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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of lyase activity
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Accession:GO:0051339 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
Synonyms:exact_synonym: lyase regulator

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activation of adenylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acr acrosin involved_in ISO (PMID:3880736) UniProt PMID:3880736 NCBI chrNW_004955413:33,721,984...33,728,088 JBrowse link
G Adrb2 adrenoceptor beta 2 involved_in ISO (PMID:15123695) HGNC-UCL PMID:15123695 NCBI chrNW_004955415:5,515,157...5,517,198
Ensembl chrNW_004955415:5,515,697...5,516,980 		JBrowse link
G Adrb3 adrenoceptor beta 3 involved_in ISO (PMID:15123695) HGNC-UCL PMID:15123695 NCBI chrNW_004955463:13,663,064...13,665,553 JBrowse link
G Calcr calcitonin receptor NOT|involved_in ISO (PMID:15563840) UniProt PMID:15563840 NCBI chrNW_004955432:10,310,776...10,391,029
Ensembl chrNW_004955432:10,309,263...10,391,141 		JBrowse link
G Drd1 dopamine receptor D1 involved_in
acts_upstream_of_or_within		 ISO (PMID:2168520)
(MGI:2450485|PMID:12488442)		 BHF-UCL
MGI		 PMID:2168520 PMID:12488442 MGI:2450485 NCBI chrNW_004955408:28,003,229...28,006,595
Ensembl chrNW_004955408:28,003,229...28,006,595 		JBrowse link
G Ghrhr growth hormone releasing hormone receptor ISO RGD PMID:9845677 RGD:1601338 NCBI chrNW_004955410:32,084,210...32,114,844
Ensembl chrNW_004955410:32,102,367...32,115,080 		JBrowse link
G Gnal G protein subunit alpha L acts_upstream_of_or_within ISO (MGI:2450485|PMID:12488442) MGI PMID:12488442 MGI:2450485 NCBI chrNW_004955402:1,182,515...1,249,301
Ensembl chrNW_004955402:1,181,133...1,248,616 		JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor involved_in ISO (MGI:5318037|PMID:10493819) RGD
BHF-UCL		 PMID:8440169 PMID:10493819 MGI:5318037 RGD:2292602 NCBI chrNW_004955441:15,205,883...15,263,617
Ensembl chrNW_004955441:15,207,252...15,242,914 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase involved_in ISO (PMID:15385642) BHF-UCL PMID:15385642 NCBI chrNW_004955429:17,980,956...18,049,723
Ensembl chrNW_004955429:18,025,932...18,049,723 		JBrowse link
G Vipr2 vasoactive intestinal peptide receptor 2 ISO RGD PMID:8224221 RGD:70054 NCBI chrNW_004955579:1,160,620...1,212,711
Ensembl chrNW_004955579:1,160,620...1,209,848 		JBrowse link
negative regulation of adenylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgrv1 adhesion G protein-coupled receptor V1 involved_in ISO (MGI:6212875|PMID:24962568) UniProt PMID:24962568 MGI:6212875 NCBI chrNW_004955418:20,603,323...21,039,891 JBrowse link
G Akap5 A-kinase anchoring protein 5 involved_in ISO PMID:22976297
(PMID:20410303), (PMID:21771783)		 RGD
UniProt		 PMID:20410303 PMID:21771783 PMID:22976297 RGD:13800547 RGD:7242424 NCBI chrNW_004955466:5,411,190...5,422,043
Ensembl chrNW_004955466:5,411,650...5,412,960 		JBrowse link
G Akap6 A-kinase anchoring protein 6 ISO RGD PMID:19574217 RGD:6902943 NCBI chrNW_004955409:28,067,814...28,516,881
Ensembl chrNW_004955409:28,077,621...28,516,944 		JBrowse link
G Akap9 A-kinase anchoring protein 9 ISO RGD PMID:18772391 RGD:2313147 NCBI chrNW_004955432:8,933,037...9,090,872
Ensembl chrNW_004955432:8,932,952...9,095,065 		JBrowse link
G Drd2 dopamine receptor D2 involved_in ISO (PMID:2531656) BHF-UCL PMID:2531656 NCBI chrNW_004955412:15,054,255...15,114,558
Ensembl chrNW_004955412:15,054,038...15,114,573 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 ISO RGD PMID:15147298 RGD:2315493 NCBI chrNW_004955583:85,255...115,140
Ensembl chrNW_004955583:85,255...115,189 		JBrowse link
G Hrh3 histamine receptor H3 ISO RGD PMID:10869375 RGD:632981 NCBI chrNW_004955528:1,819,247...1,826,707
Ensembl chrNW_004955528:1,819,247...1,826,707 		JBrowse link
G Npr3 natriuretic peptide receptor 3 ISO RGD PMID:8702617 RGD:1601497 NCBI chrNW_004955426:18,491,350...18,559,299
Ensembl chrNW_004955426:18,491,350...18,553,743 		JBrowse link
G Palm paralemmin acts_upstream_of_or_within ISO (MGI:3618440|PMID:16386234) MGI PMID:16386234 MGI:3618440 NCBI chrNW_004955495:7,044,942...7,060,022
Ensembl chrNW_004955495:7,046,261...7,055,548 		JBrowse link
negative regulation of cystathionine beta-synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in ISO (PMID:24416422) BHF-UCL PMID:24416422 NCBI chrNW_004955504:5,412,290...5,435,409
Ensembl chrNW_004955504:5,413,586...5,435,645 		JBrowse link
negative regulation of guanylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hpca hippocalcin ISO RGD PMID:15336960 RGD:9686438 NCBI chrNW_004955452:11,142,282...11,150,798
Ensembl chrNW_004955452:11,140,373...11,154,261 		JBrowse link
G Rd3 RD3 regulator of GUCY2D involved_in ISO (PMID:21928830), (PMID:30559291)
(MGI:5810226|PMID:27471269)		 UniProt PMID:21928830 PMID:27471269 PMID:30559291 MGI:5810226 NCBI chrNW_004955489:896,964...903,855 JBrowse link
negative regulation of lyase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Phpt1 phosphohistidine phosphatase 1 involved_in ISO (PMID:20110805), (PMID:20501872) BHF-UCL PMID:20110805 PMID:20501872 NCBI chrNW_004955513:4,930,951...4,932,509
Ensembl chrNW_004955513:4,930,951...4,932,509 		JBrowse link
positive regulation of aconitate hydratase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ftmt ferritin mitochondrial involved_in ISO (PMID:18160053) BHF-UCL PMID:18160053 NCBI chrNW_004955521:76,591...77,470 JBrowse link
G Fxn frataxin involved_in ISO (PMID:18160053) BHF-UCL PMID:18160053 NCBI chrNW_004955434:3,983,225...4,008,324
Ensembl chrNW_004955434:3,980,653...4,008,761 		JBrowse link
G Iscu iron-sulfur cluster assembly enzyme involved_in ISO (PMID:20436681) ARUK-UCL PMID:20436681 NCBI chrNW_004955455:9,833,924...9,840,547
Ensembl chrNW_004955455:9,833,924...9,841,619 		JBrowse link
positive regulation of adenylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 ISO RGD PMID:21143600 RGD:8693686 NCBI chrNW_004955431:19,025,663...19,027,026 JBrowse link
G Akap5 A-kinase anchoring protein 5 ISO RGD PMID:20410303 RGD:7242424 NCBI chrNW_004955466:5,411,190...5,422,043
Ensembl chrNW_004955466:5,411,650...5,412,960 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C involved_in ISO (MGI:6243790|PMID:24086669) UniProt PMID:24086669 MGI:6243790 NCBI chrNW_004955454:4,573,647...5,199,046
Ensembl chrNW_004955454:4,490,923...5,198,506 		JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D involved_in ISO (MGI:6243790|PMID:24086669) UniProt PMID:24086669 MGI:6243790 NCBI chrNW_004955430:3,450,151...3,796,983
Ensembl chrNW_004955430:3,268,953...3,794,592 		JBrowse link
G Calcr calcitonin receptor involved_in ISO (PMID:7588285), (PMID:7769107) UniProt PMID:7588285 PMID:7769107 NCBI chrNW_004955432:10,310,776...10,391,029
Ensembl chrNW_004955432:10,309,263...10,391,141 		JBrowse link
G Gcg glucagon IDA RGD PMID:2235678 RGD:11556254 RGD:150520179, RGD:11556254 NCBI chrNW_004955449:11,708,152...11,716,429
Ensembl chrNW_004955449:11,708,152...11,716,429 		JBrowse link
G Hpca hippocalcin ISO RGD PMID:15336960 RGD:9686438 NCBI chrNW_004955452:11,142,282...11,150,798
Ensembl chrNW_004955452:11,140,373...11,154,261 		JBrowse link
G Nf1 neurofibromin 1 acts_upstream_of_or_within ISO (MGI:3628716|PMID:11788835) MGI PMID:11788835 MGI:3628716 NCBI chrNW_004955481:6,145,855...6,404,179
Ensembl chrNW_004955481:6,145,855...6,404,179 		JBrowse link
G Orai1 ORAI calcium release-activated calcium modulator 1 involved_in ISO (PMID:19171672) UniProt PMID:19171672 NCBI chrNW_004955482:6,731,949...6,746,095
Ensembl chrNW_004955482:6,731,949...6,775,545 		JBrowse link
G Stim1 stromal interaction molecule 1 involved_in ISO (PMID:19171672) UniProt PMID:19171672 NCBI chrNW_004955414:19,652,990...19,849,353
Ensembl chrNW_004955414:19,652,990...19,847,964 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 ISO RGD PMID:15901773 RGD:1598578 NCBI chrNW_004955506:3,769,113...3,812,896
Ensembl chrNW_004955506:3,768,646...3,813,820 		JBrowse link
positive regulation of guanylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2b adenosine A2b receptor acts_upstream_of_or_within ISO (MGI:3794903|PMID:18340377) MGI PMID:18340377 MGI:3794903 NCBI chrNW_004955467:1,342,271...1,363,149
Ensembl chrNW_004955467:1,342,271...1,363,138 		JBrowse link
G Guca1a guanylate cyclase activator 1A ISO RGD PMID:12545196 RGD:1599357 NCBI chrNW_004955437:8,370,553...8,382,640
Ensembl chrNW_004955437:8,376,091...8,382,640 		JBrowse link
G Nos3 nitric oxide synthase 3 involved_in ISO (PMID:17502619) BHF-UCL PMID:17502619 NCBI chrNW_004955491:5,438,228...5,457,308
Ensembl chrNW_004955491:5,438,010...5,460,814 		JBrowse link
positive regulation of L-dopa decarboxylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Park7 Parkinsonism associated deglycase involved_in ISO (PMID:19703902) ParkinsonsUK-UCL PMID:19703902 NCBI chrNW_004955486:4,974,130...4,985,927
Ensembl chrNW_004955486:4,969,497...4,985,885 		JBrowse link
positive regulation of lyase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ftmt ferritin mitochondrial involved_in ISO (PMID:18160053) BHF-UCL PMID:18160053 NCBI chrNW_004955521:76,591...77,470 JBrowse link
G Fxn frataxin involved_in ISO (PMID:20053667)
(PMID:18160053)		 UniProt
BHF-UCL		 PMID:18160053 PMID:20053667 NCBI chrNW_004955434:3,983,225...4,008,324
Ensembl chrNW_004955434:3,980,653...4,008,761 		JBrowse link
regulation of adenylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gng7 G protein subunit gamma 7 involved_in ISO (MGI:2450485|PMID:12488442) UniProt PMID:12488442 MGI:2450485 NCBI chrNW_004955495:4,889,198...4,995,288
Ensembl chrNW_004955495:4,889,198...4,893,353 		JBrowse link
regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crhr1 corticotropin releasing hormone receptor 1 involved_in ISO (PMID:23863939) UniProt PMID:23863939 NCBI chrNW_004955478:10,380,185...10,390,838
Ensembl chrNW_004955478:10,379,287...10,404,825 		JBrowse link
regulation of ferrochelatase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fxn frataxin involved_in ISO (PMID:15123683) BHF-UCL PMID:15123683 NCBI chrNW_004955434:3,983,225...4,008,324
Ensembl chrNW_004955434:3,980,653...4,008,761 		JBrowse link
regulation of guanylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Guca1a guanylate cyclase activator 1A acts_upstream_of_or_within ISO (MGI:3052899|PMID:15336959) MGI PMID:15336959 MGI:3052899 NCBI chrNW_004955437:8,370,553...8,382,640
Ensembl chrNW_004955437:8,376,091...8,382,640 		JBrowse link
G Guca1b guanylate cyclase activator 1B acts_upstream_of_or_within ISO (MGI:3052899|PMID:15336959) MGI PMID:15336959 MGI:3052899 NCBI chrNW_004955437:8,384,692...8,390,946
Ensembl chrNW_004955437:8,382,299...8,390,946 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12287
    biological regulation 8889
      regulation of molecular function 2131
        regulation of catalytic activity 1414
          regulation of lyase activity 41
            negative regulation of lyase activity + 13
            positive regulation of lyase activity + 27
            regulation of L-dopa decarboxylase activity + 1
            regulation of aconitate hydratase activity + 3
            regulation of adenylate cyclase activity + 30
            regulation of cystathionine beta-synthase activity + 1
            regulation of ferrochelatase activity 1
            regulation of guanylate cyclase activity + 6
paths to the root