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ONTOLOGY REPORT - ANNOTATIONS

Term:NK T cell activation
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Accession:GO:0051132 term browser browse the term
Definition:The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
Comment:Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repetoire of variable region gene segments.
Synonyms:exact_synonym: NK T lymphocyte activation;   NKT cell activation;   NT cell activation;   natural T cell activation;   natural killer T cell activation


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NK T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLEC2B C-type lectin domain family 2 member B involved_in IDA (PMID:17057721) UniProt PMID:17057721 NCBI chr12:9,852,369...9,869,354
Ensembl chr12:9,852,369...9,869,386 		JBrowse link
G CLEC4F C-type lectin domain family 4 member F acts_upstream_of_or_within ISO (PMID:23762286) MGI PMID:23762286 NCBI chr 2:70,808,643...70,825,235
Ensembl chr 2:70,808,643...70,820,599 		JBrowse link
G KLRF1 killer cell lectin like receptor F1 involved_in IDA (PMID:17057721) UniProt PMID:17057721 NCBI chr12:9,800,052...9,845,005
Ensembl chr12:9,827,481...9,845,007 		JBrowse link
negative regulation of NK T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD300A CD300a molecule involved_in IDA (PMID:10540326) UniProt PMID:10540326 NCBI chr17:74,466,373...74,484,798
Ensembl chr17:74,466,399...74,484,794 		JBrowse link
negative regulation of NK T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ZBTB7B zinc finger and BTB domain containing 7B involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:155,001,750...155,018,523
Ensembl chr 1:155,002,630...155,018,523 		JBrowse link
NK T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ELF4 E74 like ETS transcription factor 4 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr  X:130,063,955...130,111,927
Ensembl chr  X:130,063,955...130,110,716 		JBrowse link
G IL15 interleukin 15 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10704459) Ensembl
MGI		 PMID:10704459 GO_REF:0000107 NCBI chr 4:141,636,583...141,733,987
Ensembl chr 4:141,636,583...141,733,987 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor involved_in ISO (PMID:19423665) MGI PMID:19423665 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951 		JBrowse link
positive regulation of NK T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD1D CD1d molecule acts_upstream_of_or_within ISO (PMID:10201995), (PMID:11754812), (PMID:7538697) MGI PMID:7538697 PMID:10201995 PMID:11754812 NCBI chr 1:158,178,030...158,186,427
Ensembl chr 1:158,178,030...158,186,427 		JBrowse link
G HSPH1 heat shock protein family H (Hsp110) member 1 involved_in TAS (PMID:12952910) BHF-UCL PMID:12952910 NCBI chr13:31,134,973...31,162,388
Ensembl chr13:31,134,973...31,162,388 		JBrowse link
G IL12A interleukin 12A involved_in IDA (PMID:19088061) BHF-UCL PMID:19088061 NCBI chr 3:159,988,835...159,996,019
Ensembl chr 3:159,988,835...159,996,019 		JBrowse link
G IL12B interleukin 12B involved_in IC
IDA		 (PMID:20027291)
(PMID:19088061)		 BHF-UCL PMID:19088061 PMID:20027291 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863 		JBrowse link
G IL23A interleukin 23 subunit alpha involved_in IDA
IC		 (PMID:19088061)
(PMID:20027291)		 BHF-UCL PMID:19088061 PMID:20027291 NCBI chr12:56,338,884...56,340,410
Ensembl chr12:56,334,174...56,340,410 		JBrowse link
G IL23R interleukin 23 receptor involved_in IC (PMID:19088061) BHF-UCL PMID:19088061 NCBI chr 1:67,138,637...67,265,903
Ensembl chr 1:67,138,907...67,259,979 		JBrowse link
positive regulation of NK T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL12B interleukin 12B involved_in IDA (PMID:19088061) ComplexPortal PMID:19088061 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863 		JBrowse link
G IL18 interleukin 18 involved_in IDA (PMID:19088061) BHF-UCL PMID:19088061 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096 		JBrowse link
G IL23A interleukin 23 subunit alpha involved_in IDA (PMID:19088061) ComplexPortal PMID:19088061 NCBI chr12:56,338,884...56,340,410
Ensembl chr12:56,334,174...56,340,410 		JBrowse link
G JAK2 Janus kinase 2 involved_in IDA
NAS		 (PMID:19088061) ComplexPortal PMID:19088061 NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,129,948 		JBrowse link
G RASAL3 RAS protein activator like 3 involved_in IMP (PMID:25652366) UniProt PMID:25652366 NCBI chr19:15,451,624...15,464,544
Ensembl chr19:15,451,624...15,464,544 		JBrowse link
G TYK2 tyrosine kinase 2 involved_in IDA
NAS		 (PMID:19088061) ComplexPortal PMID:19088061 NCBI chr19:10,350,533...10,380,572
Ensembl chr19:10,350,533...10,380,608 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19669
    immune system process 3226
      leukocyte activation 1138
        lymphocyte activation 932
          T cell activation 667
            alpha-beta T cell activation 222
              NK T cell activation 18
                NK T cell activation involved in immune response + 0
                NK T cell proliferation + 10
                negative regulation of NK T cell activation + 2
                positive regulation of NK T cell activation + 10
                regulation of NK T cell activation + 12
Path 2
Term Annotations click to browse term
  biological_process 19669
    cellular process 18300
      cell activation 1311
        leukocyte activation 1138
          lymphocyte activation 932
            T cell activation 667
              alpha-beta T cell activation 222
                NK T cell activation 18
                  NK T cell activation involved in immune response + 0
                  NK T cell proliferation + 10
                  negative regulation of NK T cell activation + 2
                  positive regulation of NK T cell activation + 10
                  regulation of NK T cell activation + 12
paths to the root