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ONTOLOGY REPORT - ANNOTATIONS


Term:NK T cell activation
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Accession:GO:0051132 term browser browse the term
Definition:The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
Comment:Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repetoire of variable region gene segments.
Synonyms:exact_synonym: NK T lymphocyte activation;   NKT cell activation;   NT cell activation;   natural T cell activation;   natural killer T cell activation



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NK T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clec4f C-type lectin domain family 4, member F acts_upstream_of_or_within ISO MGI:5529277 (MGI:5525181|PMID:23762286) RGD PMID:23762286 MGI:5525181 NCBI chr 4:116,129,023...116,138,744
Ensembl chr 4:116,129,023...116,138,775
JBrowse link
negative regulation of NK T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300a Cd300a molecule involved_in ISO (PMID:10540326) RGD PMID:10540326 NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674
JBrowse link
negative regulation of NK T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Zbtb7b zinc finger and BTB domain containing 7B involved_in ISO (MGI:5449456|PMID:23105140) RGD PMID:23105140 MGI:5449456 NCBI chr 2:174,795,831...174,811,980
Ensembl chr 2:174,797,453...174,814,236
JBrowse link
NK T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Elf4 E74 like ETS transcription factor 4 involved_in ISO (MGI:2388503|PMID:12387738) RGD PMID:12387738 MGI:2388503 NCBI chr  X:127,587,401...127,639,063
Ensembl chr  X:127,590,650...127,630,200
JBrowse link
G Il15 interleukin 15 acts_upstream_of_or_within ISO MGI:2136897 (MGI:1354083|PMID:10704459) RGD PMID:10704459 MGI:1354083 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor involved_in ISO MGI:2178233 (MGI:3849544|PMID:19423665) RGD PMID:19423665 MGI:3849544 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
positive regulation of NK T cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd1d1 CD1d1 molecule acts_upstream_of_or_within ISO (MGI:2180705|PMID:10201995), (MGI:3041278|PMID:11754812), (MGI:72888|PMID:7538697) RGD PMID:7538697 PMID:10201995 PMID:11754812 MGI:2180705 MGI:3041278 MGI:72888 NCBI chr 2:172,423,582...172,427,089
Ensembl chr 2:172,423,582...172,427,089
JBrowse link
G Il12a interleukin 12A involved_in ISO (PMID:19088061) RGD PMID:19088061 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B involved_in ISO (PMID:19088061) RGD PMID:19088061 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO (PMID:19088061) RGD PMID:19088061 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
positive regulation of NK T cell proliferation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il12a interleukin 12A involved_in ISO (PMID:19088061) RGD PMID:19088061 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B involved_in ISO (PMID:19088061) RGD PMID:19088061 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il12rb1 interleukin 12 receptor subunit beta 1 involved_in ISO (PMID:19088061) RGD PMID:19088061 NCBI chr16:18,620,228...18,633,207
Ensembl chr16:18,620,770...18,632,769
JBrowse link
G Il12rb2 interleukin 12 receptor subunit beta 2 involved_in ISO (PMID:19088061) RGD PMID:19088061 NCBI chr 4:96,424,615...96,515,327
Ensembl chr 4:96,426,842...96,515,289
JBrowse link
G Il18 interleukin 18 involved_in IEA
ISO
GO_REF:0000107
(PMID:19088061)
Ensembl
RGD
PMID:19088061 GO_REF:0000107 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il23a interleukin 23 subunit alpha involved_in ISO (PMID:19088061) RGD PMID:19088061 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Jak2 Janus kinase 2 involved_in ISO (PMID:19088061) RGD PMID:19088061 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Rasal3 RAS protein activator like 3 involved_in ISO (PMID:25652366) RGD PMID:25652366 NCBI chr 7:11,396,090...11,411,349
Ensembl chr 7:11,396,090...11,411,465
JBrowse link
G Tyk2 tyrosine kinase 2 involved_in ISO (PMID:19088061) RGD PMID:19088061 NCBI chr 8:19,641,881...19,667,157
Ensembl chr 8:19,641,884...19,667,044
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20091
    immune system process 2569
      leukocyte activation 1038
        lymphocyte activation 849
          T cell activation 567
            alpha-beta T cell activation 190
              NK T cell activation 16
                NK T cell activation involved in immune response + 0
                NK T cell proliferation + 13
                negative regulation of NK T cell activation + 2
                positive regulation of NK T cell activation + 10
                regulation of NK T cell activation + 12
Path 2
Term Annotations click to browse term
  biological_process 20091
    cellular process 18675
      cell activation 1190
        leukocyte activation 1038
          lymphocyte activation 849
            T cell activation 567
              alpha-beta T cell activation 190
                NK T cell activation 16
                  NK T cell activation involved in immune response + 0
                  NK T cell proliferation + 13
                  negative regulation of NK T cell activation + 2
                  positive regulation of NK T cell activation + 10
                  regulation of NK T cell activation + 12
paths to the root