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ONTOLOGY REPORT - ANNOTATIONS


Term:protein insertion into membrane
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Accession:GO:0051205 term browser browse the term
Definition:The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers.
Synonyms:exact_synonym: integral membrane protein localization;   integral membrane protein positioning;   membrane protein localization;   membrane protein positioning;   protein-membrane insertion


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protein insertion into membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cox18 cytochrome c oxidase assembly factor COX18 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr14:19,434,728...19,446,379
Ensembl chr14:19,434,753...19,446,376
JBrowse link
G Grin3b glutamate ionotropic receptor NMDA type subunit 3B involved_in IEA
ISO
GO_REF:0000107
(MGI:3688366|PMID:14602821)
Ensembl
RGD
PMID:14602821 GO_REF:0000107 MGI:3688366 NCBI chr 7:12,764,993...12,771,310
Ensembl chr 7:12,764,993...12,771,310
JBrowse link
G Oxa1l OXA1L, mitochondrial inner membrane protein involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:33,004,957...33,012,584
Ensembl chr15:33,004,133...33,012,575
JBrowse link
G Reep1 receptor accessory protein 1 involved_in ISO (PMID:15550249) RGD PMID:15550249 NCBI chr 4:99,618,622...99,735,329
Ensembl chr 4:99,618,622...99,735,319
JBrowse link
G Rtp1 receptor (chemosensory) transporter protein 1 involved_in ISO
IBA
(PMID:15550249)
PMID:21873635
RGD PMID:15550249, PMID:21873635 RGD:13792537 NCBI chr11:80,823,989...80,826,505
Ensembl chr11:80,823,989...80,826,505
JBrowse link
G Rtp2 receptor (chemosensory) transporter protein 2 involved_in IBA
ISO
PMID:21873635
(PMID:15550249)
RGD PMID:15550249, PMID:21873635 RGD:13792537 NCBI chr11:80,319,177...80,331,599
Ensembl chr11:80,319,177...80,331,599
JBrowse link
G Rtp3 receptor (chemosensory) transporter protein 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:119,260,609...119,265,501
Ensembl chr 8:119,260,618...119,265,157
JBrowse link
G Rtp4 receptor (chemosensory) transporter protein 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:80,638,945...80,650,802
Ensembl chr11:80,638,945...80,650,802
JBrowse link
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bbc3 Bcl-2 binding component 3 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:2681654 (MGI:3804133|PMID:16705087)
(PMID:17024184)
RGD PMID:16705087 PMID:17024184, PMID:21873635 MGI:3804133, RGD:13792537 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 acts_upstream_of_or_within ISO MGI:2678372 (MGI:2675761|PMID:12952892) RGD PMID:12952892 MGI:2675761 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 acts_upstream_of_or_within ISO (MGI:3607027|PMID:16227588) RGD PMID:16227588 MGI:3607027 NCBI chr 2:250,709,812...250,744,216
Ensembl chr 2:250,709,439...250,744,196
JBrowse link
positive regulation of protein insertion into mitochondrial outer membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdcd5 programmed cell death 5 involved_in ISO (PMID:16374546) RGD PMID:16374546 NCBI chr 1:91,173,473...91,178,801
Ensembl chr 1:91,173,473...91,178,801
Ensembl chr 1:91,173,473...91,178,801
JBrowse link
protein insertion into ER membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccdc47 coiled-coil domain containing 47 involved_in IEA
ISO
GO_REF:0000107
(PMID:32814900)
Ensembl
RGD
PMID:32814900 GO_REF:0000107 NCBI chr10:94,388,425...94,406,949
Ensembl chr10:94,388,430...94,406,949
JBrowse link
G Get1 guided entry of tail-anchored proteins factor 1 involved_in ISO (PMID:31417168), (PMID:32187542) RGD PMID:31417168 PMID:32187542 NCBI chr11:36,497,513...36,511,445
Ensembl chr11:36,497,509...36,511,535
JBrowse link
G Get4 guided entry of tail-anchored proteins factor 4 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:17,469,112...17,486,709
Ensembl chr12:17,469,112...17,486,157
JBrowse link
G Tram1 translocation associated membrane protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:5,215,196...5,297,337
Ensembl chr 5:5,215,196...5,316,685
JBrowse link
G Tram1l1 translocation associated membrane protein 1-like 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:228,544,418...228,546,599
Ensembl chr 2:228,544,418...228,546,599
JBrowse link
G Tram2 translocation associated membrane protein 2 involved_in ISO
IBA
(PMID:27499293)
PMID:21873635
RGD PMID:27499293, PMID:21873635 RGD:13792537 NCBI chr 9:27,117,861...27,192,166
Ensembl chr 9:27,117,869...27,192,135
JBrowse link
G Wdr83os WD repeat domain 83 opposite strand involved_in ISO (PMID:32814900) RGD PMID:32814900 NCBI chr19:26,194,336...26,195,837
Ensembl chr19:26,194,465...26,195,837
JBrowse link
protein insertion into ER membrane by stop-transfer membrane-anchor sequence term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Emc1 ER membrane protein complex subunit 1 involved_in ISO (PMID:29809151), (PMID:30415835) RGD PMID:29809151 PMID:30415835 NCBI chr 5:157,820,908...157,846,226
Ensembl chr 5:157,820,908...157,846,226
JBrowse link
G Emc10 ER membrane protein complex subunit 10 involved_in ISO
ISS
(PMID:29809151), (PMID:30415835)
GO_REF:0000024
RGD
UniProt
PMID:29809151 PMID:30415835 GO_REF:0000024 NCBI chr 1:100,495,112...100,501,468
Ensembl chr 1:100,495,119...100,501,437
JBrowse link
G Emc2 ER membrane protein complex subunit 2 involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:29809151), (PMID:30415835)
Ensembl
UniProt
RGD
PMID:29809151 PMID:30415835 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:82,338,639...82,377,389
Ensembl chr 7:82,338,663...82,377,109
JBrowse link
G Emc3 ER membrane protein complex subunit 3 involved_in ISO
ISS
(PMID:29809151), (PMID:30415835)
GO_REF:0000024
RGD
UniProt
PMID:29809151 PMID:30415835 GO_REF:0000024 NCBI chr 4:145,471,466...145,487,375
Ensembl chr 4:145,471,454...145,487,426
JBrowse link
G Emc4 ER membrane protein complex subunit 4 involved_in ISO (PMID:29809151), (PMID:30415835) RGD PMID:29809151 PMID:30415835 NCBI chr 3:103,852,139...103,857,172
Ensembl chr 3:103,852,139...103,857,158
JBrowse link
G Emc6 ER membrane protein complex subunit 6 involved_in ISO (PMID:29809151), (PMID:30415835) RGD PMID:29809151 PMID:30415835 NCBI chr10:59,741,772...59,743,338
Ensembl chr10:59,741,772...59,743,315
JBrowse link
G Emc7 ER membrane protein complex subunit 7 involved_in ISO (PMID:29809151), (PMID:30415835) RGD PMID:29809151 PMID:30415835 NCBI chr 3:103,945,276...103,955,970
Ensembl chr 3:103,945,329...103,956,007
JBrowse link
G Emc8 ER membrane protein complex subunit 8 involved_in ISS
ISO
GO_REF:0000024
(PMID:29809151), (PMID:30415835)
UniProt
RGD
PMID:29809151 PMID:30415835 GO_REF:0000024 NCBI chr19:54,235,949...54,245,810
Ensembl chr19:54,235,936...54,245,855
JBrowse link
G Emc9 ER membrane protein complex subunit 9 involved_in ISO
ISS
(PMID:29809151), (PMID:30415835)
GO_REF:0000024
RGD
UniProt
PMID:29809151 PMID:30415835 GO_REF:0000024 NCBI chr15:34,258,940...34,263,156
Ensembl chr15:34,256,374...34,263,224
JBrowse link
G Mmgt1 membrane magnesium transporter 1 involved_in ISS
ISO
GO_REF:0000024
(PMID:29809151), (PMID:30415835)
UniProt
RGD
PMID:29809151 PMID:30415835 GO_REF:0000024 NCBI chr  X:158,966,694...158,978,995
Ensembl chr  X:158,966,673...158,978,995
JBrowse link
protein insertion into membrane from inner side term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc12a1 solute carrier family 12 member 1 IDA RGD PMID:19592485 RGD:7242914 NCBI chr 3:117,421,531...117,498,372
Ensembl chr 3:117,421,604...117,498,367
JBrowse link
protein insertion into mitochondrial inner membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agk acylglycerol kinase involved_in ISO (PMID:28712724), (PMID:28712726) RGD PMID:28712724 PMID:28712726 NCBI chr 4:68,483,345...68,561,518
Ensembl chr 4:68,483,320...68,560,801
JBrowse link
G Ndufa13 NADH:ubiquinone oxidoreductase subunit A13 involved_in ISO (PMID:23271731) RGD PMID:23271731 NCBI chr16:21,275,311...21,282,246
Ensembl chr16:21,275,311...21,282,246
JBrowse link
G Romo1 reactive oxygen species modulator 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:151,688,213...151,689,813
Ensembl chr 3:151,688,454...151,689,711
Ensembl chr 3:151,688,454...151,689,711
JBrowse link
G Timm10 translocase of inner mitochondrial membrane 10 involved_in ISO
IBA
(PMID:16387659)
(MGI:3770568|PMID:14726512)
PMID:21873635
RGD PMID:14726512 PMID:16387659, PMID:21873635 MGI:3770568, RGD:13792537 NCBI chr 3:72,226,563...72,230,087
Ensembl chr 3:72,226,613...72,230,084
JBrowse link
G Timm13 translocase of inner mitochondrial membrane 13 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:11,677,340...11,678,443
Ensembl chr 7:11,677,340...11,678,442
JBrowse link
G Timm22 translocase of inner mitochondrial membrane 22 involved_in ISO
IBA
ISS
(PMID:27554484), (PMID:28712724), (PMID:28712726)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:27554484 PMID:28712724 PMID:28712726, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr10:64,556,064...64,563,822
Ensembl chr10:64,556,064...64,563,822
JBrowse link
G Timm29 translocase of inner mitochondrial membrane 29 involved_in IBA
ISO
PMID:21873635
(PMID:27554484), (PMID:28712724), (PMID:28712726)
RGD PMID:27554484 PMID:28712724 PMID:28712726, PMID:21873635 RGD:13792537 NCBI chr 8:22,625,874...22,628,843
Ensembl chr 8:22,625,874...22,628,843
JBrowse link
G Timm9 translocase of inner mitochondrial membrane 9 involved_in ISO (PMID:16387659)
(MGI:3770568|PMID:14726512)
RGD PMID:14726512 PMID:16387659 MGI:3770568 NCBI chr 6:93,549,484...93,562,314
Ensembl chr 6:93,549,484...93,562,314
JBrowse link
protein insertion into mitochondrial inner membrane from matrix term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcs1l BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:81,868,158...81,872,201
Ensembl chr 9:81,868,265...81,872,197
JBrowse link
G Cox18 cytochrome c oxidase assembly factor COX18 involved_in ISO
IBA
(PMID:28330871)
PMID:21873635
RGD PMID:28330871, PMID:21873635 RGD:13792537 NCBI chr14:19,434,728...19,446,379
Ensembl chr14:19,434,753...19,446,376
JBrowse link
G Maip1 matrix AAA peptidase interacting protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:64,095,978...64,103,908
Ensembl chr 9:64,095,978...64,103,907
JBrowse link
G Oxa1l OXA1L, mitochondrial inner membrane protein involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr15:33,004,957...33,012,584
Ensembl chr15:33,004,133...33,012,575
JBrowse link
protein insertion into mitochondrial membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cox18 cytochrome c oxidase assembly factor COX18 involved_in ISO UniProtKB:P53239 (PMID:16911509) RGD PMID:16911509 NCBI chr14:19,434,728...19,446,379
Ensembl chr14:19,434,753...19,446,376
JBrowse link
G Maip1 matrix AAA peptidase interacting protein 1 involved_in ISO
ISS
(PMID:27642048)
GO_REF:0000024
RGD
UniProt
PMID:27642048 GO_REF:0000024 NCBI chr 9:64,095,978...64,103,908
Ensembl chr 9:64,095,978...64,103,907
JBrowse link
G Tomm22 translocase of outer mitochondrial membrane 22 IMP RGD PMID:18687331 RGD:8554729 NCBI chr 7:120,901,934...120,903,684
Ensembl chr 7:120,901,934...120,903,684
JBrowse link
G Tomm40 translocase of outer mitochondrial membrane 40 IMP RGD PMID:18687331 RGD:8554729 NCBI chr 1:80,617,749...80,630,253
Ensembl chr 1:80,618,154...80,630,038
JBrowse link
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
MGI:1857429 (MGI:2675761|PMID:12952892)
Ensembl
RGD
PMID:12952892 GO_REF:0000107 MGI:2675761 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Moap1 modulator of apoptosis 1 involved_in ISO (PMID:16199525) RGD PMID:16199525 NCBI chr 6:126,620,597...126,622,532
Ensembl chr 6:126,620,602...126,622,532
JBrowse link
protein insertion into mitochondrial outer membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 involved_in ISO (PMID:15644312) RGD PMID:15644312 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 involved_in ISO
IEA
(PMID:15644312)
GO_REF:0000107
RGD
Ensembl
PMID:15644312 GO_REF:0000107 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
JBrowse link
G Samm50 SAMM50 sorting and assembly machinery component involved_in ISO
IBA
(PMID:15644312)
PMID:21873635
RGD PMID:15644312, PMID:21873635 RGD:13792537 NCBI chr 7:125,058,966...125,082,506
Ensembl chr 7:125,058,897...125,082,505
JBrowse link
G Tomm22 translocase of outer mitochondrial membrane 22 involved_in ISO (PMID:15644312) RGD PMID:15644312 NCBI chr 7:120,901,934...120,903,684
Ensembl chr 7:120,901,934...120,903,684
JBrowse link
protein insertion into plasma membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mal mal, T-cell differentiation protein involved_in ISO MGI:3053860 (MGI:5521464|PMID:22323295) RGD PMID:22323295 MGI:5521464 NCBI chr 3:120,209,647...120,233,655
Ensembl chr 3:120,209,647...120,233,655
JBrowse link
tail-anchored membrane protein insertion into ER membrane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bag6 BAG cochaperone 6 involved_in ISS
ISO
GO_REF:0000024
(PMID:20676083), (PMID:25535373)
UniProt
RGD
PMID:20676083 PMID:25535373 GO_REF:0000024 NCBI chr20:5,124,512...5,138,084
Ensembl chr20:5,125,349...5,138,084
JBrowse link
G Camlg calcium modulating ligand involved_in ISO
IDA
(PMID:23041287), (PMID:27226539) RGD PMID:23041287 PMID:27226539, PMID:23041287 RGD:42721997 NCBI chr17:9,523,792...9,534,683
Ensembl chr17:9,523,795...9,534,653
JBrowse link
G Emc1 ER membrane protein complex subunit 1 involved_in ISO (PMID:29242231) RGD PMID:29242231 NCBI chr 5:157,820,908...157,846,226
Ensembl chr 5:157,820,908...157,846,226
JBrowse link
G Emc10 ER membrane protein complex subunit 10 involved_in ISS
ISO
GO_REF:0000024
(PMID:29242231)
UniProt
RGD
PMID:29242231 GO_REF:0000024 NCBI chr 1:100,495,112...100,501,468
Ensembl chr 1:100,495,119...100,501,437
JBrowse link
G Emc2 ER membrane protein complex subunit 2 involved_in IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:29242231)
Ensembl
UniProt
RGD
PMID:29242231 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:82,338,639...82,377,389
Ensembl chr 7:82,338,663...82,377,109
JBrowse link
G Emc3 ER membrane protein complex subunit 3 involved_in ISO
ISS
(PMID:29242231)
GO_REF:0000024
RGD
UniProt
PMID:29242231 GO_REF:0000024 NCBI chr 4:145,471,466...145,487,375
Ensembl chr 4:145,471,454...145,487,426
JBrowse link
G Emc4 ER membrane protein complex subunit 4 involved_in ISO (PMID:29242231) RGD PMID:29242231 NCBI chr 3:103,852,139...103,857,172
Ensembl chr 3:103,852,139...103,857,158
JBrowse link
G Emc6 ER membrane protein complex subunit 6 involved_in ISO (PMID:29242231) RGD PMID:29242231 NCBI chr10:59,741,772...59,743,338
Ensembl chr10:59,741,772...59,743,315
JBrowse link
G Emc7 ER membrane protein complex subunit 7 involved_in ISO (PMID:29242231) RGD PMID:29242231 NCBI chr 3:103,945,276...103,955,970
Ensembl chr 3:103,945,329...103,956,007
JBrowse link
G Emc8 ER membrane protein complex subunit 8 involved_in ISO
ISS
(PMID:29242231)
GO_REF:0000024
RGD
UniProt
PMID:29242231 GO_REF:0000024 NCBI chr19:54,235,949...54,245,810
Ensembl chr19:54,235,936...54,245,855
JBrowse link
G Emc9 ER membrane protein complex subunit 9 involved_in ISO
ISS
(PMID:29242231)
GO_REF:0000024
RGD
UniProt
PMID:29242231 GO_REF:0000024 NCBI chr15:34,258,940...34,263,156
Ensembl chr15:34,256,374...34,263,224
JBrowse link
G Get1 guided entry of tail-anchored proteins factor 1 involved_in IBA
IDA
ISO
PMID:21873635
PMID:23041287
(PMID:23041287), (PMID:27226539)
RGD PMID:23041287 PMID:27226539, PMID:21873635, PMID:23041287 RGD:13792537, RGD:42721997 NCBI chr11:36,497,513...36,511,445
Ensembl chr11:36,497,509...36,511,535
JBrowse link
G Get3 guided entry of tail-anchored proteins factor 3, ATPase involved_in ISO
IDA
(PMID:23041287), (PMID:25535373)
PMID:27226539
RGD PMID:23041287 PMID:25535373, PMID:23041287, PMID:27226539 RGD:42721997, RGD:42721993 NCBI chr19:26,133,024...26,142,637
Ensembl chr19:26,133,027...26,141,111
JBrowse link
G Get4 guided entry of tail-anchored proteins factor 4 involved_in ISO (PMID:20676083), (PMID:25535373) RGD PMID:20676083 PMID:25535373 NCBI chr12:17,469,112...17,486,709
Ensembl chr12:17,469,112...17,486,157
JBrowse link
G Mmgt1 membrane magnesium transporter 1 involved_in ISO
ISS
(PMID:29242231)
GO_REF:0000024
RGD
UniProt
PMID:29242231 GO_REF:0000024 NCBI chr  X:158,966,694...158,978,995
Ensembl chr  X:158,966,673...158,978,995
JBrowse link
G Sgta small glutamine rich tetratricopeptide repeat co-chaperone alpha involved_in ISS
ISO
GO_REF:0000024
(PMID:25535373)
UniProt
RGD
PMID:25535373 GO_REF:0000024 NCBI chr 7:11,521,949...11,538,691
Ensembl chr 7:11,521,998...11,539,319
JBrowse link
G Ubl4a ubiquitin-like 4A involved_in ISO
ISS
(PMID:20676083), (PMID:25535373)
GO_REF:0000024
RGD
UniProt
PMID:20676083 PMID:25535373 GO_REF:0000024 NCBI chr  X:156,340,919...156,343,771
Ensembl chr  X:156,340,925...156,343,777
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19638
    localization 6422
      macromolecule localization 2984
        protein localization 2545
          cellular protein localization 1823
            protein insertion into membrane 53
              protein insertion into ER membrane + 22
              protein insertion into membrane from inner side + 5
              protein insertion into membrane raft + 0
              protein insertion into mitochondrial membrane + 21
              protein insertion into plasma membrane + 1
Path 2
Term Annotations click to browse term
  biological_process 19638
    localization 6422
      cellular localization 2968
        cellular macromolecule localization 1837
          cellular protein localization 1823
            protein localization to membrane 614
              establishment of protein localization to membrane 263
                protein insertion into membrane 53
                  protein insertion into ER membrane + 22
                  protein insertion into membrane from inner side + 5
                  protein insertion into membrane raft + 0
                  protein insertion into mitochondrial membrane + 21
                  protein insertion into plasma membrane + 1
paths to the root