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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of ligase activity
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Accession:GO:0051340 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6.
Synonyms:exact_synonym: ligase regulator


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negative regulation of leucine-tRNA ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rgn regucalcin IDA RGD PMID:2280766 RGD:9590217 NCBI chr  X:1,833,484...1,848,904
Ensembl chr  X:1,833,492...1,848,904
JBrowse link
positive regulation of aminoacyl-tRNA ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aimp2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 involved_in IBA
ISO
PMID:21873635
(MGI:3055639|PMID:12060739)
RGD PMID:12060739, PMID:21873635 MGI:3055639, RGD:13792537 NCBI chr12:12,738,784...12,748,345
Ensembl chr12:12,738,812...12,748,345
JBrowse link
positive regulation of DNA ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:9600082) RGD PMID:9600082 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 involved_in ISO (PMID:28002403) RGD PMID:28002403 NCBI chr 1:81,412,635...81,441,680
Ensembl chr 1:81,413,353...81,441,678
JBrowse link
positive regulation of glutamate-cysteine ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclm glutamate cysteine ligase, modifier subunit acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
(MGI:2447526|PMID:12384496), (MGI:3047441|PMID:15288121), (MGI:3607629|PMID:16081425)
PMID:21873635
RGD PMID:12384496 PMID:15288121 PMID:16081425, PMID:16137247, PMID:21873635 MGI:2447526 MGI:3047441 MGI:3607629, RGD:1582663, RGD:13792537 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
positive regulation of isoleucine-tRNA ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rpl5 ribosomal protein L5 IMP RGD PMID:1665486 RGD:11040680 NCBI chr14:2,860,963...2,867,397
Ensembl chr14:2,860,965...2,867,397
JBrowse link
positive regulation of ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mid1ip1 MID1 interacting protein 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:4454592|PMID:20457939)
UniProt
RGD
PMID:20457939 GO_REF:0000024 MGI:4454592 NCBI chr  X:13,114,557...13,119,274
Ensembl chr  X:13,114,569...13,116,743
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 acts_upstream_of_or_within ISO (MGI:5510543|PMID:19498109) RGD PMID:19498109 MGI:5510543 NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741
JBrowse link
G Xrcc4 X-ray repair cross complementing 4 involved_in IBA
ISO
PMID:21873635
(PMID:9242410)
RGD PMID:9242410, PMID:21873635 RGD:13792537 NCBI chr 2:18,674,496...18,927,463
Ensembl chr 2:18,677,220...18,927,365
JBrowse link
positive regulation of methionine-tRNA ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rpl5 ribosomal protein L5 IMP RGD PMID:1665486 RGD:11040680 NCBI chr14:2,860,963...2,867,397
Ensembl chr14:2,860,965...2,867,397
JBrowse link
positive regulation of proton-transporting ATP synthase activity, rotational mechanism term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Antkmt adenine nucleotide translocase lysine methyltransferase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:15,160,037...15,161,895
Ensembl chr10:15,159,803...15,161,938
JBrowse link
G Atpsckmt ATP synthase c subunit lysine N-methyltransferase involved_in ISO
ISS
IBA
(PMID:30530489)
GO_REF:0000024
PMID:21873635
(MGI:6277238|PMID:30530489)
RGD
UniProt
PMID:30530489, PMID:21873635 GO_REF:0000024 MGI:6277238, RGD:13792537 NCBI chr 2:84,678,892...84,694,152
Ensembl chr 2:84,678,948...84,693,988
JBrowse link
G Tmsb4x thymosin beta 4, X-linked involved_in ISO (PMID:21106936) RGD PMID:21106936 NCBI chr  X:28,593,405...28,617,267
Ensembl chr  X:28,593,405...28,595,395
JBrowse link
positive regulation of threonine-tRNA ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rpl5 ribosomal protein L5 IMP RGD PMID:8049265 RGD:1556518 NCBI chr14:2,860,963...2,867,397
Ensembl chr14:2,860,965...2,867,397
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19491
    biological regulation 13515
      regulation of molecular function 3070
        regulation of catalytic activity 2372
          regulation of ligase activity 12
            negative regulation of ligase activity + 1
            positive regulation of ligase activity + 11
            regulation of DNA ligase activity + 2
            regulation of aminoacyl-tRNA ligase activity + 3
            regulation of argininosuccinate synthase activity + 0
            regulation of glutamate-ammonia ligase activity + 0
            regulation of glutamate-cysteine ligase activity + 1
            regulation of proton-transporting ATP synthase activity, rotational mechanism + 3
paths to the root