecular function 199
          positive regulation of catalytic activity 116
            positive regulation of hydrolase activity 51
              positive regulation of GTP cyclohydrolase I activity 0
              positive regulation of GTPase activity + 14
              positive regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity 0
              positive regulation of arginase activity 0
              positive regulation of beta-galactosidase activity 0
              positive regulation of cyclic-nucleotide phosphodiesterase activity 1
              positive regulation of dUTP diphosphatase activity 1
              positive regulation of deacetylase activity + 0
              positive regulation of exo-alpha-sialidase activity 0
              positive regulation of glucosylceramidase activity 0
              positive regulation of lipase activity + 12
              positive regulation of lysozyme activity 0
              positive regulation of nuclease activity + 1
              positive regulation of peptidase activity + 18
              positive regulation of phosphatase activity + 7
              positive regulation of phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands 0
              positive regulation of urease activity 0
paths to the root