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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of lyase activity
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Accession:GO:0051339 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
Synonyms:exact_synonym: lyase regulator


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activation of adenylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACR acrosin involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr10:16,607,514...16,615,399
Ensembl chr10:16,609,915...16,615,354 		JBrowse link
G ADRB2 adrenoceptor beta 2 involved_in ISS
IEA		 HGNC-UCL
Ensembl
HGNC-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr 4:60,048,502...60,050,447
Ensembl chr 4:59,941,517...60,050,298 		JBrowse link
G ADRB2 adrenoceptor beta 2 involved_in IEA Ensembl GO_REF:0000107
G ADRB3 adrenoceptor beta 3 involved_in ISS
IEA		 HGNC-UCL
Ensembl
HGNC-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr16:27,445,601...27,446,796
Ensembl chr16:27,445,601...27,447,521 		JBrowse link
G CALCR calcitonin receptor NOT|involved_in ISO (PMID:15563840) UniProt PMID:15563840 NCBI chr14:18,923,116...19,074,904
Ensembl chr14:18,923,116...19,074,904 		JBrowse link
G CRSP-3 calcitonin receptor-stimulating peptide 3 involved_in
acts_upstream_of_or_within		 ISO (PMID:10822112), (PMID:16014619)
(MGI:77881|PMID:8582325)		 UniProt
MGI		 PMID:8582325 PMID:10822112 PMID:16014619 MGI:77881 NCBI chr21:37,676,841...37,680,643
Ensembl chr21:37,676,841...37,680,645 		JBrowse link
G DRD1 dopamine receptor D1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:2450485|PMID:12488442) MGI
Ensembl		 PMID:12488442 GO_REF:0000107 MGI:2450485 NCBI chr 4:37,550,454...37,554,641
Ensembl chr 4:37,549,708...37,553,287 		JBrowse link
G FSHR follicle stimulating hormone receptor involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:50,765,591...50,938,643
Ensembl chr10:50,770,995...50,938,474 		JBrowse link
G GHRHR growth hormone releasing hormone receptor ISO RGD PMID:9845677 RGD:1601338 NCBI chr14:43,626,862...43,638,737
Ensembl chr14:43,626,845...43,638,753 		JBrowse link
G GNAL G protein subunit alpha L acts_upstream_of_or_within ISO (MGI:2450485|PMID:12488442) MGI PMID:12488442 MGI:2450485 NCBI chr 7:77,378,134...77,521,215
Ensembl chr 7:77,413,986...77,521,042 		JBrowse link
G LGR4 leucine rich repeat containing G protein-coupled receptor 4 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr21:47,952,019...47,995,530
Ensembl chr21:47,952,890...47,996,288 		JBrowse link
G LHCGR luteinizing hormone/choriogonadotropin receptor involved_in ISO
IEA
IBA		 (PMID:21873635) RGD
Ensembl
GO_Central		 PMID:8440169 PMID:21873635 GO_REF:0000107 RGD:2292602 NCBI chr10:50,540,706...50,594,336
Ensembl chr10:50,541,960...50,598,036 		JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr20:5,892,839...5,972,672
Ensembl chr20:5,892,834...5,972,090 		JBrowse link
G RXFP1 relaxin family peptide receptor 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:55,650,869...55,745,560
Ensembl chr15:55,651,121...55,744,496 		JBrowse link
G RXFP2 relaxin family peptide receptor 2 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr25:8,307,850...8,368,438
Ensembl chr25:8,307,850...8,368,834 		JBrowse link
G TSHR thyroid stimulating hormone receptor involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:53,327,280...53,482,898
Ensembl chr 8:53,326,655...53,482,898 		JBrowse link
G VIPR2 vasoactive intestinal peptide receptor 2 ISO RGD PMID:8224221 RGD:70054 NCBI chr16:20,925,032...20,987,513
Ensembl chr16:20,927,991...20,987,785 		JBrowse link
negative regulation of adenylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADGRV1 adhesion G protein-coupled receptor V1 involved_in IEA InterPro
InterPro		 GO_REF:0000002 NCBI chr 3:17,866,459...18,351,532
Ensembl chr 3:17,866,808...18,351,532 		JBrowse link
G AKAP5 A-kinase anchoring protein 5 involved_in IEA
ISO		 Ensembl
Ensembl
RGD		 PMID:20410303 GO_REF:0000107 RGD:7242424 NCBI chr 8:38,891,637...38,902,390
Ensembl chr 8:38,896,840...38,898,126 		JBrowse link
G AKAP6 A-kinase anchoring protein 6 ISO RGD PMID:19574217 RGD:6902943 NCBI chr 8:11,403,655...11,882,684
Ensembl chr 8:11,406,280...11,874,406 		JBrowse link
G AKAP9 A-kinase anchoring protein 9 ISO RGD PMID:18772391 RGD:2313147 NCBI chr14:17,590,256...17,743,646
Ensembl chr14:17,590,772...17,740,294 		JBrowse link
G DRD2 dopamine receptor D2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:19,732,842...19,795,241
Ensembl chr 5:19,732,836...19,795,241 		JBrowse link
G DRD3 dopamine receptor D3 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr33:18,369,362...18,414,465
Ensembl chr33:18,372,865...18,412,277 		JBrowse link
G GABBR1 gamma-aminobutyric acid type B receptor subunit 1 ISO RGD PMID:15147298 RGD:2315493 NCBI chr35:26,212,274...26,243,910
Ensembl chr35:26,213,076...26,237,572 		JBrowse link
G GALR1 galanin receptor 1 involved_in IEA InterPro
InterPro		 GO_REF:0000002 NCBI chr 1:2,750,117...2,785,329
Ensembl chr 1:2,729,331...2,742,231
Ensembl chr 1:2,729,331...2,742,231 		JBrowse link
G GALR2 galanin receptor 2 involved_in IEA InterPro
InterPro		 GO_REF:0000002 NCBI chr 9:4,559,710...4,562,474
Ensembl chr 9:4,560,067...4,562,463 		JBrowse link
G GALR3 galanin receptor 3 involved_in IEA InterPro
InterPro		 GO_REF:0000002 NCBI chr10:26,814,942...26,819,725
Ensembl chr10:26,814,942...26,816,727 		JBrowse link
G HRH3 histamine receptor H3 ISO RGD PMID:10869375 RGD:632981 NCBI chr24:46,239,883...46,243,123 JBrowse link
G NPR3 natriuretic peptide receptor 3 ISO RGD PMID:8702617 RGD:1601497 NCBI chr 4:74,794,553...74,863,344
Ensembl chr 4:74,799,857...74,862,969 		JBrowse link
G P2RY13 purinergic receptor P2Y13 involved_in IEA InterPro GO_REF:0000002 NCBI chr23:45,898,698...45,902,047
Ensembl chr23:45,900,483...45,902,030 		JBrowse link
G PALM paralemmin acts_upstream_of_or_within
involved_in		 ISO
IEA
IBA		 (MGI:3618440|PMID:16386234)
(PMID:21873635)		 MGI
Ensembl
GO_Central		 PMID:16386234 PMID:21873635 GO_REF:0000107 MGI:3618440 NCBI chr20:57,847,631...57,868,790
Ensembl chr20:57,849,081...57,868,975 		JBrowse link
negative regulation of cystathionine beta-synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MTRR 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr34:6,068,572...6,119,580
Ensembl chr34:6,070,046...6,098,312 		JBrowse link
negative regulation of guanylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HPCA hippocalcin ISO RGD PMID:15336960 RGD:9686438 NCBI chr 2:68,464,631...68,473,661
Ensembl chr 2:68,465,280...68,473,310 		JBrowse link
G NHERF4 NHERF family PDZ scaffold protein 4 involved_in IEA GOC GO_REF:0000108 NCBI chr 5:14,687,868...14,692,474
Ensembl chr 5:14,687,905...14,692,128 		JBrowse link
G RD3 RD3 regulator of GUCY2D involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:9,876,003...9,887,267 JBrowse link
negative regulation of lyase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PHPT1 phosphohistidine phosphatase 1 involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr 9:48,736,310...48,737,771
Ensembl chr 9:48,736,333...48,737,725 		JBrowse link
positive regulation of aconitate hydratase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FXN frataxin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:88,288,566...88,311,228
Ensembl chr 1:88,288,566...88,311,228 		JBrowse link
G ISCU iron-sulfur cluster assembly enzyme involved_in IEA Ensembl
Ensembl		 GO_REF:0000107 NCBI chr26:18,300,800...18,307,668
Ensembl chr26:18,300,803...18,307,652 		JBrowse link
G LOC608550 ferritin heavy chain-like involved_in ISO (PMID:18160053) BHF-UCL PMID:18160053 NCBI chr11:11,512,268...11,513,672 JBrowse link
positive regulation of adenylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB1 adrenoceptor beta 1 ISO RGD PMID:21143600 RGD:8693686 NCBI chr28:24,908,224...24,909,684
Ensembl chr28:24,908,224...24,909,684 		JBrowse link
G AKAP5 A-kinase anchoring protein 5 involved_in IBA
IEA
ISO		 (PMID:21873635) GO_Central
InterPro
RGD		 PMID:20410303 PMID:21873635 GO_REF:0000002 RGD:7242424 NCBI chr 8:38,891,637...38,902,390
Ensembl chr 8:38,896,840...38,898,126 		JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C involved_in ISO (MGI:6243790|PMID:24086669) UniProt PMID:24086669 MGI:6243790 NCBI chr27:44,007,363...44,748,251
Ensembl chr27:44,008,020...44,746,429 		JBrowse link
G CACNA1D calcium voltage-gated channel subunit alpha1 D involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:36,189,986...36,488,460
Ensembl chr20:36,191,810...36,613,686 		JBrowse link
G CALCR calcitonin receptor involved_in ISO (PMID:7588285), (PMID:7769107) UniProt PMID:7588285 PMID:7769107 NCBI chr14:18,923,116...19,074,904
Ensembl chr14:18,923,116...19,074,904 		JBrowse link
G GCG glucagon ISO RGD PMID:2235678 RGD:11556254 RGD:11556254 RGD:150520179 NCBI chr36:7,544,637...7,554,171
Ensembl chr36:7,544,637...7,554,021 		JBrowse link
G HPCA hippocalcin ISO RGD PMID:15336960 RGD:9686438 NCBI chr 2:68,464,631...68,473,661
Ensembl chr 2:68,465,280...68,473,310 		JBrowse link
G NF1 neurofibromin 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (MGI:3628716|PMID:11788835) MGI
Ensembl		 PMID:11788835 GO_REF:0000107 MGI:3628716 NCBI chr 9:41,467,460...41,679,388
Ensembl chr 9:41,469,416...41,679,382 		JBrowse link
G ORAI1 ORAI calcium release-activated calcium modulator 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:7,584,276...7,599,667
Ensembl chr26:7,584,880...7,599,401 		JBrowse link
G STIM1 stromal interaction molecule 1 involved_in ISO (PMID:19171672) UniProt PMID:19171672 NCBI chr21:26,394,592...26,594,764
Ensembl chr21:26,394,811...26,593,375 		JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 ISO RGD PMID:15901773 RGD:1598578 NCBI chr 9:2,521,882...2,533,883
Ensembl chr 9:2,521,882...2,533,989 		JBrowse link
positive regulation of guanylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2B adenosine A2b receptor acts_upstream_of_or_within ISO (MGI:3794903|PMID:18340377) MGI PMID:18340377 MGI:3794903 NCBI chr 5:39,884,375...39,908,214 JBrowse link
G GUCA1A guanylate cyclase activator 1A involved_in IEA GOC GO_REF:0000108 NCBI chr12:10,786,284...10,795,974
Ensembl chr12:10,788,424...10,795,442 		JBrowse link
G GUCA1B guanylate cyclase activator 1B involved_in IEA GOC GO_REF:0000108 NCBI chr12:10,796,961...10,806,796
Ensembl chr12:10,797,921...10,834,237 		JBrowse link
G GUCA1C guanylate cyclase activator 1C involved_in IEA GOC GO_REF:0000108 NCBI chr33:14,106,331...14,141,368
Ensembl chr33:14,106,814...14,141,062 		JBrowse link
G GUCA2A guanylate cyclase activator 2A involved_in IEA GOC GO_REF:0000108 NCBI chr15:1,090,109...1,091,277
Ensembl chr15:1,090,109...1,091,375 		JBrowse link
G GUCA2B guanylate cyclase activator 2B involved_in IEA GOC GO_REF:0000108 NCBI chr15:1,094,283...1,096,605
Ensembl chr15:1,094,276...1,096,688 		JBrowse link
G NOS1 nitric oxide synthase 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr26:13,787,341...13,895,176
Ensembl chr26:13,786,309...13,962,332 		JBrowse link
G NOS2 nitric oxide synthase 2 involved_in IBA (PMID:21873635) GO_Central
GO_Central		 PMID:21873635 NCBI chr 9:42,171,821...42,210,217
Ensembl chr 9:42,171,821...42,208,588 		JBrowse link
G NOS3 nitric oxide synthase 3 involved_in IBA
IEA		 (PMID:21873635) GO_Central
GO_Central
Ensembl		 PMID:21873635 GO_REF:0000107 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277 		JBrowse link
positive regulation of L-dopa decarboxylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARK7 Parkinsonism associated deglycase involved_in ISO (PMID:19703902) ParkinsonsUK-UCL PMID:19703902 NCBI chr 5:61,576,219...61,592,325
Ensembl chr 5:61,576,069...61,592,303 		JBrowse link
positive regulation of lyase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FXN frataxin involved_in ISO (PMID:18160053)
(PMID:20053667)		 BHF-UCL
UniProt		 PMID:18160053 PMID:20053667 NCBI chr 1:88,288,566...88,311,228
Ensembl chr 1:88,288,566...88,311,228 		JBrowse link
G LOC608550 ferritin heavy chain-like involved_in ISO (PMID:18160053) BHF-UCL PMID:18160053 NCBI chr11:11,512,268...11,513,672 JBrowse link
regulation of adenylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAP1 cyclase associated actin cytoskeleton regulatory protein 1 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:2,886,661...2,913,975 JBrowse link
G CAP2 cyclase associated actin cytoskeleton regulatory protein 2 involved_in IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr35:16,336,716...16,476,166
Ensembl chr35:16,336,753...16,474,913 		JBrowse link
G GNG7 G protein subunit gamma 7 involved_in ISO (MGI:2450485|PMID:12488442) UniProt PMID:12488442 MGI:2450485 NCBI chr20:56,479,337...56,603,972 JBrowse link
G NPFFR2 neuropeptide FF receptor 2 involved_in IEA InterPro GO_REF:0000002 NCBI chr13:61,140,285...61,164,966
Ensembl chr13:61,148,828...61,164,811 		JBrowse link
regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRHR1 corticotropin releasing hormone receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:9,708,696...9,763,281
Ensembl chr 9:9,714,204...9,763,402 		JBrowse link
regulation of ferrochelatase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FXN frataxin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:88,288,566...88,311,228
Ensembl chr 1:88,288,566...88,311,228 		JBrowse link
regulation of guanylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GUCA1A guanylate cyclase activator 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:10,786,284...10,795,974
Ensembl chr12:10,788,424...10,795,442 		JBrowse link
G GUCA1B guanylate cyclase activator 1B acts_upstream_of_or_within ISO (MGI:3052899|PMID:15336959) MGI PMID:15336959 MGI:3052899 NCBI chr12:10,796,961...10,806,796
Ensembl chr12:10,797,921...10,834,237 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17438
    biological regulation 12384
      regulation of molecular function 3002
        regulation of catalytic activity 2196
          regulation of lyase activity 62
            negative regulation of lyase activity + 19
            positive regulation of lyase activity + 40
            regulation of L-dopa decarboxylase activity + 1
            regulation of aconitate hydratase activity + 3
            regulation of adenylate cyclase activity + 45
            regulation of cystathionine beta-synthase activity + 1
            regulation of ferrochelatase activity 1
            regulation of guanylate cyclase activity + 12
paths to the root