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ONTOLOGY REPORT - ANNOTATIONS

Term:hepoxilin A3 synthase activity
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Accession:GO:0051120 term browser browse the term
Definition:Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate. 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid is also known as 12S-HpETE, and (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate as hepoxilin A3.
Synonyms:xref: reactome:R-HSA-2161794 "Arachidonic acid is converted to HXA3/B3 by ALOX12";   reactome:R-HSA-8942208 "ALOXE3 isomerises 12R-HpETE to HXA3"


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hepoxilin A3 synthase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alox15 arachidonate 15-lipoxygenase IDA RGD PMID:15123652 RGD:5509794 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Aloxe3 arachidonate epidermal lipoxygenase 3 enables ISO
ISS
IBA		 (PMID:12881489), (PMID:17045234)
GO_REF:0000024
GO_REF:0000033
MGI:5496904 (MGI:3694035|PMID:17045234), (PMID:22832496)
MGI:5496904 (PMID:17045234), (PMID:22832496)		 RGD
UniProt
GO_Central		 PMID:12881489 PMID:17045234 PMID:22832496 GO_REF:0000024 GO_REF:0000033 MGI:3694035 NCBI chr10:53,830,219...53,854,328
Ensembl chr10:53,831,264...53,854,328 		JBrowse link
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  molecular_function 20736
    catalytic activity 6109
      isomerase activity 212
        hepoxilin A3 synthase activity 2
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