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ONTOLOGY REPORT - ANNOTATIONS


Term:regulation of actin nucleation
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Accession:GO:0051125 term browser browse the term
Definition:Any process that modulates the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament.


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regulation of actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vil1 villin 1 involved_in ISO (PMID:16921170), (PMID:17182858), (PMID:19808673) RGD PMID:16921170 PMID:17182858 PMID:19808673 NCBI chr 9:81,689,802...81,717,623
Ensembl chr 9:81,689,802...81,717,621
JBrowse link
G Washc5 WASH complex subunit 5 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:3573938|MGI:5910638 (MGI:5883184|PMID:27390154)
RGD PMID:27390154, PMID:21873635 MGI:5883184, RGD:13792537 NCBI chr 7:99,625,379...99,677,237
Ensembl chr 7:99,625,619...99,677,268
JBrowse link
negative regulation of actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arpin actin-related protein 2/3 complex inhibitor involved_in ISO
IBA
(PMID:24132237)
PMID:21873635
RGD PMID:24132237, PMID:21873635 RGD:13792537 NCBI chr 1:141,664,790...141,672,789
Ensembl chr 1:141,662,850...141,672,810
JBrowse link
G Coro1a coronin 1A involved_in ISO (PMID:17442961) RGD PMID:17442961 NCBI chr 1:198,123,883...198,128,890
Ensembl chr 1:198,123,884...198,128,857
JBrowse link
negative regulation of Arp2/3 complex-mediated actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Coro1b coronin 1B involved_in IEA
ISO
GO_REF:0000107
(PMID:17350576), (PMID:18775315)
Ensembl
RGD
PMID:17350576 PMID:18775315 GO_REF:0000107 NCBI chr 1:219,397,827...219,403,253
Ensembl chr 1:219,397,850...219,403,260
JBrowse link
G Ctnna2 catenin alpha 2 involved_in ISO (PMID:30013181) RGD PMID:30013181 NCBI chr 4:107,880,611...109,042,724
Ensembl chr 4:107,881,826...108,008,484
JBrowse link
G Dnai3 dynein axonemal intermediate chain 3 involved_in ISO (PMID:32128961) RGD PMID:32128961 NCBI chr 2:251,912,432...251,970,699
Ensembl chr 2:251,912,368...251,970,768
JBrowse link
G Gmfb glia maturation factor, beta involved_in IBA
IEA
PMID:21873635
GO_REF:0000002
InterPro PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr15:23,597,846...23,611,541
Ensembl chr15:23,601,368...23,606,634
JBrowse link
G Gmfg glia maturation factor, gamma involved_in
acts_upstream_of_or_within
IEA
ISO
IBA
GO_REF:0000107
(MGI:5505367|PMID:23727094)
PMID:21873635
Ensembl
RGD
PMID:23727094, PMID:21873635 GO_REF:0000107 MGI:5505367, RGD:13792537 NCBI chr 1:85,312,473...85,322,860
Ensembl chr 1:85,312,528...85,317,968
JBrowse link
G Hip1r huntingtin interacting protein 1 related involved_in ISO (MGI:5805366|PMID:17318189) RGD PMID:17318189 MGI:5805366 NCBI chr12:38,024,517...38,053,184
Ensembl chr12:38,024,519...38,053,085
JBrowse link
G Pick1 protein interacting with PRKCA 1 involved_in IDA PMID:18297063 UniProt PMID:18297063 RGD:8554748 NCBI chr 7:120,465,472...120,484,824
Ensembl chr 7:120,465,130...120,484,840
JBrowse link
positive regulation of actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fmn1 formin 1 acts_upstream_of_or_within ISO (MGI:3027450|PMID:14647292) RGD PMID:14647292 MGI:3027450 NCBI chr 3:104,783,093...105,170,761
Ensembl chr 3:104,816,987...105,086,436
JBrowse link
G Gsn gelsolin involved_in ISO (PMID:19666531) RGD PMID:19666531 NCBI chr 3:14,456,106...14,508,922
Ensembl chr 3:14,467,330...14,508,911
JBrowse link
G Magel2 MAGE family member L2 acts_upstream_of_or_within ISO MGI:1916017 (MGI:5603599|PMID:23452853) RGD PMID:23452853 MGI:5603599 NCBI chr 1:123,015,404...123,019,945
Ensembl chr 1:123,015,746...123,019,522
JBrowse link
G Scin scinderin involved_in ISO (PMID:19666531) RGD PMID:19666531 NCBI chr 6:59,975,375...60,055,075
Ensembl chr 6:59,976,003...60,054,279
JBrowse link
G Trim27 tripartite motif-containing 27 acts_upstream_of_or_within ISO MGI:1916017 (MGI:5603599|PMID:23452853) RGD PMID:23452853 MGI:5603599 NCBI chr17:45,613,863...45,626,212
Ensembl chr17:45,613,864...45,626,212
JBrowse link
G Whamm WASP homolog associated with actin, golgi membranes and microtubules involved_in ISO (PMID:18614018) RGD PMID:18614018 NCBI chr 1:143,401,986...143,430,356
Ensembl chr 1:143,401,986...143,430,356
JBrowse link
positive regulation of Arp2/3 complex-mediated actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi2 abl-interactor 2 involved_in ISO (PMID:21107423) RGD PMID:21107423 NCBI chr 9:67,234,612...67,284,504
Ensembl chr 9:67,234,303...67,282,600
JBrowse link
G Brk1 BRICK1 subunit of SCAR/WAVE actin nucleating complex involved_in ISO (PMID:21107423) RGD PMID:21107423 NCBI chr 4:145,559,206...145,574,438
Ensembl chr 4:145,559,206...145,574,438
JBrowse link
G Cyfip1 cytoplasmic FMR1 interacting protein 1 involved_in ISO (PMID:21107423) RGD PMID:21107423 NCBI chr 1:114,258,773...114,347,138
Ensembl chr 1:114,258,719...114,347,137
JBrowse link
G Fchsd2 FCH and double SH3 domains 2 involved_in ISO (PMID:29887380) RGD PMID:29887380 NCBI chr 1:166,140,025...166,395,915
Ensembl chr 1:166,125,474...166,395,915
JBrowse link
G Nckap1 NCK-associated protein 1 involved_in ISO
IEA
(PMID:21107423)
GO_REF:0000107
RGD
Ensembl
PMID:21107423 GO_REF:0000107 NCBI chr 3:67,725,180...67,804,680
Ensembl chr 3:67,725,947...67,787,990
JBrowse link
G RGD1561552 similar to WASP family 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:79,064,200...79,066,932
Ensembl chr  X:79,064,204...79,066,932
JBrowse link
G Was WASP actin nucleation promoting factor involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr  X:15,155,246...15,164,099
Ensembl chr  X:15,155,230...15,164,105
JBrowse link
G Wasf1 WASP family member 1 involved_in ISO
IBA
(PMID:21107423)
PMID:21873635
RGD PMID:21107423, PMID:21873635 RGD:13792537 NCBI chr20:48,456,191...48,503,768
Ensembl chr20:48,455,705...48,503,898
JBrowse link
G Wasf2 WASP family member 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:151,319,382...151,385,051
Ensembl chr 5:151,343,493...151,381,238
JBrowse link
G Wasf3 WASP family member 3 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:10,297,896...10,391,014
Ensembl chr12:10,298,555...10,391,270
JBrowse link
G Wasl WASP like actin nucleation promoting factor involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 4:51,677,722...51,726,212
Ensembl chr 4:51,677,722...51,726,212
JBrowse link
regulation of Arp2/3 complex-mediated actin nucleation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap1ar adaptor-related protein complex 1 associated regulatory protein acts_upstream_of_or_within ISO MGI:1923959 (MGI:5429457|PMID:22689987) RGD PMID:22689987 MGI:5429457 NCBI chr 2:232,146,418...232,178,813
Ensembl chr 2:232,147,690...232,178,671
JBrowse link
G Arf1 ADP-ribosylation factor 1 involved_in IDA PMID:23889934 UniProt PMID:23889934 RGD:8553918 NCBI chr10:45,562,700...45,579,214
Ensembl chr10:45,563,547...45,579,029
JBrowse link
G Arfip1 ADP-ribosylation factor interacting protein 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:183,503,250...183,582,798
Ensembl chr 2:183,504,330...183,582,553
JBrowse link
G Arfip2 ADP-ribosylation factor interacting protein 2 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:170,464,995...170,471,138
Ensembl chr 1:170,466,395...170,471,076
JBrowse link
G Coro1b coronin 1B involved_in IC PMID:22619279 UniProt PMID:22619279 RGD:10047170 NCBI chr 1:219,397,827...219,403,253
Ensembl chr 1:219,397,850...219,403,260
JBrowse link
G Pick1 protein interacting with PRKCA 1 involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:120,465,472...120,484,824
Ensembl chr 7:120,465,130...120,484,840
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19612
    cellular process 18457
      actin filament-based process 831
        actin cytoskeleton organization 744
          actin filament organization 466
            actin nucleation 51
              regulation of actin nucleation 32
                negative regulation of actin nucleation + 9
                positive regulation of actin nucleation + 17
                regulation of Arp2/3 complex-mediated actin nucleation + 22
Path 2
Term Annotations click to browse term
  biological_process 19612
    cellular process 18457
      cellular component organization or biogenesis 6724
        cellular component organization 6479
          regulation of cellular component organization 2589
            regulation of organelle organization 1268
              regulation of cytoskeleton organization 557
                regulation of actin cytoskeleton organization 380
                  regulation of actin filament organization 288
                    regulation of actin polymerization or depolymerization 200
                      regulation of actin filament polymerization 181
                        positive regulation of actin filament polymerization 99
                          actin nucleation 51
                            regulation of actin nucleation 32
                              negative regulation of actin nucleation + 9
                              positive regulation of actin nucleation + 17
                              regulation of Arp2/3 complex-mediated actin nucleation + 22
paths to the root