Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of lyase activity
go back to main search page
Accession:GO:0051339 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
Synonyms:exact_synonym: lyase regulator


show annotations for term's descendants           Sort by:
activation of adenylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acr acrosin involved_in ISS
ISO		 GO_REF:0000024
(PMID:3880736)		 UniProt
RGD		 PMID:3880736 GO_REF:0000024 NCBI chr 7:120,636,581...120,644,474
Ensembl chr 7:120,638,321...120,644,474 		JBrowse link
G Calca calcitonin-related polypeptide alpha involved_in
acts_upstream_of_or_within		 ISO (PMID:10822112), (PMID:16014619)
(PMID:8582325)		 RGD PMID:8582325 PMID:10822112 PMID:16014619 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105 		JBrowse link
G Drd1 dopamine receptor D1 involved_in
acts_upstream_of_or_within		 ISO (PMID:2168520)
(PMID:12488442)		 RGD PMID:2168520 PMID:12488442 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002 		JBrowse link
G Ghrhr growth hormone releasing hormone receptor IDA RGD PMID:9845677 RGD:1601338 NCBI chr 4:84,498,159...84,532,851
Ensembl chr 4:84,500,212...84,532,776 		JBrowse link
G Gnal G protein subunit alpha L acts_upstream_of_or_within ISO (PMID:12488442) RGD PMID:12488442 NCBI chr18:60,622,311...60,762,599
Ensembl chr18:60,622,311...60,762,599 		JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor involved_in IDA
ISO
IEA		 (MGI:5318037|PMID:10493819)
GO_REF:0000107		 RGD
Ensembl		 PMID:10493819 PMID:8440169 GO_REF:0000107 MGI:5318037, RGD:2292602 NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase involved_in IEA
ISO		 GO_REF:0000107
(PMID:15385642)		 Ensembl
RGD		 PMID:15385642 GO_REF:0000107 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317 		JBrowse link
G Vipr2 vasoactive intestinal peptide receptor 2 IDA RGD PMID:8224221 RGD:70054 NCBI chr 6:136,996,664...137,070,599
Ensembl chr 6:137,001,511...137,070,597 		JBrowse link
negative regulation of aconitate hydratase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir210 microRNA 210 involved_in ISO (PMID:20436681) RGD PMID:20436681 NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454 		JBrowse link
negative regulation of adenylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgrv1 adhesion G protein-coupled receptor V1 involved_in IEA
ISO		 GO_REF:0000002
(MGI:6212875|PMID:24962568)		 InterPro
RGD		 PMID:24962568 GO_REF:0000002 MGI:6212875 NCBI chr 2:11,331,434...11,911,713
Ensembl chr 2:11,331,442...11,911,688 		JBrowse link
G Akap5 A-kinase anchoring protein 5 involved_in IDA
ISO		 (PMID:20410303), (PMID:21771783)
PMID:22976297		 RGD PMID:20410303 PMID:21771783 PMID:20410303 PMID:22976297 RGD:7242424, RGD:13800547 NCBI chr 6:95,051,527...95,061,075
Ensembl chr 6:95,051,537...95,061,578 		JBrowse link
G Akap6 A-kinase anchoring protein 6 IMP RGD PMID:19574217 RGD:6902943 NCBI chr 6:70,184,101...70,624,369
Ensembl chr 6:70,184,175...70,619,738 		JBrowse link
G Akap9 A-kinase anchoring protein 9 IMP RGD PMID:18772391 RGD:2313147 NCBI chr 4:30,056,738...30,192,716
Ensembl chr 4:30,056,738...30,192,606 		JBrowse link
G Drd2 dopamine receptor D2 involved_in ISO (PMID:2531656) RGD PMID:2531656 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 IMP RGD PMID:15147298 RGD:2315493 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994 		JBrowse link
G Galr1 galanin receptor 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr18:75,772,021...75,787,577
Ensembl chr18:75,772,023...75,787,577 		JBrowse link
G Galr2 galanin receptor 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:101,513,689...101,517,176
Ensembl chr10:101,514,471...101,517,176 		JBrowse link
G Galr3 galanin receptor 3 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:110,603,525...110,608,429
Ensembl chr 7:110,605,226...110,607,685 		JBrowse link
G Gpr87 G protein-coupled receptor 87 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:143,439,741...143,440,901
Ensembl chr 2:143,439,735...143,458,190 		JBrowse link
G Hrh3 histamine receptor H3 IDA RGD PMID:10869375 RGD:632981 NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642 		JBrowse link
G Npr3 natriuretic peptide receptor 3 IDA RGD PMID:8702617 RGD:1601497 NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955 		JBrowse link
G P2ry13 purinergic receptor P2Y13 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:143,470,437...143,476,360
Ensembl chr 2:143,470,425...143,473,434 		JBrowse link
G Palm paralemmin acts_upstream_of_or_within ISO (PMID:16386234) RGD PMID:16386234 NCBI chr 7:9,886,634...9,912,389
Ensembl chr 7:9,886,643...9,912,555 		JBrowse link
negative regulation of cystathionine beta-synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in IEA
ISO		 GO_REF:0000107
(PMID:24416422)		 Ensembl
RGD		 PMID:24416422 GO_REF:0000107 NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:34,867,089...34,899,425 		JBrowse link
negative regulation of guanylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hpca hippocalcin IDA RGD PMID:15336960 RGD:9686438 NCBI chr 5:141,455,616...141,466,252
Ensembl chr 5:141,455,613...141,463,841 		JBrowse link
G Rd3 RD3 regulator of GUCY2D involved_in IEA
ISO		 GO_REF:0000107
(MGI:5810226|PMID:27471269)
(PMID:21928830), (PMID:30559291)		 Ensembl
RGD		 PMID:21928830 PMID:27471269 PMID:30559291 GO_REF:0000107 MGI:5810226 NCBI chr13:103,551,823...103,562,925
Ensembl chr13:103,552,857...103,562,622 		JBrowse link
negative regulation of lyase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Phpt1 phosphohistidine phosphatase 1 involved_in ISO (PMID:20110805), (PMID:20501872) RGD PMID:20110805 PMID:20501872 NCBI chr 3:8,392,926...8,394,325 JBrowse link
positive regulation of aconitate hydratase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ftmt ferritin mitochondrial involved_in IEA
ISO		 GO_REF:0000107
UniProtKB:Q16595 (PMID:18160053)		 Ensembl
RGD		 PMID:18160053 GO_REF:0000107 NCBI chr18:45,758,874...45,760,123
Ensembl chr18:45,758,874...45,760,123 		JBrowse link
G Fxn frataxin involved_in IEA
ISO		 GO_REF:0000107
(PMID:18160053)		 Ensembl
RGD		 PMID:18160053 GO_REF:0000107 NCBI chr 1:221,874,007...221,897,543
Ensembl chr 1:221,872,420...221,897,540 		JBrowse link
G Iscu iron-sulfur cluster assembly enzyme involved_in IEA
ISO		 GO_REF:0000107
(PMID:20436681)		 Ensembl
RGD		 PMID:20436681 GO_REF:0000107 NCBI chr12:42,852,305...42,858,150
Ensembl chr12:42,852,305...42,858,150 		JBrowse link
positive regulation of adenylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 IMP RGD PMID:21143600 RGD:8693686 NCBI chr 1:255,771,962...255,774,973
Ensembl chr 1:255,771,597...255,807,259 		JBrowse link
G Akap5 A-kinase anchoring protein 5 involved_in IDA
IEA		 GO_REF:0000002 InterPro
RGD		 PMID:20410303 GO_REF:0000002, RGD:7242424 NCBI chr 6:95,051,527...95,061,075
Ensembl chr 6:95,051,537...95,061,578 		JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C involved_in ISS
ISO		 GO_REF:0000024
(MGI:6243790|PMID:24086669)		 UniProt
RGD		 PMID:24086669 GO_REF:0000024 MGI:6243790 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648 		JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D involved_in ISS
ISO		 GO_REF:0000024
(MGI:6243790|PMID:24086669)		 UniProt
RGD		 PMID:24086669 GO_REF:0000024 MGI:6243790 NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215 		JBrowse link
G Gcg glucagon ISO RGD (All species) (All species) NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929 		JBrowse link
G Hpca hippocalcin IDA RGD PMID:15336960 RGD:9686438 NCBI chr 5:141,455,616...141,466,252
Ensembl chr 5:141,455,613...141,463,841 		JBrowse link
G Nf1 neurofibromin 1 involved_in
acts_upstream_of_or_within		 ISS
ISO		 GO_REF:0000024
MGI:1857444 (PMID:11788835)		 HGNC-UCL
RGD		 PMID:11788835 GO_REF:0000024 NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658 		JBrowse link
G Orai1 ORAI calcium release-activated calcium modulator 1 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:19171672)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:19171672 GO_REF:0000024 GO_REF:0000107 NCBI chr12:33,533,151...33,548,361
Ensembl chr12:33,534,344...33,548,405 		JBrowse link
G Stim1 stromal interaction molecule 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:19171672)		 UniProt
RGD		 PMID:19171672 GO_REF:0000024 NCBI chr 1:156,656,246...156,818,777
Ensembl chr 1:156,656,013...156,818,363 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 IMP RGD PMID:15901773 RGD:1598578 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
positive regulation of guanylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2b adenosine A2B receptor acts_upstream_of_or_within ISO MGI:3773754 (PMID:18340377) RGD PMID:18340377 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772 		JBrowse link
G Guca1a guanylate cyclase activator 1A IDA RGD PMID:12545196 RGD:1599357 NCBI chr 9:13,588,988...13,598,566
Ensembl chr 9:13,588,525...13,598,565 		JBrowse link
G Nos3 nitric oxide synthase 3 involved_in IEA
ISO		 GO_REF:0000107
(PMID:17502619)		 Ensembl
RGD		 PMID:17502619 GO_REF:0000107 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
positive regulation of lyase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ftmt ferritin mitochondrial involved_in ISO (PMID:18160053) RGD PMID:18160053 NCBI chr18:45,758,874...45,760,123
Ensembl chr18:45,758,874...45,760,123 		JBrowse link
G Fxn frataxin involved_in ISO (PMID:18160053), (PMID:20053667) RGD PMID:18160053 PMID:20053667 NCBI chr 1:221,874,007...221,897,543
Ensembl chr 1:221,872,420...221,897,540 		JBrowse link
regulation of adenylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gng7 G protein subunit gamma 7 involved_in ISO (MGI:2450485|PMID:12488442) RGD PMID:12488442 MGI:2450485 NCBI chr 7:8,697,458...8,761,239
Ensembl chr 7:8,697,521...8,761,240 		JBrowse link
G Npffr2 neuropeptide FF receptor 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr14:18,513,120...18,558,074
Ensembl chr14:18,513,277...18,521,919 		JBrowse link
regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crhr1 corticotropin releasing hormone receptor 1 involved_in ISO (PMID:23863939) RGD PMID:23863939 NCBI chr10:89,040,186...89,083,481
Ensembl chr10:89,040,203...89,083,481 		JBrowse link
regulation of ferrochelatase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fxn frataxin involved_in IEA
ISO		 GO_REF:0000107
(PMID:15123683)		 Ensembl
RGD		 PMID:15123683 GO_REF:0000107 NCBI chr 1:221,874,007...221,897,543
Ensembl chr 1:221,872,420...221,897,540 		JBrowse link
regulation of guanylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Guca1a guanylate cyclase activator 1A acts_upstream_of_or_within ISO MGI:1194489 (PMID:15336959) RGD PMID:15336959 NCBI chr 9:13,588,988...13,598,566
Ensembl chr 9:13,588,525...13,598,565 		JBrowse link
G Guca1b guanylate cyclase activator 1B acts_upstream_of_or_within ISO MGI:102770 (PMID:15336959) RGD PMID:15336959 NCBI chr 9:13,599,619...13,607,455
Ensembl chr 9:13,599,619...13,607,455 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20115
    biological regulation 13552
      regulation of molecular function 1972
        regulation of catalytic activity 1357
          regulation of lyase activity 45
            negative regulation of lyase activity + 19
            positive regulation of lyase activity + 24
            regulation of L-dopa decarboxylase activity + 0
            regulation of aconitate hydratase activity + 4
            regulation of adenylate cyclase activity + 34
            regulation of cystathionine beta-synthase activity + 1
            regulation of ferrochelatase activity 1
            regulation of guanylate cyclase activity + 6
paths to the root