Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of lyase activity
go back to main search page
Accession:GO:0051339 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
Synonyms:exact_synonym: lyase regulator



show annotations for term's descendants           Sort by:
activation of adenylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACR acrosin involved_in ISS
IEA
UniProt
Ensembl
UniProt
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 5:30,127...36,005
Ensembl chr 5:30,127...36,005
JBrowse link
G ADRB2 adrenoceptor beta 2 involved_in ISS
IEA
HGNC-UCL
Ensembl
HGNC-UCL
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr 2:150,032,649...150,035,591
Ensembl chr 2:150,033,579...150,040,731
JBrowse link
G ADRB3 adrenoceptor beta 3 involved_in ISS
IEA
HGNC-UCL
Ensembl
GO_REF:0000024 GO_REF:0000107 NCBI chr15:48,468,803...48,478,370
Ensembl chr15:48,475,144...48,479,562
JBrowse link
G CALCB calcitonin-related polypeptide beta involved_in
acts_upstream_of_or_within
ISO (PMID:10822112), (PMID:16014619)
(MGI:77881|PMID:8582325)
UniProt
MGI
PMID:8582325 PMID:10822112 PMID:16014619 MGI:77881 NCBI chr 2:44,043,135...44,048,651 JBrowse link
G CALCR calcitonin receptor NOT|involved_in ISO (PMID:15563840) UniProt PMID:15563840 NCBI chr 9:73,279,874...73,403,516
Ensembl chr 9:73,279,879...73,403,436
JBrowse link
G DRD1 dopamine receptor D1 involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:2450485|PMID:12488442) Ensembl
Ensembl
MGI
PMID:12488442 GO_REF:0000107 MGI:2450485 NCBI chr16:49,189,555...49,193,722
Ensembl chr16:49,189,602...49,191,976
JBrowse link
G FSHR follicle stimulating hormone receptor involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr 3:91,607,236...91,775,255
Ensembl chr 3:91,607,305...91,774,683
JBrowse link
G GHRHR growth hormone releasing hormone receptor ISO RGD PMID:9845677 RGD:1601338 NCBI chr18:42,030,505...42,046,178
Ensembl chr18:42,030,510...42,046,184
JBrowse link
G GNAL G protein subunit alpha L acts_upstream_of_or_within ISO (MGI:2450485|PMID:12488442) MGI PMID:12488442 MGI:2450485 NCBI chr 6:97,342,468...97,429,334
Ensembl chr 6:97,342,474...97,429,364
JBrowse link
G LGR4 leucine rich repeat containing G protein-coupled receptor 4 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:32,871,837...32,979,150
Ensembl chr 2:32,871,871...32,979,148
JBrowse link
G LHCGR luteinizing hormone/choriogonadotropin receptor involved_in IBA
IEA
ISO
(PMID:21873635) GO_Central
Ensembl
GO_Central
RGD
PMID:8440169 PMID:21873635 GO_REF:0000107 RGD:2292602 NCBI chr 3:91,964,415...92,023,821
Ensembl chr 3:91,964,415...92,021,398
JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr13:68,581,128...68,657,911
Ensembl chr13:68,580,812...68,657,829
JBrowse link
G RXFP1 relaxin family peptide receptor 1 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr 8:47,473,465...47,603,332
Ensembl chr 8:47,473,788...47,601,357
JBrowse link
G RXFP2 relaxin family peptide receptor 2 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr11:8,266,898...8,321,021
Ensembl chr11:8,282,517...8,321,020
JBrowse link
G TSHR thyroid stimulating hormone receptor involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr 7:103,768,260...103,925,777
Ensembl chr 7:103,768,296...103,925,922
JBrowse link
G VIPR2 vasoactive intestinal peptide receptor 2 ISO RGD PMID:8224221 RGD:70054 NCBI chr18:396,379...466,408
Ensembl chr18:396,263...518,102
JBrowse link
negative regulation of adenylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADGRV1 adhesion G protein-coupled receptor V1 involved_in IEA InterPro
InterPro
GO_REF:0000002 NCBI chr 2:97,703,648...98,277,847
Ensembl chr 2:97,735,053...98,275,748
JBrowse link
G AKAP5 A-kinase anchoring protein 5 involved_in IEA
ISO
Ensembl
Ensembl
RGD
PMID:20410303 GO_REF:0000107 RGD:7242424 NCBI chr 7:88,538,938...88,544,330
Ensembl chr 7:88,538,984...88,547,392
JBrowse link
G AKAP6 A-kinase anchoring protein 6 ISO RGD PMID:19574217 RGD:6902943 NCBI chr 7:66,913,541...67,462,147
Ensembl chr 7:66,915,881...67,375,177
JBrowse link
G AKAP9 A-kinase anchoring protein 9 ISO RGD PMID:18772391 RGD:2313147 NCBI chr 9:71,895,615...72,054,898
Ensembl chr 9:71,895,635...72,054,897
JBrowse link
G DRD2 dopamine receptor D2 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr 9:41,068,618...41,135,262
Ensembl chr 9:41,068,779...41,133,599
JBrowse link
G DRD3 dopamine receptor D3 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr13:145,769,294...145,817,997
Ensembl chr13:145,771,774...145,819,168
JBrowse link
G GABBR1 gamma-aminobutyric acid type B receptor subunit 1 ISO RGD PMID:15147298 RGD:2315493 NCBI chr 7:22,547,938...22,577,639
Ensembl chr 7:22,540,381...22,578,619
JBrowse link
G GALR1 galanin receptor 1 involved_in IEA InterPro
InterPro
GO_REF:0000002 NCBI chr 1:147,442,977...147,466,731
Ensembl chr 1:147,443,821...147,463,542
JBrowse link
G GALR2 galanin receptor 2 involved_in IEA InterPro
InterPro
GO_REF:0000002 NCBI chr12:5,360,232...5,364,396
Ensembl chr12:5,359,582...5,363,095
JBrowse link
G GALR3 galanin receptor 3 involved_in IEA InterPro
InterPro
GO_REF:0000002 NCBI chr 5:10,024,332...10,027,171
Ensembl chr 5:10,023,746...10,026,120
JBrowse link
G HRH3 histamine receptor H3 ISO RGD PMID:10869375 RGD:632981 NCBI chr17:61,622,865...61,627,278
Ensembl chr17:61,622,938...61,627,278
JBrowse link
G NPR3 natriuretic peptide receptor 3 ISO RGD PMID:8702617 RGD:1601497 NCBI chr16:18,841,540...18,929,813
Ensembl chr16:18,842,039...18,929,805
JBrowse link
G P2RY13 purinergic receptor P2Y13 involved_in IEA InterPro
InterPro
GO_REF:0000002 NCBI chr13:91,509,441...91,513,687
Ensembl chr13:91,507,276...91,513,181
JBrowse link
G PALM paralemmin involved_in
acts_upstream_of_or_within
IBA
IEA
ISO
(PMID:21873635)
(MGI:3618440|PMID:16386234)
GO_Central
Ensembl
GO_Central
MGI
Ensembl
PMID:16386234 PMID:21873635 GO_REF:0000107 MGI:3618440 NCBI chr 2:77,619,199...77,644,561
Ensembl chr 2:77,619,199...77,644,673
JBrowse link
negative regulation of cystathionine beta-synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr16:74,245,214...74,270,828
Ensembl chr16:74,245,228...74,270,783
JBrowse link
negative regulation of guanylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HPCA hippocalcin ISO RGD PMID:15336960 RGD:9686438 NCBI chr 6:89,187,544...89,197,049
Ensembl chr 6:89,188,133...89,197,045
JBrowse link
G NHERF4 NHERF family PDZ scaffold protein 4 involved_in IEA GOC GO_REF:0000108 NCBI chr 9:46,401,377...46,409,804
Ensembl chr 9:46,401,713...46,406,219
JBrowse link
G RD3 RD3 regulator of GUCY2D involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 9:131,712,858...131,716,179
Ensembl chr 9:131,705,229...131,719,288
JBrowse link
negative regulation of lyase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PHPT1 phosphohistidine phosphatase 1 involved_in ISO (PMID:20110805), (PMID:20501872) BHF-UCL PMID:20110805 PMID:20501872
positive regulation of aconitate hydratase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FTMT ferritin mitochondrial involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 2:125,391,524...125,395,066
Ensembl chr 2:125,392,394...125,393,122
JBrowse link
G FXN frataxin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:222,412,485...222,433,224
Ensembl chr 1:222,412,509...222,454,776
JBrowse link
G ISCU iron-sulfur cluster assembly enzyme involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr14:42,216,103...42,222,570
Ensembl chr14:42,216,111...42,222,711
JBrowse link
positive regulation of adenylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB1 adrenoceptor beta 1 ISO RGD PMID:21143600 RGD:8693686 NCBI chr14:124,400,330...124,401,739
Ensembl chr14:124,400,330...124,401,739
JBrowse link
G AKAP5 A-kinase anchoring protein 5 involved_in IBA
IEA
ISO
(PMID:21873635) GO_Central
InterPro
GO_Central
RGD
PMID:20410303 PMID:21873635 GO_REF:0000002 RGD:7242424 NCBI chr 7:88,538,938...88,544,330
Ensembl chr 7:88,538,984...88,547,392
JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C involved_in ISO (MGI:6243790|PMID:24086669) UniProt PMID:24086669 MGI:6243790 NCBI chr 5:69,016,954...69,448,428
Ensembl chr 5:69,275,176...69,448,430
JBrowse link
G CACNA1D calcium voltage-gated channel subunit alpha1 D involved_in ISO (MGI:6243790|PMID:24086669) UniProt PMID:24086669 MGI:6243790 NCBI chr13:35,568,534...35,911,483
Ensembl chr13:35,436,519...35,909,662
JBrowse link
G CALCR calcitonin receptor involved_in ISO (PMID:7588285), (PMID:7769107) UniProt PMID:7588285 PMID:7769107 NCBI chr 9:73,279,874...73,403,516
Ensembl chr 9:73,279,879...73,403,436
JBrowse link
G GCG glucagon ISO RGD PMID:2235678 RGD:11556254 RGD:11556254 RGD:150520179 NCBI chr15:68,800,557...68,810,268
Ensembl chr15:68,800,560...68,810,242
JBrowse link
G HPCA hippocalcin ISO RGD PMID:15336960 RGD:9686438 NCBI chr 6:89,187,544...89,197,049
Ensembl chr 6:89,188,133...89,197,045
JBrowse link
G NF1 neurofibromin 1 acts_upstream_of_or_within ISO (MGI:3628716|PMID:11788835) MGI PMID:11788835 MGI:3628716 NCBI chr12:43,487,098...43,754,205
Ensembl chr12:43,489,813...43,753,969
JBrowse link
G ORAI1 ORAI calcium release-activated calcium modulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr14:31,012,212...31,028,008
Ensembl chr14:31,011,644...31,027,993
JBrowse link
G STIM1 stromal interaction molecule 1 involved_in ISO (PMID:19171672) UniProt PMID:19171672 NCBI chr 9:6,066,612...6,270,090
Ensembl chr 9:6,066,617...6,270,575
JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 ISO RGD PMID:15901773 RGD:1598578 NCBI chr12:3,254,794...3,300,835
Ensembl chr12:3,254,493...3,300,835
JBrowse link
positive regulation of guanylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2B adenosine A2b receptor acts_upstream_of_or_within
involved_in
ISO
IEA
(MGI:3794903|PMID:18340377) MGI
Ensembl
PMID:18340377 GO_REF:0000107 MGI:3794903 NCBI chr12:59,431,834...59,449,701
Ensembl chr12:59,431,513...59,449,672
JBrowse link
G GUCA1A guanylate cyclase activator 1A involved_in IEA
ISO
GOC
RGD
PMID:12545196 GO_REF:0000108 RGD:1599357 NCBI chr 7:37,282,630...37,296,713
Ensembl chr 7:37,282,700...37,296,717
JBrowse link
G GUCA2A guanylate cyclase activator 2A involved_in IEA GOC GO_REF:0000108 NCBI chr 6:169,146,336...169,148,284
Ensembl chr 6:169,146,334...169,148,286
JBrowse link
G GUCA2B guanylate cyclase activator 2B involved_in IEA GOC GO_REF:0000108 NCBI chr 6:169,152,172...169,154,557
Ensembl chr 6:169,152,179...169,154,551
JBrowse link
G NOS1 nitric oxide synthase 1 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr14:35,112,898...35,299,297
Ensembl chr14:35,113,184...35,295,944
JBrowse link
G NOS3 nitric oxide synthase 3 involved_in IBA
IEA
(PMID:21873635) GO_Central
GO_Central
Ensembl
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943
JBrowse link
positive regulation of L-dopa decarboxylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARK7 Parkinsonism associated deglycase involved_in IEA Ensembl
Ensembl
GO_REF:0000107 NCBI chr 6:68,629,327...68,645,147
Ensembl chr 6:68,629,214...68,645,516
JBrowse link
positive regulation of lyase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FTMT ferritin mitochondrial involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:125,391,524...125,395,066
Ensembl chr 2:125,392,394...125,393,122
JBrowse link
G FXN frataxin involved_in ISO (PMID:18160053)
(PMID:20053667)
BHF-UCL
UniProt
PMID:18160053 PMID:20053667 NCBI chr 1:222,412,485...222,433,224
Ensembl chr 1:222,412,509...222,454,776
JBrowse link
regulation of adenylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAP1 cyclase associated actin cytoskeleton regulatory protein 1 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr 6:95,811,485...95,840,576
Ensembl chr 6:95,812,179...95,840,570
JBrowse link
G CAP2 cyclase associated actin cytoskeleton regulatory protein 2 involved_in IBA (PMID:21873635) GO_Central
GO_Central
PMID:21873635 NCBI chr 7:13,211,110...13,350,966
Ensembl chr 7:13,211,574...13,350,961
JBrowse link
G GNG7 G protein subunit gamma 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:75,929,877...76,083,557
Ensembl chr 2:76,039,656...76,083,555
JBrowse link
G NPFFR2 neuropeptide FF receptor 2 involved_in IEA InterPro
InterPro
GO_REF:0000002 NCBI chr 8:68,572,164...68,643,394
Ensembl chr 8:68,572,578...68,643,756
JBrowse link
regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRHR1 corticotropin releasing hormone receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:17,251,361...17,306,308
Ensembl chr12:17,252,020...17,306,285
JBrowse link
regulation of ferrochelatase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FXN frataxin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:222,412,485...222,433,224
Ensembl chr 1:222,412,509...222,454,776
JBrowse link
regulation of guanylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GUCA1A guanylate cyclase activator 1A involved_in
acts_upstream_of_or_within
IEA
ISO
(MGI:3052899|PMID:15336959) Ensembl
MGI
PMID:15336959 GO_REF:0000107 MGI:3052899 NCBI chr 7:37,282,630...37,296,713
Ensembl chr 7:37,282,700...37,296,717
JBrowse link
G GUCA1B guanylate cyclase activator 1B acts_upstream_of_or_within
involved_in
ISO
IBA
(MGI:3052899|PMID:15336959)
(PMID:21873635)
MGI
GO_Central
PMID:15336959 PMID:21873635 MGI:3052899 NCBI chr 7:37,297,901...37,311,158
Ensembl chr 7:37,297,908...37,310,170
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17484
    biological regulation 12766
      regulation of molecular function 2990
        regulation of catalytic activity 2194
          regulation of lyase activity 59
            negative regulation of lyase activity + 19
            positive regulation of lyase activity + 36
            regulation of L-dopa decarboxylase activity + 1
            regulation of aconitate hydratase activity + 3
            regulation of adenylate cyclase activity + 44
            regulation of cystathionine beta-synthase activity + 1
            regulation of ferrochelatase activity 1
            regulation of guanylate cyclase activity + 10
paths to the root