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ONTOLOGY REPORT - ANNOTATIONS

Term:attachment of mitotic spindle microtubules to kinetochore
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Accession:GO:0051315 term browser browse the term
Definition:The cellular process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex in mitosis.
Comment:This class covers transient, lateral attachment to microtubules as well as stable, correctly oriented, end-on attachment (biorientation)
Synonyms:exact_synonym: attachment of spindle microtubules to kinetochore involved in mitosis;   attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation;   attachment of spindle microtubules to mitotic chromosome
 related_synonym: attachment of spindle microtubules to kinetochore during mitosis;   mitotic bipolar attachment
 alt_id: GO:0051314


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attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 involved_in ISO (PMID:22581055) RGD PMID:22581055 NCBI chr19:67,529,249...67,534,195 JBrowse link
G Cenpc centromere protein C involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:22,342,910...22,401,522 JBrowse link
G Cenpe centromere protein E involved_in ISO (PMID:15843429) RGD PMID:15843429 NCBI chr 2:226,310,970...226,369,636 JBrowse link
G Champ1 chromosome alignment maintaining phosphoprotein 1 involved_in ISO (PMID:21063390) RGD PMID:21063390 NCBI chr16:75,733,958...75,744,931 JBrowse link
G Kif2c kinesin family member 2C involved_in ISO
ISS
IEA		 (PMID:23891108)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:23891108 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:130,637,347...130,662,680 JBrowse link
G Mad1l1 mitotic arrest deficient 1 like 1 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr12:14,320,892...14,630,750 JBrowse link
G Mapre1 microtubule-associated protein, RP/EB family, member 1 involved_in ISS
ISO
IEA		 GO_REF:0000024
UniProtKB:Q96BD8 (PMID:23001180), (PMID:36592928)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:23001180 PMID:36592928 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:162,679,020...162,707,167 JBrowse link
G Mis12 MIS12 kinetochore complex component involved_in ISO
IEA
ISS		 (PMID:23891108)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:23891108 GO_REF:0000024 GO_REF:0000107 NCBI chr10:56,238,317...56,246,491 JBrowse link
G Ndc80 NDC80 kinetochore complex component involved_in ISO
IBA		 (PMID:22581055), (PMID:23891108), (PMID:25743205), (PMID:30409912)
GO_REF:0000033		 RGD
GO_Central		 PMID:22581055 PMID:23891108 PMID:25743205 PMID:30409912 GO_REF:0000033 NCBI chr 9:118,853,806...118,887,582 JBrowse link
G Nuf2 NUF2 component of NDC80 kinetochore complex involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr13:84,226,448...84,290,957 JBrowse link
G Seh1l SEH1-like nucleoporin involved_in ISO (PMID:17363900) RGD PMID:17363900 NCBI chr18:63,612,228...63,639,852 JBrowse link
G Ska1 spindle and kinetochore associated complex subunit 1 involved_in IEA
ISS
ISO		 GO_REF:0000107
GO_REF:0000024
(PMID:29487209), (PMID:36592928)		 Ensembl
UniProt
RGD		 PMID:29487209 PMID:36592928 GO_REF:0000024 GO_REF:0000107 NCBI chr18:67,794,722...67,805,037 JBrowse link
G Ska2 spindle and kinetochore associated complex subunit 2 involved_in ISS
ISO		 GO_REF:0000024
(PMID:29487209)		 UniProt
RGD		 PMID:29487209 GO_REF:0000024 NCBI chr10:72,418,707...72,436,721 JBrowse link
G Ska3 spindle and kinetochore associated complex subunit 3 involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:28479321), (PMID:29487209)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:28479321 PMID:29487209 GO_REF:0000024 GO_REF:0000107 NCBI chr15:31,951,812...31,971,010 JBrowse link
lateral attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cenpe centromere protein E involved_in ISO (PMID:23891108) RGD PMID:23891108 NCBI chr 2:226,310,970...226,369,636 JBrowse link
mitotic sister chromatid biorientation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aurkb aurora kinase B involved_in ISS
ISO
IEA		 GO_REF:0000024
(PMID:22371557)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:22371557 GO_REF:0000024 GO_REF:0000107 NCBI chr10:54,243,116...54,249,675 JBrowse link
G Bod1 biorientation of chromosomes in cell division 1 involved_in ISO (PMID:17938248), (PMID:24157919) RGD PMID:17938248 PMID:24157919 NCBI chr10:15,993,454...15,999,795 JBrowse link
negative regulation of attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Sirt1 sirtuin 1 involved_in ISO (PMID:30409912) RGD PMID:30409912 NCBI chr20:25,305,953...25,328,000 JBrowse link
positive regulation of attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 involved_in ISO (PMID:23478334) RGD PMID:23478334 NCBI chr10:86,731,649...86,747,002 JBrowse link
G Hnrnpu heterogeneous nuclear ribonucleoprotein U involved_in IEA
ISO
ISS		 GO_REF:0000107
(PMID:21242313)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:21242313 GO_REF:0000024 GO_REF:0000107 NCBI chr13:92,609,791...92,618,580 JBrowse link
G Kat2b lysine acetyltransferase 2B involved_in ISO (PMID:23001180) RGD PMID:23001180 NCBI chr 9:6,799,101...6,903,616 JBrowse link
G Kat5 lysine acetyltransferase 5 involved_in ISO
ISS
IEA		 (PMID:30409912)
GO_REF:0000024
GO_REF:0000107		 RGD
UniProt
Ensembl		 PMID:30409912 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:212,325,089...212,332,640 JBrowse link
positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aurkb aurora kinase B involved_in ISO
IEA		 (PMID:28751710)
GO_REF:0000107		 RGD
Ensembl		 PMID:28751710 GO_REF:0000107 NCBI chr10:54,243,116...54,249,675 JBrowse link
regulation of attachment of mitotic spindle microtubules to kinetochore term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk1 cyclin-dependent kinase 1 involved_in ISO
ISS		 (PMID:28479321)
GO_REF:0000024		 RGD
UniProt		 PMID:28479321 GO_REF:0000024 NCBI chr20:19,265,252...19,280,456 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20534
    cellular process 19523
      cell cycle process 1310
        mitotic cell cycle process 734
          attachment of mitotic spindle microtubules to kinetochore 22
            lateral attachment of mitotic spindle microtubules to kinetochore + 2
            mitotic sister chromatid biorientation + 2
            negative regulation of attachment of mitotic spindle microtubules to kinetochore 1
            positive regulation of attachment of mitotic spindle microtubules to kinetochore + 5
            regulation of attachment of mitotic spindle microtubules to kinetochore + 7
Path 2
Term Annotations click to browse term
  biological_process 20534
    cellular process 19523
      cellular component organization or biogenesis 7187
        cellular component organization 6903
          organelle organization 3691
            organelle fission 518
              nuclear division 459
                mitotic nuclear division 275
                  mitotic sister chromatid segregation 185
                    mitotic metaphase chromosome alignment 61
                      attachment of mitotic spindle microtubules to kinetochore 22
                        lateral attachment of mitotic spindle microtubules to kinetochore + 2
                        mitotic sister chromatid biorientation + 2
                        negative regulation of attachment of mitotic spindle microtubules to kinetochore 1
                        positive regulation of attachment of mitotic spindle microtubules to kinetochore + 5
                        regulation of attachment of mitotic spindle microtubules to kinetochore + 7
paths to the root