Any process that activates or increases the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate.
Synonyms:
exact_synonym:
3',5' cyclic nucleotide phosphodiesterase activator; positive regulation of 3',5' cyclic nucleotide phosphodiesterase activity; up regulation of cyclic nucleotide phosphodiesterase activity; upregulation of cyclic nucleotide phosphodiesterase activity
narrow_synonym:
3',5'-cyclic-AMP phosphodiesterase activator; activation of cyclic nucleotide phosphodiesterase activity; cAMP phosphodiesterase activator; positive regulation of 3',5'-cyclic-AMP phosphodiesterase activity; positive regulation of cAMP phosphodiesterase activity; positive regulation of cGMP phosphodiesterase activity; stimulation of cyclic nucleotide phosphodiesterase activity