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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of ligase activity
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Accession:GO:0051340 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6.
Synonyms:exact_synonym: ligase regulator



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negative regulation of leucine-tRNA ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rgn regucalcin IDA RGD PMID:2280766 RGD:9590217 NCBI chr  X:1,619,030...1,634,456
Ensembl chr  X:1,619,032...1,634,450
JBrowse link
positive regulation of aminoacyl-tRNA ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aimp2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 involved_in IBA
ISO
PMID:21873635
(MGI:3055639|PMID:12060739)
RGD PMID:12060739 PMID:21873635 MGI:3055639, RGD:13792537 NCBI chr12:10,701,194...10,710,772
Ensembl chr12:10,701,194...10,710,769
JBrowse link
positive regulation of DNA ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:9600082) RGD PMID:9600082 NCBI chr12:5,973,062...5,978,565
Ensembl chr12:5,901,586...5,978,565
JBrowse link
G Hmgb2 high mobility group box 2 involved_in ISO (PMID:9600082) RGD PMID:9600082 NCBI chr16:32,710,651...32,713,230
Ensembl chr16:32,710,658...32,713,140
JBrowse link
G Xrcc1 X-ray repair cross complementing 1 involved_in ISO (PMID:28002403) RGD PMID:28002403 NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
JBrowse link
positive regulation of glutamate-cysteine ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclm glutamate cysteine ligase, modifier subunit acts_upstream_of_or_within
involved_in
IDA
ISO
IBA
(MGI:2447526|PMID:12384496), (MGI:3047441|PMID:15288121), (MGI:3607629|PMID:16081425)
PMID:21873635
RGD PMID:12384496 PMID:15288121 PMID:16081425 PMID:16137247 PMID:21873635 MGI:2447526 MGI:3047441 MGI:3607629, RGD:1582663, RGD:13792537 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
positive regulation of isoleucine-tRNA ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rpl5 ribosomal protein L5 IMP RGD PMID:1665486 RGD:11040680 NCBI chr14:1,843,856...1,850,301
Ensembl chr14:1,843,770...1,850,290
JBrowse link
positive regulation of ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mid1ip1 MID1 interacting protein 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:4454592|PMID:20457939)
UniProt
RGD
PMID:20457939 GO_REF:0000024 MGI:4454592 NCBI chr  X:12,060,993...12,063,318
Ensembl chr  X:12,060,883...12,065,774
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 acts_upstream_of_or_within ISO (MGI:5510543|PMID:19498109) RGD PMID:19498109 MGI:5510543 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
JBrowse link
G Xrcc4 X-ray repair cross complementing 4 involved_in IBA
ISO
PMID:21873635
(PMID:9242410)
RGD PMID:9242410 PMID:21873635 RGD:13792537 NCBI chr 2:20,948,464...21,197,705
Ensembl chr 2:20,951,200...21,197,808
JBrowse link
positive regulation of methionine-tRNA ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rpl5 ribosomal protein L5 IMP RGD PMID:1665486 RGD:11040680 NCBI chr14:1,843,856...1,850,301
Ensembl chr14:1,843,770...1,850,290
JBrowse link
positive regulation of proton-transporting ATP synthase activity, rotational mechanism term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Antkmt adenine nucleotide translocase lysine methyltransferase involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:14,812,274...14,814,798
Ensembl chr10:14,812,269...14,814,193
JBrowse link
G Atpsckmt ATP synthase c subunit lysine N-methyltransferase involved_in ISO
ISS
IBA
(PMID:30530489)
GO_REF:0000024
PMID:21873635
(MGI:6277238|PMID:30530489)
RGD
UniProt
PMID:30530489 PMID:21873635 GO_REF:0000024 MGI:6277238, RGD:13792537 NCBI chr 2:82,603,086...82,618,325
Ensembl chr 2:82,603,009...82,618,308
JBrowse link
G Tmsb4x thymosin beta 4, X-linked involved_in ISO (PMID:21106936) RGD PMID:21106936 NCBI chr  X:27,144,677...27,146,667
Ensembl chr  X:27,128,610...27,146,667
JBrowse link
positive regulation of threonine-tRNA ligase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rpl5 ribosomal protein L5 IMP RGD PMID:8049265 RGD:1556518 NCBI chr14:1,843,856...1,850,301
Ensembl chr14:1,843,770...1,850,290
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  biological_process 19874
    biological regulation 13526
      regulation of molecular function 2734
        regulation of catalytic activity 1902
          regulation of ligase activity 13
            negative regulation of ligase activity + 1
            positive regulation of ligase activity + 12
            regulation of DNA ligase activity + 3
            regulation of aminoacyl-tRNA ligase activity + 3
            regulation of argininosuccinate synthase activity + 0
            regulation of glutamate-ammonia ligase activity + 0
            regulation of glutamate-cysteine ligase activity + 1
            regulation of proton-transporting ATP synthase activity, rotational mechanism + 3
paths to the root