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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of lyase activity
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Accession:GO:0051339 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
Synonyms:exact_synonym: lyase regulator



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activation of adenylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acr acrosin involved_in ISS
ISO
GO_REF:0000024
(PMID:3880736)
UniProt
RGD
PMID:3880736 GO_REF:0000024 NCBI chr 7:120,636,581...120,644,474
Ensembl chr 7:120,638,321...120,644,474
JBrowse link
G Adrb2 adrenoceptor beta 2 involved_in ISO (PMID:15123695) RGD PMID:15123695 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Adrb3 adrenoceptor beta 3 involved_in ISO
ISS
(PMID:15123695)
GO_REF:0000024
RGD
HGNC-UCL
PMID:15123695 GO_REF:0000024 NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552
JBrowse link
G Calca calcitonin-related polypeptide alpha involved_in
acts_upstream_of_or_within
ISO (PMID:10822112), (PMID:16014619)
(MGI:77881|PMID:8582325)
RGD PMID:8582325 PMID:10822112 PMID:16014619 MGI:77881 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Calcr calcitonin receptor NOT|involved_in ISO (PMID:15563840) RGD PMID:15563840 NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392
JBrowse link
G Calm1 calmodulin 1 IDA RGD PMID:19305019 RGD:7241269 NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227
JBrowse link
G Calm2 calmodulin 2 IDA RGD PMID:19305019 RGD:7241269 NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287
JBrowse link
G Calm3 calmodulin 3 IDA RGD PMID:19305019 RGD:7241269 NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207
JBrowse link
G Drd1 dopamine receptor D1 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
(MGI:2450485|PMID:12488442)
(PMID:2168520)
Ensembl
RGD
PMID:2168520 PMID:12488442 GO_REF:0000107 MGI:2450485 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Fshr follicle stimulating hormone receptor involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
JBrowse link
G Ghrhr growth hormone releasing hormone receptor IDA RGD PMID:9845677 RGD:1601338 NCBI chr 4:84,498,159...84,532,847
Ensembl chr 4:84,500,212...84,532,776
JBrowse link
G Gnal G protein subunit alpha L acts_upstream_of_or_within ISO (MGI:2450485|PMID:12488442) RGD PMID:12488442 MGI:2450485 NCBI chr18:60,622,311...60,762,599
Ensembl chr18:60,622,311...60,762,599
JBrowse link
G Lhcgr luteinizing hormone/choriogonadotropin receptor involved_in IDA
IEA
ISO
IBA
GO_REF:0000107
(MGI:5318037|PMID:10493819)
PMID:21873635
Ensembl
RGD
PMID:10493819 PMID:8440169 PMID:21873635 GO_REF:0000107 MGI:5318037, RGD:2292602, RGD:13792537 NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase involved_in ISO (PMID:15385642) RGD PMID:15385642 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rxfp1 relaxin family peptide receptor 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:164,772,270...164,893,484
Ensembl chr 2:164,774,799...164,893,412
JBrowse link
G Rxfp2 relaxin family peptide receptor 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:4,925,722...4,986,596
Ensembl chr12:4,925,722...4,986,596
JBrowse link
G Tshr thyroid stimulating hormone receptor involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:110,341,585...110,475,297
Ensembl chr 6:110,341,581...110,474,538
JBrowse link
G Vipr2 vasoactive intestinal peptide receptor 2 IDA RGD PMID:8224221 RGD:70054 NCBI chr 6:136,996,664...137,070,599
Ensembl chr 6:137,001,511...137,070,597
JBrowse link
negative regulation of aconitate hydratase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mir210 microRNA 210 involved_in ISO (PMID:20436681) RGD PMID:20436681 NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454
JBrowse link
negative regulation of adenylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adgrv1 adhesion G protein-coupled receptor V1 involved_in ISO
IBA
(MGI:6212875|PMID:24962568)
PMID:21873635
RGD PMID:24962568 PMID:21873635 MGI:6212875, RGD:13792537 NCBI chr 2:11,331,434...11,911,713
Ensembl chr 2:11,331,442...11,911,688
JBrowse link
G Akap5 A-kinase anchoring protein 5 involved_in IDA
ISO
PMID:22976297
(PMID:20410303), (PMID:21771783)
RGD PMID:20410303 PMID:21771783 PMID:20410303 PMID:22976297 RGD:7242424, RGD:13800547 NCBI chr 6:95,051,527...95,061,075
Ensembl chr 6:95,051,537...95,061,578
JBrowse link
G Akap6 A-kinase anchoring protein 6 IMP RGD PMID:19574217 RGD:6902943 NCBI chr 6:70,184,101...70,624,369
Ensembl chr 6:70,184,175...70,619,738
JBrowse link
G Akap9 A-kinase anchoring protein 9 IMP RGD PMID:18772391 RGD:2313147 NCBI chr 4:30,056,738...30,192,716
Ensembl chr 4:30,056,738...30,192,606
JBrowse link
G Drd2 dopamine receptor D2 involved_in ISO
IBA
(PMID:2531656)
PMID:21873635
RGD PMID:2531656 PMID:21873635 RGD:13792537 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Drd3 dopamine receptor D3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:56,879,689...56,931,901
Ensembl chr11:56,879,689...56,940,596
JBrowse link
G Gabbr1 gamma-aminobutyric acid type B receptor subunit 1 IMP RGD PMID:15147298 RGD:2315493 NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994
JBrowse link
G Galr1 galanin receptor 1 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr18:75,772,021...75,787,577
Ensembl chr18:75,772,023...75,787,577
JBrowse link
G Galr2 galanin receptor 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr10:101,513,689...101,517,176
Ensembl chr10:101,514,471...101,517,176
JBrowse link
G Galr3 galanin receptor 3 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 7:110,603,525...110,608,429
Ensembl chr 7:110,605,226...110,607,685
JBrowse link
G Gpr87 G protein-coupled receptor 87 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:143,439,741...143,440,901
Ensembl chr 2:143,439,735...143,458,190
JBrowse link
G Hrh3 histamine receptor H3 IDA RGD PMID:10869375 RGD:632981 NCBI chr 3:167,191,551...167,196,642
Ensembl chr 3:167,191,558...167,196,642
JBrowse link
G Npr3 natriuretic peptide receptor 3 IDA RGD PMID:8702617 RGD:1601497 NCBI chr 2:60,865,483...60,933,432
Ensembl chr 2:60,870,594...60,932,955
JBrowse link
G P2ry13 purinergic receptor P2Y13 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:143,470,437...143,476,360
Ensembl chr 2:143,470,425...143,473,434
JBrowse link
G Palm paralemmin involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:3618440|PMID:16386234)
RGD PMID:16386234 PMID:21873635 MGI:3618440, RGD:13792537 NCBI chr 7:9,886,634...9,912,389
Ensembl chr 7:9,886,643...9,912,555
JBrowse link
negative regulation of cystathionine beta-synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase involved_in ISO (PMID:24416422) RGD PMID:24416422 NCBI chr 1:34,866,991...34,899,425
Ensembl chr 1:34,867,089...34,899,425
JBrowse link
negative regulation of guanylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hpca hippocalcin IDA RGD PMID:15336960 RGD:9686438 NCBI chr 5:141,455,616...141,466,252
Ensembl chr 5:141,455,613...141,463,841
JBrowse link
G Pdzd3 PDZ domain containing 3 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 8:44,584,390...44,588,838
Ensembl chr 8:44,584,390...44,588,860
JBrowse link
G Rd3 RD3 regulator of GUCY2D involved_in ISO (PMID:21928830), (PMID:30559291)
(MGI:5810226|PMID:27471269)
RGD PMID:21928830 PMID:27471269 PMID:30559291 MGI:5810226 NCBI chr13:103,551,823...103,562,925
Ensembl chr13:103,552,857...103,562,622
JBrowse link
negative regulation of lyase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Phpt1 phosphohistidine phosphatase 1 involved_in ISO (PMID:20110805), (PMID:20501872) RGD PMID:20110805 PMID:20501872 NCBI chr 3:8,392,926...8,394,325 JBrowse link
positive regulation of aconitate hydratase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ftmt ferritin mitochondrial involved_in ISO UniProtKB:Q16595 (PMID:18160053) RGD PMID:18160053 NCBI chr18:45,758,874...45,760,123
Ensembl chr18:45,758,874...45,760,123
JBrowse link
G Fxn frataxin involved_in ISO
IEA
(PMID:18160053)
GO_REF:0000107
RGD
Ensembl
PMID:18160053 GO_REF:0000107 NCBI chr 1:221,874,007...221,897,841
Ensembl chr 1:221,872,420...221,897,540
JBrowse link
G Iscu iron-sulfur cluster assembly enzyme involved_in ISO (PMID:20436681) RGD PMID:20436681 NCBI chr12:42,852,305...42,858,150
Ensembl chr12:42,852,305...42,858,150
JBrowse link
positive regulation of adenylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adrb1 adrenoceptor beta 1 IMP RGD PMID:21143600 RGD:8693686 NCBI chr 1:255,772,217...255,773,617
Ensembl chr 1:255,771,597...255,807,259
JBrowse link
G Akap5 A-kinase anchoring protein 5 involved_in IDA
IBA
IEA
PMID:21873635
GO_REF:0000002
InterPro
RGD
PMID:20410303 PMID:21873635 GO_REF:0000002, RGD:7242424, RGD:13792537 NCBI chr 6:95,051,527...95,061,075
Ensembl chr 6:95,051,537...95,061,578
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C involved_in ISS
ISO
GO_REF:0000024
(MGI:6243790|PMID:24086669)
UniProt
RGD
PMID:24086669 GO_REF:0000024 MGI:6243790 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D involved_in ISS
ISO
GO_REF:0000024
(MGI:6243790|PMID:24086669)
UniProt
RGD
PMID:24086669 GO_REF:0000024 MGI:6243790 NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215
JBrowse link
G Calcr calcitonin receptor involved_in ISO (PMID:7588285), (PMID:7769107)
(PMID:7769107)
RGD PMID:7588285 PMID:7769107 NCBI chr 4:31,661,270...31,736,392
Ensembl chr 4:31,661,273...31,736,392
JBrowse link
G Gcg glucagon ISO RGD RGD:11556254 RGD:150520179 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929
JBrowse link
G Hpca hippocalcin IDA RGD PMID:15336960 RGD:9686438 NCBI chr 5:141,455,616...141,466,252
Ensembl chr 5:141,455,613...141,463,841
JBrowse link
G Nf1 neurofibromin 1 involved_in
acts_upstream_of_or_within
ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
MGI:1857444 (MGI:3628716|PMID:11788835)
HGNC-UCL
Ensembl
RGD
PMID:11788835 GO_REF:0000024 GO_REF:0000107 MGI:3628716 NCBI chr10:64,306,027...64,539,112
Ensembl chr10:64,306,301...64,536,658
JBrowse link
G Orai1 ORAI calcium release-activated calcium modulator 1 involved_in ISO
ISS
IEA
(PMID:19171672)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:19171672 GO_REF:0000024 GO_REF:0000107 NCBI chr12:33,533,151...33,548,361
Ensembl chr12:33,534,344...33,548,405
JBrowse link
G Stim1 stromal interaction molecule 1 involved_in ISO
ISS
(PMID:19171672)
GO_REF:0000024
RGD
UniProt
PMID:19171672 GO_REF:0000024 NCBI chr 1:156,656,246...156,818,777
Ensembl chr 1:156,656,013...156,818,363
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 IMP RGD PMID:15901773 RGD:1598578 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
JBrowse link
positive regulation of guanylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2b adenosine A2B receptor involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:3773754 (MGI:3794903|PMID:18340377)
Ensembl
RGD
PMID:18340377 GO_REF:0000107 MGI:3794903 NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
JBrowse link
G Guca1a guanylate cyclase activator 1A IDA RGD PMID:12545196 RGD:1599357 NCBI chr 9:13,587,695...13,598,566
Ensembl chr 9:13,588,525...13,598,565
JBrowse link
G Guca1b guanylate cyclase activator 1B involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000108
(MGI:2664110|PMID:11493703)
GOC
RGD
PMID:11493703 GO_REF:0000108 MGI:2664110 NCBI chr 9:13,599,619...13,607,455
Ensembl chr 9:13,599,619...13,607,455
JBrowse link
G Guca2a guanylate cyclase activator 2A involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:133,237,177...133,239,019
Ensembl chr 5:133,237,177...133,239,018
JBrowse link
G Guca2b guanylate cyclase activator 2B involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 5:133,246,891...133,248,941
Ensembl chr 5:133,246,909...133,248,966
JBrowse link
G Ncs1 neuronal calcium sensor 1 involved_in IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 3:14,523,220...14,568,829
Ensembl chr 3:14,523,220...14,568,829
JBrowse link
G Nos1 nitric oxide synthase 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 involved_in IBA
IEA
ISO
PMID:21873635
GO_REF:0000107
(PMID:17502619)
Ensembl
RGD
PMID:17502619 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
positive regulation of L-dopa decarboxylase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Park7 Parkinsonism associated deglycase involved_in ISS
ISO
GO_REF:0000024
(PMID:19703902)
ParkinsonsUK-UCL
RGD
PMID:19703902 GO_REF:0000024 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
positive regulation of lyase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ftmt ferritin mitochondrial involved_in ISO (PMID:18160053) RGD PMID:18160053 NCBI chr18:45,758,874...45,760,123
Ensembl chr18:45,758,874...45,760,123
JBrowse link
G Fxn frataxin involved_in ISO (PMID:18160053), (PMID:20053667) RGD PMID:18160053 PMID:20053667 NCBI chr 1:221,874,007...221,897,841
Ensembl chr 1:221,872,420...221,897,540
JBrowse link
regulation of adenylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cap1 cyclase associated actin cytoskeleton regulatory protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:135,142,108...135,168,885
Ensembl chr 5:135,142,112...135,168,769
JBrowse link
G Cap2 cyclase associated actin cytoskeleton regulatory protein 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:18,054,234...18,203,453
Ensembl chr17:18,054,431...18,203,373
JBrowse link
G Gng7 G protein subunit gamma 7 involved_in ISO (MGI:2450485|PMID:12488442) RGD PMID:12488442 MGI:2450485 NCBI chr 7:8,697,458...8,761,239
Ensembl chr 7:8,697,521...8,761,240
JBrowse link
G Npffr2 neuropeptide FF receptor 2 involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr14:18,513,277...18,521,919
Ensembl chr14:18,513,277...18,521,919
JBrowse link
regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Crhr1 corticotropin releasing hormone receptor 1 involved_in ISO (PMID:23863939) RGD PMID:23863939 NCBI chr10:89,040,203...89,083,481
Ensembl chr10:89,040,203...89,083,481
JBrowse link
regulation of ferrochelatase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fxn frataxin involved_in ISO
IEA
(PMID:15123683)
GO_REF:0000107
RGD
Ensembl
PMID:15123683 GO_REF:0000107 NCBI chr 1:221,874,007...221,897,841
Ensembl chr 1:221,872,420...221,897,540
JBrowse link
regulation of guanylate cyclase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Guca1a guanylate cyclase activator 1A acts_upstream_of_or_within ISO MGI:1194489 (MGI:3052899|PMID:15336959) RGD PMID:15336959 MGI:3052899 NCBI chr 9:13,587,695...13,598,566
Ensembl chr 9:13,588,525...13,598,565
JBrowse link
G Guca1b guanylate cyclase activator 1B acts_upstream_of_or_within
involved_in
ISO
IBA
MGI:102770 (MGI:3052899|PMID:15336959)
PMID:21873635
RGD PMID:15336959 PMID:21873635 MGI:3052899, RGD:13792537 NCBI chr 9:13,599,619...13,607,455
Ensembl chr 9:13,599,619...13,607,455
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18877
    biological regulation 13380
      regulation of molecular function 3136
        regulation of catalytic activity 2337
          regulation of lyase activity 65
            negative regulation of lyase activity + 21
            positive regulation of lyase activity + 41
            regulation of L-dopa decarboxylase activity + 1
            regulation of aconitate hydratase activity + 4
            regulation of adenylate cyclase activity + 47
            regulation of cystathionine beta-synthase activity + 1
            regulation of ferrochelatase activity 1
            regulation of guanylate cyclase activity + 12
paths to the root